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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
31/03/2021 |
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Actualizado : |
31/03/2021 |
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Tipo de producción científica : |
Trabajos en Congresos/Conferencias |
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Autor : |
MISZTAL, I.; WANG, H.; AGUILAR, I.; LEGARRA, A.; TSURUTA, S.; LOURENCO, D.; FRAGOMENI, B. O.; ZHANG, X.; MUIR, W. M.; CHENG, H. H.; OKIMOTO, R.; WING, T.; HAWKEN, R. R.; ZUMBACH, B.; FERNANDO, R. |
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Afiliación : |
IGNACY MISZTAL, University of Georgia, Athens, GA, USA; H. WANG, Genus PIC, Hendersonville, TN; IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANDRÉS LEGARRA, INRA, Toulouse, France; S. TSURUTA, University of Georgia, Athens, GA, USA; D.A.L. LOURENCO, University of Georgia, Athens, GA, USA; B. O. FRAGOMENI, University of Georgia, Athens, GA, USA; X. ZHANG, University of Georgia, Athens, GA, USA; W. M. MUIR, Purdue University, West Lafayette, IN, USA; H. H. CHENG, Cobb-Vantress Inc., Siloam Springs, AR, USA; R. OKIMOTO, Cobb-Vantress Inc., Siloam Springs, AR, USA; T. WING, Cobb-Vantress Inc., Siloam Springs, AR, USA; R. R. HAWKEN, Cobb-Vantress Inc., Siloam Springs, AR, USA; B. ZUMBACH, Cobb-Vantress Inc., Siloam Springs, AR, USA; R. FERNANDO, Department of Animal Science, Iowa State University, Ames, IA, USA. |
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Título : |
GWAS using ssGBLUP. |
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Complemento del título : |
Volume Species Breeding: Poultry, 325. |
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Fecha de publicación : |
2014 |
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Fuente / Imprenta : |
In: Proceedings of the World Congress on Genetics Applied to Livestock Production, 10., Vancouver, BC, Canada, August 17-22, 2014. p.325. |
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Idioma : |
Inglés |
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Contenido : |
ABSTRACT.
This study aimed to compare results of genome-wide associations obtained from various methodologies for GWAS when applied to two lines of broiler chicken. Each line contained >250k birds with 3 traits and 5k SNP60k genotypes. Methods included single-step GWAS, single marker model and BayesB. Mannhattan plots were based on variances of 20-SNP segments, as shorter segments produced noisy plots. Only a few segments explained >1 % of the additive variance. One segment explained >20% variance in BayesB but 3% with ssGWAS and <1% with a single marker model. In two lines, no major segment overlapped for any trait. When analyses used slices of generations (1-3,2-4,3-5,1-5), variances for the same segment varied greatly. The plots were more distinct with a new data set that included >16k genotypes, but no segment explained >1% of the variance. Strength of associations strongly depends on methodologies and details of implementations. |
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Palabras claves : |
GWAS; SNP variance; SsGBLUP. |
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Asunto categoría : |
L10 Genética y mejoramiento animal |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/15454/1/Misztal-et-al.-2014.WCGALP.pdf
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Marc : |
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100 1 $aMISZTAL, I.
245 $aGWAS using ssGBLUP.$h[electronic resource]
260 $aIn: Proceedings of the World Congress on Genetics Applied to Livestock Production, 10., Vancouver, BC, Canada, August 17-22, 2014. p.325.$c2014
520 $aABSTRACT. This study aimed to compare results of genome-wide associations obtained from various methodologies for GWAS when applied to two lines of broiler chicken. Each line contained >250k birds with 3 traits and 5k SNP60k genotypes. Methods included single-step GWAS, single marker model and BayesB. Mannhattan plots were based on variances of 20-SNP segments, as shorter segments produced noisy plots. Only a few segments explained >1 % of the additive variance. One segment explained >20% variance in BayesB but 3% with ssGWAS and <1% with a single marker model. In two lines, no major segment overlapped for any trait. When analyses used slices of generations (1-3,2-4,3-5,1-5), variances for the same segment varied greatly. The plots were more distinct with a new data set that included >16k genotypes, but no segment explained >1% of the variance. Strength of associations strongly depends on methodologies and details of implementations.
653 $aGWAS
653 $aSNP variance
653 $aSsGBLUP
700 1 $aWANG, H.
700 1 $aAGUILAR, I.
700 1 $aLEGARRA, A.
700 1 $aTSURUTA, S.
700 1 $aLOURENCO, D.
700 1 $aFRAGOMENI, B. O.
700 1 $aZHANG, X.
700 1 $aMUIR, W. M.
700 1 $aCHENG, H. H.
700 1 $aOKIMOTO, R.
700 1 $aWING, T.
700 1 $aHAWKEN, R. R.
700 1 $aZUMBACH, B.
700 1 $aFERNANDO, R.
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INIA Las Brujas (LB) |
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| Registros recuperados : 7 | |
| 1. |  | FRAGOMENI, B.O.; MISZTAL, I.; LOURENCO, D.L.; AGUILAR, I.; OKIMOTO, R.; MUIR, W.M. Changes in variance explained by top SNP windows over generations for three traits in broiler chicken Frontiers in Genetics, 2014, v.5, no.Oct., Article number 332. OPEN ACCESS. Article history: Published 01 October 2014.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : B - 2 |
| Biblioteca(s): INIA Las Brujas. |
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| 2. | | CHEN, C.Y.; MISZTAL, I.; AGUILAR, I.; LEGARRA, A.; MUIR, W.M. Effect of different genomic relationship matrices on accuracy and scale. Journal of Animal Science, 2011, v.89, no.9, p.2673-2679. Article history: Received September 29, 2010. / Accepted March 21, 2011.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : A - 1 |
| Biblioteca(s): INIA Las Brujas. |
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| 4. | | CHEN, C. Y.; MISZTAL, I.; AGUILAR, I.; TSURUTA, S.; MEUWISSEN, T.; AGGREY, S. E.; MUIR, W. M. Genome wide marker assisted selection in chicken: making the most of all data, pedigree, phenotypic, and genomic in a simple one step procedure. Volume Genetic improvement programmes: Selection using molecular information - Lecture Sessions, 0288. In: Proceedings of the World Congress on Genetics Applied to Livestock Production, 9., Leipzig, Germany, August 1-6, 2010. p. 0288. Acknowledgements: The authors thank Cobb-Vantress for access to data for this study. This study was partially funded by the Holstein Association, Smithfield Premium Genetics, and by AFRI grants 2009-65205-05665 and 2010-65205-20366 from...| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA Las Brujas. |
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| 5. | | WANG, H.; MISZTAL, I.; AGUILAR, I.; LEGARRA, A.; FERNANDO, R.L.; VITEZICA, Z.; OKIMOTO, R.; WING, T.; HAWKEN, R.; MUIR, W.M. Genome-wide association mapping including phenotypes from relatives without genotypes in a single-step (ssGWAS) for 6-week body weight in broiler chickens. Frontiers in Genetics, 2014, v.5, p.1-10. OPEN ACCESS. Article history: Received 03 March 2014 // Paper pending published 04 April 2014 // Accepted 25 April 2014 // Published online: 20 May 2014.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : B - 2 |
| Biblioteca(s): INIA Las Brujas. |
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| 6. | | CHEN, C.Y.; MISZTAL, I.; AGUILAR, I.; TSURUTA, S.; MEUWISSEN, T.H.E.; AGGREY, S.E.; WING, T.; MUIR, W.M. Genome-wide marker-assisted selection combining all pedigree phenotypic information with genotypic data in one step: An example using broiler chickens. Journal of Animal Science, 2011, v.89, no.1, p.23-28. Article history: Received April 9, 2010 / Accepted September 22, 2010.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : A - 1 |
| Biblioteca(s): INIA Las Brujas. |
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| 7. | | MISZTAL, I.; WANG, H.; AGUILAR, I.; LEGARRA, A.; TSURUTA, S.; LOURENCO, D.; FRAGOMENI, B. O.; ZHANG, X.; MUIR, W. M.; CHENG, H. H.; OKIMOTO, R.; WING, T.; HAWKEN, R. R.; ZUMBACH, B.; FERNANDO, R. GWAS using ssGBLUP. Volume Species Breeding: Poultry, 325. In: Proceedings of the World Congress on Genetics Applied to Livestock Production, 10., Vancouver, BC, Canada, August 17-22, 2014. p.325.| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA Las Brujas. |
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| Registros recuperados : 7 | |
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