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 | Acceso al texto completo restringido a Biblioteca INIA La Estanzuela. Por información adicional contacte bib_le@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA La Estanzuela. |
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Fecha : |
31/05/2022 |
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Actualizado : |
02/12/2022 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
COSTA, M.; SARAVIA, A.; UBIOS, D.; LORES, L.; DA COSTA, V.; FESTARI, M.F.; LANDEIRA, M.; RODRÍGUEZ-ZRAQUIA, S.A.; BANCHERO, G.; FREIRE, T. |
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Afiliación : |
MONIQUE COSTA, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.; ANDERSON SARAVIA DE MELO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; DIEGO UBIOS, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay.; PABLO LORES, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.; VALERIA DA COSTA, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.; MARÍA FLORENCIA FESTARI, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.; MERCEDES LANDEIRA, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay; SANTIAGO A. RODRÍGUEZ-ZRAQUIA, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.; GEORGGET ELIZABETH BANCHERO HUNZIKER, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; TERESA FREIRE, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay. |
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Título : |
Liver function markers and haematological dynamics during acute and chronic phases of experimental Fasciola hepatica infection in cattle treated with triclabendazole. |
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Fecha de publicación : |
2022 |
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Fuente / Imprenta : |
Experimental Parasitology, July 2022, Volume 238, e108285. doi://doi.org/10.1016/j.exppara.2022.108285 |
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ISSN : |
0014-4894 |
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DOI : |
10.1016/j.exppara.2022.108285 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 13 September 2021; Revised 24 May 2022; Accepted 27 May 2022; Available online 30 May 2022; Published July 2022. -- Corresponding author : Freire, T.; Facultad de Medicina, Departamento de Inmunobiología. Gral. Flores 2125, Montevideo, Uruguay; email:tfreire@fmed.edu.uy -- |
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Contenido : |
Abstract:
Fasciola hepatica, a worldwide-distributed liver fluke, is one of the causative agents of fasciolosis, a zoonotic disease that affects livestock and humans. In livestock, fasciolosis causes huge economic losses worldwide, reducing animal fertility, milk production, weight gain and condemnation of livers. In spite of the availability of drugs, such as triclabendazole (TCZ), for the treatment of fasciolosis, they do not necessarily prevent liver damage or parasite reinfection and can eventually increase parasite resistance. The aim of this research was to relate the hepatic function, haematological parameters, leukocyte counts in circulation and parasite egg shedding during F. hepatica acute and chronic phases of infection in cattle as well as to determine how these parameters change with TCZ-treatment of chronically infected cattle. Our results show that increased levels of serum aspartate aminotransferase (AST) and gamma glutamyltransferase (GGT) were detected in early stages of the experimental infection. Moreover, high circulating eosinophil count and plateletcrit levels were correlated with fluke number in livers from infected cattle. On the other hand, although TCZ-treatment in the chronic phase of infection reduced parasite burden and damage in the liver, it was not able to completely avoid them. In conclusion, our work sheds light into the physiopathological mechanisms induced during fluke infection in cattle, revealing the complexity of the host response to the infection, together with the effects of TCZ-treatment in chronically infected animals. © 2022 MenosAbstract:
Fasciola hepatica, a worldwide-distributed liver fluke, is one of the causative agents of fasciolosis, a zoonotic disease that affects livestock and humans. In livestock, fasciolosis causes huge economic losses worldwide, reducing animal fertility, milk production, weight gain and condemnation of livers. In spite of the availability of drugs, such as triclabendazole (TCZ), for the treatment of fasciolosis, they do not necessarily prevent liver damage or parasite reinfection and can eventually increase parasite resistance. The aim of this research was to relate the hepatic function, haematological parameters, leukocyte counts in circulation and parasite egg shedding during F. hepatica acute and chronic phases of infection in cattle as well as to determine how these parameters change with TCZ-treatment of chronically infected cattle. Our results show that increased levels of serum aspartate aminotransferase (AST) and gamma glutamyltransferase (GGT) were detected in early stages of the experimental infection. Moreover, high circulating eosinophil count and plateletcrit levels were correlated with fluke number in livers from infected cattle. On the other hand, although TCZ-treatment in the chronic phase of infection reduced parasite burden and damage in the liver, it was not able to completely avoid them. In conclusion, our work sheds light into the physiopathological mechanisms induced during fluke infection in cattle, revealing the complexity of the host response to ... Presentar Todo |
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Palabras claves : |
Fasciola hepatica; Fasciolosis; Fluke; LIVER; PLATAFORMA DE SALUD ANIMAL; Triclabendazole. |
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Asunto categoría : |
L73 Enfermedades de los animales |
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Marc : |
LEADER 02950naa a2200337 a 4500
001 1063184
005 2022-12-02
008 2022 bl uuuu u00u1 u #d
022 $a0014-4894
024 7 $a10.1016/j.exppara.2022.108285$2DOI
100 1 $aCOSTA, M.
245 $aLiver function markers and haematological dynamics during acute and chronic phases of experimental Fasciola hepatica infection in cattle treated with triclabendazole.$h[electronic resource]
260 $c2022
500 $aArticle history: Received 13 September 2021; Revised 24 May 2022; Accepted 27 May 2022; Available online 30 May 2022; Published July 2022. -- Corresponding author : Freire, T.; Facultad de Medicina, Departamento de Inmunobiología. Gral. Flores 2125, Montevideo, Uruguay; email:tfreire@fmed.edu.uy --
520 $aAbstract: Fasciola hepatica, a worldwide-distributed liver fluke, is one of the causative agents of fasciolosis, a zoonotic disease that affects livestock and humans. In livestock, fasciolosis causes huge economic losses worldwide, reducing animal fertility, milk production, weight gain and condemnation of livers. In spite of the availability of drugs, such as triclabendazole (TCZ), for the treatment of fasciolosis, they do not necessarily prevent liver damage or parasite reinfection and can eventually increase parasite resistance. The aim of this research was to relate the hepatic function, haematological parameters, leukocyte counts in circulation and parasite egg shedding during F. hepatica acute and chronic phases of infection in cattle as well as to determine how these parameters change with TCZ-treatment of chronically infected cattle. Our results show that increased levels of serum aspartate aminotransferase (AST) and gamma glutamyltransferase (GGT) were detected in early stages of the experimental infection. Moreover, high circulating eosinophil count and plateletcrit levels were correlated with fluke number in livers from infected cattle. On the other hand, although TCZ-treatment in the chronic phase of infection reduced parasite burden and damage in the liver, it was not able to completely avoid them. In conclusion, our work sheds light into the physiopathological mechanisms induced during fluke infection in cattle, revealing the complexity of the host response to the infection, together with the effects of TCZ-treatment in chronically infected animals. © 2022
653 $aFasciola hepatica
653 $aFasciolosis
653 $aFluke
653 $aLIVER
653 $aPLATAFORMA DE SALUD ANIMAL
653 $aTriclabendazole
700 1 $aSARAVIA, A.
700 1 $aUBIOS, D.
700 1 $aLORES, L.
700 1 $aDA COSTA, V.
700 1 $aFESTARI, M.F.
700 1 $aLANDEIRA, M.
700 1 $aRODRÍGUEZ-ZRAQUIA, S.A.
700 1 $aBANCHERO, G.
700 1 $aFREIRE, T.
773 $tExperimental Parasitology, July 2022, Volume 238, e108285. doi://doi.org/10.1016/j.exppara.2022.108285
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INIA La Estanzuela (LE) |
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| Registros recuperados : 8 | |
| 2. |  | COSTA, F.O.; DEL CAMPO, M.; SOARES DE LIMA, J.M.; BRITO, G.; PARANHOS DA COSTA, M.J.R The effect of different pre slaughter procedures on carcas and meat quality in Uruguay. In: INTERNATIONAL CONGRESS OF MEAT SCIENCE AND TECHNOLOGY (ICoMST), 60., 2014, Punta del Este, Uruguay. Proceedings... Montevideo: INIA, 2014.| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA Tacuarembó. |
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| 3. | | COSTA, F.D.O.; VALENTE, T.S.; DE TOLEDO, L.M.; AMBRÓSIO, L.A.; DEL CAMPO, M.; PARANHOS DA COSTA, M.J.R. A conceptual model of the human-animal relationships dynamics during newborn handling on cow-calf operation farms. Livestock Science, 2021, Volume 246, Article number 104462. Doi: https://doi.org/10.1016/j.livsci.2021.104462 Article history: Received 24 August 2020, Revised 23 February 2021, Accepted 24 February 2021, Available online 28 February 2021. Acknowledgements: We appreciated the support of Coordenaçao de Aperfeiçoamento de Pessoal de Nível Superior...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Tacuarembó. |
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| 4. | | COSTA, F.; BORGES, V.S.; CONDE, M.V.; SILVA, A.; VALENTE, T.; PARANHOS DA COSTA, M.J.R.; DEL CAMPO, M. Characterization of maternal protective behavior of Hereford cows and its effect on calf performance. [Resumen]. In: CONGRESO ASOCIACIÓN URUGUAYA DE PRODUCCIÓN ANIMAL (6º, Marzo, 2018, Tacuarembó, Uruguay). Resúmenes. Tacuarembó: AUPA, 2018.| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA Tacuarembó. |
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| 5. | | COSTA, F. O.; DEL CAMPO, M.; BRITO, G.; SOARES DE LIMA, J.M.; SANT´ANNA, A.; PARANHOS DA COSTA, M.J.R Lairage time and temperament effects on glycogen content in Hereford steers. In: International Congress of Meat Science and Technology, Meat for Global Sustainability, 62., 14-19th August 2016, Bangkok, Thailand.| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA Tacuarembó. |
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| 6. | | COSTA, F. O.; DEL CAMPO, M.; BRITO, G.; SOARES DE LIMA, J.M.; SANT´ANNA, A.; PARANHOS DA COSTA, M.J.R Lairage time and temperament effects on glycogen content in Hereford steers. [Poster]. In: International Congress of Meat Science and Technology, Meat for Global Sustainability, 62., 14-19th August 2016, Bangkok, Thailand.| Biblioteca(s): INIA Tacuarembó. |
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| 7. | | PARANHOS DA COSTA, M.J.R.; PELLECCHIA, A.J.R.; JANAINA S. BRAGA; BORGES, T.D.; PÁSCOA, A.G.; DEL CAMPO, M. Risks (odds ratios) of bruises on cattle carcasses in different animal categories: preliminary results. In: INTERNATIONAL CONGRESS OF MEAT SCIENCE AND TECHNOLOGY (ICoMST), 60., 2014, Punta del Este, Uruguay. Proceedings... Montevideo: INIA, 2014.| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA Tacuarembó. |
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| 8. | | PELLECCHIA, A.J.R.; BRAGA, J.S.; BORGES, T.D.; PÁSCOA, A.G.; PARANHOS DA COSTA, M.J.R.; DEL CAMPO, M. A survey about the number and age of bruises in bovine carcasses: effect of animal category. In: INTERNATIONAL CONGRESS OF MEAT SCIENCE AND TECHNOLOGY (ICoMST), 60., 2014, Punta del Este, Uruguay. Proceedings... Montevideo: INIA, 2014.| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA Tacuarembó. |
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| Registros recuperados : 8 | |
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