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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
21/02/2014 |
Actualizado : |
18/12/2018 |
Tipo de producción científica : |
Artículos Indexados |
Autor : |
MASUDA, Y.; MISZTAL, I.; TSURUTA, S.; LOURENÇO, D. A. L.; FRAGOMENI, B.; LEGARRA, A.; AGUILAR, I.; LAWLOR, T. J. |
Afiliación : |
IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Single-step genomic evaluations with 570K genotyped animals in US Holsteins. |
Fecha de publicación : |
2015 |
Fuente / Imprenta : |
Interbull Bulletin, 2015, v. 49, p. 85-89. |
Idioma : |
Inglés |
Contenido : |
ABSTRACT.
The objectives of this study were to implement and evaluate the ?Algorithm for proven and Young? (APY) for inversion of the genomic relationship matrix (G) in single-step genomic BLUP (ssGBLUP). Phenotypic data included 11,626,576 final scores on 7,093,380 US Holsteins and genotypes were available for 569,404 animals. Daughter deviations for young genotyped bulls with no classified daughters in 2009 but with at least 30 classified daughters in 2014 were computed using BLUP with all the phenotypes and pedigrees. Genomic predictions (GEBV) were obtained by ssGBLUP using phenotypes up to 2009. We calculated the G inverse with APY based on genomic recursions on a subset of ?base? animals. We tested several subsets including 9,406 bulls with at least 1 daughter, 9,046 bulls and 1052 dams, 9,046 bulls and 7,422 classified cows, and random samples of 5,000, 10,000, 15,000, 20,000, and 30,000 animals. Validation reliability was calculated as R2 with a linear regression of daughter deviations on GEBV for young genotyped bulls. The reliabilities were 0.39 with 5,000 randomly chosen base-animals, 0.45 with base-animals including bulls and cows, and 0.44 with the remaining subsets. Setting up the G inverse for all the genotypes with 10,000 base-animals took 1.3 hours and 57GB of memory. Genomic predictions with G inverse are accurate when the number of base animals is at least 10,000. Single-step genomic BLUP using the G inverse via APY is applicable to populations with a large number of genotyped animals. MenosABSTRACT.
The objectives of this study were to implement and evaluate the ?Algorithm for proven and Young? (APY) for inversion of the genomic relationship matrix (G) in single-step genomic BLUP (ssGBLUP). Phenotypic data included 11,626,576 final scores on 7,093,380 US Holsteins and genotypes were available for 569,404 animals. Daughter deviations for young genotyped bulls with no classified daughters in 2009 but with at least 30 classified daughters in 2014 were computed using BLUP with all the phenotypes and pedigrees. Genomic predictions (GEBV) were obtained by ssGBLUP using phenotypes up to 2009. We calculated the G inverse with APY based on genomic recursions on a subset of ?base? animals. We tested several subsets including 9,406 bulls with at least 1 daughter, 9,046 bulls and 1052 dams, 9,046 bulls and 7,422 classified cows, and random samples of 5,000, 10,000, 15,000, 20,000, and 30,000 animals. Validation reliability was calculated as R2 with a linear regression of daughter deviations on GEBV for young genotyped bulls. The reliabilities were 0.39 with 5,000 randomly chosen base-animals, 0.45 with base-animals including bulls and cows, and 0.44 with the remaining subsets. Setting up the G inverse for all the genotypes with 10,000 base-animals took 1.3 hours and 57GB of memory. Genomic predictions with G inverse are accurate when the number of base animals is at least 10,000. Single-step genomic BLUP using the G inverse via APY is applicable to populations with a lar... Presentar Todo |
Palabras claves : |
APY; SSGBLUP; VALIDATION. |
Asunto categoría : |
-- |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/12203/1/1382-2378-1-PB.pdf
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Marc : |
LEADER 02171naa a2200241 a 4500 001 1012457 005 2018-12-18 008 2015 bl uuuu u00u1 u #d 100 1 $aMASUDA, Y. 245 $aSingle-step genomic evaluations with 570K genotyped animals in US Holsteins.$h[electronic resource] 260 $c2015 520 $aABSTRACT. The objectives of this study were to implement and evaluate the ?Algorithm for proven and Young? (APY) for inversion of the genomic relationship matrix (G) in single-step genomic BLUP (ssGBLUP). Phenotypic data included 11,626,576 final scores on 7,093,380 US Holsteins and genotypes were available for 569,404 animals. Daughter deviations for young genotyped bulls with no classified daughters in 2009 but with at least 30 classified daughters in 2014 were computed using BLUP with all the phenotypes and pedigrees. Genomic predictions (GEBV) were obtained by ssGBLUP using phenotypes up to 2009. We calculated the G inverse with APY based on genomic recursions on a subset of ?base? animals. We tested several subsets including 9,406 bulls with at least 1 daughter, 9,046 bulls and 1052 dams, 9,046 bulls and 7,422 classified cows, and random samples of 5,000, 10,000, 15,000, 20,000, and 30,000 animals. Validation reliability was calculated as R2 with a linear regression of daughter deviations on GEBV for young genotyped bulls. The reliabilities were 0.39 with 5,000 randomly chosen base-animals, 0.45 with base-animals including bulls and cows, and 0.44 with the remaining subsets. Setting up the G inverse for all the genotypes with 10,000 base-animals took 1.3 hours and 57GB of memory. Genomic predictions with G inverse are accurate when the number of base animals is at least 10,000. Single-step genomic BLUP using the G inverse via APY is applicable to populations with a large number of genotyped animals. 653 $aAPY 653 $aSSGBLUP 653 $aVALIDATION 700 1 $aMISZTAL, I. 700 1 $aTSURUTA, S. 700 1 $aLOURENÇO, D. A. L. 700 1 $aFRAGOMENI, B. 700 1 $aLEGARRA, A. 700 1 $aAGUILAR, I. 700 1 $aLAWLOR, T. J. 773 $tInterbull Bulletin, 2015$gv. 49, p. 85-89.
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INIA Las Brujas (LB) |
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| Acceso al texto completo restringido a Biblioteca INIA La Estanzuela. Por información adicional contacte bib_le@inia.org.uy. |
Registro completo
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Biblioteca (s) : |
INIA La Estanzuela. |
Fecha actual : |
01/03/2019 |
Actualizado : |
15/01/2020 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Circulación / Nivel : |
Internacional - -- |
Autor : |
HAMOND, C.; SILVEIRA, C.S.; BURONI, F.; SUANES, A.; NIEVES, C.; SALABERRY, X.; ARÁOZ, V.; COSTA, R.A. DA; RIVERO, R.; GIANNITTI, F.; ZARANTONELLI, L. |
Afiliación : |
CAMILA HAMOND, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay.//Unidad Mixta Pasteur + INIA (UMPI), Institut Pasteur de Montevideo, Uruguay.; CAROLINE DA SILVA SILVEIRA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FLORENCIA BURONI, División Laboratorios Veterinarios Miguel C. Rubino, Laboratorio Regional Noroeste, Ministerio de Ganadería Agricultura y Pesca, Paysandú, Uruguay.; ALEJANDRA SUANES, Departamento de Bacteriología, División Laboratorios Veterinarios Miguel C. Rubino, Sede Central, Ministerio de Ganadería Agricultura y Pesca, Montevideo, Uruguay.; CECILIA NIEVES, Unidad Mixta Pasteur + INIA (UMPI), Institut Pasteur de Montevideo, Uruguay.//Laboratorio de Microbiología Molecular & Estructural, Institut Pasteur de Montevideo, Montevideo, UruguaY.; XIMENA SALABERRY, Departamento de Bacteriología, División Laboratorios Veterinarios Miguel C. Rubino, Sede Central, Ministerio de Ganadería Agricultura y Pesca, Montevideo, Uruguay.; VIRGINIA ARÁOZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; RICARDO ALMEIDA DA COSTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; RODOLFO RIVERO, División Laboratorios Veterinarios Miguel C. Rubino, Laboratorio Regional Noroeste, Ministerio de Ganadería Agricultura y Pesca, Paysandú, Uruguay.; FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay.//6Veterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, USA.; Unidad Mixta Pasteur + INIA (UMPI), Institut Pasteur de Montevideo, Montevideo, Uruguay./Laboratorio de Microbiología Molecular & Estructural, Institut Pasteur de Montevideo, Montevideo, Uruguay. |
Título : |
Leptospira interrogans serogroup Pomona serovar Kennewicki infection in two sheep flocks with acute leptospirosis in Uruguay. |
Fecha de publicación : |
2019 |
Fuente / Imprenta : |
Transboundary and Emerging Diseases ,2019 May, Vol. 66 (3), p. 1186-1194. DOI: https://doi.org/10.1111/tbed.13133 |
DOI : |
10.1111/tbed.13133 |
Idioma : |
Inglés |
Notas : |
Article history: First published: 26 January 2019 /Received: 17 August 2018 / Revised: 18 January 2019 / Accepted: 19 January 2019. |
Contenido : |
Abstract:Acute leptospirosis is an infrequent disease in sheep that can cause jaundice, haemolysis, haemoglobinuria, hepatitis and nephritis. In most reports the diagnoses have been made by clinical, pathological or serological evidence without isolation or direct identi?cation of the agent. Here, we report one con?rmed and one presumptive outbreak of acute leptospirosis in suckling lambs from two unrelated sheep farms in Uruguay with mortalities of 9/60 (15%) and 9/163 (5.5%) lambs. Both outbreaks occurred in Sep?Oct 2017 after heavy rainfall and ?ooding events. The main gross and histologic pathological ?ndings in two autopsied lambs, one from each farm, included severe di?use jaundice, haemoglobinuria, acute necrotizing hepatitis with cholestasis and interstitial nephritis. Leptospira interrogans serogroup Pomona serovar Kennewicki was isolated from sheep in both ?ocks and the same genotype was identi?ed directly in clinical samples from infected animals, including one of the deceased lambs subjected to autopsy, by ampli?cation and partial sequencing of rrs and secY genes. This serovar has recently been identi?ed in infected cattle and humans in Uruguay . The impact of Leptospira spp. infection in ovine health, and the epidemiologic role of sheep as reservoirs of leptospirosis for humans and animals need further investigation. © 2019 Blackwell Verlag GmbH |
Palabras claves : |
ACUTE LEPTOSPIROSIS; ENFERMEDADES DE LOS RUMIANTES; MOLECULAR DIAGNOSTICS; MORTALITY; PLATAFORMA DE SALUD ANIMAL; SALUD ANIMAL; SHEEP. |
Thesagro : |
OVEJA; URUGUAY. |
Asunto categoría : |
L73 Enfermedades de los animales |
Marc : |
LEADER 02629naa a2200373 a 4500 001 1059551 005 2020-01-15 008 2019 bl uuuu u00u1 u #d 024 7 $a10.1111/tbed.13133$2DOI 100 1 $aHAMOND, C. 245 $aLeptospira interrogans serogroup Pomona serovar Kennewicki infection in two sheep flocks with acute leptospirosis in Uruguay.$h[electronic resource] 260 $c2019 500 $aArticle history: First published: 26 January 2019 /Received: 17 August 2018 / Revised: 18 January 2019 / Accepted: 19 January 2019. 520 $aAbstract:Acute leptospirosis is an infrequent disease in sheep that can cause jaundice, haemolysis, haemoglobinuria, hepatitis and nephritis. In most reports the diagnoses have been made by clinical, pathological or serological evidence without isolation or direct identi?cation of the agent. Here, we report one con?rmed and one presumptive outbreak of acute leptospirosis in suckling lambs from two unrelated sheep farms in Uruguay with mortalities of 9/60 (15%) and 9/163 (5.5%) lambs. Both outbreaks occurred in Sep?Oct 2017 after heavy rainfall and ?ooding events. The main gross and histologic pathological ?ndings in two autopsied lambs, one from each farm, included severe di?use jaundice, haemoglobinuria, acute necrotizing hepatitis with cholestasis and interstitial nephritis. Leptospira interrogans serogroup Pomona serovar Kennewicki was isolated from sheep in both ?ocks and the same genotype was identi?ed directly in clinical samples from infected animals, including one of the deceased lambs subjected to autopsy, by ampli?cation and partial sequencing of rrs and secY genes. This serovar has recently been identi?ed in infected cattle and humans in Uruguay . The impact of Leptospira spp. infection in ovine health, and the epidemiologic role of sheep as reservoirs of leptospirosis for humans and animals need further investigation. © 2019 Blackwell Verlag GmbH 650 $aOVEJA 650 $aURUGUAY 653 $aACUTE LEPTOSPIROSIS 653 $aENFERMEDADES DE LOS RUMIANTES 653 $aMOLECULAR DIAGNOSTICS 653 $aMORTALITY 653 $aPLATAFORMA DE SALUD ANIMAL 653 $aSALUD ANIMAL 653 $aSHEEP 700 1 $aSILVEIRA, C.S. 700 1 $aBURONI, F. 700 1 $aSUANES, A. 700 1 $aNIEVES, C. 700 1 $aSALABERRY, X. 700 1 $aARÁOZ, V. 700 1 $aCOSTA, R.A. DA 700 1 $aRIVERO, R. 700 1 $aGIANNITTI, F. 700 1 $aZARANTONELLI, L. 773 $tTransboundary and Emerging Diseases ,2019 May, Vol. 66 (3), p. 1186-1194. DOI: https://doi.org/10.1111/tbed.13133
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