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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
21/02/2014 |
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Actualizado : |
18/12/2018 |
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Tipo de producción científica : |
Artículos Indexados |
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Autor : |
MISZTAL, I.; FRAGOMENI, B.; LOURENÇO, D. A. L.; TSURUTA, S.; MASUDA, Y.; AGUILAR, I.; LEGARRA, A.; LAWLOR, T. J. |
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Afiliación : |
IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Efficient inversion of genomic relationship matrix by the Algorithm for Proven and Young (APY). |
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Fecha de publicación : |
2015 |
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Fuente / Imprenta : |
Interbull Bulletin, 2015, v. 49, p. 111-116. |
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Idioma : |
Inglés |
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Contenido : |
ABSTRACT.
The purpose of this study was to evaluate properties of the inverse of the genomic relationship matrix derived with the algorithm for proven and young (APY) and the accuracy of genomic selection in single-step genomic best linear unbiased prediction (ssGBLUP). The APY implements genomic recursions on a subset of genotyped animals. When that subset is small, the cost of APY is approximately linear in memory and computations, effectively removing restrictions on the number of genotypes. Tests involved 10 102 702 final scores from 6 930 618 Holstein cows. A total of 100 000 animals with genotypes were used in the analyses and included 23 174 sires, 27 215 cows and 49 611 young animals. Genomic estimated breeding values (GEBVs) were calculated using ssGBLUP with a regular inverse of the genomic relationship matrix (G) and with G inverse from APY. Many subsets were tested including only sires, only cows and random samples from 2 000 to 20 000 animals. When the number of animals in the subset was ≥15,000, the correlations between GEBV with APY and
GEBV with the regular inverse were ≥0.99. Best convergence rate was achieved with random samples. A theory on APY was derived and is based on the fact that additive effects of animals in the subset are linear functions of the effects of independent chromosome segments (ICSs); the number of segments is a function of the effective population size. Accuracy of GEBV with APY can be slightly superior to that of a regular inverse. The inverse with APY is computed from G, which in turn is derived from single nucleotide polymorphism (SNP) BLUP and indirectly from BayesB or other SNP-based prediction methods. Strategies like SNP selection, SNP weighting, and use of causative SNPs from sequence analysis can be incorporated in APY without additional cost. The APY removes size limitations from ssGBLUP and facilitates a model with a complex genetic architecture. MenosABSTRACT.
The purpose of this study was to evaluate properties of the inverse of the genomic relationship matrix derived with the algorithm for proven and young (APY) and the accuracy of genomic selection in single-step genomic best linear unbiased prediction (ssGBLUP). The APY implements genomic recursions on a subset of genotyped animals. When that subset is small, the cost of APY is approximately linear in memory and computations, effectively removing restrictions on the number of genotypes. Tests involved 10 102 702 final scores from 6 930 618 Holstein cows. A total of 100 000 animals with genotypes were used in the analyses and included 23 174 sires, 27 215 cows and 49 611 young animals. Genomic estimated breeding values (GEBVs) were calculated using ssGBLUP with a regular inverse of the genomic relationship matrix (G) and with G inverse from APY. Many subsets were tested including only sires, only cows and random samples from 2 000 to 20 000 animals. When the number of animals in the subset was ≥15,000, the correlations between GEBV with APY and
GEBV with the regular inverse were ≥0.99. Best convergence rate was achieved with random samples. A theory on APY was derived and is based on the fact that additive effects of animals in the subset are linear functions of the effects of independent chromosome segments (ICSs); the number of segments is a function of the effective population size. Accuracy of GEBV with APY can be slightly superior to that of a regular... Presentar Todo |
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Palabras claves : |
BIG POPULATION; GENOMIC RECURSION; INVERSION; SINGLE-STEP METHOD. |
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Asunto categoría : |
-- |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/12204/1/1387-2387-1-PB.pdf
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Marc : |
LEADER 02658naa a2200253 a 4500
001 1012458
005 2018-12-18
008 2015 bl uuuu u00u1 u #d
100 1 $aMISZTAL, I.
245 $aEfficient inversion of genomic relationship matrix by the Algorithm for Proven and Young (APY).$h[electronic resource]
260 $c2015
520 $aABSTRACT. The purpose of this study was to evaluate properties of the inverse of the genomic relationship matrix derived with the algorithm for proven and young (APY) and the accuracy of genomic selection in single-step genomic best linear unbiased prediction (ssGBLUP). The APY implements genomic recursions on a subset of genotyped animals. When that subset is small, the cost of APY is approximately linear in memory and computations, effectively removing restrictions on the number of genotypes. Tests involved 10 102 702 final scores from 6 930 618 Holstein cows. A total of 100 000 animals with genotypes were used in the analyses and included 23 174 sires, 27 215 cows and 49 611 young animals. Genomic estimated breeding values (GEBVs) were calculated using ssGBLUP with a regular inverse of the genomic relationship matrix (G) and with G inverse from APY. Many subsets were tested including only sires, only cows and random samples from 2 000 to 20 000 animals. When the number of animals in the subset was ≥15,000, the correlations between GEBV with APY and GEBV with the regular inverse were ≥0.99. Best convergence rate was achieved with random samples. A theory on APY was derived and is based on the fact that additive effects of animals in the subset are linear functions of the effects of independent chromosome segments (ICSs); the number of segments is a function of the effective population size. Accuracy of GEBV with APY can be slightly superior to that of a regular inverse. The inverse with APY is computed from G, which in turn is derived from single nucleotide polymorphism (SNP) BLUP and indirectly from BayesB or other SNP-based prediction methods. Strategies like SNP selection, SNP weighting, and use of causative SNPs from sequence analysis can be incorporated in APY without additional cost. The APY removes size limitations from ssGBLUP and facilitates a model with a complex genetic architecture.
653 $aBIG POPULATION
653 $aGENOMIC RECURSION
653 $aINVERSION
653 $aSINGLE-STEP METHOD
700 1 $aFRAGOMENI, B.
700 1 $aLOURENÇO, D. A. L.
700 1 $aTSURUTA, S.
700 1 $aMASUDA, Y.
700 1 $aAGUILAR, I.
700 1 $aLEGARRA, A.
700 1 $aLAWLOR, T. J.
773 $tInterbull Bulletin, 2015$gv. 49, p. 111-116.
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Registro original : |
INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
11/05/2023 |
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Actualizado : |
11/05/2023 |
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Tipo de producción científica : |
Trabajos en Congresos/Conferencias |
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Autor : |
CIUFFO, C.; ARÉVALO, A.P.; GARCIA, F.; PERDOMO, T.; CRISPO, M.; GIANNITTI, F.; BUSCHIAZZO, A.; ZARANTONELLI, L. |
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Afiliación : |
CAMILA CIUFFO, Unidad Mixta UMPI, Institut Pasteur Montevideo + INIA, Montevideo, Uruguay; ANA PAULA ARÉVALO, Unidad de Biotecnología en Animales de Laboratorio.; FEDERICO GARCIA, Unidad Mixta UMPI, Institut Pasteur Montevideo + INIA, Montevideo, Uruguay; TERESITA YISELL PERDOMO TORRES, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARTINA CRISPO, Unidad de Biotecnología en Animales de Laboratorio; FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ALEJANDRO BUSCHIAZZO, Laboratorio de Microbiología Molecular y Estructural, Institut Pasteur de Montevideo, Montevideo, Uruguay; LETICIA ZARANTONELLI, Unidad Mixta UMPI, Institut Pasteur Montevideo + INIA, Montevideo, Uruguay; Laboratorio de Microbiología Molecular y Estructural, Institut Pasteur de Montevideo, Montevideo, Uruguay. |
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Título : |
Estudio y caracterización de una variante autóctona de Leptospira para su potencial uso como antígeno en vacunas de uso veterinario. |
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Fecha de publicación : |
2022 |
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Fuente / Imprenta : |
In: Jornadas Uruguayas de Buiatría, 49., 2022. Paysandú, Uruguay: Centro Médico Veterinario de Paysandú; Filial de la Sociedad de Medicina Veterinaria del Uruguaya; Sociedad Uruguaya de Buiatría, 9 al 11 Junio 2022. p.192-194. |
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Páginas : |
p.192-194. |
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Idioma : |
Español |
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Contenido : |
RESUMEN: En Uruguay, Leptospira interrogans serogrupo Pomona serovar Kennewicki es una de las variantes más frecuentemente aislada en bovinos. Las vacunas actualmente disponibles contra leptospirosis bovina no incluyen esta variante autóctona. En este trabajo evaluamos la capacidad infectiva e inmunogénica de la variante autóctona de L. interrogans Pomona Kennewicki aislada de bovinos, en un modelo murino de infección sub-letal y crónica utilizando una vía de infección natural. Los resultados obtenidos demuestran la capacidad infectiva, de diseminación sanguínea, colonización del parénquima renal e inmunogenicidad de este aislamiento autóctono validando así su potencial uso como antígeno de interés a ser incluido en la formulación de vacunas anti-leptospira de uso veterinario en Uruguay y la región. --------------- SUMMARY: Leptospira interrogans serogroup Pomona serovar Kennewicki is one of the most frequently isolated variants in cattle in Uruguay. Currently available vaccine against bovine leptospirosis do not include this autochthonous strain. In this work we evaluated the infective and immunogenic capacity of the autochthonous variant of L.
interrogans Pomona Kennewicki isolated from bovines, in a chronic sublethal murine model using a natural route of infection. The results demonstrate the infective capacity, blood dissemination, colonization of the renal parenchyma and immunogenicity of this autochthonous isolate, thus validating its potential use as an antigen of interest to be included in the formulation of anti-leptospira vaccines for veterinary use in Uruguay and the region. MenosRESUMEN: En Uruguay, Leptospira interrogans serogrupo Pomona serovar Kennewicki es una de las variantes más frecuentemente aislada en bovinos. Las vacunas actualmente disponibles contra leptospirosis bovina no incluyen esta variante autóctona. En este trabajo evaluamos la capacidad infectiva e inmunogénica de la variante autóctona de L. interrogans Pomona Kennewicki aislada de bovinos, en un modelo murino de infección sub-letal y crónica utilizando una vía de infección natural. Los resultados obtenidos demuestran la capacidad infectiva, de diseminación sanguínea, colonización del parénquima renal e inmunogenicidad de este aislamiento autóctono validando así su potencial uso como antígeno de interés a ser incluido en la formulación de vacunas anti-leptospira de uso veterinario en Uruguay y la región. --------------- SUMMARY: Leptospira interrogans serogroup Pomona serovar Kennewicki is one of the most frequently isolated variants in cattle in Uruguay. Currently available vaccine against bovine leptospirosis do not include this autochthonous strain. In this work we evaluated the infective and immunogenic capacity of the autochthonous variant of L.
interrogans Pomona Kennewicki isolated from bovines, in a chronic sublethal murine model using a natural route of infection. The results demonstrate the infective capacity, blood dissemination, colonization of the renal parenchyma and immunogenicity of this autochthonous isolate, thus validating its potential use as an antigen of int... Presentar Todo |
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Palabras claves : |
PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA. |
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Thesagro : |
BOVINOS DE CARNE; LEPTOSPIRA. |
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Asunto categoría : |
-- |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/17132/1/Ciuffo-C.-et.al-Buiatria-Paysandu-2022.pdf
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Marc : |
LEADER 02587nam a2200241 a 4500
001 1064118
005 2023-05-11
008 2022 bl uuuu u01u1 u #d
100 1 $aCIUFFO, C.
245 $aEstudio y caracterización de una variante autóctona de Leptospira para su potencial uso como antígeno en vacunas de uso veterinario.$h[electronic resource]
260 $aIn: Jornadas Uruguayas de Buiatría, 49., 2022. Paysandú, Uruguay: Centro Médico Veterinario de Paysandú; Filial de la Sociedad de Medicina Veterinaria del Uruguaya; Sociedad Uruguaya de Buiatría, 9 al 11 Junio 2022. p.192-194.$c2022
300 $ap.192-194.
520 $aRESUMEN: En Uruguay, Leptospira interrogans serogrupo Pomona serovar Kennewicki es una de las variantes más frecuentemente aislada en bovinos. Las vacunas actualmente disponibles contra leptospirosis bovina no incluyen esta variante autóctona. En este trabajo evaluamos la capacidad infectiva e inmunogénica de la variante autóctona de L. interrogans Pomona Kennewicki aislada de bovinos, en un modelo murino de infección sub-letal y crónica utilizando una vía de infección natural. Los resultados obtenidos demuestran la capacidad infectiva, de diseminación sanguínea, colonización del parénquima renal e inmunogenicidad de este aislamiento autóctono validando así su potencial uso como antígeno de interés a ser incluido en la formulación de vacunas anti-leptospira de uso veterinario en Uruguay y la región. --------------- SUMMARY: Leptospira interrogans serogroup Pomona serovar Kennewicki is one of the most frequently isolated variants in cattle in Uruguay. Currently available vaccine against bovine leptospirosis do not include this autochthonous strain. In this work we evaluated the infective and immunogenic capacity of the autochthonous variant of L. interrogans Pomona Kennewicki isolated from bovines, in a chronic sublethal murine model using a natural route of infection. The results demonstrate the infective capacity, blood dissemination, colonization of the renal parenchyma and immunogenicity of this autochthonous isolate, thus validating its potential use as an antigen of interest to be included in the formulation of anti-leptospira vaccines for veterinary use in Uruguay and the region.
650 $aBOVINOS DE CARNE
650 $aLEPTOSPIRA
653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA
700 1 $aARÉVALO, A.P.
700 1 $aGARCIA, F.
700 1 $aPERDOMO, T.
700 1 $aCRISPO, M.
700 1 $aGIANNITTI, F.
700 1 $aBUSCHIAZZO, A.
700 1 $aZARANTONELLI, L.
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