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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
16/08/2022 |
Actualizado : |
27/04/2023 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
MCWHORTER, T.M.; BERMANN, M.; GARCIA, A.L.S.; LEGARRA, A.; AGUILAR, I.; MISZTAL, I.; LOURENCO, D. |
Afiliación : |
TAYLOR M. MCWHORTER, Department of Animal and Dairy Science, University of Georgia, Athens, Georgia, USA; MATIAS BERMANN, Department of Animal and Dairy Science, University of Georgia, Athens, Georgia, USA; ANDRE L. S. GARCIA, Department of Animal and Dairy Science, University of Georgia, Athens, Georgia, USA; ANDRÉS LEGARRA, UMR GenPhySE, Institut National de la Recherche Agronomique, Castanet- Tolosan, France; IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; IGNACY MISZTAL, Department of Animal and Dairy Science, University of Georgia, Athens, Georgia, USA; DANIELA LOURENCO, Department of Animal and Dairy Science, University of Georgia, Athens, Georgia, USA. |
Título : |
Implication of the order of blending and tuning when computing the genomic relationship matrix in single-step GBLUP. |
Fecha de publicación : |
2023 |
Fuente / Imprenta : |
Journal of Animal Breeding and Genetics, 2023, volume 140, issue 1, pp. 60-78. OPEN ACCESS. doi: https://doi.org/10.1111/jbg.12734 |
ISSN : |
0931-2668; eISSN: 1439-0388 |
DOI : |
10.1111/jbg.12734 |
Idioma : |
Inglés |
Notas : |
Article history: Received 18 March 2019; Revised 15 July 2019; Accepted: 29 July 2019; First published 10 August 2022.
Correspondence: McWhorter, T.M.; Department of Animal and Dairy Science, University of Georgia, Athens, GA, United States; email:taylor.mcwhorter@uga.edu --
This study was partially funded by Agriculture and Food Research Initiative Competitive Grant no. 2020?67015?31030 from the U.S. Department of Agriculture, Australian Government's National Institute of Food and Agriculture (Washington, DC). -- This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. License Creative Commons: https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Contenido : |
ABSTRACT.- Single-step genomic BLUP (ssGBLUP) relies on the combination of the genomic ((Formula presented.)) and pedigree relationship matrices for all ((Formula presented.)) and genotyped ((Formula presented.)) animals. The procedure ensures (Formula presented.) and (Formula presented.) are compatible so that both matrices refer to the same genetic base (?tuning?). Then (Formula presented.) is combined with a proportion of (Formula presented.) (?blending?) to avoid singularity problems and to account for the polygenic component not accounted for by markers. This computational procedure has been implemented in the reverse order (blending before tuning) following the sequential research developments. However, blending before tuning may result in less optimal tuning because the blended matrix already contains a proportion of (Formula presented.). In this study, the impact of ?tuning before blending? was compared with ?blending before tuning? on genomic estimated breeding values (GEBV), single nucleotide polymorphism (SNP) effects and indirect predictions (IP) from ssGBLUP using American Angus Association and Holstein Association USA, Inc. data. Two slightly different tuning methods were used; one that adjusts the mean diagonals and off-diagonals of (Formula presented.) to be similar to those in (Formula presented.) and another one that adjusts based on the average difference between all elements of (Formula presented.) and (Formula presented.). Over 6 million Angus growth records and 5.9 million Holstein udder depth records were available. Genomic information was available on 51,478 Angus and 105,116 Holstein animals. Average realized relationship estimates among groups of animals were similar across scenarios. Scatterplots show that GEBV, SNP effects and IP did not noticeably change for all animals in the evaluation regardless of the order of computations and when using blending parameter of 0.05. Formulas were derived to determine the blending parameter that maximizes changes in the genomic relationship matrix and GEBV when changing the order of blending and tuning. Algebraically, the change is maximized when the blending parameter is equal to 0.5. Overall, tuning (Formula presented.) before blending, regardless of blending parameter used, had a negligible impact on genomic predictions and SNP effects in this study. © 2022 The Authors. Journal of Animal Breeding and Genetics published by John Wiley & Sons Ltd. MenosABSTRACT.- Single-step genomic BLUP (ssGBLUP) relies on the combination of the genomic ((Formula presented.)) and pedigree relationship matrices for all ((Formula presented.)) and genotyped ((Formula presented.)) animals. The procedure ensures (Formula presented.) and (Formula presented.) are compatible so that both matrices refer to the same genetic base (?tuning?). Then (Formula presented.) is combined with a proportion of (Formula presented.) (?blending?) to avoid singularity problems and to account for the polygenic component not accounted for by markers. This computational procedure has been implemented in the reverse order (blending before tuning) following the sequential research developments. However, blending before tuning may result in less optimal tuning because the blended matrix already contains a proportion of (Formula presented.). In this study, the impact of ?tuning before blending? was compared with ?blending before tuning? on genomic estimated breeding values (GEBV), single nucleotide polymorphism (SNP) effects and indirect predictions (IP) from ssGBLUP using American Angus Association and Holstein Association USA, Inc. data. Two slightly different tuning methods were used; one that adjusts the mean diagonals and off-diagonals of (Formula presented.) to be similar to those in (Formula presented.) and another one that adjusts based on the average difference between all elements of (Formula presented.) and (Formula presented.). Over 6 million Angus growth rec... Presentar Todo |
Palabras claves : |
Genetic base; Indirect predictions; Residual polygenic effect; Scaling of genomic matrices; Single-step genomic best linear unbiased prediction. |
Asunto categoría : |
L10 Genética y mejoramiento animal |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/16748/1/J-Animal-Breeding-Genetics-2022-McWhorter-Implication-of-the-order-of-blending-and-tuning-when-computing-the-genomic.pdf
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jbg.12734?download=true
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Marc : |
LEADER 04321naa a2200289 a 4500 001 1063528 005 2023-04-27 008 2023 bl uuuu u00u1 u #d 022 $a0931-2668; eISSN: 1439-0388 024 7 $a10.1111/jbg.12734$2DOI 100 1 $aMCWHORTER, T.M. 245 $aImplication of the order of blending and tuning when computing the genomic relationship matrix in single-step GBLUP.$h[electronic resource] 260 $c2023 500 $aArticle history: Received 18 March 2019; Revised 15 July 2019; Accepted: 29 July 2019; First published 10 August 2022. Correspondence: McWhorter, T.M.; Department of Animal and Dairy Science, University of Georgia, Athens, GA, United States; email:taylor.mcwhorter@uga.edu -- This study was partially funded by Agriculture and Food Research Initiative Competitive Grant no. 2020?67015?31030 from the U.S. Department of Agriculture, Australian Government's National Institute of Food and Agriculture (Washington, DC). -- This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. License Creative Commons: https://creativecommons.org/licenses/by-nc-nd/4.0/ 520 $aABSTRACT.- Single-step genomic BLUP (ssGBLUP) relies on the combination of the genomic ((Formula presented.)) and pedigree relationship matrices for all ((Formula presented.)) and genotyped ((Formula presented.)) animals. The procedure ensures (Formula presented.) and (Formula presented.) are compatible so that both matrices refer to the same genetic base (?tuning?). Then (Formula presented.) is combined with a proportion of (Formula presented.) (?blending?) to avoid singularity problems and to account for the polygenic component not accounted for by markers. This computational procedure has been implemented in the reverse order (blending before tuning) following the sequential research developments. However, blending before tuning may result in less optimal tuning because the blended matrix already contains a proportion of (Formula presented.). In this study, the impact of ?tuning before blending? was compared with ?blending before tuning? on genomic estimated breeding values (GEBV), single nucleotide polymorphism (SNP) effects and indirect predictions (IP) from ssGBLUP using American Angus Association and Holstein Association USA, Inc. data. Two slightly different tuning methods were used; one that adjusts the mean diagonals and off-diagonals of (Formula presented.) to be similar to those in (Formula presented.) and another one that adjusts based on the average difference between all elements of (Formula presented.) and (Formula presented.). Over 6 million Angus growth records and 5.9 million Holstein udder depth records were available. Genomic information was available on 51,478 Angus and 105,116 Holstein animals. Average realized relationship estimates among groups of animals were similar across scenarios. Scatterplots show that GEBV, SNP effects and IP did not noticeably change for all animals in the evaluation regardless of the order of computations and when using blending parameter of 0.05. Formulas were derived to determine the blending parameter that maximizes changes in the genomic relationship matrix and GEBV when changing the order of blending and tuning. Algebraically, the change is maximized when the blending parameter is equal to 0.5. Overall, tuning (Formula presented.) before blending, regardless of blending parameter used, had a negligible impact on genomic predictions and SNP effects in this study. © 2022 The Authors. Journal of Animal Breeding and Genetics published by John Wiley & Sons Ltd. 653 $aGenetic base 653 $aIndirect predictions 653 $aResidual polygenic effect 653 $aScaling of genomic matrices 653 $aSingle-step genomic best linear unbiased prediction 700 1 $aBERMANN, M. 700 1 $aGARCIA, A.L.S. 700 1 $aLEGARRA, A. 700 1 $aAGUILAR, I. 700 1 $aMISZTAL, I. 700 1 $aLOURENCO, D. 773 $tJournal of Animal Breeding and Genetics, 2023, volume 140, issue 1, pp. 60-78. OPEN ACCESS. doi: https://doi.org/10.1111/jbg.12734
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161. | | ROSAS, J.E.; ALE, L.; REBOLLO, I.; SCHEFFEL, S.; AGUILAR, I.; MOLINA, F.; PÉREZ DE VIDA, F. Boosting INIA's Rice Breeding Program with molecular quantitative genetics approaches. [Abstract]. In: International Temperate Rice Conference (7., 2020, Pelotas, RS), Science & Innovation: feeding a world of 10 billion people: proceedings. Pelotas RS, Brasil, February 9-12, 2020. Brasília, DF : Embrapa, 2020.Tipo: Abstracts/Resúmenes |
Biblioteca(s): INIA Treinta y Tres. |
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162. | | BALMELLI, G.; SIMETO, S.; CASTILLO, A.; GASPARRI, P.; CABRERA, D.; AGUILAR, I.; QUEZADA, M.; DA SILVA, C.; GIORELLO, F. Breeding for resistance to Teratosphaeria nubilosa on Eucalyptus globulus. In: Pesquisa florestal brasileira = Brazilian journal of forestry research., v. 39, e201902043, Special issue, 2019. Colombo : Embrapa Florestas, 2019. Congreso IUFRO, 25., Curitiba, Brasil, 29 setiembre-05 octubre, 2019. Abstracts. p. 173Tipo: Abstracts/Resúmenes |
Biblioteca(s): INIA Tacuarembó. |
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163. | | BRUNES, L.C.; FARIA, C.U.D.; MAGNABOSCO, C.U.; LOBO, R.B.; PERIPOLLI, E.; AGUILAR, I.; BALDI, F. Genomic prediction ability and genetic parameters for residual feed intake calculated using different approaches and their associations with growth, reproductive, and carcass traits in Nellore cattle. Journal of Applied Genetics, 2023, Volume 64, Issue 1, Pages 159 - 167. doi: https://doi.org/10.1007/s13353-022-00734-8 Article history: Received 25 February 2022; Revised 3 September 2022; Accepted 26 October 2022; Published online 15 November 2022; Published February 2023. -- Corresponding author: Brunes, L.C.; Animal Performance Center, Embrapa...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Las Brujas. |
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164. | | GRASSO, A.; GOLDBERG, V.; NAVAJAS, E.; IRIARTE, W.; GIMENO, D.; AGUILAR, I.; MEDRANO, J.F.; RINCÓN, G.; CIAPPESONI, G. Genomic variation and population structure detected by single nucleotide polymorphism arrays in Corriedale, Merino and Creole sheep. Genetics and Molecular Biology, 2014, v.37, n.2, p.389-395. Article history: Received: August 29, 2013 / Accepted: March 16, 2014.Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : B - 1 |
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166. | | CHEN, C. Y.; MISZTAL, I.; AGUILAR, I.; TSURUTA, S.; MEUWISSEN, T.; AGGREY, S. E.; MUIR, W. M. Genome wide marker assisted selection in chicken: making the most of all data, pedigree, phenotypic, and genomic in a simple one step procedure. Volume Genetic improvement programmes: Selection using molecular information - Lecture Sessions, 0288. In: Proceedings of the World Congress on Genetics Applied to Livestock Production, 9., Leipzig, Germany, August 1-6, 2010. p. 0288. Acknowledgements: The authors thank Cobb-Vantress for access to data for this study. This study was partially funded by the Holstein Association, Smithfield Premium Genetics, and by AFRI grants 2009-65205-05665 and 2010-65205-20366 from...Tipo: Trabajos en Congresos/Conferencias |
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167. | | RODRÍGUEZ, J.D.; PERIPOLLI, E.; LONDOÑO-GIL, M.; ESPIGOLAN, R.; LÔBO, R. B.; LÓPEZ-CORREA, R.; AGUILAR, I.; BALDI, F. Effect of minor allele frequency and density of single nucleotide polymorphism marker arrays on imputation performance and prediction ability using the single-step genomic Best Linear Unbiased Prediction in a simulated beef cattle population. Research paper. Animal Production Science. 2023, volume 63, issue 9, p. 844-852. https://doi.org/10.1071/AN21581 Article history: Submitted 1 December 2021, Accepted 1 March 2023, Published 4 April 2023. -- Correspondence to: Juan Diego Rodríguez,
Universidade Estadual Paulista (Unesp), Faculdade de Ciências Agrarias e Veterinárias, Departamento...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
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168. | | MISZTAL, I.; FRAGOMENI, B.; LOURENÇO, D. A. L.; TSURUTA, S.; MASUDA, Y.; AGUILAR, I.; LEGARRA, A.; LAWLOR, T. J. Efficient inversion of genomic relationship matrix by the Algorithm for Proven and Young (APY). Interbull Bulletin, 2015, v. 49, p. 111-116.Tipo: Artículos Indexados |
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169. | | MASUDA, Y.; MISZTAL, I.; TSURUTA, S.; LEGARRA, A.; AGUILAR, I.; LOURENCO, D.A.L.; FRAGOMENI, B.O.; LAWLOR, T.J. Implementation of genomic recursions in single-step genomic best linear unbiased predictor for US Holsteins with a large number of genotyped animals. Journal of Dairy Science, 2016, v.99, no.3, p.1968-1974. OPEN ACCESS OPEN ACCESS. Received 19 October 2015, Accepted 1 December 2015, Available online 21 January 2016Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
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170. | | MCWHORTER, T.M.; BERMANN, M.; GARCIA, A.L.S.; LEGARRA, A.; AGUILAR, I.; MISZTAL, I.; LOURENCO, D. Implication of the order of blending and tuning when computing the genomic relationship matrix in single-step GBLUP. Journal of Animal Breeding and Genetics, 2023, volume 140, issue 1, pp. 60-78. OPEN ACCESS. doi: https://doi.org/10.1111/jbg.12734 Article history: Received 18 March 2019; Revised 15 July 2019; Accepted: 29 July 2019; First published 10 August 2022.
Correspondence: McWhorter, T.M.; Department of Animal and Dairy Science, University of Georgia, Athens, GA, United...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
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171. | | NEGRI, R.; AGUILAR, I.; FELTES, G. L.; MACHADO, J. D.; NETO, J. B.; COSTA-MAIA, F. M.; COBUCI, J. A. Inclusion of bioclimatic variables in genetic evaluations of dairy cattle.[Open Access]. Animal Bioscience [Asian-Australasian Journal of Animal Sciences], Volume 34, Issue 2, February 2021, Pages 163-171. Doi: https://doi.org/10.5713/ajas.19.0960 Article history: Submitted Dec 16, 2019 / Revised Mar 27, 2020 / Accepted Apr 28, 2020.
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172. | | RAVAGNOLO, O.; NAVAJAS, E.; AGUILAR, I.; CIAPPESONI, G.; LEMA, O.M.; MONTOSSI, F.; PERAZA, P.; DALLA RIZZA, M. Mejoramiento genético animal e importancia del banco de ADN. ln: INIA TACUAREMBÓ. UNIDAD DE BIOTECNOLOGÍA INIA. Jornada técnica. Jornada de Agrobiotecnología INIA, 15 NOVIEMBRE, Tacuarembó, Biotecnología para el sector productivo: situación actual y perspectivas. Tacuarembó (Uruguay): INIA, 2012. p. 4-7 (INIA Serie Actividades de Difusión; 702)Tipo: Actividades de Difusión |
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173. | | LOURENCO, D.A.L.; MISZTAL, I.; TSURUTA, S.; AGUILAR, I.; EZRA, E.; RON, M.; SHIRAK, A.; WELLER, J.I. Methods for genomic evaluation of a relatively small genotyped dairy population and effect of genotyped cow information in multiparity analyses. Journal of Dairy Science, 2014, v.97, no.3, p.1742-1752. OPEN ACCESS. Article history: Received September 10, 2013. / Accepted December 6, 2013.Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : A - 1 |
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174. | | FRAGOMENI, B.O.; LOURENCO, D.A.L.; TSURUTA, S.; MASUDA, Y.; AGUILAR, I.; LEGARRA, A.; LAWLOR, T.J.; MIZTAL, I. Hot topic: Use of genomic recursions in single-step genomic best linear unbiased predictor (BLUP) with a large number of genotypes. Journal of Dairy Science, 2015, v.98, no.6, p.4090-4094. OPEN ACCESS. Article history: Received November 18, 2014 / Accepted March 13, 2015 / Published online: April 8, 2015.Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
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175. | | LOURENCO, D.; TSURUTA, S.; FRAGOMENI, B.; MASUDA, Y.; AGUILAR, I.; LEGARRA, A.; MILLER, S.; MOSER, D.; MISZTAL, I. Single-step genomic BLUP for national beef cattle evaluation in US: from initial developments to final implementation. Volume Species - Bovine (beef) 1, 495. In: Proceedings of the World Congress on Genetics Applied to Livestock Production, 11., Aotea Centre Auckland, New Zealand: WCGALP, ICAR, 11-16 feb 2018.Tipo: Trabajos en Congresos/Conferencias |
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176. | | MASUDA, Y.; MISZTAL, I.; TSURUTA, S.; LOURENÇO, D. A. L.; FRAGOMENI, B.; LEGARRA, A.; AGUILAR, I.; LAWLOR, T. J. Single-step genomic evaluations with 570K genotyped animals in US Holsteins. Interbull Bulletin, 2015, v. 49, p. 85-89.Tipo: Artículos Indexados |
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177. | | FORNERIS, N. S.; LEGARRA, A.; VITEZICA, Z. G.; TSURUTA, S.; AGUILAR, I.; MISZTAL, I.; CANTET, R. J. C. Quality control of genotypes using heritability estimates of gene content at the marker. Genetics, 2015, v. 199, p. 675-681. OPEN ACCESS. Manuscript received September 26, 2014; accepted for publication December 18, 2014; published Early Online January 6, 2015.Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
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178. | | FORNERIS, N. S.; LEGARRA, A.; VITEZICA, Z. G.; TSURUTA, S.; AGUILAR, I.; CANTET, R.J.C.; MISZTAL, I. Quality control of genotypes using heritability estimates of gene content. Volume Genetic Improvement Programs: Selection using molecular information (Posters), 471. In: Proceedings of the World Congress on Genetics Applied to Livestock Production, 10., Vancouver, BC, Canada, August 17-22, 2014. p.471.Tipo: Trabajos en Congresos/Conferencias |
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179. | | Aguilar, I.; Pravia, M.I.; Ravagnolo, O.; Chiappesoni, G.; Mattos, M.; Ahlig, I.; Urioste, J.; Naya, H. Servicio de evaluación de reproductores Aberdeen Angus Las Brujas, Canelones (Uruguay): INIA, 2004. 23 pBiblioteca(s): INIA La Estanzuela. |
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180. | | LONDOÑO-GIL, M.; LÓPEZ-CORREA, R.; AGUILAR, I.; MAGNABOSCO, C.U.; HIDALGO, J.; BUSSIMAN, F.; BALDI, F.; LOURENCO, D. Strategies for genomic predictions of an indicine multi-breed population using single-step GBLUP. Journal of Animal Breeding and Genetics, 2024. https://doi.org/10.1111/jbg.12882 - [Early view] Article history: Received 22 March 2024, Revised 10 May 2024, Accepted 15 May 2024. -- Corresponding author: Londoño-Gil, M.; Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista Júlio de Mesquita Filho, Via de...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
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