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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
21/02/2014 |
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Actualizado : |
18/12/2018 |
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Tipo de producción científica : |
Artículos Indexados |
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Autor : |
AGUILAR, I.; LEGARRA, A.; TSURUTA, S.; MISZTAL, I. |
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Afiliación : |
IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Genetic evaluation using unsymmetric single step genomic methodology with large number of genotypes. |
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Fecha de publicación : |
2013 |
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Fuente / Imprenta : |
Interbull Bulletin, 2013, v. 47, p. 222-225. |
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Idioma : |
Inglés |
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Contenido : |
ABSTRACT.
The single step genomic methodology provides a unified framework to integrate phenotypic, pedigree and genomic information in the prediction of breeding values. Minimal modifications of current softwares are necessary in order to incorporate extra relationship matrices, however computing such matrices has a cubic cost. Recently, a system of equations relaxing the computing cost of creating the inverse of the genomic relationship matrix was presented, which creates an unsymmetric system of equations. Bi Conjugate Gradient Stabilized solvers (BiCGSTAB) were proposed to solve unsymmetric system of equations and also can be used with iteration on data programs, resulting in a good choice for solving large-scale genetic evaluations. Here we describe the implementation of a large genetic evaluation using unsymmetric solvers within the iteration on data framework. Comparison with the regular single-step methodology is presented and the effects of different preconditioners and data structures on the convergence pattern were studied. A large scale genetic evaluation was feasible, however required more rounds to get convergence compared with the regular single-step. More sophisticated preconditioners are necessary to improve the convergence for solving unsymmetric single-step genomic evaluations. |
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Palabras claves : |
BICGSTAB; GENETIC EVALUATION; GENOMIC SELECTION; SINGLE-STEP. |
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Asunto categoría : |
-- |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/12205/1/1326-2215-1-PB.pdf
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Marc : |
LEADER 01912naa a2200205 a 4500
001 1012459
005 2018-12-18
008 2013 bl uuuu u00u1 u #d
100 1 $aAGUILAR, I.
245 $aGenetic evaluation using unsymmetric single step genomic methodology with large number of genotypes.$h[electronic resource]
260 $c2013
520 $aABSTRACT. The single step genomic methodology provides a unified framework to integrate phenotypic, pedigree and genomic information in the prediction of breeding values. Minimal modifications of current softwares are necessary in order to incorporate extra relationship matrices, however computing such matrices has a cubic cost. Recently, a system of equations relaxing the computing cost of creating the inverse of the genomic relationship matrix was presented, which creates an unsymmetric system of equations. Bi Conjugate Gradient Stabilized solvers (BiCGSTAB) were proposed to solve unsymmetric system of equations and also can be used with iteration on data programs, resulting in a good choice for solving large-scale genetic evaluations. Here we describe the implementation of a large genetic evaluation using unsymmetric solvers within the iteration on data framework. Comparison with the regular single-step methodology is presented and the effects of different preconditioners and data structures on the convergence pattern were studied. A large scale genetic evaluation was feasible, however required more rounds to get convergence compared with the regular single-step. More sophisticated preconditioners are necessary to improve the convergence for solving unsymmetric single-step genomic evaluations.
653 $aBICGSTAB
653 $aGENETIC EVALUATION
653 $aGENOMIC SELECTION
653 $aSINGLE-STEP
700 1 $aLEGARRA, A.
700 1 $aTSURUTA, S.
700 1 $aMISZTAL, I.
773 $tInterbull Bulletin, 2013$gv. 47, p. 222-225.
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Registro original : |
INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Treinta y Tres. |
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Fecha actual : |
19/05/2016 |
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Actualizado : |
15/10/2019 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
A - 2 |
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Autor : |
MITCHELL, L.M.; RAMILLA, M.J.; QUINTANS, G.; KING, M.E.; GEBBIE, F.E.; ROBINSON, J.J. |
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Afiliación : |
SAC, Animal Biology Division, Craibstone, Estate, Bucksburn, Aberdeen.; SAC, Animal Biology Division, Craibstone, Estate, Bucksburn, Aberdeen.; GRACIELA QUINTANS ILARIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. SAC, Animal Biology Division, Craibstone, Estate, Bucksburn, Aberdeen.; SAC, Animal Biology Division, Craibstone, Estate, Bucksburn, Aberdeen.; SAC, Animal Biology Division, Craibstone, Estate, Bucksburn, Aberdeen.; SAC, Animal Biology Division, Craibstone, Estate, Bucksburn, Aberdeen. |
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Título : |
Effect of diet and GnRH administration on post-pastum ovarian cyclicity in autumn-lambing ewes. |
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Fecha de publicación : |
2003 |
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Fuente / Imprenta : |
Animal Reproduction Science, 2003, v. 76, p. 67-79. |
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DOI : |
10.1016/S0378-4320(02)00239-7 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 1 May 2002 // received in revised form 22 October 2002 // accepted 8 November 2002.
Doi: https://doi.org/10.1016/S0378-4320(02)00239-7 |
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Contenido : |
Abstract:
Using autumn-lambing ewes, this study investigated (i) the effects of diet on gonadotrophin secretion and responsiveness of the hypothalamic-pituitary-ovarian axis to exogenous GnRH during the early post-partum period; and (ii) whether ovulation prior to completion of uterine involution results in an increased incidence of aberrant ovarian cycles. Thirty-two ewes rearing 1.9±0.12 lambs were equally allocated to two dietary treatments at lambing (22 October ±0.2 day). Diets comprised ad libitum hay and 1.5 kg per ewe per day of one of two concentrates (11.5 MJ ME, 195 g CP per kg) containing 300 g kg?1 cracked maize grain (M) or 300 g kg?1 sugar beet pellets (S). Half of the ewes on each diet (G) received 25 i.v. injections of 250 ng GnRH in 2 ml 0.9% saline at 2 h intervals from days 12–14 post-partum while remaining ewes (N) were monitored for the resumption of spontaneous ovarian cyclicity. Blood samples were obtained from all ewes throughout the study (lambing to 18 December) for measurement of circulating hormone concentrations and the uteri and ovaries of all ewes were examined via laparoscopy on day 21 post-partum. There were no effects of dietary treatment on ewe daily live weight loss, lamb daily live weight gain or the immediate post-partum increase in circulating FSH concentrations. Diet did not affect insulin concentrations or LH pulse frequency on day 12 post-partum but LH pulse amplitude was lower in ewes fed concentrate M compared to concentrate S (1.4±0.10 versus 1.7±0.12 ng ml?1, respectively, P<0.05) and this was associated with an increased interval to the resumption of spontaneous ovarian cycles (35±3.1 versus 26±2.1 day, respectively, P<0.05). Administration of exogenous GnRH increased (P<0.05) the proportion of ewes on both diets that ovulated within 20 days of parturition and advanced the onset of ovarian cyclicity in ewes fed concentrate M by 9.5 days (significance of interaction, P<0.05). Four ewes, all of which ovulated before day 22 post-partum, had extended luteal activity while in remaining ewes, duration of the first luteal phase was inversely related to the time of first ovulation (r2=0.16, P<0.05). Results demonstrate that (i) the onset of ovarian cyclicity is influenced by diet and can be advanced by administration of exogenous GnRH; and (ii) ovulation during the early post-partum period is associated with an increased incidence of extended luteal activity. MenosAbstract:
Using autumn-lambing ewes, this study investigated (i) the effects of diet on gonadotrophin secretion and responsiveness of the hypothalamic-pituitary-ovarian axis to exogenous GnRH during the early post-partum period; and (ii) whether ovulation prior to completion of uterine involution results in an increased incidence of aberrant ovarian cycles. Thirty-two ewes rearing 1.9±0.12 lambs were equally allocated to two dietary treatments at lambing (22 October ±0.2 day). Diets comprised ad libitum hay and 1.5 kg per ewe per day of one of two concentrates (11.5 MJ ME, 195 g CP per kg) containing 300 g kg?1 cracked maize grain (M) or 300 g kg?1 sugar beet pellets (S). Half of the ewes on each diet (G) received 25 i.v. injections of 250 ng GnRH in 2 ml 0.9% saline at 2 h intervals from days 12–14 post-partum while remaining ewes (N) were monitored for the resumption of spontaneous ovarian cyclicity. Blood samples were obtained from all ewes throughout the study (lambing to 18 December) for measurement of circulating hormone concentrations and the uteri and ovaries of all ewes were examined via laparoscopy on day 21 post-partum. There were no effects of dietary treatment on ewe daily live weight loss, lamb daily live weight gain or the immediate post-partum increase in circulating FSH concentrations. Diet did not affect insulin concentrations or LH pulse frequency on day 12 post-partum but LH pulse amplitude was lower in ewes fed concentrate M compared to concentrate S (1.... Presentar Todo |
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Thesagro : |
ALIMENTACION ANIMAL; CICLO ESTRAL; DIETA; OVEJA; REPRODUCCION ANIMAL. |
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Asunto categoría : |
-- |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/5724/1/Quintans-arb-2003-1.pdf
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Marc : |
LEADER 03362naa a2200265 a 4500
001 1054832
005 2019-10-15
008 2003 bl uuuu u00u1 u #d
024 7 $a10.1016/S0378-4320(02)00239-7$2DOI
100 1 $aMITCHELL, L.M.
245 $aEffect of diet and GnRH administration on post-pastum ovarian cyclicity in autumn-lambing ewes.$h[electronic resource]
260 $c2003
500 $aArticle history: Received 1 May 2002 // received in revised form 22 October 2002 // accepted 8 November 2002. Doi: https://doi.org/10.1016/S0378-4320(02)00239-7
520 $aAbstract: Using autumn-lambing ewes, this study investigated (i) the effects of diet on gonadotrophin secretion and responsiveness of the hypothalamic-pituitary-ovarian axis to exogenous GnRH during the early post-partum period; and (ii) whether ovulation prior to completion of uterine involution results in an increased incidence of aberrant ovarian cycles. Thirty-two ewes rearing 1.9±0.12 lambs were equally allocated to two dietary treatments at lambing (22 October ±0.2 day). Diets comprised ad libitum hay and 1.5 kg per ewe per day of one of two concentrates (11.5 MJ ME, 195 g CP per kg) containing 300 g kg?1 cracked maize grain (M) or 300 g kg?1 sugar beet pellets (S). Half of the ewes on each diet (G) received 25 i.v. injections of 250 ng GnRH in 2 ml 0.9% saline at 2 h intervals from days 12–14 post-partum while remaining ewes (N) were monitored for the resumption of spontaneous ovarian cyclicity. Blood samples were obtained from all ewes throughout the study (lambing to 18 December) for measurement of circulating hormone concentrations and the uteri and ovaries of all ewes were examined via laparoscopy on day 21 post-partum. There were no effects of dietary treatment on ewe daily live weight loss, lamb daily live weight gain or the immediate post-partum increase in circulating FSH concentrations. Diet did not affect insulin concentrations or LH pulse frequency on day 12 post-partum but LH pulse amplitude was lower in ewes fed concentrate M compared to concentrate S (1.4±0.10 versus 1.7±0.12 ng ml?1, respectively, P<0.05) and this was associated with an increased interval to the resumption of spontaneous ovarian cycles (35±3.1 versus 26±2.1 day, respectively, P<0.05). Administration of exogenous GnRH increased (P<0.05) the proportion of ewes on both diets that ovulated within 20 days of parturition and advanced the onset of ovarian cyclicity in ewes fed concentrate M by 9.5 days (significance of interaction, P<0.05). Four ewes, all of which ovulated before day 22 post-partum, had extended luteal activity while in remaining ewes, duration of the first luteal phase was inversely related to the time of first ovulation (r2=0.16, P<0.05). Results demonstrate that (i) the onset of ovarian cyclicity is influenced by diet and can be advanced by administration of exogenous GnRH; and (ii) ovulation during the early post-partum period is associated with an increased incidence of extended luteal activity.
650 $aALIMENTACION ANIMAL
650 $aCICLO ESTRAL
650 $aDIETA
650 $aOVEJA
650 $aREPRODUCCION ANIMAL
700 1 $aRAMILLA, M.J.
700 1 $aQUINTANS, G.
700 1 $aKING, M.E.
700 1 $aGEBBIE, F.E.
700 1 $aROBINSON, J.J.
773 $tAnimal Reproduction Science, 2003$gv. 76, p. 67-79.
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