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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
20/02/2024 |
Actualizado : |
20/02/2024 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
MACHADO, M.; MARTÍNEZ, R.; ANDRES, S.; SUMARAH, M.W.; RENAUD, J.B.; ARMIÉN, A.G.; BARROS, C.S.L.; RIET-CORREA, F.; MENCHACA, A.; SCHILD, C. |
Afiliación : |
MIZAEL MACHADO DA COSTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; RAFAEL MARTÍNEZ, acuarembó, 45000, Uruguay, Tacuarembó, 45000, Uruguay; SOL ANDRES, CENUR Noreste, Universidad de la República, Tacuarembó, 45000, Uruguay; MARK W. SUMARAH, London Research and Development Centre, Agriculture & Agri-Food Canada, London, N5V 4T3, ON, Canada; JUSTIN B. RENAUD, London Research and Development Centre, Agriculture & Agri-Food Canada, London, N5V 4T3, ON, Canada; ANÍBAL G. ARMIÉN, California Animal Health & Food Safety Laboratory System (CAHFS), School of Veterinary Medicine, University of California, Davis, 95616, CA, United States; CLAUDIO S. L. BARROS, Faculdade de Medicina Veterinária e Zootecnia (FMZV), Universidade Federal de Mato Grosso do Sul (, UFMS, Campo Grande 79070-900, Mato Grosso do Sul, Brazil; FRANKLIN RIET-CORREA AMARAL, Programa de Pós-Graduação em Ciência Animal nos Trópicos, Universidade Federal da Bahia (UFBA, Salvador, Bahia, 49170-110, Brazil; JOSE ALEJO MENCHACA BARBEITO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CARLOS SCHILD, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; California Animal Health and Food Safety Laboratory System-San Bernardino Branch, University of California, San Bernardino, 92408, CA, United States. |
Título : |
Poisoning by Baccharis coridifolia in early-weaned beef calves: pathological study and new macrocyclic trichothecene identification. |
Fecha de publicación : |
2023 |
Fuente / Imprenta : |
Toxins. 2023; 15(12):681. https://doi.org/10.3390/toxins15120681 -- OPEN ACCESS. |
ISSN : |
eISSN 2072-6651 |
DOI : |
10.3390/toxins15120681 |
Idioma : |
Inglés |
Notas : |
Article history: Submission received: 19 October 2023; Revised: 20 November 2023; Accepted: 27 November 2023; Published: 1 December 2023. -- Supplementary Materials: The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/toxins15120681/s1 -- This article belongs to the Special Issue Toxins: 15th Anniversary (https://www.mdpi.com/journal/toxins/special_issues/U270856NY7 ). --
Reaxys Chemistry database information. Substances: Trichothecene, Roridin A. -- Funding: This research received no external funding. --
Acknowledgments: We thank Alejandra Custodio from Plataforma de Investigación en Salud Animal (PSA) of Instituto Nacional de Investigación Agropecuaria (INIA) for technical assistance with the histologic techniques, Ana Laura Vildoza for support with postmortem examination, Christina Heard (CAHFS) for the electron microscopy preparations, and Megan Kelman (AAFC) for technical support. Mizael Machado and Alejo Menchaca are researchers of the "Sistema Nacional de Investigadores" (SNI, ANII) of Uruguay. -- Document type: Article Gold Open Access, Article Green Open Access. -- Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
Contenido : |
ABSTRACT.- This study investigated two outbreaks of spontaneous poisoning by Baccharis coridifolia (Asteraceae) in early-weaned beef calves in Tacuarembó, Uruguay. A total of 34 affected calves showed signs of salivation, anorexia, apathy, marked dehydration, and diarrhea. Deaths occurred 36-72 h after consumption and mortality varied from 37.5% to 43.3% for outbreak 1 and outbreak 2, respectively. The main pathological findings include diffuse severe necrosis of the prestomachs and lymphoid tissues. Ultrastructurally, epithelial cells of the rumen showed swelling, lysis of the organelles, degradation of intercellular attachments, and degradation of the nuclear chromatin. Using LC-MS with diagnostic fragmentation filtering, 56 macrocyclic trichothecenes including glycosyl and malonyl conjugates were identified. The total concentration of macrocyclic trichothecenes, including conjugates, was estimated to be 1.2 ± 0.1 mg/g plant material. This is the first report of these malonyl-glucose conjugates from Baccharis coridifolia. © 2023 by the authors. |
Palabras claves : |
Baccharis; Mio-mio; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA; Poisonous plants; Ruminants; Toxicity; Uruguay. |
Asunto categoría : |
L01 Ganadería |
URL : |
https://www.mdpi.com/2072-6651/15/12/681/pdf
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Marc : |
LEADER 03530naa a2200349 a 4500 001 1064468 005 2024-02-20 008 2023 bl uuuu u00u1 u #d 022 $aeISSN 2072-6651 024 7 $a10.3390/toxins15120681$2DOI 100 1 $aMACHADO, M. 245 $aPoisoning by Baccharis coridifolia in early-weaned beef calves$bpathological study and new macrocyclic trichothecene identification.$h[electronic resource] 260 $c2023 500 $aArticle history: Submission received: 19 October 2023; Revised: 20 November 2023; Accepted: 27 November 2023; Published: 1 December 2023. -- Supplementary Materials: The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/toxins15120681/s1 -- This article belongs to the Special Issue Toxins: 15th Anniversary (https://www.mdpi.com/journal/toxins/special_issues/U270856NY7 ). -- Reaxys Chemistry database information. Substances: Trichothecene, Roridin A. -- Funding: This research received no external funding. -- Acknowledgments: We thank Alejandra Custodio from Plataforma de Investigación en Salud Animal (PSA) of Instituto Nacional de Investigación Agropecuaria (INIA) for technical assistance with the histologic techniques, Ana Laura Vildoza for support with postmortem examination, Christina Heard (CAHFS) for the electron microscopy preparations, and Megan Kelman (AAFC) for technical support. Mizael Machado and Alejo Menchaca are researchers of the "Sistema Nacional de Investigadores" (SNI, ANII) of Uruguay. -- Document type: Article Gold Open Access, Article Green Open Access. -- Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 520 $aABSTRACT.- This study investigated two outbreaks of spontaneous poisoning by Baccharis coridifolia (Asteraceae) in early-weaned beef calves in Tacuarembó, Uruguay. A total of 34 affected calves showed signs of salivation, anorexia, apathy, marked dehydration, and diarrhea. Deaths occurred 36-72 h after consumption and mortality varied from 37.5% to 43.3% for outbreak 1 and outbreak 2, respectively. The main pathological findings include diffuse severe necrosis of the prestomachs and lymphoid tissues. Ultrastructurally, epithelial cells of the rumen showed swelling, lysis of the organelles, degradation of intercellular attachments, and degradation of the nuclear chromatin. Using LC-MS with diagnostic fragmentation filtering, 56 macrocyclic trichothecenes including glycosyl and malonyl conjugates were identified. The total concentration of macrocyclic trichothecenes, including conjugates, was estimated to be 1.2 ± 0.1 mg/g plant material. This is the first report of these malonyl-glucose conjugates from Baccharis coridifolia. © 2023 by the authors. 653 $aBaccharis 653 $aMio-mio 653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA 653 $aPoisonous plants 653 $aRuminants 653 $aToxicity 653 $aUruguay 700 1 $aMARTÍNEZ, R. 700 1 $aANDRES, S. 700 1 $aSUMARAH, M.W. 700 1 $aRENAUD, J.B. 700 1 $aARMIÉN, A.G. 700 1 $aBARROS, C.S.L. 700 1 $aRIET-CORREA, F. 700 1 $aMENCHACA, A. 700 1 $aSCHILD, C. 773 $tToxins. 2023; 15(12):681. https://doi.org/10.3390/toxins15120681 -- OPEN ACCESS.
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4. | | PARODI, P.; BAZZANO, V.; ARMÚA-FERNÁNDEZ, M.T.; FÉLIX, M.L.; CARVALHO, L.A.; FREIRE, J.; VENZAL, J.M. Molecular survey of Piroplasmida, Hepatozoon spp. and Anaplasmataceae in anemic and thrombocytopenic dogs from Uruguay. Original article. Veterinary Parasitology: Regional Studies and Reports. 2024, Volume 51, 101027. https://doi.org/10.1016/j.vprsr.2024.101027 Article history: Received 28 February 2024, Revised 8 April 2024, Accepted 17 April 2024, Available online 21 April 2024, Version of Record 23 April 2024. -- Corresponding author at: Rivera 1350, CP 50000 Salto, Uruguay. E-mail...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Las Brujas. |
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5. | | VERA, G.; CONDON, F.; VÁZQUEZ, D. Soybean germplasm characterization for human consumption aptitude in Uruguay. [Caracterização do germoplasma de soja com aptidão ao consumo humano no Uruguai.] Original article. Brazilian Journal of Food Technology. 2024, Volume 27, Pages 1-17. https://doi.org/10.1590/1981-6723.04823 -- OPEN ACCESS. Article history: Received 19 Apr 2023, Accepted 21 Nov 2023, Publication in this collection 02 Feb 2024, Date of issue 2024. -- Correspondence: Vázquez, D.; Instituto Nacional de Investigación Agropecuaria (INIA), Agroalimentos, Ruta 50,...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Las Brujas. |
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7. | | GIANNITTI, F.; DORSCH, M.; SCHILD, C.; CAFFARENA, D.; SVERLOW, K.; ARMIÉN , A.; RIET-CORREA, F. O-053 Pathological and immunohistochemical evidence of a possible Francisellaceae family member causing ovine abortion in Uruguay: Should we be concerned about tularemia in South America?. [conference abstract]. Animal - science proceedings, March 2023, Volume 14, Issue 1, Page 94. doi: https://doi.org/10.1016/j.anscip.2023.01.129 Article history: Available online 13 March 2023, Version of Record 13 March 2023. -- Corresponding author: Corresponding author: Federico Giannitti. E-mail: fgiannitti@inia.org.uy -- Acknowledgements and funding: INIA's grant PL_27. --...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Las Brujas. |
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8. | | CASAUX, M.L.; NETO, W.S.; SCHILD, C.; COSTA, R.A. DA; MACÍAS-RIOSECO, M.; CAFFARENA, D.; SILVEIRA, C.S.; ARÁOZ, V.; DONCEL, B.; GIANNITTI, F.; FRAGA, M. Epidemiological and clinicopathological findings in 15 fatal outbreaks of salmonellosis in dairy calves and virulence genes in the causative Salmonella enterica Typhimurium and Dublin strains. Veterinary Microbiology - Research Paper. Brazilian Journal of Microbiology, 2023, volume 54, isuue 1, pp. 475-490. doi: https://doi.org/10.1007/s42770-022-00898-9 Article history: Received 06 December 2021; Accepted 20 December 2022; Published 05 January 2023. -- Correspondence author: Fraga, M.; Plataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria (INIA),...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Las Brujas. |
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12. | | REBOLLO, I.; SCHEFFEL, S.; BLANCO, P.H.; MOLINA, F.; MARTÍNEZ, S.; CARRACELAS, G.; PÉREZ DE VIDA, F.; ROSAS, J.E. Instituto Nacional de Investigación Agropecuaria (INIA) Rice Breeding Program Historical Dataset. [Dataset]. DRYAD Dataset, 2024. https://doi.org/10.5061/dryad.x69p8czn8 Correspondence author: Juan E. Rosas, email: jrosas@inia.org.uy -- Publication date: February 16, 2024. -- This dataset is embargoed and will be released when the associated article is published. Lists of files and downloads will become...Tipo: Artículos Indexados |
Biblioteca(s): INIA Las Brujas. |
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13. | | SCHILD, C.; BOABAID, F.M.; OLIVEIRA, L.G.S.; ARMENDANO, J.I.; SARAVIA, A.; CUSTODIO, A.; ALGORTA, J.; ALVAREZ, C.; JAURENA, M.; DIXON, R.M.; RIET-CORREA, F. Response of cows with osteomalacia grazing sub-tropical native pastures to phosphorus supplementation with loose mineral mix or feed blocks. Veterinary Journal. 2023, Volume 298-299, 106013. https://doi.org/10.1016/j.tvjl.2023.106013 Article history: Accepted 20 June 2023; Available online 22 June 2023. -- Correspondence author: Riet-Correa, F.; Programa de pós-graduação em Ciência Animal nos Trópicos, Escola de Medicina Veterinária e Zootecnia, Universidade Federal...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Las Brujas. |
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14. | | MACHADO, M.; MARTÍNEZ, R.; ANDRES, S.; SUMARAH, M.W.; RENAUD, J.B.; ARMIÉN, A.G.; BARROS, C.S.L.; RIET-CORREA, F.; MENCHACA, A.; SCHILD, C. Poisoning by Baccharis coridifolia in early-weaned beef calves: pathological study and new macrocyclic trichothecene identification. Toxins. 2023; 15(12):681. https://doi.org/10.3390/toxins15120681 -- OPEN ACCESS. Article history: Submission received: 19 October 2023; Revised: 20 November 2023; Accepted: 27 November 2023; Published: 1 December 2023. -- Supplementary Materials: The following supporting information can be downloaded at:...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Las Brujas. |
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15. | | MUSSIO, P.; MARTÍNEZ, I.; LUZARDO, S.; NAVARRO, A.; LEOTTA, G.; VARELA, G. Phenotypic and genotypic characterization of Shiga toxin-producing Escherichia coli strains recovered from bovine carcasses in Uruguay. Original research. Frontiers in Microbiology, 2023, volume 14, article 1130170. OPEN ACCESS. doi: https://doi.org/10.3389/fmicb.2023.1130170 Article history: Received 22 December 2022; Accepted 13 February 2023; Published 06 March 2023. -- Correspondence authors: Paula Mussio, email: paumussio@gmail.com ; Gustavo Varela, email: gvarela@higiene.edu.uy -- Edited by: Vinicius...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Las Brujas. |
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16. | | PARODI, P.; ARMÚA-FERNÁNDEZ, M.T.; SCHANZEMBACH, M.; MIR, D.; BENÍTEZ-GALEANO, M.J.; RODRÍGUEZ-OSORIO, N.; RIVERO, R.; VENZAL, J.M. Characterization of strains of Anaplasma marginale from clinical cases in bovine using major surface protein 1a in Uruguay. Frontiers in Veterinary Science, September 2022, Volume 920, Article 990228. OPEN ACCESS. doi: https://doi.org/10.3389/fvets.2022.990228 Article history: Received 09 July 2022; Accepted 30 August 2022; Published 20 September 2022. -- Correspondence author: Parodi, P.; Instituto Nacional de Investigación Agropecuaria (INIA), Plataforma de Salud Animal, Estación...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Las Brujas. |
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17. | | TANA-HERNÁNDEZ, L.; CABRERA, A.; VALENTÍN, A.; GONZÁLEZ, F.; FIERRO, S.; DORSCH, M.; GIANNITTI, F.; FRANCIA, M. Development and evaluation of detection and control techniques based on serological and molecular methodologies for Toxoplasma gondii in sheep in Uruguay. 103. (abstract) Área temática: Biología Celular y Molecular. In: Physiological Mini Reviews, 2022, volume 15, Special Issue: III (3er) Congreso Nacional de Biociencias Octubre 2022, Montevideo, Uruguay. p.117. Resumen publicado en las jornadas de BIOCIENCIAS: II Jornadas Binacionales Argentina-Uruguay; III Congreso Nacional 2022 "Ciencia para el desarrollo sustentable".Tipo: Abstracts/Resúmenes |
Biblioteca(s): INIA Las Brujas. |
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19. | | GRAHMANN, K.; TERRA, J.A.; ELLERBROCK, R.; RUBIO, V.; BARRO, R.; CAMAÑO, A.; QUINCKE, A. Data accuracy and method validation of chemical soil properties in long-term experiments: Standard operating procedures for a non-certified soil laboratory in Latin America. Geoderma Regional, 2022. Volume 28, Article number e00487. OPEN ACCESS. doi: https://doi.org/10.1016/j.geodrs.2022.e00487 Article history: Received 9 May 2021, Revised 20 December 2021, Accepted 2 February 2022, Available online 6 February 2022.Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA La Estanzuela; INIA Las Brujas; INIA Treinta y Tres. |
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20. | | PARODI, P.; ARMÚA-FERNÁNDEZ, M.T.; CORBELLINI, L.G.; RIVERO, R.; MIRABALLES, C.; RIET-CORREA, F.; VENZAL, J.M. Description of bovine babesiosis and anaplasmosis outbreaks in northern Uruguay between 2016 and 2018. Veterinary Parasitology: Regional Studies and Reports, 2022, Volume 29, Article number 100700. doi: https://doi.org/10.1016/j.vprsr.2022.100700 Article history: Received 7 April 2021; Received in revised form 27 November 2021; Accepted 26 January 2022; Available online 2 February 2022.
Corresponding author: Parodi, P.; Instituto Nacional de Investigación Agropecuaria,...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Las Brujas. |
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Registros recuperados : 2,958 | |
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