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| Registros recuperados : 5 | |
| 1. |  | AGUILAR, I.; MISZTAL, I.; TSURUTA, S.; LEGARRA, A.; WANG, H. PREGSF90 - POSTGSF90: Computational tools for the implementation of single-step genomic selection and genome-wide association with ungenotyped individuals in BLUPF90 programs. Volume Methods and Tools: Statistical and genomic tools for mapping QTL and genes (Posters), 680. In: Proceedings of the World Congress on Genetics Applied to Livestock Production, 10., Vancouver, BC, Canada, August 17-22, 2014. p.680.| Biblioteca(s): INIA Las Brujas. |
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| 3. | | LOURENCO, D.A.L.; MISZTAL, I.; WANG, H.; AGUILAR, I.; TSURUTA, S.; BERTRAND, J.K. Prediction accuracy for a simulated maternally affected trait of beef cattle using different genomic evaluation models. Journal of Animal Science, 2013, v.91, no.9, p.4090-4098. Article history: Published online July 26, 2013.
This study was partially funded by the American Angus Association (St. Joseph, MO) and the USDA Agriculture and Food Research Initiative (Grant no. 2009-65205-05665 from the USDA National...| Biblioteca(s): INIA Las Brujas. |
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| 4. | | WANG, H.; MISZTAL, I.; AGUILAR, I.; LEGARRA, A.; FERNANDO, R.L.; VITEZICA, Z.; OKIMOTO, R.; WING, T.; HAWKEN, R.; MUIR, W.M. Genome-wide association mapping including phenotypes from relatives without genotypes in a single-step (ssGWAS) for 6-week body weight in broiler chickens. Frontiers in Genetics, 2014, v.5, p.1-10. OPEN ACCESS. Article history: Received 03 March 2014 // Paper pending published 04 April 2014 // Accepted 25 April 2014 // Published online: 20 May 2014.| Biblioteca(s): INIA Las Brujas. |
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| 5. | | MISZTAL, I.; WANG, H.; AGUILAR, I.; LEGARRA, A.; TSURUTA, S.; LOURENCO, D.; FRAGOMENI, B. O.; ZHANG, X.; MUIR, W. M.; CHENG, H. H.; OKIMOTO, R.; WING, T.; HAWKEN, R. R.; ZUMBACH, B.; FERNANDO, R. GWAS using ssGBLUP. Volume Species Breeding: Poultry, 325. In: Proceedings of the World Congress on Genetics Applied to Livestock Production, 10., Vancouver, BC, Canada, August 17-22, 2014. p.325.| Biblioteca(s): INIA Las Brujas. |
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| Registros recuperados : 5 | |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
29/09/2014 |
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Actualizado : |
15/10/2019 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
B - 2 |
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Autor : |
WANG, H.; MISZTAL, I.; AGUILAR, I.; LEGARRA, A.; MUIR, W.M. |
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Afiliación : |
IGNACIO AGUILAR GARCIA, Instituto Nacional de Investigación Agropecuaria (INIA), Uruguay. |
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Título : |
Genome-wide association mapping including phenotypes from relatives without genotypes. |
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Fecha de publicación : |
2012 |
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Fuente / Imprenta : |
Genetics Research, 2012, v.94, no.2, p.73-83. OPEN ACCESS. |
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ISSN : |
0016-6723 |
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DOI : |
10.1017/S0016672312000274 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 19 September 2011 / Revised 8 December 2011 and 9 March 2012. / Accepted 13 March 2012. |
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Contenido : |
ABSTRACT.
A common problem for genome-wide association analysis (GWAS) is lack of power for detection of quantitative trait loci (QTLs) and precision for fine mapping. Here, we present a statistical method, termed single-step GBLUP (ssGBLUP), which increases both power and precision without increasing genotyping costs by taking advantage of phenotypes from other related and unrelated subjects. The procedure achieves these goals by blending traditional pedigree relationships with those derived from genetic markers, and by conversion of estimated breeding values (EBVs) to marker effects and weights. Additionally, the application of mixed model approaches allow for both simple and complex analyses that involve multiple traits and confounding factors, such as environmental, epigenetic or maternal environmental effects. Efficiency of the method was examined using simulations with 15 800 subjects, of which 1500 were genotyped. Thirty QTLs were simulated across genome and assumed heritability was 05. Comparisons included ssGBLUP applied directly to phenotypes, BayesB and classical GWAS (CGWAS) with deregressed proofs. An average accuracy of prediction 089 was obtained by ssGBLUP after one iteration, which was 001 higher than by BayesB. Power and precision for GWAS applications were evaluated by the correlation between true QTL effects and the sum of m adjacent single nucleotide polymorphism (SNP) effects. The highest correlations were 082 and 074 for ssGBLUP and CGWAS with m=8, and 083 for BayesB with m=16. Standard deviations of the correlations across replicates were several times higher in BayesB than in ssGBLUP. The ssGBLUP method with marker weights is faster, more accurate and easier to implement for GWAS applications without computing pseudo-data.
© Cambridge University Press 2012. MenosABSTRACT.
A common problem for genome-wide association analysis (GWAS) is lack of power for detection of quantitative trait loci (QTLs) and precision for fine mapping. Here, we present a statistical method, termed single-step GBLUP (ssGBLUP), which increases both power and precision without increasing genotyping costs by taking advantage of phenotypes from other related and unrelated subjects. The procedure achieves these goals by blending traditional pedigree relationships with those derived from genetic markers, and by conversion of estimated breeding values (EBVs) to marker effects and weights. Additionally, the application of mixed model approaches allow for both simple and complex analyses that involve multiple traits and confounding factors, such as environmental, epigenetic or maternal environmental effects. Efficiency of the method was examined using simulations with 15 800 subjects, of which 1500 were genotyped. Thirty QTLs were simulated across genome and assumed heritability was 05. Comparisons included ssGBLUP applied directly to phenotypes, BayesB and classical GWAS (CGWAS) with deregressed proofs. An average accuracy of prediction 089 was obtained by ssGBLUP after one iteration, which was 001 higher than by BayesB. Power and precision for GWAS applications were evaluated by the correlation between true QTL effects and the sum of m adjacent single nucleotide polymorphism (SNP) effects. The highest correlations were 082 and 074 for ssGBLUP and CGWAS with m=8, an... Presentar Todo |
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Thesagro : |
ANIMALES; CRIA; FENOTIPOS; GENOTIPO; MARCADORES GENÉTICOS; MEJORAMIENTO GENÉTICO ANIMAL. |
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Asunto categoría : |
L10 Genética y mejoramiento animal |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/3348/1/Aguilar-I.-2012.-Genet.Res.Camb.-v.942-p.73-83.pdf
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Marc : |
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100 1 $aWANG, H.
245 $aGenome-wide association mapping including phenotypes from relatives without genotypes.$h[electronic resource]
260 $c2012
500 $aArticle history: Received 19 September 2011 / Revised 8 December 2011 and 9 March 2012. / Accepted 13 March 2012.
520 $aABSTRACT. A common problem for genome-wide association analysis (GWAS) is lack of power for detection of quantitative trait loci (QTLs) and precision for fine mapping. Here, we present a statistical method, termed single-step GBLUP (ssGBLUP), which increases both power and precision without increasing genotyping costs by taking advantage of phenotypes from other related and unrelated subjects. The procedure achieves these goals by blending traditional pedigree relationships with those derived from genetic markers, and by conversion of estimated breeding values (EBVs) to marker effects and weights. Additionally, the application of mixed model approaches allow for both simple and complex analyses that involve multiple traits and confounding factors, such as environmental, epigenetic or maternal environmental effects. Efficiency of the method was examined using simulations with 15 800 subjects, of which 1500 were genotyped. Thirty QTLs were simulated across genome and assumed heritability was 05. Comparisons included ssGBLUP applied directly to phenotypes, BayesB and classical GWAS (CGWAS) with deregressed proofs. An average accuracy of prediction 089 was obtained by ssGBLUP after one iteration, which was 001 higher than by BayesB. Power and precision for GWAS applications were evaluated by the correlation between true QTL effects and the sum of m adjacent single nucleotide polymorphism (SNP) effects. The highest correlations were 082 and 074 for ssGBLUP and CGWAS with m=8, and 083 for BayesB with m=16. Standard deviations of the correlations across replicates were several times higher in BayesB than in ssGBLUP. The ssGBLUP method with marker weights is faster, more accurate and easier to implement for GWAS applications without computing pseudo-data. © Cambridge University Press 2012.
650 $aANIMALES
650 $aCRIA
650 $aFENOTIPOS
650 $aGENOTIPO
650 $aMARCADORES GENÉTICOS
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773 $tGenetics Research, 2012$gv.94, no.2, p.73-83. OPEN ACCESS.
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