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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
20/02/2024 |
Actualizado : |
20/02/2024 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
MACHADO, M.; MARTÍNEZ, R.; ANDRES, S.; SUMARAH, M.W.; RENAUD, J.B.; ARMIÉN, A.G.; BARROS, C.S.L.; RIET-CORREA, F.; MENCHACA, A.; SCHILD, C. |
Afiliación : |
MIZAEL MACHADO DA COSTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; RAFAEL MARTÍNEZ, acuarembó, 45000, Uruguay, Tacuarembó, 45000, Uruguay; SOL ANDRES, CENUR Noreste, Universidad de la República, Tacuarembó, 45000, Uruguay; MARK W. SUMARAH, London Research and Development Centre, Agriculture & Agri-Food Canada, London, N5V 4T3, ON, Canada; JUSTIN B. RENAUD, London Research and Development Centre, Agriculture & Agri-Food Canada, London, N5V 4T3, ON, Canada; ANÍBAL G. ARMIÉN, California Animal Health & Food Safety Laboratory System (CAHFS), School of Veterinary Medicine, University of California, Davis, 95616, CA, United States; CLAUDIO S. L. BARROS, Faculdade de Medicina Veterinária e Zootecnia (FMZV), Universidade Federal de Mato Grosso do Sul (, UFMS, Campo Grande 79070-900, Mato Grosso do Sul, Brazil; FRANKLIN RIET-CORREA AMARAL, Programa de Pós-Graduação em Ciência Animal nos Trópicos, Universidade Federal da Bahia (UFBA, Salvador, Bahia, 49170-110, Brazil; JOSE ALEJO MENCHACA BARBEITO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CARLOS SCHILD, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; California Animal Health and Food Safety Laboratory System-San Bernardino Branch, University of California, San Bernardino, 92408, CA, United States. |
Título : |
Poisoning by Baccharis coridifolia in early-weaned beef calves: pathological study and new macrocyclic trichothecene identification. |
Fecha de publicación : |
2023 |
Fuente / Imprenta : |
Toxins. 2023; 15(12):681. https://doi.org/10.3390/toxins15120681 -- OPEN ACCESS. |
ISSN : |
eISSN 2072-6651 |
DOI : |
10.3390/toxins15120681 |
Idioma : |
Inglés |
Notas : |
Article history: Submission received: 19 October 2023; Revised: 20 November 2023; Accepted: 27 November 2023; Published: 1 December 2023. -- Supplementary Materials: The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/toxins15120681/s1 -- This article belongs to the Special Issue Toxins: 15th Anniversary (https://www.mdpi.com/journal/toxins/special_issues/U270856NY7 ). --
Reaxys Chemistry database information. Substances: Trichothecene, Roridin A. -- Funding: This research received no external funding. --
Acknowledgments: We thank Alejandra Custodio from Plataforma de Investigación en Salud Animal (PSA) of Instituto Nacional de Investigación Agropecuaria (INIA) for technical assistance with the histologic techniques, Ana Laura Vildoza for support with postmortem examination, Christina Heard (CAHFS) for the electron microscopy preparations, and Megan Kelman (AAFC) for technical support. Mizael Machado and Alejo Menchaca are researchers of the "Sistema Nacional de Investigadores" (SNI, ANII) of Uruguay. -- Document type: Article Gold Open Access, Article Green Open Access. -- Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
Contenido : |
ABSTRACT.- This study investigated two outbreaks of spontaneous poisoning by Baccharis coridifolia (Asteraceae) in early-weaned beef calves in Tacuarembó, Uruguay. A total of 34 affected calves showed signs of salivation, anorexia, apathy, marked dehydration, and diarrhea. Deaths occurred 36-72 h after consumption and mortality varied from 37.5% to 43.3% for outbreak 1 and outbreak 2, respectively. The main pathological findings include diffuse severe necrosis of the prestomachs and lymphoid tissues. Ultrastructurally, epithelial cells of the rumen showed swelling, lysis of the organelles, degradation of intercellular attachments, and degradation of the nuclear chromatin. Using LC-MS with diagnostic fragmentation filtering, 56 macrocyclic trichothecenes including glycosyl and malonyl conjugates were identified. The total concentration of macrocyclic trichothecenes, including conjugates, was estimated to be 1.2 ± 0.1 mg/g plant material. This is the first report of these malonyl-glucose conjugates from Baccharis coridifolia. © 2023 by the authors. |
Palabras claves : |
Baccharis; Mio-mio; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA; Poisonous plants; Ruminants; Toxicity; Uruguay. |
Asunto categoría : |
L01 Ganadería |
URL : |
https://www.mdpi.com/2072-6651/15/12/681/pdf
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Marc : |
LEADER 03462naa a2200349 a 4500 001 1064468 005 2024-02-20 008 2023 bl uuuu u00u1 u #d 022 $aeISSN 2072-6651 024 7 $a10.3390/toxins15120681$2DOI 100 1 $aMACHADO, M. 245 $aPoisoning by Baccharis coridifolia in early-weaned beef calves$bpathological study and new macrocyclic trichothecene identification.$h[electronic resource] 260 $c2023 500 $aArticle history: Submission received: 19 October 2023; Revised: 20 November 2023; Accepted: 27 November 2023; Published: 1 December 2023. -- Supplementary Materials: The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/toxins15120681/s1 -- This article belongs to the Special Issue Toxins: 15th Anniversary (https://www.mdpi.com/journal/toxins/special_issues/U270856NY7 ). -- Reaxys Chemistry database information. Substances: Trichothecene, Roridin A. -- Funding: This research received no external funding. -- Acknowledgments: We thank Alejandra Custodio from Plataforma de Investigación en Salud Animal (PSA) of Instituto Nacional de Investigación Agropecuaria (INIA) for technical assistance with the histologic techniques, Ana Laura Vildoza for support with postmortem examination, Christina Heard (CAHFS) for the electron microscopy preparations, and Megan Kelman (AAFC) for technical support. Mizael Machado and Alejo Menchaca are researchers of the "Sistema Nacional de Investigadores" (SNI, ANII) of Uruguay. -- Document type: Article Gold Open Access, Article Green Open Access. -- Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 520 $aABSTRACT.- This study investigated two outbreaks of spontaneous poisoning by Baccharis coridifolia (Asteraceae) in early-weaned beef calves in Tacuarembó, Uruguay. A total of 34 affected calves showed signs of salivation, anorexia, apathy, marked dehydration, and diarrhea. Deaths occurred 36-72 h after consumption and mortality varied from 37.5% to 43.3% for outbreak 1 and outbreak 2, respectively. The main pathological findings include diffuse severe necrosis of the prestomachs and lymphoid tissues. Ultrastructurally, epithelial cells of the rumen showed swelling, lysis of the organelles, degradation of intercellular attachments, and degradation of the nuclear chromatin. Using LC-MS with diagnostic fragmentation filtering, 56 macrocyclic trichothecenes including glycosyl and malonyl conjugates were identified. The total concentration of macrocyclic trichothecenes, including conjugates, was estimated to be 1.2 ± 0.1 mg/g plant material. This is the first report of these malonyl-glucose conjugates from Baccharis coridifolia. © 2023 by the authors. 653 $aBaccharis 653 $aMio-mio 653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA 653 $aPoisonous plants 653 $aRuminants 653 $aToxicity 653 $aUruguay 700 1 $aMARTÍNEZ, R. 700 1 $aANDRES, S. 700 1 $aSUMARAH, M.W. 700 1 $aRENAUD, J.B. 700 1 $aARMIÉN, A.G. 700 1 $aBARROS, C.S.L. 700 1 $aRIET-CORREA, F. 700 1 $aMENCHACA, A. 700 1 $aSCHILD, C. 773 $tToxins. 2023; 15(12):681. https://doi.org/10.3390/toxins15120681 -- OPEN ACCESS.
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INIA Las Brujas (LB) |
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Biblioteca (s) : |
INIA La Estanzuela; INIA Las Brujas; INIA Tacuarembó. |
Fecha actual : |
21/02/2014 |
Actualizado : |
03/02/2018 |
Tipo de producción científica : |
Capítulo en Libro Técnico-Científico |
Autor : |
REAL, D. |
Afiliación : |
DANIEL REAL FERREIRO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Proyecto: Leguminosas forrajeras para la región basáltica |
Fecha de publicación : |
1998 |
Fuente / Imprenta : |
In: BERRETTA, E.J. (Ed.). Seminario de actualización en tecnologías para basalto. INIA Tacuarembó, 3-4 diciembre 1998. Montevideo (Uruguay): INIA, 1998. |
Páginas : |
p. 43-51 |
Serie : |
(INIA Serie Técnica ; 102) |
ISSN : |
1688-9266 |
Idioma : |
Español |
Notas : |
INIA Tacuarembó |
Contenido : |
En este trabajo se presentarán los antecedentes para la estrategia 1 (incorporación de nuevas especies a la comunidad nativa) y las nuevas líneas de investigación comenzadas en mejoramiento genético de forrajeras para ser usadas en mejoramientos de campo. |
Thesagro : |
BASALTO; FITOMEJORAMIENTO; LEGUMINOSAS; SUELO BASALTICO. |
Asunto categoría : |
-- A50 Investigación agraria |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/7810/1/ST-102-43-51.pdf
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Marc : |
LEADER 00938naa a2200217 a 4500 001 1012094 005 2018-02-03 008 1998 bl uuuu u00u1 u #d 022 $a1688-9266 100 1 $aREAL, D. 245 $aProyecto$bLeguminosas forrajeras para la región basáltica 260 $c1998 300 $ap. 43-51 490 $a(INIA Serie Técnica ; 102) 500 $aINIA Tacuarembó 520 $aEn este trabajo se presentarán los antecedentes para la estrategia 1 (incorporación de nuevas especies a la comunidad nativa) y las nuevas líneas de investigación comenzadas en mejoramiento genético de forrajeras para ser usadas en mejoramientos de campo. 650 $aBASALTO 650 $aFITOMEJORAMIENTO 650 $aLEGUMINOSAS 650 $aSUELO BASALTICO 773 $tIn: BERRETTA, E.J. (Ed.). Seminario de actualización en tecnologías para basalto. INIA Tacuarembó, 3-4 diciembre 1998. Montevideo (Uruguay): INIA, 1998.
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