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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
21/01/2020 |
Actualizado : |
21/01/2020 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
DE CARVALHO NUNES, L.; STEGELMEIER, B. L.; COOK, D.; PFISTER, J. A.; GARDNER, D. R.; RIET-CORREA, F.; WEICH, K. D. |
Afiliación : |
LOUISIANE DE CARVALHO NUNES, Department of Veterinary Science, Federal University of Espírito Santo, Alegre, Espírito Santo, Brazil; BRYAN L. STEGELMEIER, USDA-ARS Poisonous Plant Research Laboratory, USA; DANIEL COOK, USDA-ARS Poisonous Plant Research Laboratory, USA; JAMES A. PFISTER, USDA-ARS Poisonous Plant Research Laboratory, USA; DALE R. GARDNER, USDA-ARS Poisonous Plant Research Laboratory, USA; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; Veterinary Hospital, Center for Health and Rural Technology, Patos Campus, Federal University of Campina Grande, Brazil; KEVIN D. WELCH, USDA-ARS Poisonous Plant Research Laboratory, USA. |
Título : |
Clinical and pathological comparison of Astragalus lentiginosus and Ipomoea carnea poisoning in goats. |
Fecha de publicación : |
2019 |
Fuente / Imprenta : |
Toxicon, 5 December, 2019, Volume 171, Pages 20-28. Doi: 10.1016/j.toxicon.2019.09.016 |
ISSN : |
0041-0101 |
DOI : |
10.1016/j.toxicon.2019.09.016 |
Idioma : |
Inglés |
Notas : |
Article history: Received 12 July 2019; Received in revised form 12 September 2019; Accepted 16 September 2019; Available online 19 September 2019. |
Contenido : |
ABSTRACT.
The indolizidine alkaloid swainsonine, found in some Astragalus and Oxytropis (i.e., locoweed) species, is a potent cellular glycosidase inhibitor that often poisons livestock. Other toxic genera such as some Ipomoea species also contain swainsonine as well as calystegines which are similar polyhydroxy alkaloids. The toxicity of calystegines is poorly characterized; however, they are also potent glycoside inhibitors capable of intestinal and cellular glycoside dysfunction. The objective of this study was to directly compare A. lentiginosus and I. carnea poisoning in goats to better characterize the role of the calystegines. Three groups of four goats each were treated with ground alfalfa (control), I. carnea or A. lentiginosus to obtain daily doses of 0.0, 1.5, and 1.5 mg swainsonine/kg bw per day, respectively, for 45 days. Animals were observed daily and weekly body weights, serum enzyme activities, and serum swainsonine concentrations were determined. At day 45 all animals were euthanized and necropsied. Goats treated with A. lentiginosus and I. carnea developed clinical disease characterized by mild intention tremors and proprioceptive deficits. Goats treated with A. lentiginosus developed clinical disease sooner and with greater consistency. No differences in body weight, serum swainsonine concentrations and serum enzyme activity were observed between goats treated with A. lentiginosus and I. carnea. Additionally, there were no differences in the microscopic and histochemical studies of the visceral and neurologic lesions observed between goats treated with A. lentiginosus and I. carnea. These findings suggest that I. carnea-induced clinical signs and lesions are due to swainsonine and that calystegines contribute little or nothing to toxicity in goats in the presence of swainsonine.
© 2019 MenosABSTRACT.
The indolizidine alkaloid swainsonine, found in some Astragalus and Oxytropis (i.e., locoweed) species, is a potent cellular glycosidase inhibitor that often poisons livestock. Other toxic genera such as some Ipomoea species also contain swainsonine as well as calystegines which are similar polyhydroxy alkaloids. The toxicity of calystegines is poorly characterized; however, they are also potent glycoside inhibitors capable of intestinal and cellular glycoside dysfunction. The objective of this study was to directly compare A. lentiginosus and I. carnea poisoning in goats to better characterize the role of the calystegines. Three groups of four goats each were treated with ground alfalfa (control), I. carnea or A. lentiginosus to obtain daily doses of 0.0, 1.5, and 1.5 mg swainsonine/kg bw per day, respectively, for 45 days. Animals were observed daily and weekly body weights, serum enzyme activities, and serum swainsonine concentrations were determined. At day 45 all animals were euthanized and necropsied. Goats treated with A. lentiginosus and I. carnea developed clinical disease characterized by mild intention tremors and proprioceptive deficits. Goats treated with A. lentiginosus developed clinical disease sooner and with greater consistency. No differences in body weight, serum swainsonine concentrations and serum enzyme activity were observed between goats treated with A. lentiginosus and I. carnea. Additionally, there were no differences in the microscopic a... Presentar Todo |
Palabras claves : |
Astragalus; Calystegines; Ipomoea; Locoweed; PLATAFORMA SALUD ANIMAL; Swainsonine. |
Asunto categoría : |
A50 Investigación agraria |
Marc : |
LEADER 02878naa a2200301 a 4500 001 1060655 005 2020-01-21 008 2019 bl uuuu u00u1 u #d 022 $a0041-0101 024 7 $a10.1016/j.toxicon.2019.09.016$2DOI 100 1 $aDE CARVALHO NUNES, L. 245 $aClinical and pathological comparison of Astragalus lentiginosus and Ipomoea carnea poisoning in goats.$h[electronic resource] 260 $c2019 500 $aArticle history: Received 12 July 2019; Received in revised form 12 September 2019; Accepted 16 September 2019; Available online 19 September 2019. 520 $aABSTRACT. The indolizidine alkaloid swainsonine, found in some Astragalus and Oxytropis (i.e., locoweed) species, is a potent cellular glycosidase inhibitor that often poisons livestock. Other toxic genera such as some Ipomoea species also contain swainsonine as well as calystegines which are similar polyhydroxy alkaloids. The toxicity of calystegines is poorly characterized; however, they are also potent glycoside inhibitors capable of intestinal and cellular glycoside dysfunction. The objective of this study was to directly compare A. lentiginosus and I. carnea poisoning in goats to better characterize the role of the calystegines. Three groups of four goats each were treated with ground alfalfa (control), I. carnea or A. lentiginosus to obtain daily doses of 0.0, 1.5, and 1.5 mg swainsonine/kg bw per day, respectively, for 45 days. Animals were observed daily and weekly body weights, serum enzyme activities, and serum swainsonine concentrations were determined. At day 45 all animals were euthanized and necropsied. Goats treated with A. lentiginosus and I. carnea developed clinical disease characterized by mild intention tremors and proprioceptive deficits. Goats treated with A. lentiginosus developed clinical disease sooner and with greater consistency. No differences in body weight, serum swainsonine concentrations and serum enzyme activity were observed between goats treated with A. lentiginosus and I. carnea. Additionally, there were no differences in the microscopic and histochemical studies of the visceral and neurologic lesions observed between goats treated with A. lentiginosus and I. carnea. These findings suggest that I. carnea-induced clinical signs and lesions are due to swainsonine and that calystegines contribute little or nothing to toxicity in goats in the presence of swainsonine. © 2019 653 $aAstragalus 653 $aCalystegines 653 $aIpomoea 653 $aLocoweed 653 $aPLATAFORMA SALUD ANIMAL 653 $aSwainsonine 700 1 $aSTEGELMEIER, B. L. 700 1 $aCOOK, D. 700 1 $aPFISTER, J. A. 700 1 $aGARDNER, D. R. 700 1 $aRIET-CORREA, F. 700 1 $aWEICH, K. D. 773 $tToxicon, 5 December, 2019, Volume 171, Pages 20-28. Doi: 10.1016/j.toxicon.2019.09.016
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha actual : |
19/07/2022 |
Actualizado : |
20/07/2022 |
Tipo de producción científica : |
Abstracts/Resúmenes |
Autor : |
MARQUES, C. B.; DE BARBIERI, I.; VELAZCO, J.I.; NAVAJAS, E.; CIAPPESONI, G. |
Afiliación : |
CAMILA BALCONI MARQUES, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; LUIS IGNACIO DE BARBIERI ETCHEBERRY, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JOSÉ IGNACIO VELAZCO DE LOS REYES, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ELLY ANA NAVAJAS VALENTINI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CARLOS GABRIEL CIAPPESONI SCARONE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Correlations between Methane Emissions and Production Traits in Australian Merino Sheep. [Abstract & Poster]. |
Fecha de publicación : |
2022 |
Fuente / Imprenta : |
In: GGAA - 8th International Greenhouse Gas & Animal Agriculture Conference. Book of Abstracts. June 5-9 2022, Orlando, Florida, USA. p.189. Conference website: https://conference.ifas.ufl.edu/ggaa/ |
Idioma : |
Inglés |
Notas : |
Corresponding author: Camila Balconi Marques, email: cbalconi@inia.org.uy ---
This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Grant Agreement number 772787.
Conference website, GGAA 2022 (Orlando, Florida, USA), June 5-9, 2022, 8th International Greenhouse Gas & Animal Agriculture Conference: https://conference.ifas.ufl.edu/ggaa/ |
Contenido : |
ABSTRACT.- Variability of methane (CH4) emission in sheep and impact of selecting low emitting individuals are investigated as part of greenhouse gas mitigation strategies. This study aimed to estimate the correlations between CH4 and different production traits in Australian Merino. |
Palabras claves : |
Greenhouse gas mitigation strategies; Methane (CH4) emission; SHEEP. |
Asunto categoría : |
L01 Ganadería |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/16585/1/Balconi-et-al-1-GGAA-2022-pp189.pdf
http://www.ainfo.inia.uy/digital/bitstream/item/16586/1/Poster-1-CBM.pdf
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Marc : |
LEADER 01476nam a2200205 a 4500 001 1063434 005 2022-07-20 008 2022 bl uuuu u00u1 u #d 100 1 $aMARQUES, C. B. 245 $aCorrelations between Methane Emissions and Production Traits in Australian Merino Sheep. [Abstract & Poster].$h[electronic resource] 260 $aIn: GGAA - 8th International Greenhouse Gas & Animal Agriculture Conference. Book of Abstracts. June 5-9 2022, Orlando, Florida, USA. p.189. Conference website: https://conference.ifas.ufl.edu/ggaa/$c2022 500 $aCorresponding author: Camila Balconi Marques, email: cbalconi@inia.org.uy --- This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Grant Agreement number 772787. Conference website, GGAA 2022 (Orlando, Florida, USA), June 5-9, 2022, 8th International Greenhouse Gas & Animal Agriculture Conference: https://conference.ifas.ufl.edu/ggaa/ 520 $aABSTRACT.- Variability of methane (CH4) emission in sheep and impact of selecting low emitting individuals are investigated as part of greenhouse gas mitigation strategies. This study aimed to estimate the correlations between CH4 and different production traits in Australian Merino. 653 $aGreenhouse gas mitigation strategies 653 $aMethane (CH4) emission 653 $aSHEEP 700 1 $aDE BARBIERI, I. 700 1 $aVELAZCO, J.I. 700 1 $aNAVAJAS, E. 700 1 $aCIAPPESONI, G.
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