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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
07/10/2014 |
Actualizado : |
09/10/2019 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
VITEZICA, Z.G.; AGUILAR, I.; MISZTAL, I.; LEGARRA, A. |
Afiliación : |
IGNACIO AGUILAR GARCIA, Instituto Nacional de Investigación Agropecuaria (INIA), Uruguay. |
Título : |
Bias in genomic predictions for populations under selection. |
Fecha de publicación : |
2011 |
Fuente / Imprenta : |
Genetics Research, 2011, v.93 no.5, p.357-366. |
ISSN : |
0016-6723 |
DOI : |
10.1017/S001667231100022X |
Idioma : |
Inglés |
Notas : |
Article history: Received 27 January 2011 / Revised 27 March 2011 / Published online 18 July 2011. |
Contenido : |
ABSTRACT.
Prediction of genetic merit or disease risk using genetic marker information is becoming a common practice for selection of livestock and plant species. For the successful application of genome-wide marker-assisted selection (GWMAS), genomic predictions should be accurate and unbiased. The effect of selection on bias and accuracy of genomic predictions was studied in two simulated animal populations under weak or strong selection and with several heritabilities. Prediction of genetic values was by best-linear unbiased prediction (BLUP) using data either from relatives summarized in pseudodata for genotyped individuals (multiple-step method) or using all available data jointly (single-step method). The single-step method combined genomic- and pedigree-based relationship matrices. Predictions by the multiple-step method were biased. Predictions by a single-step method were less biased and more accurate but under strong selection were less accurate. When genomic relationships were shifted by a constant, the single-step method was unbiased and the most accurate. The value of that constant, which adjusts for non-random selection of genotyped individuals, can be derived analytically.
© 2011 Cambridge University Press. |
Thesagro : |
DETECCIÓN DE QTLS; MARCADORES GENÉTICOS; MEJORAMIENTO GENÉTICO ANIMAL. |
Asunto categoría : |
L10 Genética y mejoramiento animal |
Marc : |
LEADER 01990naa a2200229 a 4500 001 1050957 005 2019-10-09 008 2011 bl uuuu u00u1 u #d 022 $a0016-6723 024 7 $a10.1017/S001667231100022X$2DOI 100 1 $aVITEZICA, Z.G. 245 $aBias in genomic predictions for populations under selection.$h[electronic resource] 260 $c2011 500 $aArticle history: Received 27 January 2011 / Revised 27 March 2011 / Published online 18 July 2011. 520 $aABSTRACT. Prediction of genetic merit or disease risk using genetic marker information is becoming a common practice for selection of livestock and plant species. For the successful application of genome-wide marker-assisted selection (GWMAS), genomic predictions should be accurate and unbiased. The effect of selection on bias and accuracy of genomic predictions was studied in two simulated animal populations under weak or strong selection and with several heritabilities. Prediction of genetic values was by best-linear unbiased prediction (BLUP) using data either from relatives summarized in pseudodata for genotyped individuals (multiple-step method) or using all available data jointly (single-step method). The single-step method combined genomic- and pedigree-based relationship matrices. Predictions by the multiple-step method were biased. Predictions by a single-step method were less biased and more accurate but under strong selection were less accurate. When genomic relationships were shifted by a constant, the single-step method was unbiased and the most accurate. The value of that constant, which adjusts for non-random selection of genotyped individuals, can be derived analytically. © 2011 Cambridge University Press. 650 $aDETECCIÓN DE QTLS 650 $aMARCADORES GENÉTICOS 650 $aMEJORAMIENTO GENÉTICO ANIMAL 700 1 $aAGUILAR, I. 700 1 $aMISZTAL, I. 700 1 $aLEGARRA, A. 773 $tGenetics Research, 2011$gv.93 no.5, p.357-366.
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INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha actual : |
11/11/2016 |
Actualizado : |
29/05/2018 |
Tipo de producción científica : |
Actividades de Difusión |
Autor : |
INIA (INSTITUTO NACIONAL DE INVESTIGACIÓN AGROPECUARIA); INIA LAS BRUJAS; BIOTECNOLOGÍA |
Afiliación : |
ESTACIÓN EXPERIMENTAL "WILSON FERREIRA ALDUNATE", INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; UNIDAD DE BIOTECNOLOGÍA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Apostando a la investigación para un futuro innovador. Jornada de Agrobiotecnología, IX. |
Complemento del título : |
Jornada Técnica, Montevideo (UY), 30 octubre 2015. |
Fecha de publicación : |
2015 |
Fuente / Imprenta : |
Canelones (Uruguay): INIA , 2015. |
Páginas : |
36 p. |
Serie : |
(Actividades de Difusión; 755) |
ISSN : |
1688-9258 |
Idioma : |
Español |
Palabras claves : |
COLECCIÓN NACIONAL DE CEPAS DE RIZOBIOS; DIVERSIDAD MICROBIANA; PÉPTIDOS ANTIMICROBIANOS; PRODUCCIÓN DE HAPLOIDES-DUPLICADOS; RECURSOS GENÉTICOS MICROBIANOS. |
Thesagro : |
AGROBIOTECNOLOGIA; ARROZ; BIOTECNOLOGIA; BOVINOS DE CARNE; CEBADA; ENFERMEDADES DE LOS ANIMALES; FERTILIDAD DEL SUELO; FIJACION DEL NITROGENO; MEJORAMIENTO GENETICO ANIMAL; OVINOS; PAPA; RIZOBIOS; SUELOS; TRIGO. |
Asunto categoría : |
-- |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/6333/1/SAD-755-Biotecnologia.pdf
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Marc : |
LEADER 01169nam a2200385 a 4500 001 1056038 005 2018-05-29 008 2015 bl uuuu u00u1 u #d 022 $a1688-9258 100 1 $aINIA (INSTITUTO NACIONAL DE INVESTIGACIÓN AGROPECUARIA) 245 $aApostando a la investigación para un futuro innovador. Jornada de Agrobiotecnología, IX. 260 $aCanelones (Uruguay): INIA $c2015 300 $a36 p. 490 $a(Actividades de Difusión; 755) 650 $aAGROBIOTECNOLOGIA 650 $aARROZ 650 $aBIOTECNOLOGIA 650 $aBOVINOS DE CARNE 650 $aCEBADA 650 $aENFERMEDADES DE LOS ANIMALES 650 $aFERTILIDAD DEL SUELO 650 $aFIJACION DEL NITROGENO 650 $aMEJORAMIENTO GENETICO ANIMAL 650 $aOVINOS 650 $aPAPA 650 $aRIZOBIOS 650 $aSUELOS 650 $aTRIGO 653 $aCOLECCIÓN NACIONAL DE CEPAS DE RIZOBIOS 653 $aDIVERSIDAD MICROBIANA 653 $aPÉPTIDOS ANTIMICROBIANOS 653 $aPRODUCCIÓN DE HAPLOIDES-DUPLICADOS 653 $aRECURSOS GENÉTICOS MICROBIANOS 700 1 $aINIA LAS BRUJAS 700 1 $aBIOTECNOLOGÍA
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