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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
30/06/2023 |
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Actualizado : |
30/06/2023 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
GIANNITTI, F.; GARCÍA, J. P.; ADAMS, V.; ARMENDANO, J.; BEINGESSER, J.; ROOD, J.; UZAL, F. A. |
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Afiliación : |
FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JORGE P. GARCÍA, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina; VICKI ADAMS, Monash University, Parkville, Victoria, Australia; JOAQUÍN I. ARMENDANO, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina; JULIANN BEINGESSER, California Animal Health and Food Safety Laboratoy, University of California at Davis, San Bernardino, CA; JULIAN I. ROOD, Monash University, Parkville, Victoria, Australia; FRANCISCO A. UZAL, Monash University, Parkville, Victoria, Australia. |
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Título : |
Experimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions. |
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Complemento del título : |
Infectious Disease - Original Article. |
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Fecha de publicación : |
2023 |
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Fuente / Imprenta : |
Veterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669 |
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ISSN : |
0300-9858 (print); 1544-2217 (online). |
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DOI : |
10.1177/03009858231171669 |
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Idioma : |
Inglés |
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Notas : |
Article history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral Ave, San Bernardino, CA 92408, USA. Email: fauzal@ucdavis.edu -- Funding: This work was supported by grant R01 AI056177 from the National Institute of Allergy and Infectious Diseases (NIAID). Research at Monash University was also supported by funding provided by the Australian Research Council to the Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics (grant no. CE0562063). -- |
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Contenido : |
ABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 groups. The authors conclude that no specific gross or histologic renal lesions are observed in sheep with experimental acute type D enterotoxemia. © The Author(s) 2023 MenosABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 ... Presentar Todo |
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Palabras claves : |
Clostridium perfringens type D; Enterotoxemia; ETX; Experimental infection; Kidneys; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA; Renal pathology; Sheep. |
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Asunto categoría : |
L10 Genética y mejoramiento animal |
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Marc : |
LEADER 03352naa a2200325 a 4500
001 1064216
005 2023-06-30
008 2023 bl uuuu u00u1 u #d
022 $a0300-9858 (print); 1544-2217 (online).
024 7 $a10.1177/03009858231171669$2DOI
100 1 $aGIANNITTI, F.
245 $aExperimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions.$h[electronic resource]
260 $c2023
500 $aArticle history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral Ave, San Bernardino, CA 92408, USA. Email: fauzal@ucdavis.edu -- Funding: This work was supported by grant R01 AI056177 from the National Institute of Allergy and Infectious Diseases (NIAID). Research at Monash University was also supported by funding provided by the Australian Research Council to the Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics (grant no. CE0562063). --
520 $aABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 groups. The authors conclude that no specific gross or histologic renal lesions are observed in sheep with experimental acute type D enterotoxemia. © The Author(s) 2023
653 $aClostridium perfringens type D
653 $aEnterotoxemia
653 $aETX
653 $aExperimental infection
653 $aKidneys
653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA
653 $aRenal pathology
653 $aSheep
700 1 $aGARCÍA, J. P.
700 1 $aADAMS, V.
700 1 $aARMENDANO, J.
700 1 $aBEINGESSER, J.
700 1 $aROOD, J.
700 1 $aUZAL, F. A.
773 $tVeterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669
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| 21. |  | DORSCH, M.; CASAUX, M.L.; CALLEROS, L.; ARÁOZ, V.; CAFFARENA, D.; MONESIGLIO, M.C.; BARCELLOS, M.; SILVEIRA, C.S.; PERDOMO, T.; BANCHERO, G.; UZAL, F.A.; FRAGA, M.; GIANNITTI, F. Corrigendum to "Placentitis and abortion caused by a multidrug resistant strain of Campylobacter fetus subspecies fetus in a sheep in Uruguay". (Revista Argentina de Microbiologia (2022) 54(1) (25-30), (S0325754121000389), (10.1016/j.ram.2021.02.005)). Erratum. Revista Argentina de Microbiologia. 2023, Volume 55, Issue 4, Pages 397-398. https://doi.org/10.1016/j.ram.2023.11.002 -- OPEN ACCESS. Article history: Available online 21 December 2023; Version of Record 21 December 2023. -- Correspondence: Giannitti, F.; Plataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria (INIA),...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 25. | | CASAUX, M.L.; NETO, W.S.; SCHILD, C.; COSTA, R.A. DA; MACÍAS-RIOSECO, M.; CAFFARENA, D.; SILVEIRA, C.S.; ARÁOZ, V.; DONCEL, B.; GIANNITTI, F.; FRAGA, M. Epidemiological and clinicopathological findings in 15 fatal outbreaks of salmonellosis in dairy calves and virulence genes in the causative Salmonella enterica Typhimurium and Dublin strains. Veterinary Microbiology - Research Paper. Brazilian Journal of Microbiology, 2023, volume 54, isuue 1, pp. 475-490. doi: https://doi.org/10.1007/s42770-022-00898-9 Article history: Received 06 December 2021; Accepted 20 December 2022; Published 05 January 2023. -- Correspondence author: Fraga, M.; Plataforma de Investigación en Salud Animal, Instituto Nacional de Investigación...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 26. | | CIBILS-STEWART, X.; CALISTRO, P.; BARAIBAR, N.; GIAMBIASI, M.; GIANNITTI, F.; MACHADO, M.; SILVEIRA, C.S.; MENCHACA, A.; CAFFARENA, D.; SARAVIA, A. Escarabajo siete de oro (Astylus atromaculatus): actualización y recomendaciones en vísperas del verano 2024. Producción animal. Revista INIA Uruguay, Diciembre 2023, no.75 p.35-39. (Revista INIA; 75).| Tipo: Artículos en Revistas Agropecuarias |
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| 28. | | BUSCHIAZZO, M.; MERINO, N.; DE MORI, J.; PASSADORE, A.; VILLARINO, A.; BERTOLA, B.; CONIBERTI, A.; FASIOLO, C. FPTA 353: Culmina una etapa y se evoluciona a una vitivinicultura cada vez más sostenible. Proyectos FPTA. Revista INIA Uruguay, Junio 2023, no.73, p.89-92. (Revista INIA; 73).| Tipo: Artículos en Revistas Agropecuarias |
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| 30. | | VIETA, A.; ORIHUELA, C.; FASIOLO, C.; BAO, L.; LORENZO, E.; GALVÁN, G.; WATERSTON, S.; IURATO, A.; PRIMO, P.; MARTÍNEZ, F-; GODÍN, A.; VIANA, V. FPTA 383: Programa de integración de herramientas biológicas y culturales para el control de plagas y enfermedades en horticultura. Proyectos FPTA. Revista INIA Uruguay, Marzo 2023, no.72, p.112-114. (Revista INIA; 72).| Tipo: Artículos en Revistas Agropecuarias |
| Biblioteca(s): INIA Las Brujas. |
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| 31. | | GIANNITTI, F.; GARCÍA, J. P.; ADAMS, V.; ARMENDANO, J.; BEINGESSER, J.; ROOD, J.; UZAL, F. A. Experimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions. Infectious Disease - Original Article. Veterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669 Article history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral Ave,...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
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| 39. | | MACHADO, M.; OLIVEIRA, L.G.S.; SCHILD, C.; BOABAID, F.; LUCAS, M.; BURONI, F.; CASTRO, M. B.; RIET-CORREA, F. Lantana camara poisoning in cattle that took refuge during a storm in a forest invaded by this plant. Toxicon, 2023, Volume 229, article 107124. https://doi.org/10.1016/j.toxicon.2023.107124 Article history: Received 8 March 2023; Received in revised form 7 April 2023; Accepted 10 April 2023; Available online 11 April 2023. -- Corresponding author: Riet-Correa, F.; Instituto Nacional de Investigación Agropecuaria,...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
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