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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
14/06/2022 |
Actualizado : |
14/06/2022 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
JARA, E.; PEÑAGARICANO, F.; ARMSTRONG, E.; CIAPPESONI, G.; IRIARTE, A.; NAVAJAS, E. |
Afiliación : |
EUGENIO JARA, Unidad de Genética y Mejora Animal, Departamento de Producción Animal, Facultad de Veterinaria, Universidad de la República, Montevideo 11600, Uruguay; FRANCISCO PEÑAGARICANO, Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706, United State; EILEEN ARMSTRONG, Unidad de Genética y Mejora Animal, Departamento de Producción Animal, Facultad de Veterinaria, Universidad de la República, 11600, Montevideo, Uruguay; CARLOS GABRIEL CIAPPESONI SCARONE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANDRÉS IRIARTE, Laboratorio de Biología Computacional, Departamento de Desarrollo Biotecnológico, Instituto de Higiene, Facultad de Medicina, Universidad de la República, 11600, Montevideo, Uruguay; ELLY ANA NAVAJAS VALENTINI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Revealing the genetic basis of eyelid pigmentation in Hereford cattle. |
Fecha de publicación : |
2022 |
Fuente / Imprenta : |
Journal of Animal Science, 2022, Volume 100, Issue 5. doi: https://doi.org/10.1093/jas/skac110 |
ISSN : |
1525-3163 |
DOI : |
10.1093/jas/skac110 |
Idioma : |
Inglés |
Notas : |
Article history: Received December 14, 2021; Accepted April 4, 2022; Advance access publication 7 April 2022.
Corresponding author: Eugenio Jara, email: eugeniojara19@gmail.com -- |
Contenido : |
ABSTRACT - Ocular squamous cell carcinoma and infectious keratoconjunctivitis are common ocular pathologies in Hereford cattle with considerable economic impact. Both pathologies have been associated with low eyelid pigmentation, and thus, genetic selection for higher eyelid pigmentation could reduce their incidence. The objective of the present study was to reveal the genetic basis of eyelid pigmentation in Hereford cattle. The analysis included a single-step genome-wide association study (ssGWAS) and a subsequent gene-set analysis in order to identify individual genes, genetic mechanisms, and biological pathways implicated in this trait. Data consisted of eyelid pigmentation records in 1,165 Hereford bulls and steers, visually assessed in five categories between 0% and 100%. Genotypic data for 774,660 single-nucleotide polymorphism markers were available for 886 animals with pigmentation records. Pedigree information of three generations of ancestors of animals with phenotype was considered in this study, with a total of 4,929 animals. Our analyses revealed that eyelid pigmentation is a moderately heritable trait, with heritability estimates around 0.41. The ssGWAS identified at least eight regions, located on BTA1, BTA3, BTA5, BTA14, BTA16, BTA18, BTA19, and BTA24, associated with eyelid pigmentation. These regions harbor genes that are directly implicated in melanocyte biology and skin pigmentation, such as ADCY8, PLD1, KITLG, and PRKCA. The gene-set analysis revealed several functional terms closely related to melanogenesis, such as positive regulation of melanocyte differentiation and regulation of ERK1 and ERK2 cascade. Overall, our findings provide evidence that eyelid pigmentation is a heritable trait influenced by many loci. Indeed, the ssGWAS detected several candidate genes that are directly implicated in melanocyte biology, including melanogenesis. This study contributes to a better understanding of the genetic and biological basis of eyelid pigmentation and presents novel information that could aid to design breeding strategies for reducing the incidence of ocular pathologies in cattle. Additional research on the genetic link between eyelid pigmentation and ocular pathologies is needed. © The Author(s) 2022. MenosABSTRACT - Ocular squamous cell carcinoma and infectious keratoconjunctivitis are common ocular pathologies in Hereford cattle with considerable economic impact. Both pathologies have been associated with low eyelid pigmentation, and thus, genetic selection for higher eyelid pigmentation could reduce their incidence. The objective of the present study was to reveal the genetic basis of eyelid pigmentation in Hereford cattle. The analysis included a single-step genome-wide association study (ssGWAS) and a subsequent gene-set analysis in order to identify individual genes, genetic mechanisms, and biological pathways implicated in this trait. Data consisted of eyelid pigmentation records in 1,165 Hereford bulls and steers, visually assessed in five categories between 0% and 100%. Genotypic data for 774,660 single-nucleotide polymorphism markers were available for 886 animals with pigmentation records. Pedigree information of three generations of ancestors of animals with phenotype was considered in this study, with a total of 4,929 animals. Our analyses revealed that eyelid pigmentation is a moderately heritable trait, with heritability estimates around 0.41. The ssGWAS identified at least eight regions, located on BTA1, BTA3, BTA5, BTA14, BTA16, BTA18, BTA19, and BTA24, associated with eyelid pigmentation. These regions harbor genes that are directly implicated in melanocyte biology and skin pigmentation, such as ADCY8, PLD1, KITLG, and PRKCA. The gene-set analysis revealed se... Presentar Todo |
Palabras claves : |
Beef cattle; Melanocyte biology; Ocular pathologies. |
Asunto categoría : |
L01 Ganadería |
Marc : |
LEADER 03180naa a2200253 a 4500 001 1063291 005 2022-06-14 008 2022 bl uuuu u00u1 u #d 022 $a1525-3163 024 7 $a10.1093/jas/skac110$2DOI 100 1 $aJARA, E. 245 $aRevealing the genetic basis of eyelid pigmentation in Hereford cattle.$h[electronic resource] 260 $c2022 500 $aArticle history: Received December 14, 2021; Accepted April 4, 2022; Advance access publication 7 April 2022. Corresponding author: Eugenio Jara, email: eugeniojara19@gmail.com -- 520 $aABSTRACT - Ocular squamous cell carcinoma and infectious keratoconjunctivitis are common ocular pathologies in Hereford cattle with considerable economic impact. Both pathologies have been associated with low eyelid pigmentation, and thus, genetic selection for higher eyelid pigmentation could reduce their incidence. The objective of the present study was to reveal the genetic basis of eyelid pigmentation in Hereford cattle. The analysis included a single-step genome-wide association study (ssGWAS) and a subsequent gene-set analysis in order to identify individual genes, genetic mechanisms, and biological pathways implicated in this trait. Data consisted of eyelid pigmentation records in 1,165 Hereford bulls and steers, visually assessed in five categories between 0% and 100%. Genotypic data for 774,660 single-nucleotide polymorphism markers were available for 886 animals with pigmentation records. Pedigree information of three generations of ancestors of animals with phenotype was considered in this study, with a total of 4,929 animals. Our analyses revealed that eyelid pigmentation is a moderately heritable trait, with heritability estimates around 0.41. The ssGWAS identified at least eight regions, located on BTA1, BTA3, BTA5, BTA14, BTA16, BTA18, BTA19, and BTA24, associated with eyelid pigmentation. These regions harbor genes that are directly implicated in melanocyte biology and skin pigmentation, such as ADCY8, PLD1, KITLG, and PRKCA. The gene-set analysis revealed several functional terms closely related to melanogenesis, such as positive regulation of melanocyte differentiation and regulation of ERK1 and ERK2 cascade. Overall, our findings provide evidence that eyelid pigmentation is a heritable trait influenced by many loci. Indeed, the ssGWAS detected several candidate genes that are directly implicated in melanocyte biology, including melanogenesis. This study contributes to a better understanding of the genetic and biological basis of eyelid pigmentation and presents novel information that could aid to design breeding strategies for reducing the incidence of ocular pathologies in cattle. Additional research on the genetic link between eyelid pigmentation and ocular pathologies is needed. © The Author(s) 2022. 653 $aBeef cattle 653 $aMelanocyte biology 653 $aOcular pathologies 700 1 $aPEÑAGARICANO, F. 700 1 $aARMSTRONG, E. 700 1 $aCIAPPESONI, G. 700 1 $aIRIARTE, A. 700 1 $aNAVAJAS, E. 773 $tJournal of Animal Science, 2022, Volume 100, Issue 5. doi: https://doi.org/10.1093/jas/skac110
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INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha actual : |
20/06/2015 |
Actualizado : |
20/06/2015 |
Tipo de producción científica : |
Informes Agroclimáticos |
Autor : |
GIMENEZ, A.; CASTAÑO, J.; CAL, A.; TISCORNIA, G.; SCHIAVI, C. |
Afiliación : |
AGUSTIN EDUARDO GIMENEZ FUREST, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JOSE PEDRO CASTAÑO SANCHEZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ADRIAN TABARE CAL ALVAREZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; GUADALUPE TISCORNIA TOSAR, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CARLOS IGNACIO SCHIAVI RAMPELBERG, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Informe Agroclimático 2014 - Situación a Setiembre. |
Fecha de publicación : |
2014 |
Fuente / Imprenta : |
Montevideo (Uruguay): INIA, 2014. |
Páginas : |
4 p. |
Idioma : |
Español |
Palabras claves : |
AGROCLIMA; AGROCLIMATOLOGÍA; BOLETIN AGROCLIMÁTICO; CARACTERIZACIÓN AGROCLIMÁTICA; DIRECCION VIENTO; ESTACIONES AGROMETEOROLOGICAS; ESTACIONES AUTOMATICAS; ESTACIONES INIA; ESTADO DEL TIEMPO; ESTRÉS HÍDRICO; GRAFICAS AGROCLIMATICOS; GRAS; HELIOFANOGRAFO; INFORMACION SATELITAL; INUNDACIONES; LLUVIAS DIARIAS; MAXIMA; MEDIA; MINIMA; PANEL SOLAR; PERSPECTIVAS CLIMATICAS; PLUVIOMETRO; PRECIPITACION NACIONAL; PREVENCION HELADAS; PRONOSTICO; SENSOR; SIMETRICO; TANQUE A; TERMOCUPLAS; TERMOHIDROGRAFO; VARIABLES AGROCLIMATICAS; VELETA. |
Thesagro : |
AGROCLIMATOLOGIA; CAMBIO CLIMATICO; CLIMA; CLIMATOLOGIA; ESTACIONES METEOROLOGICAS; ESTRES HIDRICO; EVAPORACION; EVAPOTRANSPIRACION; HUMEDAD; HUMEDAD RELATIVA; LLUVIA; METEOROLOGIA; PERSPECTIVAS; PLUVIOMETROS; PRONOSTICO DEL TIEMPO; SENSORES; SISTEMAS; SISTEMAS DE INFORMACION; SUELO; TEMPERATURA; TERMOMETROS. |
Asunto categoría : |
P40 Meteorología y climatología |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/4739/1/Inf.Agr.-setiembre-2014.pdf
http://www.inia.uy/Publicaciones/Paginas/Informe-agroclimatico-2014---Situacion-Setiembre.aspx
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Marc : |
LEADER 02068nam a2200793 a 4500 001 1052895 005 2015-06-20 008 2014 bl uuuu u0uu1 u #d 100 1 $aGIMENEZ, A. 245 $aInforme Agroclimático 2014 - Situación a Setiembre.$h[electronic resource] 260 $aMontevideo (Uruguay): INIA$c2014 300 $a4 p. 650 $aAGROCLIMATOLOGIA 650 $aCAMBIO CLIMATICO 650 $aCLIMA 650 $aCLIMATOLOGIA 650 $aESTACIONES METEOROLOGICAS 650 $aESTRES HIDRICO 650 $aEVAPORACION 650 $aEVAPOTRANSPIRACION 650 $aHUMEDAD 650 $aHUMEDAD RELATIVA 650 $aLLUVIA 650 $aMETEOROLOGIA 650 $aPERSPECTIVAS 650 $aPLUVIOMETROS 650 $aPRONOSTICO DEL TIEMPO 650 $aSENSORES 650 $aSISTEMAS 650 $aSISTEMAS DE INFORMACION 650 $aSUELO 650 $aTEMPERATURA 650 $aTERMOMETROS 653 $aAGROCLIMA 653 $aAGROCLIMATOLOGÍA 653 $aBOLETIN AGROCLIMÁTICO 653 $aCARACTERIZACIÓN AGROCLIMÁTICA 653 $aDIRECCION VIENTO 653 $aESTACIONES AGROMETEOROLOGICAS 653 $aESTACIONES AUTOMATICAS 653 $aESTACIONES INIA 653 $aESTADO DEL TIEMPO 653 $aESTRÉS HÍDRICO 653 $aGRAFICAS AGROCLIMATICOS 653 $aGRAS 653 $aHELIOFANOGRAFO 653 $aINFORMACION SATELITAL 653 $aINUNDACIONES 653 $aLLUVIAS DIARIAS 653 $aMAXIMA 653 $aMEDIA 653 $aMINIMA 653 $aPANEL SOLAR 653 $aPERSPECTIVAS CLIMATICAS 653 $aPLUVIOMETRO 653 $aPRECIPITACION NACIONAL 653 $aPREVENCION HELADAS 653 $aPRONOSTICO 653 $aSENSOR 653 $aSIMETRICO 653 $aTANQUE A 653 $aTERMOCUPLAS 653 $aTERMOHIDROGRAFO 653 $aVARIABLES AGROCLIMATICAS 653 $aVELETA 700 1 $aCASTAÑO, J. 700 1 $aCAL, A. 700 1 $aTISCORNIA, G. 700 1 $aSCHIAVI, C.
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