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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
21/01/2020 |
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Actualizado : |
21/01/2020 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
DE CARVALHO NUNES, L.; STEGELMEIER, B. L.; COOK, D.; PFISTER, J. A.; GARDNER, D. R.; RIET-CORREA, F.; WEICH, K. D. |
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Afiliación : |
LOUISIANE DE CARVALHO NUNES, Department of Veterinary Science, Federal University of Espírito Santo, Alegre, Espírito Santo, Brazil; BRYAN L. STEGELMEIER, USDA-ARS Poisonous Plant Research Laboratory, USA; DANIEL COOK, USDA-ARS Poisonous Plant Research Laboratory, USA; JAMES A. PFISTER, USDA-ARS Poisonous Plant Research Laboratory, USA; DALE R. GARDNER, USDA-ARS Poisonous Plant Research Laboratory, USA; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; Veterinary Hospital, Center for Health and Rural Technology, Patos Campus, Federal University of Campina Grande, Brazil; KEVIN D. WELCH, USDA-ARS Poisonous Plant Research Laboratory, USA. |
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Título : |
Clinical and pathological comparison of Astragalus lentiginosus and Ipomoea carnea poisoning in goats. |
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Fecha de publicación : |
2019 |
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Fuente / Imprenta : |
Toxicon, 5 December, 2019, Volume 171, Pages 20-28. Doi: 10.1016/j.toxicon.2019.09.016 |
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ISSN : |
0041-0101 |
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DOI : |
10.1016/j.toxicon.2019.09.016 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 12 July 2019; Received in revised form 12 September 2019; Accepted 16 September 2019; Available online 19 September 2019. |
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Contenido : |
ABSTRACT.
The indolizidine alkaloid swainsonine, found in some Astragalus and Oxytropis (i.e., locoweed) species, is a potent cellular glycosidase inhibitor that often poisons livestock. Other toxic genera such as some Ipomoea species also contain swainsonine as well as calystegines which are similar polyhydroxy alkaloids. The toxicity of calystegines is poorly characterized; however, they are also potent glycoside inhibitors capable of intestinal and cellular glycoside dysfunction. The objective of this study was to directly compare A. lentiginosus and I. carnea poisoning in goats to better characterize the role of the calystegines. Three groups of four goats each were treated with ground alfalfa (control), I. carnea or A. lentiginosus to obtain daily doses of 0.0, 1.5, and 1.5 mg swainsonine/kg bw per day, respectively, for 45 days. Animals were observed daily and weekly body weights, serum enzyme activities, and serum swainsonine concentrations were determined. At day 45 all animals were euthanized and necropsied. Goats treated with A. lentiginosus and I. carnea developed clinical disease characterized by mild intention tremors and proprioceptive deficits. Goats treated with A. lentiginosus developed clinical disease sooner and with greater consistency. No differences in body weight, serum swainsonine concentrations and serum enzyme activity were observed between goats treated with A. lentiginosus and I. carnea. Additionally, there were no differences in the microscopic and histochemical studies of the visceral and neurologic lesions observed between goats treated with A. lentiginosus and I. carnea. These findings suggest that I. carnea-induced clinical signs and lesions are due to swainsonine and that calystegines contribute little or nothing to toxicity in goats in the presence of swainsonine.
© 2019 MenosABSTRACT.
The indolizidine alkaloid swainsonine, found in some Astragalus and Oxytropis (i.e., locoweed) species, is a potent cellular glycosidase inhibitor that often poisons livestock. Other toxic genera such as some Ipomoea species also contain swainsonine as well as calystegines which are similar polyhydroxy alkaloids. The toxicity of calystegines is poorly characterized; however, they are also potent glycoside inhibitors capable of intestinal and cellular glycoside dysfunction. The objective of this study was to directly compare A. lentiginosus and I. carnea poisoning in goats to better characterize the role of the calystegines. Three groups of four goats each were treated with ground alfalfa (control), I. carnea or A. lentiginosus to obtain daily doses of 0.0, 1.5, and 1.5 mg swainsonine/kg bw per day, respectively, for 45 days. Animals were observed daily and weekly body weights, serum enzyme activities, and serum swainsonine concentrations were determined. At day 45 all animals were euthanized and necropsied. Goats treated with A. lentiginosus and I. carnea developed clinical disease characterized by mild intention tremors and proprioceptive deficits. Goats treated with A. lentiginosus developed clinical disease sooner and with greater consistency. No differences in body weight, serum swainsonine concentrations and serum enzyme activity were observed between goats treated with A. lentiginosus and I. carnea. Additionally, there were no differences in the microscopic a... Presentar Todo |
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Palabras claves : |
Astragalus; Calystegines; Ipomoea; Locoweed; PLATAFORMA SALUD ANIMAL; Swainsonine. |
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Asunto categoría : |
A50 Investigación agraria |
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Marc : |
LEADER 02878naa a2200301 a 4500
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008 2019 bl uuuu u00u1 u #d
022 $a0041-0101
024 7 $a10.1016/j.toxicon.2019.09.016$2DOI
100 1 $aDE CARVALHO NUNES, L.
245 $aClinical and pathological comparison of Astragalus lentiginosus and Ipomoea carnea poisoning in goats.$h[electronic resource]
260 $c2019
500 $aArticle history: Received 12 July 2019; Received in revised form 12 September 2019; Accepted 16 September 2019; Available online 19 September 2019.
520 $aABSTRACT. The indolizidine alkaloid swainsonine, found in some Astragalus and Oxytropis (i.e., locoweed) species, is a potent cellular glycosidase inhibitor that often poisons livestock. Other toxic genera such as some Ipomoea species also contain swainsonine as well as calystegines which are similar polyhydroxy alkaloids. The toxicity of calystegines is poorly characterized; however, they are also potent glycoside inhibitors capable of intestinal and cellular glycoside dysfunction. The objective of this study was to directly compare A. lentiginosus and I. carnea poisoning in goats to better characterize the role of the calystegines. Three groups of four goats each were treated with ground alfalfa (control), I. carnea or A. lentiginosus to obtain daily doses of 0.0, 1.5, and 1.5 mg swainsonine/kg bw per day, respectively, for 45 days. Animals were observed daily and weekly body weights, serum enzyme activities, and serum swainsonine concentrations were determined. At day 45 all animals were euthanized and necropsied. Goats treated with A. lentiginosus and I. carnea developed clinical disease characterized by mild intention tremors and proprioceptive deficits. Goats treated with A. lentiginosus developed clinical disease sooner and with greater consistency. No differences in body weight, serum swainsonine concentrations and serum enzyme activity were observed between goats treated with A. lentiginosus and I. carnea. Additionally, there were no differences in the microscopic and histochemical studies of the visceral and neurologic lesions observed between goats treated with A. lentiginosus and I. carnea. These findings suggest that I. carnea-induced clinical signs and lesions are due to swainsonine and that calystegines contribute little or nothing to toxicity in goats in the presence of swainsonine. © 2019
653 $aAstragalus
653 $aCalystegines
653 $aIpomoea
653 $aLocoweed
653 $aPLATAFORMA SALUD ANIMAL
653 $aSwainsonine
700 1 $aSTEGELMEIER, B. L.
700 1 $aCOOK, D.
700 1 $aPFISTER, J. A.
700 1 $aGARDNER, D. R.
700 1 $aRIET-CORREA, F.
700 1 $aWEICH, K. D.
773 $tToxicon, 5 December, 2019, Volume 171, Pages 20-28. Doi: 10.1016/j.toxicon.2019.09.016
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INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
09/04/2024 |
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Actualizado : |
09/04/2024 |
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Tipo de producción científica : |
Documentos |
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Autor : |
NAVAJAS, E. |
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Afiliación : |
ELLY ANA NAVAJAS VALENTINI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
I+D+I en genética de eficiencia de conversión: apuesta a la sostenibilidad ganadera. |
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Fecha de publicación : |
2022 |
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Fuente / Imprenta : |
Anuario Hereford Uruguay, 2022, p.166-171. |
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Idioma : |
Español |
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Contenido : |
En 2014 se iniciaron las mediciones de eficiencia de conversión de alimento (EfC) en la Central de Pruebas de Kiyú para contar con la información
de esta característica en la evaluación genética de la raza. La meta ha sido contribuir al aporte que realiza el programa de mejoramiento genético de la raza, sumando una característica que incide directamente en la reducción de los costos de alimentación sin afectar la producción y con impactos ambientales positivos. Actualmente las estimaciones de mérito genético (EPD) para EfC se publican anualmente, fortalecidas por información genómica, en base a los datos que se relevan en las pruebas de EfC que se desarrollan en Kiyú. |
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Palabras claves : |
CENTRAL DE PRUEBAS KIYÚ; Eficiencia de conversión de alimento (EfC); EVALUACIÓN GENÉTICA DE LA RAZA HEREFORD; I+D+I. |
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Thesagro : |
CENTRAL KIYU; HEREFORD; MEJORAMIENTO GENETICO ANIMAL. |
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Asunto categoría : |
-- |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/17562/1/Navajas-Anuario-HEREFORD-2022.pdf
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Marc : |
LEADER 01345naa a2200205 a 4500
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008 2022 bl uuuu u00u1 u #d
100 1 $aNAVAJAS, E.
245 $aI+D+I en genética de eficiencia de conversión$bapuesta a la sostenibilidad ganadera.$h[electronic resource]
260 $c2022
520 $aEn 2014 se iniciaron las mediciones de eficiencia de conversión de alimento (EfC) en la Central de Pruebas de Kiyú para contar con la información de esta característica en la evaluación genética de la raza. La meta ha sido contribuir al aporte que realiza el programa de mejoramiento genético de la raza, sumando una característica que incide directamente en la reducción de los costos de alimentación sin afectar la producción y con impactos ambientales positivos. Actualmente las estimaciones de mérito genético (EPD) para EfC se publican anualmente, fortalecidas por información genómica, en base a los datos que se relevan en las pruebas de EfC que se desarrollan en Kiyú.
650 $aCENTRAL KIYU
650 $aHEREFORD
650 $aMEJORAMIENTO GENETICO ANIMAL
653 $aCENTRAL DE PRUEBAS KIYÚ
653 $aEficiencia de conversión de alimento (EfC)
653 $aEVALUACIÓN GENÉTICA DE LA RAZA HEREFORD
653 $aI+D+I
773 $tAnuario Hereford Uruguay, 2022, p.166-171.
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