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Registro completo
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Biblioteca (s) : |
INIA La Estanzuela. |
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Fecha : |
27/11/2020 |
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Actualizado : |
27/04/2021 |
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Autor : |
GAO, L.; KOO, D.H.; JULIANA, P.; RIFE, T.; SINGH, D.; CRISTIANO LEMES DA SILVA; LUX, T.; DORN, K.M.; CLINESMITH, M.; SILVA, P.; WANG, X.; SPANNAGL, M.; MONAT, C.; FRIEBE, B.; STEUERNAGEL, B.; MUEHLBAUER, G.J.; WALKOWIAK, S.; POZNIAK, C.; SINGH, R.; STEIN, N.; MASCHER, M.; FRITZ, A.; POLAND, J. |
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Afiliación : |
LIANGLIANG GAO, Department of Plant Pathology and Wheat Genetics Resource Center, Kansas State University, 1712 Claflin Road, Manhattan, KS, 66506, USA.; DAL-HOE KOO, Department of Plant Pathology and Wheat Genetics Resource Center, Kansas State University, 1712 Claflin Road, Manhattan, KS, 66506, USA.; PHILOMIN JULIANA, Global Wheat Program, International Maize and Wheat Improvement Center (CIMMYT), El Batan, 56237, Texcoco, CP, Mexico.; TREVOR RIFE, Department of Plant Pathology and Wheat Genetics Resource Center, Kansas State University, 1712 Claflin Road, Manhattan, KS, 66506, USA.; DALJIT SINGH, Department of Plant Pathology and Wheat Genetics Resource Center, Kansas State University, 1712 Claflin Road, Manhattan, KS, 66506, USA.; CRISTIANO LEMES DA SILVA, Department of Agronomy, Kansas State University, 1712 Claflin Road, Manhattan, KS, 66506, USA.; THOMAS LUX, Plant Genome and Systems Biology (PGSB), Helmholtz Center Munich, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany.; KEVIN M DORN, Department of Plant Pathology and Wheat Genetics Resource Center, Kansas State University, 1712 Claflin Road, Manhattan, KS, 66506, USA.; MARSHALL CLINESMITH, Department of Agronomy, Kansas State University, 1712 Claflin Road, Manhattan, KS, 66506, USA.; MARIA PAULA SILVA VILLELLA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay./Department of Plant Pathology and Wheat Genetics Resource Center, Kansas State University, 1712 Claflin Road, Manhattan, KS, 66506, USA.; XU WANG, Department of Plant Pathology and Wheat Genetics Resource Center, Kansas State University, 1712 Claflin Road, Manhattan, KS, 66506, USA.; MANUEL SPANNAGL, Plant Genome and Systems Biology (PGSB), Helmholtz Center Munich, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany.; CECILE MONAT, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, Corrensstr. 3, 06466, Seeland, Germany.; BERND FRIEBE, Department of Plant Pathology and Wheat Genetics Resource Center, Kansas State University, 1712 Claflin Road, Manhattan, KS, 66506, USA.; BURKHARD STEUERNAGEL, John Innes Centre, Computational and Systems Biology, Norwich Research Park, Norwich, NR47UH, UK.; GARY J MUEHLBAUER, Department of Agronomy and Plant Genetics, University of Minnesota, 1991 Upper Buford Circle, 411 Borlaug Hall, Saint Paul, MN, 55108, USA.; SEAN WALKOWIAK, Crop Development Centre, University of Saskatchewan, Agriculture Building, 51 Campus Drive, Saskatoon, SK, S7N 5A8, Canada.; CURTIS POZNIAK, Crop Development Centre, University of Saskatchewan, Agriculture Building, 51 Campus Drive, Saskatoon, SK, S7N 5A8, Canada.; RAVI SINGH, Global Wheat Program, International Maize and Wheat Improvement Center (CIMMYT), El Batan, 56237, Texcoco, CP, Mexico.; NILS STEIN, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, Corrensstr. 3, 06466, Seeland, Germany.; MARTIN MASCHER, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, Corrensstr. 3, 06466, Seeland, Germany.; ALLAN FRITZ, Department of Agronomy, Kansas State University, 1712 Claflin Road, Manhattan, KS, 66506, USA.; JESSE POLAND, Department of Plant Pathology and Wheat Genetics Resource Center, Kansas State University, 1712 Claflin Road, Manhattan, KS, 66506, USA. |
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Título : |
The Aegilops ventricosa 2N v S segment in bread wheat: cytology, genomics and breeding. |
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Fecha de publicación : |
2021 |
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Fuente / Imprenta : |
Theoretical and Applied Genetics, volume 134, pag. 529?542, feb 2021. Open Access. Doi: https://doi.org/10.1007/s00122-020-03712-y |
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DOI : |
10.1007/s00122-020-03712-y |
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Idioma : |
Inglés |
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Notas : |
Article history:Received: 22 June 2020 / Accepted: 17 October 2020/ Published:12 November 2020/ Issue Date:February 2021 |
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Contenido : |
Abstract:
The first cytological characterization of the 2NvS segment in hexaploid wheat; complete de novo assembly and annotation of 2NvS segment; 2NvS frequency is increasing 2NvS and is associated with higher yield. The Aegilops ventricosa 2NvS translocation segment has been utilized in breeding disease-resistant wheat crops since the early 1990s. This segment is known to possess several important resistance genes against multiple wheat diseases including root knot nematode, stripe rust, leaf rust and stem rust. More recently, this segment has been associated with resistance to wheat blast, an emerging and devastating wheat disease in South America and Asia. To date, full characterization of the segment including its size, gene content and its association with grain yield is lacking. Here, we present a complete cytological and physical characterization of this agronomically important translocation in bread wheat. We de novo assembled the 2NvS segment in two wheat varieties, 'Jagger' and 'CDC Stanley,' and delineated the segment to be approximately 33 Mb. A total of 535 high-confidence genes were annotated within the 2NvS region, with > 10% belonging to the nucleotide-binding leucine-rich repeat (NLR) gene families. Identification of groups of NLR genes that are potentially N genome-specific and expressed in specific tissues can fast-track testing of candidate genes playing roles in various disease resistances. We also show the increasing frequency of 2NvS among spring and winter wheat breeding programs over two and a half decades, and the positive impact of 2NvS on wheat grain yield based on historical datasets. The significance of the 2NvS segment in wheat breeding due to resistance to multiple diseases and a positive impact on yield highlights the importance of understanding and characterizing the wheat pan-genome for better insights into molecular breeding for wheat improvement. MenosAbstract:
The first cytological characterization of the 2NvS segment in hexaploid wheat; complete de novo assembly and annotation of 2NvS segment; 2NvS frequency is increasing 2NvS and is associated with higher yield. The Aegilops ventricosa 2NvS translocation segment has been utilized in breeding disease-resistant wheat crops since the early 1990s. This segment is known to possess several important resistance genes against multiple wheat diseases including root knot nematode, stripe rust, leaf rust and stem rust. More recently, this segment has been associated with resistance to wheat blast, an emerging and devastating wheat disease in South America and Asia. To date, full characterization of the segment including its size, gene content and its association with grain yield is lacking. Here, we present a complete cytological and physical characterization of this agronomically important translocation in bread wheat. We de novo assembled the 2NvS segment in two wheat varieties, 'Jagger' and 'CDC Stanley,' and delineated the segment to be approximately 33 Mb. A total of 535 high-confidence genes were annotated within the 2NvS region, with > 10% belonging to the nucleotide-binding leucine-rich repeat (NLR) gene families. Identification of groups of NLR genes that are potentially N genome-specific and expressed in specific tissues can fast-track testing of candidate genes playing roles in various disease resistances. We also show the increasing frequency of 2NvS among spring and ... Presentar Todo |
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Palabras claves : |
BREAD WHEAT; BREEDING WHEAT IMRPVEMENT. |
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Thesagro : |
MEJORAMIENTO GENETICO DE PLANTAS; TRIGO; TRITICUM AESTIVUM. |
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Asunto categoría : |
F01 Cultivo |
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URL : |
https://link.springer.com/content/pdf/10.1007/s00122-020-03712-y.pdf
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Marc : |
LEADER 03352naa a2200469 a 4500
001 1061527
005 2021-04-27
008 2021 bl uuuu u00u1 u #d
024 7 $a10.1007/s00122-020-03712-y$2DOI
100 1 $aGAO, L.
245 $aThe Aegilops ventricosa 2N v S segment in bread wheat$bcytology, genomics and breeding.$h[electronic resource]
260 $c2021
500 $aArticle history:Received: 22 June 2020 / Accepted: 17 October 2020/ Published:12 November 2020/ Issue Date:February 2021
520 $aAbstract: The first cytological characterization of the 2NvS segment in hexaploid wheat; complete de novo assembly and annotation of 2NvS segment; 2NvS frequency is increasing 2NvS and is associated with higher yield. The Aegilops ventricosa 2NvS translocation segment has been utilized in breeding disease-resistant wheat crops since the early 1990s. This segment is known to possess several important resistance genes against multiple wheat diseases including root knot nematode, stripe rust, leaf rust and stem rust. More recently, this segment has been associated with resistance to wheat blast, an emerging and devastating wheat disease in South America and Asia. To date, full characterization of the segment including its size, gene content and its association with grain yield is lacking. Here, we present a complete cytological and physical characterization of this agronomically important translocation in bread wheat. We de novo assembled the 2NvS segment in two wheat varieties, 'Jagger' and 'CDC Stanley,' and delineated the segment to be approximately 33 Mb. A total of 535 high-confidence genes were annotated within the 2NvS region, with > 10% belonging to the nucleotide-binding leucine-rich repeat (NLR) gene families. Identification of groups of NLR genes that are potentially N genome-specific and expressed in specific tissues can fast-track testing of candidate genes playing roles in various disease resistances. We also show the increasing frequency of 2NvS among spring and winter wheat breeding programs over two and a half decades, and the positive impact of 2NvS on wheat grain yield based on historical datasets. The significance of the 2NvS segment in wheat breeding due to resistance to multiple diseases and a positive impact on yield highlights the importance of understanding and characterizing the wheat pan-genome for better insights into molecular breeding for wheat improvement.
650 $aMEJORAMIENTO GENETICO DE PLANTAS
650 $aTRIGO
650 $aTRITICUM AESTIVUM
653 $aBREAD WHEAT
653 $aBREEDING WHEAT IMRPVEMENT
700 1 $aKOO, D.H.
700 1 $aJULIANA, P.
700 1 $aRIFE, T.
700 1 $aSINGH, D.
700 1 $aCRISTIANO LEMES DA SILVA
700 1 $aLUX, T.
700 1 $aDORN, K.M.
700 1 $aCLINESMITH, M.
700 1 $aSILVA, P.
700 1 $aWANG, X.
700 1 $aSPANNAGL, M.
700 1 $aMONAT, C.
700 1 $aFRIEBE, B.
700 1 $aSTEUERNAGEL, B.
700 1 $aMUEHLBAUER, G.J.
700 1 $aWALKOWIAK, S.
700 1 $aPOZNIAK, C.
700 1 $aSINGH, R.
700 1 $aSTEIN, N.
700 1 $aMASCHER, M.
700 1 $aFRITZ, A.
700 1 $aPOLAND, J.
773 $tTheoretical and Applied Genetics, volume 134, pag. 529?542, feb 2021. Open Access. Doi: https://doi.org/10.1007/s00122-020-03712-y
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INIA La Estanzuela (LE) |
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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
26/02/2024 |
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Actualizado : |
26/02/2024 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
Internacional - -- |
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Autor : |
COSTA, M.; MANSILLA, F.; MANUEL SALA, J.; SARAVIA, A.; UBIOS, D.; LORES, P.; CAPOZZO, A.V.; FREIRE, T. |
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Afiliación : |
MONIQUE COSTA, Laboratorio de Inmunomodulación y Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay; FLORENCIA MANSILLA, Instituto de Virología e Innovaciones Tecnológicas, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas (CICVyA), INTA, Buenos Aires, Hurlingham, Argentina; JUAN MANUEL SALA, Estación Experimental Agropecuaria- Instituto Nacional de Tecnología Agropecuaria (INTA), Juan Pujol al Este s/n (3470), Corrientes, Mercedes, Argentina; ANDERSON SARAVIA DE MELO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; DIEGO UBIOS, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; PABLO LORES, Laboratorio de Inmunomodulación y Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay; ALEJANDRA VICTORIA CAPOZZO, Instituto de Virología e Innovaciones Tecnológicas, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas (CICVyA), INTA, Buenos Aires, Hurlingham, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina; TERESA FREIRE, Laboratorio de Inmunomodulación y Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo. |
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Título : |
Fasciola hepatica infection modifies lgG1 specific immune response to foot-and-mouth disease virus induced by vaccination. |
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Fecha de publicación : |
2024 |
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Fuente / Imprenta : |
Vaccine. 2024, Volume 42, Issue 3, Pages 541-547. https://doi.org/10.1016/j.vaccine.2023.12.067 |
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ISSN : |
0264-410X |
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DOI : |
10.1016/j.vaccine.2023.12.067 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 19 August 2023; Received in revised form 15 December 2023; Accepted 20 December 2023; Available online 6 January 2024. -- Correspondence: Freire, T.; UdelaR, Facultad de Medicina, Departamento de Inmunobiología, Gral. Flores 2125, Montevideo, Uruguay; email:tfreire@fmed.edu.uy -- Funding: Financial supports were provided by Programa de Desarrollo de Ciencias Básicas ( PEDECIBA ), Comisión Sectorial de Investigación Científica and Agencia Nacional de Investigación e Innovación (SNI-ANII and FCE_1_2019_1_156295) to Teresa Freire. Funding by GFRA Research to Florencia Mansilla was also provided. M. Costa was funded by ANII and CAP. A. V. Capozzo is a researcher of CONICET , Argentina. -- Supplementary data to this article can be found online at https://doi.org/10.1016/j.vaccine.2023.12.067 |
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Contenido : |
ABSTRACT.- Fasciola hepatica, a worldwide distributed helminth, has a robust immunoregulatory effect in the host, increasing the susceptibility to secondary infections. Foot and mouth disease (FMD) is a highly contagious acute vesicular viral disease effectively controlled by vaccination in endemic regions. Despite the evidence of immunoregulatory effects, the impact of fasciolosis on the immune response induced by FMD vaccination in cattle has never been assessed. Our objective was to evaluate whether the infection by F. hepatica in cattle influences the long-term immunity elicited by the currently used commercial FMD-inactivated vaccines. Aberdeen Angus steers negative for F. hepatica were vaccinated twice against FMD virus (FMDV) during the first 6 months of age using a commercial oil vaccine formulated with A24/Cruzeiro and O1/Campos strains. When maternal antibodies against F. hepatica were weaned (18--20 months of age) animals were divided into groups of 12 and infected or mock-infected with 500 metacercariae/animal. Individual serum samples were collected at 0-, 28-, 59-, 87- and 157-days post-infection (dpi). Indirect ELISAs were used to detect A24/Cruzeiro specific bovine IgG and IgG subtypes. The total IgG antibody levels and avidity against FMDV did not show significant differences between all the groups. The commercial vaccine induced higher IgG2 than IgG1 titers in vaccinated animals. Anti-FMDV IgG1 levels significantly decreased in the infected group at 28 dpi. In addition, the avidity of IgG1 FMDV-specific antibodies at day 28 in the infected group was reduced compared to the control. These results show that F. hepatica infection modified anamnestic responses against FMDV, reducing serum IgG1 titers and avidity. To our knowledge, this is the first report of immune-regulation of F. hepatica altering the immune response of FMD vaccines, one of the most globally used animal vaccines. © 2024 Elsevier Ltd MenosABSTRACT.- Fasciola hepatica, a worldwide distributed helminth, has a robust immunoregulatory effect in the host, increasing the susceptibility to secondary infections. Foot and mouth disease (FMD) is a highly contagious acute vesicular viral disease effectively controlled by vaccination in endemic regions. Despite the evidence of immunoregulatory effects, the impact of fasciolosis on the immune response induced by FMD vaccination in cattle has never been assessed. Our objective was to evaluate whether the infection by F. hepatica in cattle influences the long-term immunity elicited by the currently used commercial FMD-inactivated vaccines. Aberdeen Angus steers negative for F. hepatica were vaccinated twice against FMD virus (FMDV) during the first 6 months of age using a commercial oil vaccine formulated with A24/Cruzeiro and O1/Campos strains. When maternal antibodies against F. hepatica were weaned (18--20 months of age) animals were divided into groups of 12 and infected or mock-infected with 500 metacercariae/animal. Individual serum samples were collected at 0-, 28-, 59-, 87- and 157-days post-infection (dpi). Indirect ELISAs were used to detect A24/Cruzeiro specific bovine IgG and IgG subtypes. The total IgG antibody levels and avidity against FMDV did not show significant differences between all the groups. The commercial vaccine induced higher IgG2 than IgG1 titers in vaccinated animals. Anti-FMDV IgG1 levels significantly decreased in the infected group at 28 dpi.... Presentar Todo |
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Palabras claves : |
Fasciolosis; FMD vaccine; IgG avidity; Immune modulation; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA; Vaccine efficacy. |
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Asunto categoría : |
L01 Ganadería |
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Marc : |
LEADER 03751naa a2200313 a 4500
001 1064474
005 2024-02-26
008 2024 bl uuuu u00u1 u #d
022 $a0264-410X
024 7 $a10.1016/j.vaccine.2023.12.067$2DOI
100 1 $aCOSTA, M.
245 $aFasciola hepatica infection modifies lgG1 specific immune response to foot-and-mouth disease virus induced by vaccination.$h[electronic resource]
260 $c2024
500 $aArticle history: Received 19 August 2023; Received in revised form 15 December 2023; Accepted 20 December 2023; Available online 6 January 2024. -- Correspondence: Freire, T.; UdelaR, Facultad de Medicina, Departamento de Inmunobiología, Gral. Flores 2125, Montevideo, Uruguay; email:tfreire@fmed.edu.uy -- Funding: Financial supports were provided by Programa de Desarrollo de Ciencias Básicas ( PEDECIBA ), Comisión Sectorial de Investigación Científica and Agencia Nacional de Investigación e Innovación (SNI-ANII and FCE_1_2019_1_156295) to Teresa Freire. Funding by GFRA Research to Florencia Mansilla was also provided. M. Costa was funded by ANII and CAP. A. V. Capozzo is a researcher of CONICET , Argentina. -- Supplementary data to this article can be found online at https://doi.org/10.1016/j.vaccine.2023.12.067
520 $aABSTRACT.- Fasciola hepatica, a worldwide distributed helminth, has a robust immunoregulatory effect in the host, increasing the susceptibility to secondary infections. Foot and mouth disease (FMD) is a highly contagious acute vesicular viral disease effectively controlled by vaccination in endemic regions. Despite the evidence of immunoregulatory effects, the impact of fasciolosis on the immune response induced by FMD vaccination in cattle has never been assessed. Our objective was to evaluate whether the infection by F. hepatica in cattle influences the long-term immunity elicited by the currently used commercial FMD-inactivated vaccines. Aberdeen Angus steers negative for F. hepatica were vaccinated twice against FMD virus (FMDV) during the first 6 months of age using a commercial oil vaccine formulated with A24/Cruzeiro and O1/Campos strains. When maternal antibodies against F. hepatica were weaned (18--20 months of age) animals were divided into groups of 12 and infected or mock-infected with 500 metacercariae/animal. Individual serum samples were collected at 0-, 28-, 59-, 87- and 157-days post-infection (dpi). Indirect ELISAs were used to detect A24/Cruzeiro specific bovine IgG and IgG subtypes. The total IgG antibody levels and avidity against FMDV did not show significant differences between all the groups. The commercial vaccine induced higher IgG2 than IgG1 titers in vaccinated animals. Anti-FMDV IgG1 levels significantly decreased in the infected group at 28 dpi. In addition, the avidity of IgG1 FMDV-specific antibodies at day 28 in the infected group was reduced compared to the control. These results show that F. hepatica infection modified anamnestic responses against FMDV, reducing serum IgG1 titers and avidity. To our knowledge, this is the first report of immune-regulation of F. hepatica altering the immune response of FMD vaccines, one of the most globally used animal vaccines. © 2024 Elsevier Ltd
653 $aFasciolosis
653 $aFMD vaccine
653 $aIgG avidity
653 $aImmune modulation
653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA
653 $aVaccine efficacy
700 1 $aMANSILLA, F.
700 1 $aMANUEL SALA, J.
700 1 $aSARAVIA, A.
700 1 $aUBIOS, D.
700 1 $aLORES, P.
700 1 $aCAPOZZO, A.V.
700 1 $aFREIRE, T.
773 $tVaccine. 2024, Volume 42, Issue 3, Pages 541-547. https://doi.org/10.1016/j.vaccine.2023.12.067
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