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| Registros recuperados : 165 | |
| 101. |  | MACEDO, F.; NAVAJAS, E.; AGUILAR, I.; GRASSO, A.; PIERUCCIONI, F.; CIAPPESONI, G. New parentage testing SNP panel for commercial breeds will be a useful tool for conservation of creole sheep. Volume Genetic Improvement Programs: Selection for harsh environments and management of animal genetic resources (Posters), , 441. In: Proceedings of the World Congress on Genetics Applied to Livestock Production, 10., Vancouver, BC, Canada, August 17-22, 2014. p. 441. 3 p.| Biblioteca(s): INIA Las Brujas. |
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| 102. | | GRASSO, A.; GOLDBERG, V.; IRIARTE, W.; GIMENO,D.; CASTELLS, D.; RINCON, G.; NAVAJAS, E.; CIAPPESONI, G. Nuevas herramientas moleculares para la selección en ovinos: ejemplo de caso resistencia a parásitos gastrointestinales ln: Jornada técnica, VI Jornada de agrobiotecnología. INIA Las Brujas, 20 de octubre de 2012 Conocimiento intensivo para el sector productivo: situación actual y perspectivas. Canelones (UY): INIA, 2012. 7-9 (Serie Actividades de Difusión; 698)| Biblioteca(s): INIA Las Brujas. |
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| 105. | | CIAPPESONI, G.; NAVAJAS, E.; BAPTISTA, R.; AGUILAR, I.; PERAZA, P.; CARRACELAS, B.; DE BARBIERI, I. Proyecto SMARTER. INIA ya está en el Mundial de la Genética Ovina. Producción Animal. Revista INIA Uruguay, Marzo 2022, no.68, p.15-18. (Revista INIA; 68).| Biblioteca(s): INIA Las Brujas. |
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| 106. | | DE BARBIERI, I.; NAVAJAS, E.; DOUHARD, F.; CONINGTON, J.; Z. RAMOS; CIAPPESONI, G. PL-8 A review of sheep resilience. [conference abstract]. Animal - science proceedings, March 2023, Volume 14, Issue 1, Pages 11-12. doi: https://doi.org/10.1016/j.anscip.2023.01.009 Article history: Available online 13 March 2023, Version of Record 13 March 2023. -- Corresponding author: Ignacio de Barbieri. E-mail: idebarbieri@inia.org.uy --
Acknowledgments: Authors acknowledge the contribution of the projects...| Biblioteca(s): INIA Las Brujas. |
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| 109. | | BLUMETTO, O.; DE BARBIERI, I.; NAVAJAS, E.; BAETHGEN, W.; VERA, B.; BECOÑA, G.; CIAPPESONI, G. Regenerative livestock farming in Uruguay. Montevideo (UY): INIA, 2023. 23 p. (INIA, Special Edition). Technical review: Ing. Agr. PhD Verónica Ciganda y DMV PhD Georgget Banchero. -- This publication derives from the research work of the Natural Resources, Production and Environment Area, within the framework of the Extensive Livestock...| Biblioteca(s): INIA Las Brujas. |
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| 110. | | NAVAJAS, E.; RAVAGNOLO, O.; AGUILAR, I.; CIAPPESONI, G.; PERAZA, P.; DALLA RIZZA, M.; MONTOSSI, F. Selección genómica animal: quién, cómo y dónde. ln: INIA TACUAREMBÓ. UNIDAD DE BIOTECNOLOGÍA INIA. Jornada técnica. Jornada de Agrobiotecnología INIA, 15 NOVIEMBRE, Tacuarembó, Biotecnología para el sector productivo: situación actual y perspectivas. Tacuarembó (Uruguay): INIA, 2012. p. 17-19 (INIA Serie Actividades de Difusión; 702) INIA Tacuarembó| Biblioteca(s): INIA Tacuarembó. |
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| 111. | | SAWALHA, R. M.; NAVAJAS, E.; DUTHIE, C. A.; ROEHE, R.; ROUGHSEDGE, T.; WALL, E. Selection response in UK sheep breeding program with the application of genomic selection and inclusion of production efficiency traits. Volume Genetic improvement programmes: Selection using molecular information - Poster Sessions, 0752. In: Proceedings of the World Congress on Genetics Applied to Livestock Production, 9., Leipzig, Germany, August 1-6, 2010. p. 0752.| Biblioteca(s): INIA Las Brujas. |
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| 112. | | NAVAJAS, E.; GARRICK, D.J.; PLEASANTS, A.B.; MORRIS, C.A. Superiority of a biochemically-based approach for the detection of a quantitative trait locus affecting ultimate pH. Session 11. Growth and meat quality Communication No. 11-16. In: Proceedings of the World Congress on Genetics Applied to Livestock Production, 7., Montpellier, France, August 19-23, 2002, p. 11-16.| Biblioteca(s): INIA Las Brujas. |
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| 113. | | VERA, B.; NAVAJAS, E.; DE BARBIERI, I.; VAN LIER, E.; CIAPPESONI, G. Predicciones genómicas para rasgos productivos y de valor ambiental en ovinos Merino Australiano. [resumen]. In: REDBIO México 2022, XI Congreso, "Biotecnología productiva y sostenible". Libro de resúmenes. 12-14 octubre 2022, Yucatán, México. p.122. Este trabajo fue parcialmente financiado por los proyectos SMARTER (772787), RUMIAR, GrassToGas, CSIC I+D-2018-287.| Biblioteca(s): INIA Las Brujas. |
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| 114. | | VERA, B.; MONZALVO, C.; NAVAJAS, E.; DE BARBIERI, I.; CARRACELAS, B.; VAN LIER, E.; CIAPPESONI, G. Predicción del valor genético de ovinos en predios comerciales para emisión de metano, eficiencia de conversión y características productivas. Revista INIA Uruguay, Diciembre 2022, no.71, p. 34-37. (Revista INIA; 71)| Biblioteca(s): INIA Treinta y Tres. |
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| 115. | | LAMBE, N.R.; NAVAJAS, E.; BÜNGER, L.; FISHER, A.V.; ROEHE, R.; SIMM, G. Prediction of lamb carcass composition and meat quality using combinations of post-mortem measurements. Meat Science, 2009, Volume 81, Issue 4, Pages 711-719. doi: https://doi.org/10.1016/j.meatsci.2008.10.025 Article history: Received 27 August 2008; Received in revised form 28 October 2008; Accepted 31 October 2008.| Biblioteca(s): INIA Las Brujas. |
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| 116. | | LAMBE, N.R.; NAVAJAS, E.; FISHER, A.V.; SIMM, G.; ROEHE, R.; BÜNGER, L. Prediction of lamb meat eating quality in two divergent breeds using various live animal and carcass measurements. Meat Science, 2009, Volume 83, Issue 3, Pages 366-375. doi: https://doi.org/10.1016/j.meatsci.2009.06.007 Article history: Received 13 January 2009; Received in revised form 25 May 2009; Accepted 2 June 2009.| Biblioteca(s): INIA Las Brujas. |
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| 117. | | JARA, E.; PEÑAGARICANO, F.; ARMSTRONG, E.; CIAPPESONI, G.; IRIARTE, A.; NAVAJAS, E. Revealing the genetic basis of eyelid pigmentation in Hereford cattle. Journal of Animal Science, 2022, Volume 100, Issue 5. doi: https://doi.org/10.1093/jas/skac110 Article history: Received December 14, 2021; Accepted April 4, 2022; Advance access publication 7 April 2022.
Corresponding author: Eugenio Jara, email: eugeniojara19@gmail.com --| Biblioteca(s): INIA Las Brujas. |
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| 118. | | DE BARBIERI, I.; BLUMETTO, O.; NAVAJAS, E.; LUZARDO, S.; MONTOSSI, F.; CIAPPESONI, G. Valorización de la producción ovina: animales, personas y ambiente. AMBIENTE. En: Cueto, M.I.; Maurino, J.; Giovannini, N.; Bruno Galarraga, M.M. (eds.). Actualización en Producción Ovina 2022: memorias del 10 Curso "Hacia sistemas más sustentables", San Carlos de Bariloche 14 al 15 de noviembre de 2022. p. 32-37. Se reconoce el aporte de los proyectos RUMIAR (CL38 financiado por INIA), Smarter (financiado por H2020, n°772787), y GrasstoGas (ERA-NET SusAn, ERA-NET FACCE
ERA-GAS y ERA-NET ICT-AGRI 2) para desarrollar el trabajo presentado.| Biblioteca(s): INIA Las Brujas. |
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| Registros recuperados : 165 | |
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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
14/06/2022 |
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Actualizado : |
14/06/2022 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
Internacional - -- |
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Autor : |
JARA, E.; PEÑAGARICANO, F.; ARMSTRONG, E.; CIAPPESONI, G.; IRIARTE, A.; NAVAJAS, E. |
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Afiliación : |
EUGENIO JARA, Unidad de Genética y Mejora Animal, Departamento de Producción Animal, Facultad de Veterinaria, Universidad de la República, Montevideo 11600, Uruguay; FRANCISCO PEÑAGARICANO, Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706, United State; EILEEN ARMSTRONG, Unidad de Genética y Mejora Animal, Departamento de Producción Animal, Facultad de Veterinaria, Universidad de la República, 11600, Montevideo, Uruguay; CARLOS GABRIEL CIAPPESONI SCARONE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANDRÉS IRIARTE, Laboratorio de Biología Computacional, Departamento de Desarrollo Biotecnológico, Instituto de Higiene, Facultad de Medicina, Universidad de la República, 11600, Montevideo, Uruguay; ELLY ANA NAVAJAS VALENTINI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Revealing the genetic basis of eyelid pigmentation in Hereford cattle. |
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Fecha de publicación : |
2022 |
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Fuente / Imprenta : |
Journal of Animal Science, 2022, Volume 100, Issue 5. doi: https://doi.org/10.1093/jas/skac110 |
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ISSN : |
1525-3163 |
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DOI : |
10.1093/jas/skac110 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received December 14, 2021; Accepted April 4, 2022; Advance access publication 7 April 2022.
Corresponding author: Eugenio Jara, email: eugeniojara19@gmail.com -- |
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Contenido : |
ABSTRACT - Ocular squamous cell carcinoma and infectious keratoconjunctivitis are common ocular pathologies in Hereford cattle with considerable economic impact. Both pathologies have been associated with low eyelid pigmentation, and thus, genetic selection for higher eyelid pigmentation could reduce their incidence. The objective of the present study was to reveal the genetic basis of eyelid pigmentation in Hereford cattle. The analysis included a single-step genome-wide association study (ssGWAS) and a subsequent gene-set analysis in order to identify individual genes, genetic mechanisms, and biological pathways implicated in this trait. Data consisted of eyelid pigmentation records in 1,165 Hereford bulls and steers, visually assessed in five categories between 0% and 100%. Genotypic data for 774,660 single-nucleotide polymorphism markers were available for 886 animals with pigmentation records. Pedigree information of three generations of ancestors of animals with phenotype was considered in this study, with a total of 4,929 animals. Our analyses revealed that eyelid pigmentation is a moderately heritable trait, with heritability estimates around 0.41. The ssGWAS identified at least eight regions, located on BTA1, BTA3, BTA5, BTA14, BTA16, BTA18, BTA19, and BTA24, associated with eyelid pigmentation. These regions harbor genes that are directly implicated in melanocyte biology and skin pigmentation, such as ADCY8, PLD1, KITLG, and PRKCA. The gene-set analysis revealed several functional terms closely related to melanogenesis, such as positive regulation of melanocyte differentiation and regulation of ERK1 and ERK2 cascade. Overall, our findings provide evidence that eyelid pigmentation is a heritable trait influenced by many loci. Indeed, the ssGWAS detected several candidate genes that are directly implicated in melanocyte biology, including melanogenesis. This study contributes to a better understanding of the genetic and biological basis of eyelid pigmentation and presents novel information that could aid to design breeding strategies for reducing the incidence of ocular pathologies in cattle. Additional research on the genetic link between eyelid pigmentation and ocular pathologies is needed. © The Author(s) 2022. MenosABSTRACT - Ocular squamous cell carcinoma and infectious keratoconjunctivitis are common ocular pathologies in Hereford cattle with considerable economic impact. Both pathologies have been associated with low eyelid pigmentation, and thus, genetic selection for higher eyelid pigmentation could reduce their incidence. The objective of the present study was to reveal the genetic basis of eyelid pigmentation in Hereford cattle. The analysis included a single-step genome-wide association study (ssGWAS) and a subsequent gene-set analysis in order to identify individual genes, genetic mechanisms, and biological pathways implicated in this trait. Data consisted of eyelid pigmentation records in 1,165 Hereford bulls and steers, visually assessed in five categories between 0% and 100%. Genotypic data for 774,660 single-nucleotide polymorphism markers were available for 886 animals with pigmentation records. Pedigree information of three generations of ancestors of animals with phenotype was considered in this study, with a total of 4,929 animals. Our analyses revealed that eyelid pigmentation is a moderately heritable trait, with heritability estimates around 0.41. The ssGWAS identified at least eight regions, located on BTA1, BTA3, BTA5, BTA14, BTA16, BTA18, BTA19, and BTA24, associated with eyelid pigmentation. These regions harbor genes that are directly implicated in melanocyte biology and skin pigmentation, such as ADCY8, PLD1, KITLG, and PRKCA. The gene-set analysis revealed se... Presentar Todo |
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Palabras claves : |
Beef cattle; Melanocyte biology; Ocular pathologies. |
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Asunto categoría : |
L01 Ganadería |
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Marc : |
LEADER 03180naa a2200253 a 4500
001 1063291
005 2022-06-14
008 2022 bl uuuu u00u1 u #d
022 $a1525-3163
024 7 $a10.1093/jas/skac110$2DOI
100 1 $aJARA, E.
245 $aRevealing the genetic basis of eyelid pigmentation in Hereford cattle.$h[electronic resource]
260 $c2022
500 $aArticle history: Received December 14, 2021; Accepted April 4, 2022; Advance access publication 7 April 2022. Corresponding author: Eugenio Jara, email: eugeniojara19@gmail.com --
520 $aABSTRACT - Ocular squamous cell carcinoma and infectious keratoconjunctivitis are common ocular pathologies in Hereford cattle with considerable economic impact. Both pathologies have been associated with low eyelid pigmentation, and thus, genetic selection for higher eyelid pigmentation could reduce their incidence. The objective of the present study was to reveal the genetic basis of eyelid pigmentation in Hereford cattle. The analysis included a single-step genome-wide association study (ssGWAS) and a subsequent gene-set analysis in order to identify individual genes, genetic mechanisms, and biological pathways implicated in this trait. Data consisted of eyelid pigmentation records in 1,165 Hereford bulls and steers, visually assessed in five categories between 0% and 100%. Genotypic data for 774,660 single-nucleotide polymorphism markers were available for 886 animals with pigmentation records. Pedigree information of three generations of ancestors of animals with phenotype was considered in this study, with a total of 4,929 animals. Our analyses revealed that eyelid pigmentation is a moderately heritable trait, with heritability estimates around 0.41. The ssGWAS identified at least eight regions, located on BTA1, BTA3, BTA5, BTA14, BTA16, BTA18, BTA19, and BTA24, associated with eyelid pigmentation. These regions harbor genes that are directly implicated in melanocyte biology and skin pigmentation, such as ADCY8, PLD1, KITLG, and PRKCA. The gene-set analysis revealed several functional terms closely related to melanogenesis, such as positive regulation of melanocyte differentiation and regulation of ERK1 and ERK2 cascade. Overall, our findings provide evidence that eyelid pigmentation is a heritable trait influenced by many loci. Indeed, the ssGWAS detected several candidate genes that are directly implicated in melanocyte biology, including melanogenesis. This study contributes to a better understanding of the genetic and biological basis of eyelid pigmentation and presents novel information that could aid to design breeding strategies for reducing the incidence of ocular pathologies in cattle. Additional research on the genetic link between eyelid pigmentation and ocular pathologies is needed. © The Author(s) 2022.
653 $aBeef cattle
653 $aMelanocyte biology
653 $aOcular pathologies
700 1 $aPEÑAGARICANO, F.
700 1 $aARMSTRONG, E.
700 1 $aCIAPPESONI, G.
700 1 $aIRIARTE, A.
700 1 $aNAVAJAS, E.
773 $tJournal of Animal Science, 2022, Volume 100, Issue 5. doi: https://doi.org/10.1093/jas/skac110
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