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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
08/03/2023 |
Actualizado : |
15/03/2023 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
RAMOS, Z.; GARRICK , D. J.; BLAIR, H. T.; VERA, B.; CIAPPESONI, G.; KENYON, P. R. |
Afiliación : |
ZULLY MARGOT RAMOS ALVEZ, School of Agriculture and Environment, Massey University, Palmerston North 4410, New Zealand; DORIAN J. GARRICK, School of Agriculture and Environment, Massey University, Palmerston North 4410, New Zealand; HUGH T. BLAIR, School of Agriculture and Environment, Massey University, Palmerston North 4410, New Zealand; BRENDA VERA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CARLOS GABRIEL CIAPPESONI SCARONE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; PAUL R. KENYON, School of Agriculture and Environment, Massey University, Palmerston North 4410, New Zealand. |
Título : |
Genomic regions associated with wool, growth and reproduction traits in Uruguayan Merino Sheep. |
Fecha de publicación : |
2023 |
Fuente / Imprenta : |
Genes, 2023, volume 14, issue 1, article 167. OPEN ACCESS. doi: https://doi.org/10.3390/genes14010167 |
ISSN : |
2073-4425 |
DOI : |
10.3390/genes14010167 |
Idioma : |
Inglés |
Notas : |
Article history: Received 13 December 2022; Revised 29 December 2022; Accepted 4 January 2023; Published 7 January 2023. -- Correspondence author: Zully Ramos, email: z.ramosalvez@massey.ac.nz -- Academic Editor: Qiuyue Liu -- This article belongs to the Section Animal Genetics and Genomics (https://www.mdpi.com/journal/genes/sections/Animal_Genetics_Genomics ) -- FUNDING: his research was funded by the Regional Consortium for Innovation in Ultrafine Wool (CRILU), the European Union?s Horizon 2020 research and innovation program under the grant agreement n°772787 (Smarter) and the National Institute of Agricultural Research of Uruguay (INIA_CL_38: Rumiar). This study was supported by two Ph.D. scholarships (from the National Agency for Investigation and Innovation of Uruguay, ANII, and Massey University, New Zealand), awarded to Zully Ramos. -- LICENSSE: Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). --
Supplementary Materials The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/genes14010167/s1, Table S1: Enrichment analysis. |
Contenido : |
The aim of this study was to identify genomic regions and genes associated with the fiber diameter (FD), clean fleece weight (CFW), live weight (LW), body condition score (BCS), pregnancy rate (PR) and lambing potential (LP) of Uruguayan Merino sheep. Phenotypic records of approximately 2000 mixed-age ewes were obtained from a Merino nucleus flock. Genome-wide association studies were performed utilizing single-step Bayesian analysis. For wool traits, a total of 35 genomic windows surpassed the significance threshold (PVE > 0.25%). The proportion of the total additive genetic variance explained by those windows was 4.85 and 9.06% for FD and CFW, respectively. There were 42 windows significantly associated with LWM, which collectively explained 43.2% of the additive genetic variance. For BCS, 22 relevant windows accounted for more than 40% of the additive genetic variance, whereas for the reproduction traits, 53 genomic windows (24 and 29 for PR and LP, respectively) reached the suggestive threshold of 0.25% of the PVE. Within the top 10 windows for each trait, we identified several genes showing potential associations with the wool (e.g., IGF-1, TGFB2R, PRKCA), live weight (e.g., CAST, LAP3, MED28, HERC6), body condition score (e.g., CDH10, TMC2, SIRPA, CPXM1) or reproduction traits (e.g., ADCY1, LEPR, GHR, LPAR2) of the mixed-age ewes. Copyright: © 2023 by the authors |
Palabras claves : |
Body condition score; Fiber diameter; Gene; GWAS; Reproduction; Sheep. |
Asunto categoría : |
L10 Genética y mejoramiento animal |
URL : |
https://www.mdpi.com/2073-4425/14/1/167/pdf
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Marc : |
LEADER 03484naa a2200289 a 4500 001 1063971 005 2023-03-15 008 2023 bl uuuu u00u1 u #d 022 $a2073-4425 024 7 $a10.3390/genes14010167$2DOI 100 1 $aRAMOS, Z. 245 $aGenomic regions associated with wool, growth and reproduction traits in Uruguayan Merino Sheep.$h[electronic resource] 260 $c2023 500 $aArticle history: Received 13 December 2022; Revised 29 December 2022; Accepted 4 January 2023; Published 7 January 2023. -- Correspondence author: Zully Ramos, email: z.ramosalvez@massey.ac.nz -- Academic Editor: Qiuyue Liu -- This article belongs to the Section Animal Genetics and Genomics (https://www.mdpi.com/journal/genes/sections/Animal_Genetics_Genomics ) -- FUNDING: his research was funded by the Regional Consortium for Innovation in Ultrafine Wool (CRILU), the European Union?s Horizon 2020 research and innovation program under the grant agreement n°772787 (Smarter) and the National Institute of Agricultural Research of Uruguay (INIA_CL_38: Rumiar). This study was supported by two Ph.D. scholarships (from the National Agency for Investigation and Innovation of Uruguay, ANII, and Massey University, New Zealand), awarded to Zully Ramos. -- LICENSSE: Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). -- Supplementary Materials The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/genes14010167/s1, Table S1: Enrichment analysis. 520 $aThe aim of this study was to identify genomic regions and genes associated with the fiber diameter (FD), clean fleece weight (CFW), live weight (LW), body condition score (BCS), pregnancy rate (PR) and lambing potential (LP) of Uruguayan Merino sheep. Phenotypic records of approximately 2000 mixed-age ewes were obtained from a Merino nucleus flock. Genome-wide association studies were performed utilizing single-step Bayesian analysis. For wool traits, a total of 35 genomic windows surpassed the significance threshold (PVE > 0.25%). The proportion of the total additive genetic variance explained by those windows was 4.85 and 9.06% for FD and CFW, respectively. There were 42 windows significantly associated with LWM, which collectively explained 43.2% of the additive genetic variance. For BCS, 22 relevant windows accounted for more than 40% of the additive genetic variance, whereas for the reproduction traits, 53 genomic windows (24 and 29 for PR and LP, respectively) reached the suggestive threshold of 0.25% of the PVE. Within the top 10 windows for each trait, we identified several genes showing potential associations with the wool (e.g., IGF-1, TGFB2R, PRKCA), live weight (e.g., CAST, LAP3, MED28, HERC6), body condition score (e.g., CDH10, TMC2, SIRPA, CPXM1) or reproduction traits (e.g., ADCY1, LEPR, GHR, LPAR2) of the mixed-age ewes. Copyright: © 2023 by the authors 653 $aBody condition score 653 $aFiber diameter 653 $aGene 653 $aGWAS 653 $aReproduction 653 $aSheep 700 1 $aGARRICK , D. J. 700 1 $aBLAIR, H. T. 700 1 $aVERA, B. 700 1 $aCIAPPESONI, G. 700 1 $aKENYON, P. R. 773 $tGenes, 2023, volume 14, issue 1, article 167. OPEN ACCESS. doi: https://doi.org/10.3390/genes14010167
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141. | | NICOLINI, M.P.; KELLY, L.; CIAPPESONI, G.; DE BARBIERI, I.; MEDEROS, A.; RODRIGUEZ, A.; MONTOSSI, F. Biotecnología en el control de parásitos gastrointestinales en ovinos. ln: INIA Tacuarembó. Estación Experimental Glencoe. Proyecto Merino Fino del Uruguay: octava distribución de carneros generados en el núcleo fundacional de Merino fino de la Unidad Experimental Glencoe, 1999-2007, Paysandú, 13 de diciembre, 2006. Tacuarembó (Uruguay): INIA, 2007. p. 48-49 (INIA Serie Actividades de Difusión ; 523)Biblioteca(s): INIA Tacuarembó. |
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147. | | NAVAJAS, E.; RAVAGNOLO, O.; AGUILAR, I.; CIAPPESONI, G.; PERAZA, P.; DALLA RIZZA, M.; MONTOSSI, F. Desarrollo de una plataforma en selección genómica enfocada en el progreso genético animal. ln: Jornada técnica, VI Jornada de agrobiotecnología. INIA Las Brujas, 20 de octubre de 2012 Conocimiento intensivo para el sector productivo: situación actual y perspectivas. Canelones (UY): INIA, 2012. 10-12 (Serie Actividades de Difusión; 698)Tipo: Actividades de Difusión |
Biblioteca(s): INIA Las Brujas. |
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148. | | RAMOS, Z.; DE BARBIERI, I.; MONZALVO, C.; MONTOSSI, F.; CIAPPESONI, G. Desarrollo de un Núcleo informativo de alto desempeño reproductivo en el Basalto para la raza Corriedale. [Resumen]. In: CONGRESO ASOCIACIÓN URUGUAYA DE PRODUCCIÓN ANIMAL (6º, Marzo, 2018, Tacuarembó, Uruguay). Resúmenes. Tacuarembó: AUPA, 2018. p. 123Tipo: Abstracts/Resúmenes |
Biblioteca(s): INIA Tacuarembó. |
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149. | | RAVAGNOLO, O.; BRANDA, A.; BRITO, G.; CIAPPESONI, G.; RINCÓN, G.; LA MANNA, A.; BANCHERO, G. Descripción de información de un panel de SNP para carne en .engorde de novillos Hereford. ln: INIA TACUAREMBÓ. INSTITUTO NACIONAL DE CARNES. Calidad de carnes. SEMINARIO DE ACTUALIZACIÓN TÉCNICA, 20-21 de setiembre, Tacuarembó, 2010. Montevideo (Uruguay): INIA, 2010.Tipo: Trabajos en Congresos/Conferencias |
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151. | | PIERUCCIONI, F.; SAURA, M.; VILLANUEVA, B.; MACEDO, F.; CIAPPESONI, G.; NAVAJAS, E. Desequilibrio de ligamiento y tamaño efectivo en los ovinos criollos uruguayos del Parque Nacional de San Miguel. GGM 17 - COMUNICACIONES LIBRES - GGM. GENÓMICA Y GENÉTICA MOLECULAR In: JOURNAL OF BASIC & APPLIED GENETICS, 2016, Vol.27, Iss. 1 (Supp.). XVI LATIN AMERICAN CONGRESS OF GENETICS, IV CONGRESS OF THE URUGUAYAN SOCIETY OF GENETICS, XLIX ANNUAL MEETING OF THE GENETICS SOCIETY OF CHILE, XLV ARGENTINE CONGRESS OF GENETICS, 9-12 October 2016. PROCEEDINGS. Montevideo (Uruguay): SAG, 2016. p. 263Tipo: Trabajos en Congresos/Conferencias |
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152. | | FRIONI, N.; FARIELLO, M.I.; FERNÁNDEZ-CALERO, T.; GRASSO, N.; CIAPPESONI, G. Detection of selection signatures for gastrointestinal helminths resistance in Merino and Corriedale sheep. GMA 7 - COMUNICACIONES LIBRES - GMA. GENÉTICA Y MEJORAMIENTO ANIMAL In: JOURNAL OF BASIC & APPLIED GENETICS, 2016, Vol.27, Iss. 1 (Supp.). XVI LATIN AMERICAN CONGRESS OF GENETICS, IV CONGRESS OF THE URUGUAYAN SOCIETY OF GENETICS, XLIX ANNUAL MEETING OF THE GENETICS SOCIETY OF CHILE, XLV ARGENTINE CONGRESS OF GENETICS, 9-12 October 2016. PROCEEDINGS. Montevideo (Uruguay): SAG, 2016. p. 190Tipo: Trabajos en Congresos/Conferencias |
Biblioteca(s): INIA Las Brujas. |
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157. | | DE BARBIERI, I.; BUCETA, F.; CROSA, I.; FERNANDEZ ABELLA, D.; CIAPPESONI, G. Efecto del biotipo merino (fino, superfino y ultrafino) en el vigor y termorregulación del cordero al nacimiento. In: BERRETTA, E.; MONTOSSI, F.; BRITO, G. (Ed.). Alternativas tecnológicas para los sistemas ganaderos del basalto. Montevideo, UY: INIA, 2014. p. 379-383 (Serie Técnica; 217)Tipo: Capítulo en Libro Técnico-Científico |
Biblioteca(s): INIA Tacuarembó; INIA Treinta y Tres. |
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158. | | LUZARDO, S.; MONTOSSI, F.; SAN JULIÁN, R.; BRITO, G.; DE BARBIERI, I.; CIAPPESONI, G. Efecto de diferentes sistemas de alimentación con niveles crecientes de suplementación, en la performance animal, calidad de la canal y la carne de corderos cruza corriedale - merino dohne. ln: INIA TACUAREMBÓ. INSTITUTO NACIONAL DE CARNES. Calidad de carnes. SEMINARIO DE ACTUALIZACIÓN TÉCNICA, 20-21 de setiembre, Tacuarembó, 2010. Montevideo (Uruguay): INIA, 2010.Tipo: Trabajos en Congresos/Conferencias |
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159. | | CIAPPESONI, G.; RAVAGNOLO, O.; GIMENO, D.; MONTOSSI, F.; DE BARBIERI, I. Estimation of genetic parameters and genetic trends for wool production and quality for the Uruguayan Merino. In: Proceedings of the World Congress on Genetics Applied to Livestock Production, 8., Belo Horizonte, Minas Gerais, Brazil, August 13-18, 2006, p. 05.04. Acknowledgements: This work would not have been possible without the support of ARU (Asociación Rural del Uruguay) and SCMAU (Association of the Uruguayan Merino Breeders of Uruguay).Tipo: Trabajos en Congresos/Conferencias |
Biblioteca(s): INIA Las Brujas. |
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