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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
13/11/2015 |
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Actualizado : |
08/02/2023 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
LEGARRA, A.; CHRISTENSEN, O.F.; VITEZICA, Z.G.; AGUILAR, I.; MISZTAL, I. |
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Afiliación : |
IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Ancestral relationships using metafounders: Finite ancestral populations and across population relationships. |
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Fecha de publicación : |
2015 |
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Fuente / Imprenta : |
Genetics, 2015, v.200, no.2, p. 455-468. OPEN ACCESS. doi: https://doi.org/10.1534/genetics.115.177014 |
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ISSN : |
0016-6731 |
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DOI : |
10.1534/genetics.115.177014 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 12 February 2015; Accepted 03 April 2015; Published 14 April 2015. -- |
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Contenido : |
ABSTRACT.
Recent use of genomic (marker-based) relationships shows that relationships exist within and across base population (breeds or lines). However, current treatment of pedigree relationships is unable to consider relationships within or across base populations, although such relationships must exist due to finite size of the ancestral population and connections between populations. This complicates the conciliation of both approaches and, in particular, combining pedigree with genomic relationships. We present a coherent theoretical framework to consider base population in pedigree relationships. We suggest a conceptual framework that considers each ancestral population as a finite-sized pool of gametes. This generates across-individual relationships and contrasts with the classical view which each population is considered as an infinite, unrelated pool. Several ancestral populations may be connected and therefore related. Each ancestral population can be represented as a ?metafounder,? a pseudo-individual included as founder of the pedigree and similar to an ?unknown parent group.? Metafounders have self- and across relationships according to a set of parameters, which measure ancestral relationships, i.e., homozygozities within populations and relationships across populations. These parameters can be estimated from existing pedigree and marker genotypes using maximum likelihood or a method based on summary statistics, for arbitrarily complex pedigrees. Equivalences of genetic variance and variance components between the classical and this new parameterization are shown. Segregation variance on crosses of populations is modeled. Efficient algorithms for computation of relationship matrices, their inverses, and inbreeding coefficients are presented. Use of metafounders leads to compatibility of genomic and pedigree relationship matrices and to simple computing algorithms. Examples and code are given.
© 2015 by the Genetics Society of America. MenosABSTRACT.
Recent use of genomic (marker-based) relationships shows that relationships exist within and across base population (breeds or lines). However, current treatment of pedigree relationships is unable to consider relationships within or across base populations, although such relationships must exist due to finite size of the ancestral population and connections between populations. This complicates the conciliation of both approaches and, in particular, combining pedigree with genomic relationships. We present a coherent theoretical framework to consider base population in pedigree relationships. We suggest a conceptual framework that considers each ancestral population as a finite-sized pool of gametes. This generates across-individual relationships and contrasts with the classical view which each population is considered as an infinite, unrelated pool. Several ancestral populations may be connected and therefore related. Each ancestral population can be represented as a ?metafounder,? a pseudo-individual included as founder of the pedigree and similar to an ?unknown parent group.? Metafounders have self- and across relationships according to a set of parameters, which measure ancestral relationships, i.e., homozygozities within populations and relationships across populations. These parameters can be estimated from existing pedigree and marker genotypes using maximum likelihood or a method based on summary statistics, for arbitrarily complex pedigrees. Equivalences... Presentar Todo |
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Palabras claves : |
Base populations; Genetic drift; GenPred; Marker genotypes; Pedigree; Relationships; Shared data resource. |
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Thesagro : |
GENOMICA; GENOTIPOS; MARCADORES MOLECULARES. |
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Asunto categoría : |
L10 Genética y mejoramiento animal |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/5186/1/Aguilar-I.-2015.-Genetics.pdf
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Marc : |
LEADER 03053naa a2200325 a 4500
001 1053877
005 2023-02-08
008 2015 bl uuuu u00u1 u #d
022 $a0016-6731
024 7 $a10.1534/genetics.115.177014$2DOI
100 1 $aLEGARRA, A.
245 $aAncestral relationships using metafounders$bFinite ancestral populations and across population relationships.$h[electronic resource]
260 $c2015
500 $aArticle history: Received 12 February 2015; Accepted 03 April 2015; Published 14 April 2015. --
520 $aABSTRACT. Recent use of genomic (marker-based) relationships shows that relationships exist within and across base population (breeds or lines). However, current treatment of pedigree relationships is unable to consider relationships within or across base populations, although such relationships must exist due to finite size of the ancestral population and connections between populations. This complicates the conciliation of both approaches and, in particular, combining pedigree with genomic relationships. We present a coherent theoretical framework to consider base population in pedigree relationships. We suggest a conceptual framework that considers each ancestral population as a finite-sized pool of gametes. This generates across-individual relationships and contrasts with the classical view which each population is considered as an infinite, unrelated pool. Several ancestral populations may be connected and therefore related. Each ancestral population can be represented as a ?metafounder,? a pseudo-individual included as founder of the pedigree and similar to an ?unknown parent group.? Metafounders have self- and across relationships according to a set of parameters, which measure ancestral relationships, i.e., homozygozities within populations and relationships across populations. These parameters can be estimated from existing pedigree and marker genotypes using maximum likelihood or a method based on summary statistics, for arbitrarily complex pedigrees. Equivalences of genetic variance and variance components between the classical and this new parameterization are shown. Segregation variance on crosses of populations is modeled. Efficient algorithms for computation of relationship matrices, their inverses, and inbreeding coefficients are presented. Use of metafounders leads to compatibility of genomic and pedigree relationship matrices and to simple computing algorithms. Examples and code are given. © 2015 by the Genetics Society of America.
650 $aGENOMICA
650 $aGENOTIPOS
650 $aMARCADORES MOLECULARES
653 $aBase populations
653 $aGenetic drift
653 $aGenPred
653 $aMarker genotypes
653 $aPedigree
653 $aRelationships
653 $aShared data resource
700 1 $aCHRISTENSEN, O.F.
700 1 $aVITEZICA, Z.G.
700 1 $aAGUILAR, I.
700 1 $aMISZTAL, I.
773 $tGenetics, 2015$gv.200, no.2, p. 455-468. OPEN ACCESS. doi: https://doi.org/10.1534/genetics.115.177014
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Registro original : |
INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
05/05/2023 |
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Actualizado : |
05/05/2023 |
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Tipo de producción científica : |
Abstracts/Resúmenes |
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Autor : |
SEIXAS, J.N.; SANGIMINO, J.; GIANNITTI, F.; DORSCH, M.; CESAR, D.; RABENECK, D.M.; SILVA-FLANNERY, L.; FAIR, P.; RITTER, J.M. |
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Afiliación : |
JOSILENE N SEIXAS, Infectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA; JULIANNE SANGIMINO, White Rose Mobile Vets PLLC, Pittsburgh, PA, USA; FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MATÍAS ANDRÉS DORSCH, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; DEBORAH CESAR, Private practice, Montevideo, Uruguay; DEMI B. RABENECK, Infectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA; LUCIANA SILVA-FLANNERY, Infectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA; PAMELA FAIR, Infectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA; JANA M. RITTER, Infectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA. |
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Título : |
Identification of unexpected Mycobateria in feline and canine cutaneous lesions by PCR on formalin-fixed paraffin-embedded tissues. [abstract]. |
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Fecha de publicación : |
2022 |
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Fuente / Imprenta : |
In: ACVP (Annual Meeting, American College of Veterinary Pathologists) and ASVCP (American Society for Veterinary Clinical Pathology) Annual Meeting, Boston, Massachusetts, USA. November 12-15, 2022. |
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Idioma : |
Inglés |
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Contenido : |
We report cutaneous mycobacterial infections in a cat and a dog with unexpected mycobacteria identified by PCR on formalin-fixed paraffin-embedded (FFPE) skin biopsy tissues. A 2-year-old indoor domestic cat from Pennsylvania, USA had subcutaneous nodules in the axillae, hindlimbs, and along the ventrum. Biopsy showed nodular histiocytic infiltrates with abundant intracellular acid-fast bacilli and mycobacterial immunolabeling, compatible with feline lepromatous leprosy. |
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Palabras claves : |
PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA. |
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Thesagro : |
MYCOBACTERIUM. |
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Asunto categoría : |
L20 Ecología animal |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/17093/1/Giannitti-ACVP-2022-abstract.pdf
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Marc : |
LEADER 01372nam a2200229 a 4500
001 1064080
005 2023-05-05
008 2022 bl uuuu u01u1 u #d
100 1 $aSEIXAS, J.N.
245 $aIdentification of unexpected Mycobateria in feline and canine cutaneous lesions by PCR on formalin-fixed paraffin-embedded tissues. [abstract].$h[electronic resource]
260 $aIn: ACVP (Annual Meeting, American College of Veterinary Pathologists) and ASVCP (American Society for Veterinary Clinical Pathology) Annual Meeting, Boston, Massachusetts, USA. November 12-15$c2022
520 $aWe report cutaneous mycobacterial infections in a cat and a dog with unexpected mycobacteria identified by PCR on formalin-fixed paraffin-embedded (FFPE) skin biopsy tissues. A 2-year-old indoor domestic cat from Pennsylvania, USA had subcutaneous nodules in the axillae, hindlimbs, and along the ventrum. Biopsy showed nodular histiocytic infiltrates with abundant intracellular acid-fast bacilli and mycobacterial immunolabeling, compatible with feline lepromatous leprosy.
650 $aMYCOBACTERIUM
653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA
700 1 $aSANGIMINO, J.
700 1 $aGIANNITTI, F.
700 1 $aDORSCH, M.
700 1 $aCESAR, D.
700 1 $aRABENECK, D.M.
700 1 $aSILVA-FLANNERY, L.
700 1 $aFAIR, P.
700 1 $aRITTER, J.M.
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