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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
16/03/2020 |
Actualizado : |
10/08/2020 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
AGUILAR, I.; FERNÁNDEZ, E.N.; BLASCO, A.; RAVAGNOLO, O.; LEGARRA, A. |
Afiliación : |
IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; EDUARDO N. FERNÁNDEZ, Cátedra de Mejora y Conservación de Recursos Genéticos e Instituto de Investigación sobre Producción Agropecuaria, Ambiente y Salud, Facultad de Ciencias Agrarias, UNLZ, Buenos Aires, Argentina; AGUSTÍN BLASCO, Institute for Animal Science and Technology, Universitat Politècnica de València, València, Spain; OLGA RAVAGNOLO GUMILA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANDRÉS LEGARRA, UMR GenPhySE, INRA Toulouse, Castanet Tolosan, France. |
Título : |
Effects of ignoring inbreeding in model-based accuracy for BLUP and SSGBLUP. |
Fecha de publicación : |
2020 |
Fuente / Imprenta : |
Journal of Animal Breeding and Genetics, 1 July 2020, Volume 137, Issue 4, pp. 356-364. Doi: https://doi.org/10.1111/jbg.12470 |
ISSN : |
0931-2668 |
DOI : |
10.1111/jbg.12470 |
Idioma : |
Inglés |
Notas : |
Article history: Received: 22 August 2019 / Revised: 10 December 2019 / Accepted: 11 January 2020 / First published:20 February 2020
Corresponding author: Aguilar, I.; email:iaguilar@inia.org.uy
Funding information: FEDER; INRA; Universidad Nacional de Lomas de Zamora; European Unions' Horizon 2020 Research & Innovation Programme, Grant/Award Number: N°772787 |
Contenido : |
ABSTRACT.
Model-based accuracy, defined as the theoretical correlation between true and estimated breeding value, can be obtained for each individual as a function of its prediction error variance (PEV) and inbreeding coefficient F, in BLUP, GBLUP and SSGBLUP genetic evaluations. However, for computational convenience, inbreeding is often ignored in two places. First, in the computation of reliability = 1-PEV/(1 + F). Second, in the set-up, using Henderson's rules, of the inverse of the pedigree-based relationship matrix A. Both approximations have an effect in the computation of model-based accuracy and result in wrong values. In this work, first we present a reminder of the theory and extend it to SSGBLUP. Second, we quantify the error of ignoring inbreeding with real data in three scenarios: BLUP evaluation and SSGBLUP in Uruguayan dairy cattle, and BLUP evaluations in a line of rabbit closed for >40 generations with steady increase of inbreeding up to an average of 0.30. We show that ignoring inbreeding in the set-up of the A-inverse is equivalent to assume that non-inbred animals are actually inbred. This results in an increase of apparent PEV that is negligible for dairy cattle but considerable for rabbit. Ignoring inbreeding in reliability = 1-PEV/(1 + F) leads to underestimation of reliability for BLUP evaluations, and this underestimation is very large for rabbit. For SSGBLUP in dairy cattle, it leads to both underestimation and overestimation of reliability, both for genotyped and non-genotyped animals. We strongly recommend to include inbreeding both in the set-up of A-inverse and in the computation of reliability from PEVs.
© 2020 Blackwell Verlag GmbH MenosABSTRACT.
Model-based accuracy, defined as the theoretical correlation between true and estimated breeding value, can be obtained for each individual as a function of its prediction error variance (PEV) and inbreeding coefficient F, in BLUP, GBLUP and SSGBLUP genetic evaluations. However, for computational convenience, inbreeding is often ignored in two places. First, in the computation of reliability = 1-PEV/(1 + F). Second, in the set-up, using Henderson's rules, of the inverse of the pedigree-based relationship matrix A. Both approximations have an effect in the computation of model-based accuracy and result in wrong values. In this work, first we present a reminder of the theory and extend it to SSGBLUP. Second, we quantify the error of ignoring inbreeding with real data in three scenarios: BLUP evaluation and SSGBLUP in Uruguayan dairy cattle, and BLUP evaluations in a line of rabbit closed for >40 generations with steady increase of inbreeding up to an average of 0.30. We show that ignoring inbreeding in the set-up of the A-inverse is equivalent to assume that non-inbred animals are actually inbred. This results in an increase of apparent PEV that is negligible for dairy cattle but considerable for rabbit. Ignoring inbreeding in reliability = 1-PEV/(1 + F) leads to underestimation of reliability for BLUP evaluations, and this underestimation is very large for rabbit. For SSGBLUP in dairy cattle, it leads to both underestimation and overestimation of reliability, both f... Presentar Todo |
Palabras claves : |
BREEDING; Genomic predictions; GENOMICS. |
Asunto categoría : |
L10 Genética y mejoramiento animal |
Marc : |
LEADER 02789naa a2200241 a 4500 001 1060921 005 2020-08-10 008 2020 bl uuuu u00u1 u #d 022 $a0931-2668 024 7 $a10.1111/jbg.12470$2DOI 100 1 $aAGUILAR, I. 245 $aEffects of ignoring inbreeding in model-based accuracy for BLUP and SSGBLUP.$h[electronic resource] 260 $c2020 500 $aArticle history: Received: 22 August 2019 / Revised: 10 December 2019 / Accepted: 11 January 2020 / First published:20 February 2020 Corresponding author: Aguilar, I.; email:iaguilar@inia.org.uy Funding information: FEDER; INRA; Universidad Nacional de Lomas de Zamora; European Unions' Horizon 2020 Research & Innovation Programme, Grant/Award Number: N°772787 520 $aABSTRACT. Model-based accuracy, defined as the theoretical correlation between true and estimated breeding value, can be obtained for each individual as a function of its prediction error variance (PEV) and inbreeding coefficient F, in BLUP, GBLUP and SSGBLUP genetic evaluations. However, for computational convenience, inbreeding is often ignored in two places. First, in the computation of reliability = 1-PEV/(1 + F). Second, in the set-up, using Henderson's rules, of the inverse of the pedigree-based relationship matrix A. Both approximations have an effect in the computation of model-based accuracy and result in wrong values. In this work, first we present a reminder of the theory and extend it to SSGBLUP. Second, we quantify the error of ignoring inbreeding with real data in three scenarios: BLUP evaluation and SSGBLUP in Uruguayan dairy cattle, and BLUP evaluations in a line of rabbit closed for >40 generations with steady increase of inbreeding up to an average of 0.30. We show that ignoring inbreeding in the set-up of the A-inverse is equivalent to assume that non-inbred animals are actually inbred. This results in an increase of apparent PEV that is negligible for dairy cattle but considerable for rabbit. Ignoring inbreeding in reliability = 1-PEV/(1 + F) leads to underestimation of reliability for BLUP evaluations, and this underestimation is very large for rabbit. For SSGBLUP in dairy cattle, it leads to both underestimation and overestimation of reliability, both for genotyped and non-genotyped animals. We strongly recommend to include inbreeding both in the set-up of A-inverse and in the computation of reliability from PEVs. © 2020 Blackwell Verlag GmbH 653 $aBREEDING 653 $aGenomic predictions 653 $aGENOMICS 700 1 $aFERNÁNDEZ, E.N. 700 1 $aBLASCO, A. 700 1 $aRAVAGNOLO, O. 700 1 $aLEGARRA, A. 773 $tJournal of Animal Breeding and Genetics, 1 July 2020, Volume 137, Issue 4, pp. 356-364. Doi: https://doi.org/10.1111/jbg.12470
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INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Tacuarembó. |
Fecha actual : |
21/02/2014 |
Actualizado : |
25/07/2018 |
Tipo de producción científica : |
Trabajos en Congresos/Conferencias |
Autor : |
MONTOSSI, F.; SAN JULIAN, R.; BRITO, G.; DE LOS CAMPOS, G.; GANZABAL, A.; DIGHIERO, A.; DE BARBIERI, I.; CASTRO, L.; ROBAINA, R.; PIGURINA, G.; DE MATTOS, D.; NOLLA, M. |
Afiliación : |
FABIO MARCELO MONTOSSI PORCHILE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ROBERTO SAN JULIAN SANCHEZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; GUSTAVO WALTER BRITO DIAZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; GUSTAVO DE LOS CAMPOS, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANDRES RICARDO GANZABAL PLANINICH, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ALEJANDRO DIGHIERO FASCIOLI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; LUIS IGNACIO DE BARBIERI ETCHEBERRY, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; INAC (Instituto Nacional de Carnes).; DANIEL DE MATTOS, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Producción de carne ovina de calidad con la Raza Corriedale: Recientes avances y desafíos de la innovación tecnológica en el contexo de la cadena cárnica ovina del Urguay. |
Fecha de publicación : |
2003 |
Fuente / Imprenta : |
ln: CONGRESO MUNDIAL CORRIEDALE, 12, 2003, SET 1-10: MONTEVIDEO, URUGUAY. Montevideo (Uruguay): INIA; SUL; Sociedad Criadores de Corriedale, 2003. |
Páginas : |
p. 74-90 |
Idioma : |
Español |
Notas : |
Instituto Nacional de Investigación Agropecuaria, Uruguay; Sociedad Criadores de Corriedale; Secretariado Uruguayo de la Lana |
Contenido : |
Introducción. Potenciales de producción. Calidad de canal. Calidad de carne. Terneza. PH. Color de la carne. Valoración organoléptica de la carne ovina uruguaya (análisis sensorial y test de consumidores) en los mercados destino. Auditoría de la calidad de carne ovina del Uruguay. Consideraciones finales. Bibliografía. |
Palabras claves : |
CORRIEDALE BREED; MEAT PRODUCTION; QUALITY MEAT; RECENT ADVANCES; SHEEP; TECHNOLOGY. |
Thesagro : |
CALIDAD; CARNE; CORRIEDALE; TECNOLOGÍA; URUGUAY. |
Asunto categoría : |
L01 Ganadería |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/10883/1/Produccion-de-carne-2003.pdf
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Marc : |
LEADER 01639nam a2200397 a 4500 001 1026147 005 2018-07-25 008 2003 bl uuuu u01u1 u #d 100 1 $aMONTOSSI, F. 245 $aProducción de carne ovina de calidad con la Raza Corriedale$bRecientes avances y desafíos de la innovación tecnológica en el contexo de la cadena cárnica ovina del Urguay. 260 $aln: CONGRESO MUNDIAL CORRIEDALE, 12, 2003, SET 1-10: MONTEVIDEO, URUGUAY. Montevideo (Uruguay): INIA; SUL; Sociedad Criadores de Corriedale$c2003 300 $ap. 74-90 500 $aInstituto Nacional de Investigación Agropecuaria, Uruguay; Sociedad Criadores de Corriedale; Secretariado Uruguayo de la Lana 520 $aIntroducción. Potenciales de producción. Calidad de canal. Calidad de carne. Terneza. PH. Color de la carne. Valoración organoléptica de la carne ovina uruguaya (análisis sensorial y test de consumidores) en los mercados destino. Auditoría de la calidad de carne ovina del Uruguay. Consideraciones finales. Bibliografía. 650 $aCALIDAD 650 $aCARNE 650 $aCORRIEDALE 650 $aTECNOLOGÍA 650 $aURUGUAY 653 $aCORRIEDALE BREED 653 $aMEAT PRODUCTION 653 $aQUALITY MEAT 653 $aRECENT ADVANCES 653 $aSHEEP 653 $aTECHNOLOGY 700 1 $aSAN JULIAN, R. 700 1 $aBRITO, G. 700 1 $aDE LOS CAMPOS, G. 700 1 $aGANZABAL, A. 700 1 $aDIGHIERO, A. 700 1 $aDE BARBIERI, I. 700 1 $aCASTRO, L. 700 1 $aROBAINA, R. 700 1 $aPIGURINA, G. 700 1 $aDE MATTOS, D. 700 1 $aNOLLA, M.
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