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Registros recuperados : 8 | |
2. | | MACHADO, M.; SCHILD, C.; PRELIASCO, M.; BALSERINI, A.; MEDEIROS, R.M.T.; BARROS, S.S.; RIET-CORREA, F. Enzootic calcinosis in sheep in Uruguay: a brief review and report of two outbreaks. [Calcinose enzoótica em ovinos no Uruguai: revisão de literatura e descrição de dois surtos.]. Pesquisa Veterinaria Brasileira, November 2020, Volume 40, Issue 11, Pages 831-836. OPEN ACCESS. Doi: http://dx.doi.org/10.1590/1678-5150-pvb-6766 Article history: Received on August 8, 2020./Accepted for publication on August 24, 2020. Part of the Doctoral Thesis of the first author.Biblioteca(s): INIA La Estanzuela. |
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3. | | MACHADO, M.; CASTRO, M.B.; WILSON, T. M.; GONÇALVES , A. A. B.; PORTIANSKY, E.; RIET-CORREA, F.; BARROS, S. S. Poisoning by Nierembergia veitchii: Effects on vascular smooth muscle cells in the pathogenesis of enzootic calcinosis. Veterinary Pathology, 2022, Volume 59, Issue 5, pages 814-823. doi: https://doi.org/10.1177/03009858221098430 Article history: Article first published online May 19, 2022; Published online September 2022. -- Corresponding Author: Franklin Riet-Correa, Postgraduate Program in Animal Science in the Tropics, School of Veterinary Medicine and Animal...Biblioteca(s): INIA Las Brujas. |
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4. | | OLINDA, R. G.; MAIA, L. A.; FRADE, M. T. S.; SOARES, M. P.; BARROS, S. S.; DRIEMEIER, D.; RIET-CORREA, F.; DANTAS, A. F. M. Degenerative axonopathy associated with copper deficiency in pigs. (Axonopatia degenerativa associada com deficiência de cobre em suínos). Pesquisa Veterinária Brasileira, Rio de Janeiro v. 37, n. 9, p. 911-915, setembro. 2017. Article history: 1 Received on May 29, 2016 // Accepted for publication on November 11, 2016.Biblioteca(s): INIA La Estanzuela. |
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5. | | MACHADO, M.; QUEIROZ, CINTIA R.R.; WILSON, T. M.; SOUSA, D.E.R.; SOTO-BLANCO, B.; ARMIÉN, A.G.; BARROS, S.S.; RIET-CORREA, F.; CASTRO, M.B. Neurological and gastrointestinal manifestations of spontaneous poisoning by Ricinus communis in goats. Toxicon, July 2022, vol. 214, pages 74-77. doi: https://doi.org/10.1016/j.toxicon.2022.05.004 Article history: Received 20 April 2022; Received in revised form 4 May 2022; Accepted 13 May 2022; Available online 20 May 2022.
Corresponding author: Machado, M.; Instituto Nacional de Investigación Agropecuaria, Plataforma de Salud...Biblioteca(s): INIA Las Brujas. |
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6. | | SCHILD, C.; BOABAID, F.; MACHADO, M.; SARAVIA, A.; OLIVEIRA, L.G.S.; DIAZ, S.; VILDOZA, A. L.; MARTÍNEZ, A.; MARTÍNEZ, R.; BARROS, S.S.; RIET-CORREA, F. Nierembergia rivularis poisoning in cattle. Toxicon, December 2021, Volume 204, Pages 21- 30. doi: https://doi.org/10.1016/j.toxicon.2021.10.009 Article history: Received 16 August 2021; Received in revised form 19 October 2021; Accepted 20 October 2021; Available online 26 October 2021.
Corresponding authors: Riet-Correa, F.; Programa de Posgraduação Em Ciencia Animal Nos...Biblioteca(s): INIA Las Brujas. |
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7. | | MACHADO, M.; QUEIROZ C.R.R.; WILSON T.M.; SOUSA D.E.R.; CASTRO M.B.; SARAVIA, A.; LEE S.T.; ARMIEN A.G.; BARROS S.S.; RIET-CORREA, F. Endemic Xanthium strumarium poisoning in cattle in flooded areas of the Araguari River, Minas Gerais, Brazil. Toxicon, 2021, volume 200, pages 23-29. Doi: https://doi.org/10.1016/j.toxicon.2021.06.019 Article history: Received 22 May 2021; Received in revised form 29 June 2021; Accepted 30 June 2021; Available online 2 July 2021.
Corresponding author: Riet-Correa, F.; Graduate Program in Animal Science in the Tropics, Escola de...Biblioteca(s): INIA Las Brujas. |
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8. | | MACHADO, M; WILSON, T.M.; RIBEIRO DE SOUSA, D.E.; LOPES CÂMARA , A.C.; FURLAN, F.H.; SILVA ALMEIDA E MACÊDO, J.T; PUPIN, R.C.; AMARAL DE LEMOS, R.A; ARMIÉN, A.G.; BARROS, S.S.; RIET-CORREA, F.; BOTELHO DE CASTRO, M. Fatal lancehead pit viper (Bothrops spp.) envenomation in horses. Toxicon, December 2019, Volume 170, Pages 41-50. Article history: Received 9 May 2019/ Revised 16 July 2019/ Accepted 1 September 2019/ Available online 6 September 2019.Biblioteca(s): INIA La Estanzuela. |
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Registros recuperados : 8 | |
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| Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha actual : |
07/06/2022 |
Actualizado : |
30/11/2022 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Circulación / Nivel : |
Internacional - -- |
Autor : |
MACHADO, M.; CASTRO, M.B.; WILSON, T. M.; GONÇALVES , A. A. B.; PORTIANSKY, E.; RIET-CORREA, F.; BARROS, S. S. |
Afiliación : |
MIZAEL MACHADO DA COSTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MÁRCIO B. CASTRO, University of Brasilia, Brasília, Brazil; TAIS M. WILSON, University of Brasilia, Brasília, Brazil; ALEXANDRA A. B. GONÇALVES, University of Brasilia, Brasília, Brazil; ENRIQUE L. PORTIANSKY, National University of La Plata, La Plata, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; Federal University of Bahia, Salvador, Brazil; SEVERO S. BARROS, Federal University of Santa Maria, Rio Grande do Sul, Brazil. |
Título : |
Poisoning by Nierembergia veitchii: Effects on vascular smooth muscle cells in the pathogenesis of enzootic calcinosis. |
Fecha de publicación : |
2022 |
Fuente / Imprenta : |
Veterinary Pathology, 2022, Volume 59, Issue 5, pages 814-823. doi: https://doi.org/10.1177/03009858221098430 |
ISSN : |
0300-9858 |
DOI : |
10.1177/03009858221098430 |
Idioma : |
Inglés |
Notas : |
Article history: Article first published online May 19, 2022; Published online September 2022. -- Corresponding Author: Franklin Riet-Correa, Postgraduate Program in Animal Science in the Tropics, School of Veterinary Medicine and Animal Science, Federal University of Bahia, Salvador, Bahia 40170-110, Brazil. Email: franklinrietcorrea@gmail.com -- This work was funded by National Institute of Agricultural Research (INIA) of Uruguay (Project CL 44), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil, (Finance Code 001) and National University of La Plata (Project V270). A postgraduate scholarship was provided to Mizael Machado by INIA, Uruguay. |
Contenido : |
ABSTRACT - Vascular mineralization is a hallmark of enzootic calcinosis. Histopathological, ultrastructural, and immunohistochemical investigations were performed on the external carotid arteries of seven sheep naturally poisoned by Nierembergia veitchii. Histologically, moderate to marked hyperplasia of the tunica intima was observed without mineralization. The tunica media exhibited mild to severe mineralization and osteochondroid metaplasia. Sheep with enzootic calcinosis showed arterial overexpression of osteopontin and tissue-nonspecific alkaline phosphatase and immunolabeling for osteonectin and osteocalcin in both intima and media layers of the tested arteries. The main ultrastructural finding in the tunica media was a marked phenotypic change of vascular smooth muscle cells from a contractile phenotype (VSMC-C) into a synthetic phenotype (VSMC-S). In the tunica media, VSMC-S produced matrix and extracellular vesicles, forming mineralizable granules associated with arterial mineralization. VSMC-S were also present in the tunica intima, but matrix and extracellular vesicles and mineralization were not observed. The absence of matrix and extracellular vesicles in the intimal hyperplasia, even in the presence of noncollagenous bone proteins, tissue-nonspecific alkaline phosphatase, and vitamin D receptors, reinforces the hypothesis that the presence of matrix and extracellular vesicles are crucial for the development of vascular mineralization in enzootic calcinosis. It is proposed that the two different VSMC-S phenotypes in calcinosis are due to the expression of at least two genetically different types of these cells induced by the action of 1,25(OH)2D3. © The Author(s) 2022. MenosABSTRACT - Vascular mineralization is a hallmark of enzootic calcinosis. Histopathological, ultrastructural, and immunohistochemical investigations were performed on the external carotid arteries of seven sheep naturally poisoned by Nierembergia veitchii. Histologically, moderate to marked hyperplasia of the tunica intima was observed without mineralization. The tunica media exhibited mild to severe mineralization and osteochondroid metaplasia. Sheep with enzootic calcinosis showed arterial overexpression of osteopontin and tissue-nonspecific alkaline phosphatase and immunolabeling for osteonectin and osteocalcin in both intima and media layers of the tested arteries. The main ultrastructural finding in the tunica media was a marked phenotypic change of vascular smooth muscle cells from a contractile phenotype (VSMC-C) into a synthetic phenotype (VSMC-S). In the tunica media, VSMC-S produced matrix and extracellular vesicles, forming mineralizable granules associated with arterial mineralization. VSMC-S were also present in the tunica intima, but matrix and extracellular vesicles and mineralization were not observed. The absence of matrix and extracellular vesicles in the intimal hyperplasia, even in the presence of noncollagenous bone proteins, tissue-nonspecific alkaline phosphatase, and vitamin D receptors, reinforces the hypothesis that the presence of matrix and extracellular vesicles are crucial for the development of vascular mineralization in enzootic calcinosis. It ... Presentar Todo |
Palabras claves : |
Arterial mineralization; Arteries; Enzootic calcinosis; Exosomes; Pathogenesis; PLATAFORMA DE SALUD ANIMAL; Toxicity; Vascular smooth muscle cells. |
Asunto categoría : |
L50 Fisiología y bioquímica animal |
Marc : |
LEADER 03391nam a2200313 a 4500 001 1063233 005 2022-11-30 008 2022 bl uuuu u01u1 u #d 022 $a0300-9858 024 7 $a10.1177/03009858221098430$2DOI 100 1 $aMACHADO, M. 245 $aPoisoning by Nierembergia veitchii$bEffects on vascular smooth muscle cells in the pathogenesis of enzootic calcinosis.$h[electronic resource] 260 $aVeterinary Pathology, 2022, Volume 59, Issue 5, pages 814-823. doi: https://doi.org/10.1177/03009858221098430$c1177 500 $aArticle history: Article first published online May 19, 2022; Published online September 2022. -- Corresponding Author: Franklin Riet-Correa, Postgraduate Program in Animal Science in the Tropics, School of Veterinary Medicine and Animal Science, Federal University of Bahia, Salvador, Bahia 40170-110, Brazil. Email: franklinrietcorrea@gmail.com -- This work was funded by National Institute of Agricultural Research (INIA) of Uruguay (Project CL 44), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil, (Finance Code 001) and National University of La Plata (Project V270). A postgraduate scholarship was provided to Mizael Machado by INIA, Uruguay. 520 $aABSTRACT - Vascular mineralization is a hallmark of enzootic calcinosis. Histopathological, ultrastructural, and immunohistochemical investigations were performed on the external carotid arteries of seven sheep naturally poisoned by Nierembergia veitchii. Histologically, moderate to marked hyperplasia of the tunica intima was observed without mineralization. The tunica media exhibited mild to severe mineralization and osteochondroid metaplasia. Sheep with enzootic calcinosis showed arterial overexpression of osteopontin and tissue-nonspecific alkaline phosphatase and immunolabeling for osteonectin and osteocalcin in both intima and media layers of the tested arteries. The main ultrastructural finding in the tunica media was a marked phenotypic change of vascular smooth muscle cells from a contractile phenotype (VSMC-C) into a synthetic phenotype (VSMC-S). In the tunica media, VSMC-S produced matrix and extracellular vesicles, forming mineralizable granules associated with arterial mineralization. VSMC-S were also present in the tunica intima, but matrix and extracellular vesicles and mineralization were not observed. The absence of matrix and extracellular vesicles in the intimal hyperplasia, even in the presence of noncollagenous bone proteins, tissue-nonspecific alkaline phosphatase, and vitamin D receptors, reinforces the hypothesis that the presence of matrix and extracellular vesicles are crucial for the development of vascular mineralization in enzootic calcinosis. It is proposed that the two different VSMC-S phenotypes in calcinosis are due to the expression of at least two genetically different types of these cells induced by the action of 1,25(OH)2D3. © The Author(s) 2022. 653 $aArterial mineralization 653 $aArteries 653 $aEnzootic calcinosis 653 $aExosomes 653 $aPathogenesis 653 $aPLATAFORMA DE SALUD ANIMAL 653 $aToxicity 653 $aVascular smooth muscle cells 700 1 $aCASTRO, M.B. 700 1 $aWILSON, T. M. 700 1 $aGONÇALVES , A. A. B. 700 1 $aPORTIANSKY, E. 700 1 $aRIET-CORREA, F. 700 1 $aBARROS, S. S.
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