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| 66. |  | LEADLEY, P.; GONZALEZ, A.; OBURA, D.; KRUG, C.B.; LONDOÑO-MURCIA, M.C.; MILLETTE, K.L.; RADULOVICI, A.; RANKOVIC, A.; SHANNON, L.J.; ARCHER, E.; ATO ARMAH, F.; NIC BAX, N,; CHAUDHARI, K.; COSTELLO, M.J.; DÁVALOS, L.M.; ROQUE, F DE O; DECLERCK, F.; DEE, L.E.; ESSL, F.; FERRIER, S.; GENOVESI, P.; GUARIGUATA, M.R.; HASHIMOTO, S.; IFEJIKA SPERANZA, CH.; ISBELL, F.; KOK, M.; LAVERY, S.D.; LECLÈRE, D.; LOYOLA, R.; LWASA, S.; MCGEOCH, M.; MORI, A.S.; NICHOLSON, E.; OCHOA, J.M.; ÖLLERER, K.; POLASKY, S.; RONDININI, C.; SCHROER, S.; SELOMANE, O.; SHEN, X.; STRASSBURG, B.; RASHID SUMAILA, U.; TITTENSOR, D.P.; TURAK, E.; URBINA, L.; VALLEJOS, M.; VÁZQUEZ-DOMÍNGUEZ, E.; VERBURG, P.H.; VISCONTI, P.; WOODLEY, S.; XU, J. Achieving global biodiversity goals by 2050 requires urgent and integrated actions. One Earth, 2022, Volume 5, Issue 6, Pages 597-603. doi: https://doi.org/10.1016/j.oneear.2022.05.009 Artticle history: Available online 17 June 2022, Version of Record 17 June 2022.| Biblioteca(s): INIA La Estanzuela. |
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| 69. | | MAURENTE BERÓN, M.; FERNÁNDEZ-CIGANDA, S.; GIANNITTI, F.; FRAGA, M. Comparison of PCR and qPCR for the detection of Mycobacterium avium subsp. paratuberculosis in feces and milk of dairy cows in Uruguay: a longitudinal study. (ID-P47). [poster-Infectious Diseases] Session: Posters. In: World Buiatrics Congress (WBC), 31 st., Abstract Book, Madrid, Spain, September 4-8, 2022.| Biblioteca(s): INIA Las Brujas. |
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| 70. | | GIANNITTI, F.; SILVEIRA, C.S.; BULLOCK, H.; BERON, M.; FERNÁNDEZ-CIGANDA, S.; BENÍTEZ-GALEANO, M.J.; RODRÍGUEZ-OSORIO, N.; SILVA-FLANNERY, L.; PERDOMO, T.; CABRERA, A.; PUENTES, R.; COLINA, R.; RITTER, J.M.; CASTELLS, M. Bovine Polyomavirus-1 (Epsilonpolyomavirus bovis): An emerging fetal pathogen of cattle that causes renal lesions resembling Polyomavirus-associated nephropathy of humans. Viruses, 2022; 14 (9): 2042. OPEN ACCESS. doi: https://doi.org/10.3390/v14092042 Article history: Received 12 August 2022; Revised 8 September 2022: Accepted 9 September 2022; Published 14 September 2022.
Academic Editors: Fernando Bauermann and Mayara Maggioli.
Correspondence authors: Giannitti, F.; Plataforma de...| Biblioteca(s): INIA Las Brujas. |
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| 71. | | RABAZA, A.; FRAGA, M.; ZARANTONELLI, L.; PÉREZ-LORENZO, C.; HIRIGOYEN, D.; GIANNITTI, F. Brote de Fiebre Q: ejemplo del rol de los bovinos como centinelas epidemiológicos. [presentación oral] En: Infectología al Día. Jornada Científico Académica de la Cátedra de Enfermedades Infecciosas, 21a., Facultad de Medicina, Universidad de la República, Montevideo, Uruguay. Ago. 12-13, 2022.| Biblioteca(s): INIA Las Brujas. |
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| 72. | | SILVEIRA, C.S.; ARÁOZ, V.; CAFFARENA, D.; RIET-CORREA, F.; MIRABALLES, C.; GIANNITTI, F. Brote de intoxicación espontánea por larvas de Perreyia flavipes en un rodeo de bovinos Heredord de Flores, Uruguay. In: Jornadas Uruguayas de Buiatría, 49., 2022. Paysandú, Uruguay: Centro Médico Veterinario de Paysandú; Filial de la Sociedad de Medicina Veterinaria del Uruguaya; Sociedad Uruguaya de Buiatría, 9 al 11 Junio 2022.| Biblioteca(s): INIA Las Brujas. |
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| 73. | | PELOCHE, D.; COURDIN, V.; CIDADE, G.; GONZÁLEZ, E.; MALARINI, F.; MAS, L.; MORAN, E.; PEREYRA, M.; SANCHIS, M.; ALVAREZ, S. Cultivos de servicio: características de su adopción en los sistemas agrícolas. Proyectos FPTA. Revista INIA Uruguay, Setiembre 2022, no.70, p.97-101. (Revista INIA; 70).| Biblioteca(s): INIA Las Brujas. |
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| 74. | | ARAGUNDE VIEYTES, R.; VIÑOLES, C.; GASTAL, G.D.A.; CAVESTANY, D. Equine chorionic gonadotropin administered on day 5 of a 7-days fixed-time artificial insemination program improves ovulation synchrony and corpus luteum function in anestrous beef cows Theriogenology, January 2023, Volume 195, Pages 62-68. doi: https://doi.org/10.1016/j.theriogenology.2022.10.016 Article history: Received 17 June 2022; Received in revised form 5 October 2022; Accepted 12 October 2022; Available online 17 October 2022.
Correspondence authors: Gastal, G.D.A.; Ruta 11, Km 50, Colonia del Sacramento, Colonia,...| Biblioteca(s): INIA Las Brujas. |
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| 75. | | SILVEIRA, C.S.; GRILLI, M.J.; BERON, M.; CAFFARENA, D.; FRAGA, M.; GIANNITTI, F.; FERNÁNDEZ-CIGANDA, S. Detecção e quantificação do vírus da leucose bovina em terneiros neonatos de estabelecimentos leiteiros do Uruguai. [resumo] In: Encontro Nacional de Diagnóstico Veterinário (ENDIVET), 11, Resumos, Cuiabá, Mato Grosso, Brazil, Novembro 21-23, 2022.| Biblioteca(s): INIA Las Brujas. |
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| 78. | | TANA-HERNÁNDEZ, L.; CABRERA, A.; VALENTÍN, A.; GONZÁLEZ, F.; FIERRO, S.; DORSCH, M.; GIANNITTI, F.; FRANCIA, M. Development and evaluation of detection and control techniques based on serological and molecular methodologies for Toxoplasma gondii in sheep in Uruguay. 103. (abstract) Área temática: Biología Celular y Molecular. In: Physiological Mini Reviews, 2022, volume 15, Special Issue: III (3er) Congreso Nacional de Biociencias Octubre 2022, Montevideo, Uruguay. p.117. Resumen publicado en las jornadas de BIOCIENCIAS: II Jornadas Binacionales Argentina-Uruguay; III Congreso Nacional 2022 "Ciencia para el desarrollo sustentable".| Biblioteca(s): INIA Las Brujas. |
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| 79. | | DORSCH, M.; FRANCIA, M.E.; TANA, L.R.; GONZÁLEZ, F.C.; CABRERA, A.; CALLEROS, L.; SANGUINETTI, M.; BARCELLOS, M.; ZARANTONELLI, L; CIUFFO, C.; MAYA, L.; CASTELLS, M.; MIRAZO, S.; SILVEIRA, C.S.; RABAZA, A.; CAFFARENA, D.; DONCEL, B.; ARÁOZ, V.; MATTO, C.; RMENDANO, J.I.; SALADA, S.; FRAGA, M.; FIERRO, S.; GIANNITTI, F. Diagnostic investigation of 100 cases of abortion in sheep in Uruguay: 2015-2021. Frontiers in Veterinary Science, 2022; i. 9:904786. OPEN ACCESS. Doi: https://doi.org/10.3389/fvets.2022.904786. Article history: Received: 25 March 2022/Accepted: 13 April 2022/Published: 19 May 2022.| Biblioteca(s): INIA La Estanzuela. |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
06/10/2022 |
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Actualizado : |
06/10/2022 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
Internacional - -- |
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Autor : |
GIANNITTI, F.; SILVEIRA, C.S.; BULLOCK, H.; BERON, M.; FERNÁNDEZ-CIGANDA, S.; BENÍTEZ-GALEANO, M.J.; RODRÍGUEZ-OSORIO, N.; SILVA-FLANNERY, L.; PERDOMO, T.; CABRERA, A.; PUENTES, R.; COLINA, R.; RITTER, J.M.; CASTELLS, M. |
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Afiliación : |
FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CAROLINE DA SILVA SILVEIRA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; HANNAH BULLOCK, Synergy America Inc., Atlanta, GA 30329, USA; MARINA MAURENTE BERON, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; SOFÍA FERNÁNDEZ-CIGANDA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARÍA JOSÉ BENÍTEZ-GALEANO, Unidad de Genómica y Bioinformática, Departamento de Ciencias Biológicas, Centro Universitario Regional (CENUR) Litoral Norte, Universidad de la República, Salto 50000, Uruguay; NÉLIDA RODRÍGUEZ-OSORIO, Unidad de Genómica y Bioinformática, Departamento de Ciencias Biológicas, Centro Universitario Regional (CENUR) Litoral Norte, Universidad de la República, Salto 50000, Uruguay; LUCIANA SILVA-FLANNERY, Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention (CDC), Atlanta, GA 30329, USA; TERESITA YISELL PERDOMO TORRES, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANDRÉS CABRERA, Facultad de Veterinaria, Universidad de la República, Montevideo 13000, Uruguay; Laboratorio de Interacciones Hospedero-Patógeno, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay; RODRIGO PUENTES, Facultad de Veterinaria, Universidad de la República, Montevideo 13000, Uruguay; RODNEY COLINA, Laboratorio de Virología Molecular, Departamento de Ciencias Biológicas, Centro Universitario Regional (CENUR) Litoral Norte, Universidad de la República, Salto 50000, Uruguay; JANA M. RITTER, Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention (CDC), Atlanta, GA 30329, USA; MATÍAS CASTELLS, Laboratorio de Virología Molecular, Departamento de Ciencias Biológicas, Centro Universitario Regional (CENUR) Litoral Norte, Universidad de la República, Salto 50000, Uruguay. |
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Título : |
Bovine Polyomavirus-1 (Epsilonpolyomavirus bovis): An emerging fetal pathogen of cattle that causes renal lesions resembling Polyomavirus-associated nephropathy of humans. |
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Fecha de publicación : |
2022 |
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Fuente / Imprenta : |
Viruses, 2022; 14 (9): 2042. OPEN ACCESS. doi: https://doi.org/10.3390/v14092042 |
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ISSN : |
1999-4915 |
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DOI : |
10.3390/v14092042 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 12 August 2022; Revised 8 September 2022: Accepted 9 September 2022; Published 14 September 2022.
Academic Editors: Fernando Bauermann and Mayara Maggioli.
Correspondence authors: Giannitti, F.; Plataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria (INIA), Estación Experimental La Estanzuela, Colonia, Uruguay; email:fgiannitti@inia.org.uy - Castells, M.; Laboratorio de Virología Molecular, Departamento de Ciencias Biológicas, Centro Universitario Regional (CENUR) Litoral Norte, Universidad de la República, Salto, Uruguay; email:matiascastellsbauer@gmail.com --
Funding: Instituto Nacional de Investigación Agropecuaria (INIA), grant PL_27 N-23398. -- This article belongs to the Special Issue Pathogenesis and Host Responses to Viral Diseases in Livestock Species: https://www.mdpi.com/journal/viruses/special_issues/pathogenesis_livestock |
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Contenido : |
ABSTRACT.- Bovine polyomavirus-1 (BoPyV-1, Epsilonpolyomavirus bovis) is widespread in cattle and has been detected in commercialized beef at supermarkets in the USA and Germany. BoPyV-1 has been questioned as a probable zoonotic agent with documented increase in seropositivity in people exposed to cattle. However, to date, BoPyV-1 has not been causally associated with pathology or disease in any animal species, including humans. Here we describe and illustrate pathological findings in an aborted bovine fetus naturally infected with BoPyV-1, providing evidence of its pathogenicity and probable abortigenic potential. Our results indicate that: (i) BoPyV-1 can cause severe kidney lesions in cattle, including tubulointerstitial nephritis with cytopathic changes and necrosis in tubular epithelial cells, tubular and interstitial inflammation, and interstitial fibroplasia; (ii) lesions are at least partly attributable to active viral replication in renal tubular epithelial cells, which have abundant intranuclear viral inclusions; (iii) BoPyV-1 large T (LT) antigen, resulting from early viral gene expression, can be detected in infected renal tubular epithelial cells using a monoclonal antibody raised against Simian Virus-40 polyomavirus LT antigen; and (iv) there is productive BoPyV-1 replication and virion assembly in the nuclei of renal tubular epithelial cells, as demonstrated by the ultrastructural observation of abundant arrays of viral particles with typical polyomavirus morphology. Altogether, these lesions resemble the "cytopathic-inflammatory pathology pattern" proposed in the pathogenesis of Human polyomavirus-1-associated nephropathy in immunocompromised people and kidney allograft recipients. Additionally, we sequenced the complete genome of the BoPyV-1 infecting the fetus, which represents the first whole genome of a BoPyV-1 from the Southern Hemisphere. Lastly, the BoPyV-1 strain infecting this fetus was isolated, causing a cytopathic effect in Madin-Darby bovine kidney cells. We conclude that BoPyV-1 is pathogenic to the bovine fetus under natural circumstances. Further insights into the epidemiology, biology, clinical relevance, and zoonotic potential of BoPyV-1 are needed. © 2022 by the authors. MenosABSTRACT.- Bovine polyomavirus-1 (BoPyV-1, Epsilonpolyomavirus bovis) is widespread in cattle and has been detected in commercialized beef at supermarkets in the USA and Germany. BoPyV-1 has been questioned as a probable zoonotic agent with documented increase in seropositivity in people exposed to cattle. However, to date, BoPyV-1 has not been causally associated with pathology or disease in any animal species, including humans. Here we describe and illustrate pathological findings in an aborted bovine fetus naturally infected with BoPyV-1, providing evidence of its pathogenicity and probable abortigenic potential. Our results indicate that: (i) BoPyV-1 can cause severe kidney lesions in cattle, including tubulointerstitial nephritis with cytopathic changes and necrosis in tubular epithelial cells, tubular and interstitial inflammation, and interstitial fibroplasia; (ii) lesions are at least partly attributable to active viral replication in renal tubular epithelial cells, which have abundant intranuclear viral inclusions; (iii) BoPyV-1 large T (LT) antigen, resulting from early viral gene expression, can be detected in infected renal tubular epithelial cells using a monoclonal antibody raised against Simian Virus-40 polyomavirus LT antigen; and (iv) there is productive BoPyV-1 replication and virion assembly in the nuclei of renal tubular epithelial cells, as demonstrated by the ultrastructural observation of abundant arrays of viral particles with typical polyomavirus mor... Presentar Todo |
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Palabras claves : |
Abortion; Cattle; Emerging diseases; Epsilonpolyomavirus bovis; Nephropathy; Next generation sequencing; Pathology; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL; Polyomavirus; Reproductive diseases; Viral diseases. |
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Asunto categoría : |
L20 Ecología animal |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/16810/1/viruses-14-02042-v2.pdf
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Marc : |
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001 1063641
005 2022-10-06
008 2022 bl uuuu u00u1 u #d
022 $a1999-4915
024 7 $a10.3390/v14092042$2DOI
100 1 $aGIANNITTI, F.
245 $aBovine Polyomavirus-1 (Epsilonpolyomavirus bovis)$bAn emerging fetal pathogen of cattle that causes renal lesions resembling Polyomavirus-associated nephropathy of humans.$h[electronic resource]
260 $c2022
500 $aArticle history: Received 12 August 2022; Revised 8 September 2022: Accepted 9 September 2022; Published 14 September 2022. Academic Editors: Fernando Bauermann and Mayara Maggioli. Correspondence authors: Giannitti, F.; Plataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria (INIA), Estación Experimental La Estanzuela, Colonia, Uruguay; email:fgiannitti@inia.org.uy - Castells, M.; Laboratorio de Virología Molecular, Departamento de Ciencias Biológicas, Centro Universitario Regional (CENUR) Litoral Norte, Universidad de la República, Salto, Uruguay; email:matiascastellsbauer@gmail.com -- Funding: Instituto Nacional de Investigación Agropecuaria (INIA), grant PL_27 N-23398. -- This article belongs to the Special Issue Pathogenesis and Host Responses to Viral Diseases in Livestock Species: https://www.mdpi.com/journal/viruses/special_issues/pathogenesis_livestock
520 $aABSTRACT.- Bovine polyomavirus-1 (BoPyV-1, Epsilonpolyomavirus bovis) is widespread in cattle and has been detected in commercialized beef at supermarkets in the USA and Germany. BoPyV-1 has been questioned as a probable zoonotic agent with documented increase in seropositivity in people exposed to cattle. However, to date, BoPyV-1 has not been causally associated with pathology or disease in any animal species, including humans. Here we describe and illustrate pathological findings in an aborted bovine fetus naturally infected with BoPyV-1, providing evidence of its pathogenicity and probable abortigenic potential. Our results indicate that: (i) BoPyV-1 can cause severe kidney lesions in cattle, including tubulointerstitial nephritis with cytopathic changes and necrosis in tubular epithelial cells, tubular and interstitial inflammation, and interstitial fibroplasia; (ii) lesions are at least partly attributable to active viral replication in renal tubular epithelial cells, which have abundant intranuclear viral inclusions; (iii) BoPyV-1 large T (LT) antigen, resulting from early viral gene expression, can be detected in infected renal tubular epithelial cells using a monoclonal antibody raised against Simian Virus-40 polyomavirus LT antigen; and (iv) there is productive BoPyV-1 replication and virion assembly in the nuclei of renal tubular epithelial cells, as demonstrated by the ultrastructural observation of abundant arrays of viral particles with typical polyomavirus morphology. Altogether, these lesions resemble the "cytopathic-inflammatory pathology pattern" proposed in the pathogenesis of Human polyomavirus-1-associated nephropathy in immunocompromised people and kidney allograft recipients. Additionally, we sequenced the complete genome of the BoPyV-1 infecting the fetus, which represents the first whole genome of a BoPyV-1 from the Southern Hemisphere. Lastly, the BoPyV-1 strain infecting this fetus was isolated, causing a cytopathic effect in Madin-Darby bovine kidney cells. We conclude that BoPyV-1 is pathogenic to the bovine fetus under natural circumstances. Further insights into the epidemiology, biology, clinical relevance, and zoonotic potential of BoPyV-1 are needed. © 2022 by the authors.
653 $aAbortion
653 $aCattle
653 $aEmerging diseases
653 $aEpsilonpolyomavirus bovis
653 $aNephropathy
653 $aNext generation sequencing
653 $aPathology
653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL
653 $aPolyomavirus
653 $aReproductive diseases
653 $aViral diseases
700 1 $aSILVEIRA, C.S.
700 1 $aBULLOCK, H.
700 1 $aBERON, M.
700 1 $aFERNÁNDEZ-CIGANDA, S.
700 1 $aBENÍTEZ-GALEANO, M.J.
700 1 $aRODRÍGUEZ-OSORIO, N.
700 1 $aSILVA-FLANNERY, L.
700 1 $aPERDOMO, T.
700 1 $aCABRERA, A.
700 1 $aPUENTES, R.
700 1 $aCOLINA, R.
700 1 $aRITTER, J.M.
700 1 $aCASTELLS, M.
773 $tViruses, 2022; 14 (9): 2042. OPEN ACCESS. doi: https://doi.org/10.3390/v14092042
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