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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
15/04/2021 |
Actualizado : |
15/04/2021 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
COSTA, D.; LÉVESQUE, S.; KUMAR, N.; FRESIA, P.; FERRÉS, I.; LAWLEY, T. D.; IRAOLA, G. |
Afiliación : |
DANIELA COSTA, Microbial Genomics Laboratory, Institut Pasteur Montevideo, Montevideo, Uruguay; Sección Genética Evolutiva, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay; SIMON LÉVESQUE, Laboratoire de Santé Publique du Québec, Quebec City, Canada; NITIN KUMAR, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; PABLO FRESIA, Unidad Mixta UMPI, Institut Pasteur Montevideo + INIA, Montevideo, Uruguay; IGNACIO FERRÉS, Microbial Genomics Laboratory, Institut Pasteur Montevideo, Montevideo, Uruguay; TREVOR D. LAWLEY, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; GREGORIO IRAOLA, Microbial Genomics Laboratory, Institut Pasteur Montevideo, Montevideo, Uruguay; Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Center for Integrative Biology, Universidad Mayor, Santiago de Chile, Chile. |
Título : |
Pangenome analysis reveals genetic isolation in Campylobacter hyointestinalis subspecies adapted to different mammalian hosts. |
Fecha de publicación : |
2021 |
Fuente / Imprenta : |
Scientific Reports, 2021, Volume 11, Issue 1, Article number 3431. OPEN ACCESS. Doi: https://doi.org/10.1038/s41598-021-82993-9 |
ISSN : |
2045-2322 |
DOI : |
10.1038/s41598-021-82993-9 |
Idioma : |
Inglés |
Notas : |
Article history: Received 12 February 2018; Accepted 24 January 2021; Published 09 February 2021. |
Contenido : |
ABSTRACT.
Campylobacter hyointestinalis is an emerging pathogen currently divided in two subspecies: C. hyointestinalis subsp. lawsonii which is predominantly recovered from pigs, and C. hyointestinalis subsp. hyointestinalis which can be found in a much wider range of mammalian hosts. Despite C. hyointestinalis being reported as an emerging pathogen, its evolutionary and host-associated diversification patterns are still vastly unexplored. For this reason, we generated whole-genome sequences of 13 C. hyointestinalis subsp. hyointestinalis strains and performed a comprehensive comparative analysis including publicly available C. hyointestinalis subsp. hyointestinalis and C. hyointestinalis subsp. lawsonii genomes, to gain insight into the genomic variation of these differentially-adapted subspecies. Both subspecies are distinct phylogenetic lineages which present an apparent barrier to homologous recombination, suggesting genetic isolation. This is further supported by accessory gene patterns that recapitulate the core genome phylogeny. Additionally, C. hyointestinalis subsp. hyointestinalis presents a bigger and more diverse accessory genome, which probably reflects its capacity to colonize different mammalian hosts unlike C. hyointestinalis subsp. lawsonii that is presumably host-restricted. This greater plasticity in the accessory genome of C. hyointestinalis subsp. hyointestinalis correlates to a higher incidence of genome-wide recombination events, that may be the underlying mechanism driving its diversification. Concordantly, both subspecies present distinct patterns of gene families involved in genome plasticity and DNA repair like CRISPR-associated proteins and restriction-modification systems. Together, our results provide an overview of the genetic mechanisms shaping the genomes of C. hyointestinalis subspecies, contributing to understand the biology of Campylobacter species that are increasingly recognized as emerging pathogens.
© 2021, The Author(s). MenosABSTRACT.
Campylobacter hyointestinalis is an emerging pathogen currently divided in two subspecies: C. hyointestinalis subsp. lawsonii which is predominantly recovered from pigs, and C. hyointestinalis subsp. hyointestinalis which can be found in a much wider range of mammalian hosts. Despite C. hyointestinalis being reported as an emerging pathogen, its evolutionary and host-associated diversification patterns are still vastly unexplored. For this reason, we generated whole-genome sequences of 13 C. hyointestinalis subsp. hyointestinalis strains and performed a comprehensive comparative analysis including publicly available C. hyointestinalis subsp. hyointestinalis and C. hyointestinalis subsp. lawsonii genomes, to gain insight into the genomic variation of these differentially-adapted subspecies. Both subspecies are distinct phylogenetic lineages which present an apparent barrier to homologous recombination, suggesting genetic isolation. This is further supported by accessory gene patterns that recapitulate the core genome phylogeny. Additionally, C. hyointestinalis subsp. hyointestinalis presents a bigger and more diverse accessory genome, which probably reflects its capacity to colonize different mammalian hosts unlike C. hyointestinalis subsp. lawsonii that is presumably host-restricted. This greater plasticity in the accessory genome of C. hyointestinalis subsp. hyointestinalis correlates to a higher incidence of genome-wide recombination events, that may be the under... Presentar Todo |
Palabras claves : |
Computational biology and bioinformatics; Evolution; Microbiology. |
Asunto categoría : |
A50 Investigación agraria |
URL : |
https://www.nature.com/articles/s41598-021-82993-9.pdf
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Marc : |
LEADER 02962naa a2200265 a 4500 001 1061986 005 2021-04-15 008 2021 bl uuuu u00u1 u #d 022 $a2045-2322 024 7 $a10.1038/s41598-021-82993-9$2DOI 100 1 $aCOSTA, D. 245 $aPangenome analysis reveals genetic isolation in Campylobacter hyointestinalis subspecies adapted to different mammalian hosts.$h[electronic resource] 260 $c2021 500 $aArticle history: Received 12 February 2018; Accepted 24 January 2021; Published 09 February 2021. 520 $aABSTRACT. Campylobacter hyointestinalis is an emerging pathogen currently divided in two subspecies: C. hyointestinalis subsp. lawsonii which is predominantly recovered from pigs, and C. hyointestinalis subsp. hyointestinalis which can be found in a much wider range of mammalian hosts. Despite C. hyointestinalis being reported as an emerging pathogen, its evolutionary and host-associated diversification patterns are still vastly unexplored. For this reason, we generated whole-genome sequences of 13 C. hyointestinalis subsp. hyointestinalis strains and performed a comprehensive comparative analysis including publicly available C. hyointestinalis subsp. hyointestinalis and C. hyointestinalis subsp. lawsonii genomes, to gain insight into the genomic variation of these differentially-adapted subspecies. Both subspecies are distinct phylogenetic lineages which present an apparent barrier to homologous recombination, suggesting genetic isolation. This is further supported by accessory gene patterns that recapitulate the core genome phylogeny. Additionally, C. hyointestinalis subsp. hyointestinalis presents a bigger and more diverse accessory genome, which probably reflects its capacity to colonize different mammalian hosts unlike C. hyointestinalis subsp. lawsonii that is presumably host-restricted. This greater plasticity in the accessory genome of C. hyointestinalis subsp. hyointestinalis correlates to a higher incidence of genome-wide recombination events, that may be the underlying mechanism driving its diversification. Concordantly, both subspecies present distinct patterns of gene families involved in genome plasticity and DNA repair like CRISPR-associated proteins and restriction-modification systems. Together, our results provide an overview of the genetic mechanisms shaping the genomes of C. hyointestinalis subspecies, contributing to understand the biology of Campylobacter species that are increasingly recognized as emerging pathogens. © 2021, The Author(s). 653 $aComputational biology and bioinformatics 653 $aEvolution 653 $aMicrobiology 700 1 $aLÉVESQUE, S. 700 1 $aKUMAR, N. 700 1 $aFRESIA, P. 700 1 $aFERRÉS, I. 700 1 $aLAWLEY, T. D. 700 1 $aIRAOLA, G. 773 $tScientific Reports, 2021, Volume 11, Issue 1, Article number 3431. OPEN ACCESS. Doi: https://doi.org/10.1038/s41598-021-82993-9
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INIA Las Brujas (LB) |
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha actual : |
20/06/2015 |
Actualizado : |
20/06/2015 |
Tipo de producción científica : |
Informes Agroclimáticos |
Autor : |
GIMENEZ, A.; CASTAÑO, J.; FUREST, J.; CAL, A.; TISCORNIA, G.; SCHIAVI, C. |
Afiliación : |
AGUSTIN EDUARDO GIMENEZ FUREST, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JOSE PEDRO CASTAÑO SANCHEZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JOSE MARIA FUREST CROCCO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ADRIAN TABARE CAL ALVAREZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; GUADALUPE TISCORNIA TOSAR, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CARLOS IGNACIO SCHIAVI RAMPELBERG, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Informe Agroclimático 2013 - Situación a Mayo. |
Fecha de publicación : |
2013 |
Fuente / Imprenta : |
Montevideo (Uruguay): INIA, 2013. |
Páginas : |
4 p. |
Idioma : |
Español |
Palabras claves : |
AGROCLIMA; AGROCLIMATOLOGÍA; BOLETIN AGROCLIMÁTICO; CARACTERIZACIÓN AGROCLIMÁTICA; DIRECCION VIENTO; ESTACIONES AGROMETEOROLOGICAS; ESTACIONES AUTOMATICAS; ESTACIONES INIA; ESTADO DEL TIEMPO; ESTRÉS HÍDRICO; GRAFICAS AGROCLIMATICOS; GRAS; HELIOFANOGRAFO; INFORMACION SATELITAL; INUNDACIONES; LLUVIAS DIARIAS; MAXIMA; MEDIA; MINIMA; PANEL SOLAR; PERSPECTIVAS CLIMATICAS; PLUVIOMETRO; PRECIPITACION NACIONAL; PREVENCION HELADAS; PRONOSTICO; SENSOR; SIMETRICO; TANQUE A; TERMOCUPLAS; TERMOHIDROGRAFO; VARIABLES AGROCLIMATICAS; VELETA. |
Thesagro : |
AGROCLIMATOLOGIA; CAMBIO CLIMATICO; CLIMA; CLIMATOLOGIA; ESTACIONES METEOROLOGICAS; ESTRES HIDRICO; EVAPORACION; EVAPOTRANSPIRACION; HUMEDAD; HUMEDAD RELATIVA; LLUVIA; METEOROLOGIA; PERSPECTIVAS; PLUVIOMETROS; PRONOSTICO DEL TIEMPO; SENSORES; SISTEMAS; SISTEMAS DE INFORMACION; SUELO; TEMPERATURA; TERMOMETROS. |
Asunto categoría : |
P40 Meteorología y climatología |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/4723/1/Inf.Agr.-mayo-2013.pdf
http://www.inia.uy/Publicaciones/Paginas/Informe-agroclimatico-2013-Situacion-Mayo.aspx
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Marc : |
LEADER 02090nam a2200805 a 4500 001 1052879 005 2015-06-20 008 2013 bl uuuu u0uu1 u #d 100 1 $aGIMENEZ, A. 245 $aInforme Agroclimático 2013 - Situación a Mayo.$h[electronic resource] 260 $aMontevideo (Uruguay): INIA$c2013 300 $a4 p. 650 $aAGROCLIMATOLOGIA 650 $aCAMBIO CLIMATICO 650 $aCLIMA 650 $aCLIMATOLOGIA 650 $aESTACIONES METEOROLOGICAS 650 $aESTRES HIDRICO 650 $aEVAPORACION 650 $aEVAPOTRANSPIRACION 650 $aHUMEDAD 650 $aHUMEDAD RELATIVA 650 $aLLUVIA 650 $aMETEOROLOGIA 650 $aPERSPECTIVAS 650 $aPLUVIOMETROS 650 $aPRONOSTICO DEL TIEMPO 650 $aSENSORES 650 $aSISTEMAS 650 $aSISTEMAS DE INFORMACION 650 $aSUELO 650 $aTEMPERATURA 650 $aTERMOMETROS 653 $aAGROCLIMA 653 $aAGROCLIMATOLOGÍA 653 $aBOLETIN AGROCLIMÁTICO 653 $aCARACTERIZACIÓN AGROCLIMÁTICA 653 $aDIRECCION VIENTO 653 $aESTACIONES AGROMETEOROLOGICAS 653 $aESTACIONES AUTOMATICAS 653 $aESTACIONES INIA 653 $aESTADO DEL TIEMPO 653 $aESTRÉS HÍDRICO 653 $aGRAFICAS AGROCLIMATICOS 653 $aGRAS 653 $aHELIOFANOGRAFO 653 $aINFORMACION SATELITAL 653 $aINUNDACIONES 653 $aLLUVIAS DIARIAS 653 $aMAXIMA 653 $aMEDIA 653 $aMINIMA 653 $aPANEL SOLAR 653 $aPERSPECTIVAS CLIMATICAS 653 $aPLUVIOMETRO 653 $aPRECIPITACION NACIONAL 653 $aPREVENCION HELADAS 653 $aPRONOSTICO 653 $aSENSOR 653 $aSIMETRICO 653 $aTANQUE A 653 $aTERMOCUPLAS 653 $aTERMOHIDROGRAFO 653 $aVARIABLES AGROCLIMATICAS 653 $aVELETA 700 1 $aCASTAÑO, J. 700 1 $aFUREST, J. 700 1 $aCAL, A. 700 1 $aTISCORNIA, G. 700 1 $aSCHIAVI, C.
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