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Registro completo
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Biblioteca (s) : |
INIA La Estanzuela. |
Fecha : |
31/05/2022 |
Actualizado : |
02/12/2022 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
COSTA, M.; SARAVIA, A.; UBIOS, D.; LORES, L.; DA COSTA, V.; FESTARI, M.F.; LANDEIRA, M.; RODRÍGUEZ-ZRAQUIA, S.A.; BANCHERO, G.; FREIRE, T. |
Afiliación : |
MONIQUE COSTA, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.; ANDERSON SARAVIA DE MELO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; DIEGO UBIOS, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay.; PABLO LORES, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.; VALERIA DA COSTA, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.; MARÍA FLORENCIA FESTARI, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.; MERCEDES LANDEIRA, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay; SANTIAGO A. RODRÍGUEZ-ZRAQUIA, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.; GEORGGET ELIZABETH BANCHERO HUNZIKER, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; TERESA FREIRE, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay. |
Título : |
Liver function markers and haematological dynamics during acute and chronic phases of experimental Fasciola hepatica infection in cattle treated with triclabendazole. |
Fecha de publicación : |
2022 |
Fuente / Imprenta : |
Experimental Parasitology, July 2022, Volume 238, e108285. doi://doi.org/10.1016/j.exppara.2022.108285 |
ISSN : |
0014-4894 |
DOI : |
10.1016/j.exppara.2022.108285 |
Idioma : |
Inglés |
Notas : |
Article history: Received 13 September 2021; Revised 24 May 2022; Accepted 27 May 2022; Available online 30 May 2022; Published July 2022. -- Corresponding author : Freire, T.; Facultad de Medicina, Departamento de Inmunobiología. Gral. Flores 2125, Montevideo, Uruguay; email:tfreire@fmed.edu.uy -- |
Contenido : |
Abstract:
Fasciola hepatica, a worldwide-distributed liver fluke, is one of the causative agents of fasciolosis, a zoonotic disease that affects livestock and humans. In livestock, fasciolosis causes huge economic losses worldwide, reducing animal fertility, milk production, weight gain and condemnation of livers. In spite of the availability of drugs, such as triclabendazole (TCZ), for the treatment of fasciolosis, they do not necessarily prevent liver damage or parasite reinfection and can eventually increase parasite resistance. The aim of this research was to relate the hepatic function, haematological parameters, leukocyte counts in circulation and parasite egg shedding during F. hepatica acute and chronic phases of infection in cattle as well as to determine how these parameters change with TCZ-treatment of chronically infected cattle. Our results show that increased levels of serum aspartate aminotransferase (AST) and gamma glutamyltransferase (GGT) were detected in early stages of the experimental infection. Moreover, high circulating eosinophil count and plateletcrit levels were correlated with fluke number in livers from infected cattle. On the other hand, although TCZ-treatment in the chronic phase of infection reduced parasite burden and damage in the liver, it was not able to completely avoid them. In conclusion, our work sheds light into the physiopathological mechanisms induced during fluke infection in cattle, revealing the complexity of the host response to the infection, together with the effects of TCZ-treatment in chronically infected animals. © 2022 MenosAbstract:
Fasciola hepatica, a worldwide-distributed liver fluke, is one of the causative agents of fasciolosis, a zoonotic disease that affects livestock and humans. In livestock, fasciolosis causes huge economic losses worldwide, reducing animal fertility, milk production, weight gain and condemnation of livers. In spite of the availability of drugs, such as triclabendazole (TCZ), for the treatment of fasciolosis, they do not necessarily prevent liver damage or parasite reinfection and can eventually increase parasite resistance. The aim of this research was to relate the hepatic function, haematological parameters, leukocyte counts in circulation and parasite egg shedding during F. hepatica acute and chronic phases of infection in cattle as well as to determine how these parameters change with TCZ-treatment of chronically infected cattle. Our results show that increased levels of serum aspartate aminotransferase (AST) and gamma glutamyltransferase (GGT) were detected in early stages of the experimental infection. Moreover, high circulating eosinophil count and plateletcrit levels were correlated with fluke number in livers from infected cattle. On the other hand, although TCZ-treatment in the chronic phase of infection reduced parasite burden and damage in the liver, it was not able to completely avoid them. In conclusion, our work sheds light into the physiopathological mechanisms induced during fluke infection in cattle, revealing the complexity of the host response to ... Presentar Todo |
Palabras claves : |
Fasciola hepatica; Fasciolosis; Fluke; LIVER; PLATAFORMA DE SALUD ANIMAL; Triclabendazole. |
Asunto categoría : |
L73 Enfermedades de los animales |
Marc : |
LEADER 02950naa a2200337 a 4500 001 1063184 005 2022-12-02 008 2022 bl uuuu u00u1 u #d 022 $a0014-4894 024 7 $a10.1016/j.exppara.2022.108285$2DOI 100 1 $aCOSTA, M. 245 $aLiver function markers and haematological dynamics during acute and chronic phases of experimental Fasciola hepatica infection in cattle treated with triclabendazole.$h[electronic resource] 260 $c2022 500 $aArticle history: Received 13 September 2021; Revised 24 May 2022; Accepted 27 May 2022; Available online 30 May 2022; Published July 2022. -- Corresponding author : Freire, T.; Facultad de Medicina, Departamento de Inmunobiología. Gral. Flores 2125, Montevideo, Uruguay; email:tfreire@fmed.edu.uy -- 520 $aAbstract: Fasciola hepatica, a worldwide-distributed liver fluke, is one of the causative agents of fasciolosis, a zoonotic disease that affects livestock and humans. In livestock, fasciolosis causes huge economic losses worldwide, reducing animal fertility, milk production, weight gain and condemnation of livers. In spite of the availability of drugs, such as triclabendazole (TCZ), for the treatment of fasciolosis, they do not necessarily prevent liver damage or parasite reinfection and can eventually increase parasite resistance. The aim of this research was to relate the hepatic function, haematological parameters, leukocyte counts in circulation and parasite egg shedding during F. hepatica acute and chronic phases of infection in cattle as well as to determine how these parameters change with TCZ-treatment of chronically infected cattle. Our results show that increased levels of serum aspartate aminotransferase (AST) and gamma glutamyltransferase (GGT) were detected in early stages of the experimental infection. Moreover, high circulating eosinophil count and plateletcrit levels were correlated with fluke number in livers from infected cattle. On the other hand, although TCZ-treatment in the chronic phase of infection reduced parasite burden and damage in the liver, it was not able to completely avoid them. In conclusion, our work sheds light into the physiopathological mechanisms induced during fluke infection in cattle, revealing the complexity of the host response to the infection, together with the effects of TCZ-treatment in chronically infected animals. © 2022 653 $aFasciola hepatica 653 $aFasciolosis 653 $aFluke 653 $aLIVER 653 $aPLATAFORMA DE SALUD ANIMAL 653 $aTriclabendazole 700 1 $aSARAVIA, A. 700 1 $aUBIOS, D. 700 1 $aLORES, L. 700 1 $aDA COSTA, V. 700 1 $aFESTARI, M.F. 700 1 $aLANDEIRA, M. 700 1 $aRODRÍGUEZ-ZRAQUIA, S.A. 700 1 $aBANCHERO, G. 700 1 $aFREIRE, T. 773 $tExperimental Parasitology, July 2022, Volume 238, e108285. doi://doi.org/10.1016/j.exppara.2022.108285
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INIA La Estanzuela (LE) |
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Registro completo
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Biblioteca (s) : |
INIA La Estanzuela; INIA Tacuarembó. |
Fecha actual : |
21/02/2014 |
Actualizado : |
25/05/2015 |
Tipo de producción científica : |
Actividades de Difusión |
Autor : |
GARCÍA, J.A. |
Afiliación : |
JAIME ANTONIO GARCIA RADICH, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Gramíneas bianuales. |
Fecha de publicación : |
1995 |
Fuente / Imprenta : |
ln: Día de Campo, 1995, La Estanzuela, Colonia, UY. Pasturas y ovinos. La Estanzuela: INIA, 1995. |
Páginas : |
p. 8. |
Serie : |
(Serie Actividades de Difusión, 78). |
ISSN : |
1688-9258. |
Idioma : |
Español |
Palabras claves : |
CEBADILLA TIJERETA; HOLCUS LA MAGNOLIA; HOLCUS LANATUS; LOLIUM MULTIFLORUM X FESTUCA PRATENSIS; PRODUCCIÓN DE FORRAJE; RAIGRÁS BIANUAL; RAIGRÁS PERENNE. |
Thesagro : |
AVENA; BROMUS CATHARTICUS; FESTUCA; FESTUCA ARUNDINACEA; FITOMEJORAMIENTO; GRAMINEAS FORRAJERAS; HOLCUS; LOLIUM MULTIFLORUM; LOLIUM PERENNE. |
Asunto categoría : |
-- F30 Genética vegetal y fitomejoramiento |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/4528/1/UY.INIA.1995.SAD.no.78.p.8-gramineas-bianuales-GARCIA.pdf
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Marc : |
LEADER 00966naa a2200337 a 4500 001 1044243 005 2015-05-25 008 1995 bl uuuu u00u1 u #d 022 $a1688-9258. 100 1 $aGARCÍA, J.A. 245 $aGramíneas bianuales. 260 $c1995 300 $ap. 8. 490 $a(Serie Actividades de Difusión, 78). 650 $aAVENA 650 $aBROMUS CATHARTICUS 650 $aFESTUCA 650 $aFESTUCA ARUNDINACEA 650 $aFITOMEJORAMIENTO 650 $aGRAMINEAS FORRAJERAS 650 $aHOLCUS 650 $aLOLIUM MULTIFLORUM 650 $aLOLIUM PERENNE 653 $aCEBADILLA TIJERETA 653 $aHOLCUS LA MAGNOLIA 653 $aHOLCUS LANATUS 653 $aLOLIUM MULTIFLORUM X FESTUCA PRATENSIS 653 $aPRODUCCIÓN DE FORRAJE 653 $aRAIGRÁS BIANUAL 653 $aRAIGRÁS PERENNE 773 $tln: Día de Campo, 1995, La Estanzuela, Colonia, UY. Pasturas y ovinos. La Estanzuela: INIA, 1995.
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