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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
21/01/2020 |
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Actualizado : |
21/01/2020 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
DE CARVALHO NUNES, L.; STEGELMEIER, B. L.; COOK, D.; PFISTER, J. A.; GARDNER, D. R.; RIET-CORREA, F.; WEICH, K. D. |
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Afiliación : |
LOUISIANE DE CARVALHO NUNES, Department of Veterinary Science, Federal University of Espírito Santo, Alegre, Espírito Santo, Brazil; BRYAN L. STEGELMEIER, USDA-ARS Poisonous Plant Research Laboratory, USA; DANIEL COOK, USDA-ARS Poisonous Plant Research Laboratory, USA; JAMES A. PFISTER, USDA-ARS Poisonous Plant Research Laboratory, USA; DALE R. GARDNER, USDA-ARS Poisonous Plant Research Laboratory, USA; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; Veterinary Hospital, Center for Health and Rural Technology, Patos Campus, Federal University of Campina Grande, Brazil; KEVIN D. WELCH, USDA-ARS Poisonous Plant Research Laboratory, USA. |
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Título : |
Clinical and pathological comparison of Astragalus lentiginosus and Ipomoea carnea poisoning in goats. |
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Fecha de publicación : |
2019 |
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Fuente / Imprenta : |
Toxicon, 5 December, 2019, Volume 171, Pages 20-28. Doi: 10.1016/j.toxicon.2019.09.016 |
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ISSN : |
0041-0101 |
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DOI : |
10.1016/j.toxicon.2019.09.016 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 12 July 2019; Received in revised form 12 September 2019; Accepted 16 September 2019; Available online 19 September 2019. |
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Contenido : |
ABSTRACT.
The indolizidine alkaloid swainsonine, found in some Astragalus and Oxytropis (i.e., locoweed) species, is a potent cellular glycosidase inhibitor that often poisons livestock. Other toxic genera such as some Ipomoea species also contain swainsonine as well as calystegines which are similar polyhydroxy alkaloids. The toxicity of calystegines is poorly characterized; however, they are also potent glycoside inhibitors capable of intestinal and cellular glycoside dysfunction. The objective of this study was to directly compare A. lentiginosus and I. carnea poisoning in goats to better characterize the role of the calystegines. Three groups of four goats each were treated with ground alfalfa (control), I. carnea or A. lentiginosus to obtain daily doses of 0.0, 1.5, and 1.5 mg swainsonine/kg bw per day, respectively, for 45 days. Animals were observed daily and weekly body weights, serum enzyme activities, and serum swainsonine concentrations were determined. At day 45 all animals were euthanized and necropsied. Goats treated with A. lentiginosus and I. carnea developed clinical disease characterized by mild intention tremors and proprioceptive deficits. Goats treated with A. lentiginosus developed clinical disease sooner and with greater consistency. No differences in body weight, serum swainsonine concentrations and serum enzyme activity were observed between goats treated with A. lentiginosus and I. carnea. Additionally, there were no differences in the microscopic and histochemical studies of the visceral and neurologic lesions observed between goats treated with A. lentiginosus and I. carnea. These findings suggest that I. carnea-induced clinical signs and lesions are due to swainsonine and that calystegines contribute little or nothing to toxicity in goats in the presence of swainsonine.
© 2019 MenosABSTRACT.
The indolizidine alkaloid swainsonine, found in some Astragalus and Oxytropis (i.e., locoweed) species, is a potent cellular glycosidase inhibitor that often poisons livestock. Other toxic genera such as some Ipomoea species also contain swainsonine as well as calystegines which are similar polyhydroxy alkaloids. The toxicity of calystegines is poorly characterized; however, they are also potent glycoside inhibitors capable of intestinal and cellular glycoside dysfunction. The objective of this study was to directly compare A. lentiginosus and I. carnea poisoning in goats to better characterize the role of the calystegines. Three groups of four goats each were treated with ground alfalfa (control), I. carnea or A. lentiginosus to obtain daily doses of 0.0, 1.5, and 1.5 mg swainsonine/kg bw per day, respectively, for 45 days. Animals were observed daily and weekly body weights, serum enzyme activities, and serum swainsonine concentrations were determined. At day 45 all animals were euthanized and necropsied. Goats treated with A. lentiginosus and I. carnea developed clinical disease characterized by mild intention tremors and proprioceptive deficits. Goats treated with A. lentiginosus developed clinical disease sooner and with greater consistency. No differences in body weight, serum swainsonine concentrations and serum enzyme activity were observed between goats treated with A. lentiginosus and I. carnea. Additionally, there were no differences in the microscopic a... Presentar Todo |
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Palabras claves : |
Astragalus; Calystegines; Ipomoea; Locoweed; PLATAFORMA SALUD ANIMAL; Swainsonine. |
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Asunto categoría : |
A50 Investigación agraria |
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Marc : |
LEADER 02878naa a2200301 a 4500
001 1060655
005 2020-01-21
008 2019 bl uuuu u00u1 u #d
022 $a0041-0101
024 7 $a10.1016/j.toxicon.2019.09.016$2DOI
100 1 $aDE CARVALHO NUNES, L.
245 $aClinical and pathological comparison of Astragalus lentiginosus and Ipomoea carnea poisoning in goats.$h[electronic resource]
260 $c2019
500 $aArticle history: Received 12 July 2019; Received in revised form 12 September 2019; Accepted 16 September 2019; Available online 19 September 2019.
520 $aABSTRACT. The indolizidine alkaloid swainsonine, found in some Astragalus and Oxytropis (i.e., locoweed) species, is a potent cellular glycosidase inhibitor that often poisons livestock. Other toxic genera such as some Ipomoea species also contain swainsonine as well as calystegines which are similar polyhydroxy alkaloids. The toxicity of calystegines is poorly characterized; however, they are also potent glycoside inhibitors capable of intestinal and cellular glycoside dysfunction. The objective of this study was to directly compare A. lentiginosus and I. carnea poisoning in goats to better characterize the role of the calystegines. Three groups of four goats each were treated with ground alfalfa (control), I. carnea or A. lentiginosus to obtain daily doses of 0.0, 1.5, and 1.5 mg swainsonine/kg bw per day, respectively, for 45 days. Animals were observed daily and weekly body weights, serum enzyme activities, and serum swainsonine concentrations were determined. At day 45 all animals were euthanized and necropsied. Goats treated with A. lentiginosus and I. carnea developed clinical disease characterized by mild intention tremors and proprioceptive deficits. Goats treated with A. lentiginosus developed clinical disease sooner and with greater consistency. No differences in body weight, serum swainsonine concentrations and serum enzyme activity were observed between goats treated with A. lentiginosus and I. carnea. Additionally, there were no differences in the microscopic and histochemical studies of the visceral and neurologic lesions observed between goats treated with A. lentiginosus and I. carnea. These findings suggest that I. carnea-induced clinical signs and lesions are due to swainsonine and that calystegines contribute little or nothing to toxicity in goats in the presence of swainsonine. © 2019
653 $aAstragalus
653 $aCalystegines
653 $aIpomoea
653 $aLocoweed
653 $aPLATAFORMA SALUD ANIMAL
653 $aSwainsonine
700 1 $aSTEGELMEIER, B. L.
700 1 $aCOOK, D.
700 1 $aPFISTER, J. A.
700 1 $aGARDNER, D. R.
700 1 $aRIET-CORREA, F.
700 1 $aWEICH, K. D.
773 $tToxicon, 5 December, 2019, Volume 171, Pages 20-28. Doi: 10.1016/j.toxicon.2019.09.016
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Registro original : |
INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
31/03/2021 |
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Actualizado : |
31/03/2021 |
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Tipo de producción científica : |
Trabajos en Congresos/Conferencias |
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Autor : |
CARDOSO, F. F.; SOLLERO, B. P.; COMIN, H. B.; GOMES, C. G.; ROSO, V. M.; HIGA, R. H.; CAETANO, A. R.; YOKOO, M. J.; AGUILAR, I. |
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Afiliación : |
FERNANDO F. CARDOSO, Embrapa Southern Region Animal Husbandry, Bagé; BRUNA P. SOLLERO, Embrapa Southern Region Animal Husbandry, Bagé; HELENA B. COMIN, Embrapa Southern Region Animal Husbandry, Bagé; CLAUDIA G GOMES, Embrapa Southern Region Animal Husbandry, Bagé; VANERLEI M. ROSO, Gensys Associated Consultants, Porto Alegre; ROBERTO H. HIGA, Embrapa Agriculture Informatics, Campinas; ALEXANDRE R. CAETANO, Embrapa Genetic Resources & Biotechnology, Brasilia, Brazil; MARCOS J. YOKOO, Embrapa Southern Region Animal Husbandry, Bagé; IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Accuracy of genomic prediction for tick resistance in Braford and Hereford cattle. |
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Complemento del título : |
Volume Species Breeding: Beef cattle (Posters), 713. |
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Fecha de publicación : |
2014 |
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Fuente / Imprenta : |
In: Proceedings of the World Congress on Genetics Applied to Livestock Production, 10., Vancouver, BC, Canada, August 17-22, 2014. p.713. |
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Idioma : |
Inglés |
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Notas : |
Acknowledgments: Research supported by CNPq - National Council for Scientific and Technological Development grant 478992/2012-2, Embrapa - Brazilian Agricultural Research Corporation grants 02.09.07.004 and 01.11.07.002.07, and CAPES - Coordination for the Improvement of Higher Level Personnel grant PNPD 02645/09-2. Authors acknowledge the Delta G Connection for providing animals and data for this research. |
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Contenido : |
ABSTRACT.
This work aimed to determine the accuracy and bias of genomic predictions of Braford (BO) and Hereford (HH) cattle genetic resistance to ticks. Repeated 10,673 tick counts were obtained from 3,435 BO and 928 HH cattle from Delta G Connection breeding program. A subset of 2,803 BO and 652 HH samples were genotyped and 41,045 markers remained after quality control. Log transformed records were adjusted by a pedigree repeatability model to estimate breeding values (EBV), subsequently used to obtained deregressed EBV. Data were split into five subsets for cross-validation using k-means and random clustering. Genomic predictions with moderate accuracies (0.38 to 0.60) were obtained by best unbiased linear prediction (GBLUP), BayesB and single step GBLUP indicating that, despite some bias, genomic selection could be used as practical tool to improve cattle genetic resistance to ticks. |
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Palabras claves : |
Beef cattle; Genomic selection; Health; Tick resistance. |
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Asunto categoría : |
L10 Genética y mejoramiento animal |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/15450/1/Cardoso-et-al.-2014.-WCGALP.pdf
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Marc : |
LEADER 02130nam a2200265 a 4500
001 1061926
005 2021-03-31
008 2014 bl uuuu u01u1 u #d
100 1 $aCARDOSO, F. F.
245 $aAccuracy of genomic prediction for tick resistance in Braford and Hereford cattle.$h[electronic resource]
260 $aIn: Proceedings of the World Congress on Genetics Applied to Livestock Production, 10., Vancouver, BC, Canada, August 17-22, 2014. p.713.$c2014
500 $aAcknowledgments: Research supported by CNPq - National Council for Scientific and Technological Development grant 478992/2012-2, Embrapa - Brazilian Agricultural Research Corporation grants 02.09.07.004 and 01.11.07.002.07, and CAPES - Coordination for the Improvement of Higher Level Personnel grant PNPD 02645/09-2. Authors acknowledge the Delta G Connection for providing animals and data for this research.
520 $aABSTRACT. This work aimed to determine the accuracy and bias of genomic predictions of Braford (BO) and Hereford (HH) cattle genetic resistance to ticks. Repeated 10,673 tick counts were obtained from 3,435 BO and 928 HH cattle from Delta G Connection breeding program. A subset of 2,803 BO and 652 HH samples were genotyped and 41,045 markers remained after quality control. Log transformed records were adjusted by a pedigree repeatability model to estimate breeding values (EBV), subsequently used to obtained deregressed EBV. Data were split into five subsets for cross-validation using k-means and random clustering. Genomic predictions with moderate accuracies (0.38 to 0.60) were obtained by best unbiased linear prediction (GBLUP), BayesB and single step GBLUP indicating that, despite some bias, genomic selection could be used as practical tool to improve cattle genetic resistance to ticks.
653 $aBeef cattle
653 $aGenomic selection
653 $aHealth
653 $aTick resistance
700 1 $aSOLLERO, B. P.
700 1 $aCOMIN, H. B.
700 1 $aGOMES, C. G.
700 1 $aROSO, V. M.
700 1 $aHIGA, R. H.
700 1 $aCAETANO, A. R.
700 1 $aYOKOO, M. J.
700 1 $aAGUILAR, I.
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