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| 1. |  | ZHANG, X.; LOURENCO, D.; MISZTAL, I.; AGUILAR, I.; LEGARRA, A. Weighted single-step genomic BLUP: an iterative approach for accurate calculation of GEBV and GWAS. Volume Methods and Tools: Statistical and genomic tools for mapping QTL and genes (Posters), 681. In: Proceedings of the World Congress on Genetics Applied to Livestock Production, 10., Vancouver, BC, Canada, August 17-22, 2014. p.681.| Biblioteca(s): INIA Las Brujas. |
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| Registros recuperados : 1 | |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
31/03/2021 |
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Actualizado : |
31/03/2021 |
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Tipo de producción científica : |
Trabajos en Congresos/Conferencias |
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Autor : |
ZHANG, X.; LOURENCO, D.; MISZTAL, I.; AGUILAR, I.; LEGARRA, A. |
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Afiliación : |
XINYUE ZHANG, University of Georgia, Athens, Georgia, USA; DANIELA AL LOURENCO, University of Georgia, Athens, Georgia, USA; IGNACY MISZTAL, University of Georgia, Athens, Georgia, USA; IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANDRÉS LEGARRA, Institut National de la Recherche Agronomique (INRA), Castanet-Tolosan, France. |
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Título : |
Weighted single-step genomic BLUP: an iterative approach for accurate calculation of GEBV and GWAS. |
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Complemento del título : |
Volume Methods and Tools: Statistical and genomic tools for mapping QTL and genes (Posters), 681. |
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Fecha de publicación : |
2014 |
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Fuente / Imprenta : |
In: Proceedings of the World Congress on Genetics Applied to Livestock Production, 10., Vancouver, BC, Canada, August 17-22, 2014. p.681. |
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Idioma : |
Inglés |
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Contenido : |
ABSTRACT.
Three different procedures were implemented to calculate weights for a genomic relationship matrix to restrict the shrinkage along iterations of weighted single-step genomic BLUP (WssGBLUP). The procedures as well as BayesC were tested with 3 simulated data sets. Prediction accuracy for WssGBLUP improved at 2nd or 3rd iteration by updating only the top number of SNP equal to 1 × or 3 × the number of QTL; accuracy increased after 3rd iteration and remained stable by using weights proportional to 2pi(1- pi)ui2+ constant. Except in the 5 QTL scenario, accuracies with all WssGBLUP procedures were higher than with BayesC. Noise in Manhattan plots was small with 5 and 100 QTL but large with 500 QTL. |
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Palabras claves : |
GWAS; WssGBLUP. |
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Asunto categoría : |
L10 Genética y mejoramiento animal |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/15446/1/Zhang-et-al.-2014.-WCGALP.pdf
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Marc : |
LEADER 01338nam a2200181 a 4500
001 1061922
005 2021-03-31
008 2014 bl uuuu u01u1 u #d
100 1 $aZHANG, X.
245 $aWeighted single-step genomic BLUP$ban iterative approach for accurate calculation of GEBV and GWAS.$h[electronic resource]
260 $aIn: Proceedings of the World Congress on Genetics Applied to Livestock Production, 10., Vancouver, BC, Canada, August 17-22, 2014. p.681.$c2014
520 $aABSTRACT. Three different procedures were implemented to calculate weights for a genomic relationship matrix to restrict the shrinkage along iterations of weighted single-step genomic BLUP (WssGBLUP). The procedures as well as BayesC were tested with 3 simulated data sets. Prediction accuracy for WssGBLUP improved at 2nd or 3rd iteration by updating only the top number of SNP equal to 1 × or 3 × the number of QTL; accuracy increased after 3rd iteration and remained stable by using weights proportional to 2pi(1- pi)ui2+ constant. Except in the 5 QTL scenario, accuracies with all WssGBLUP procedures were higher than with BayesC. Noise in Manhattan plots was small with 5 and 100 QTL but large with 500 QTL.
653 $aGWAS
653 $aWssGBLUP
700 1 $aLOURENCO, D.
700 1 $aMISZTAL, I.
700 1 $aAGUILAR, I.
700 1 $aLEGARRA, A.
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Registro original : |
INIA Las Brujas (LB) |
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