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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
15/11/2015 |
Actualizado : |
09/10/2019 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
FRAGOMENI, B.O.; MISZTAL, I.; LOURENCO, D.L.; AGUILAR, I.; OKIMOTO, R.; MUIR, W.M. |
Afiliación : |
IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Changes in variance explained by top SNP windows over generations for three traits in broiler chicken |
Fecha de publicación : |
2014 |
Fuente / Imprenta : |
Frontiers in Genetics, 2014, v.5, no.Oct., Article number 332. OPEN ACCESS. |
ISSN : |
1664-8021 |
DOI : |
10.3389/fgene.2014.00332 |
Idioma : |
Inglés |
Notas : |
Article history: Published 01 October 2014. |
Contenido : |
ABSTRACT.
The purpose of this study was to determine if the set of genomic regions inferred as accounting for the majority of genetic variation in quantitative traits remain stable over multiple generations of selection. The data set contained phenotypes for five generations of broiler chicken for body weight, breast meat, and leg score. The population consisted of 294,632 animals over five generations and also included genotypes of 41,036 single nucleotide polymorphism (SNP) for 4,866 animals, after quality control. The SNP effects were calculated by a GWAS type analysis using single step genomic BLUP approach for generations 1-3, 2-4, 3-5, and 1-5. Variances were calculated for windows of 20 SNP. The top ten windows for each trait that explained the largest fraction of the genetic variance across generations were examined. Across generations, the top 10 windows explained more than 0.5% but less than 1% of the total variance. Also, the pattern of the windows was not consistent across generations. The windows that explained the greatest variance changed greatly among the combinations of generations, with a few exceptions. In many cases, a window identified as top for one combination, explained less than 0.1% for the other combinations. We conclude that identification of top SNP windows for a population may have little predictive power for genetic selection in the following generations for the traits here evaluated.
© 2014 Fragomeni, Misztal, Lourenco, Aguilar, Okimoto and Muir. MenosABSTRACT.
The purpose of this study was to determine if the set of genomic regions inferred as accounting for the majority of genetic variation in quantitative traits remain stable over multiple generations of selection. The data set contained phenotypes for five generations of broiler chicken for body weight, breast meat, and leg score. The population consisted of 294,632 animals over five generations and also included genotypes of 41,036 single nucleotide polymorphism (SNP) for 4,866 animals, after quality control. The SNP effects were calculated by a GWAS type analysis using single step genomic BLUP approach for generations 1-3, 2-4, 3-5, and 1-5. Variances were calculated for windows of 20 SNP. The top ten windows for each trait that explained the largest fraction of the genetic variance across generations were examined. Across generations, the top 10 windows explained more than 0.5% but less than 1% of the total variance. Also, the pattern of the windows was not consistent across generations. The windows that explained the greatest variance changed greatly among the combinations of generations, with a few exceptions. In many cases, a window identified as top for one combination, explained less than 0.1% for the other combinations. We conclude that identification of top SNP windows for a population may have little predictive power for genetic selection in the following generations for the traits here evaluated.
© 2014 Fragomeni, Misztal, Lourenco, Aguilar, Okimoto and... Presentar Todo |
Palabras claves : |
Gene identification; Genome-wide association study; Genomic selection; QTL; SsGBLUP. |
Thesagro : |
MEJORAMIENTO GENETICO ANIMAL; POLLO DE ENGORDE. |
Asunto categoría : |
L10 Genética y mejoramiento animal |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/5195/1/Aguilar-I.-2014.-Frontiers-in-Genetics.pdf
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Marc : |
LEADER 02443naa a2200301 a 4500 001 1053891 005 2019-10-09 008 2014 bl uuuu u00u1 u #d 022 $a1664-8021 024 7 $a10.3389/fgene.2014.00332$2DOI 100 1 $aFRAGOMENI, B.O. 245 $aChanges in variance explained by top SNP windows over generations for three traits in broiler chicken$h[electronic resource] 260 $c2014 500 $aArticle history: Published 01 October 2014. 520 $aABSTRACT. The purpose of this study was to determine if the set of genomic regions inferred as accounting for the majority of genetic variation in quantitative traits remain stable over multiple generations of selection. The data set contained phenotypes for five generations of broiler chicken for body weight, breast meat, and leg score. The population consisted of 294,632 animals over five generations and also included genotypes of 41,036 single nucleotide polymorphism (SNP) for 4,866 animals, after quality control. The SNP effects were calculated by a GWAS type analysis using single step genomic BLUP approach for generations 1-3, 2-4, 3-5, and 1-5. Variances were calculated for windows of 20 SNP. The top ten windows for each trait that explained the largest fraction of the genetic variance across generations were examined. Across generations, the top 10 windows explained more than 0.5% but less than 1% of the total variance. Also, the pattern of the windows was not consistent across generations. The windows that explained the greatest variance changed greatly among the combinations of generations, with a few exceptions. In many cases, a window identified as top for one combination, explained less than 0.1% for the other combinations. We conclude that identification of top SNP windows for a population may have little predictive power for genetic selection in the following generations for the traits here evaluated. © 2014 Fragomeni, Misztal, Lourenco, Aguilar, Okimoto and Muir. 650 $aMEJORAMIENTO GENETICO ANIMAL 650 $aPOLLO DE ENGORDE 653 $aGene identification 653 $aGenome-wide association study 653 $aGenomic selection 653 $aQTL 653 $aSsGBLUP 700 1 $aMISZTAL, I. 700 1 $aLOURENCO, D.L. 700 1 $aAGUILAR, I. 700 1 $aOKIMOTO, R. 700 1 $aMUIR, W.M. 773 $tFrontiers in Genetics, 2014$gv.5, no.Oct., Article number 332. OPEN ACCESS.
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INIA Las Brujas (LB) |
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Biblioteca (s) : |
INIA Treinta y Tres. |
Fecha actual : |
19/09/2014 |
Actualizado : |
03/02/2018 |
Tipo de producción científica : |
Capítulo en Libro Técnico-Científico |
Autor : |
SOARES DE LIMA, J.; RAVAGNOLO, O.; MONTOSSI, F. |
Afiliación : |
JUAN MANUEL SOARES DE LIMA LAPETINA, Instituto Nacional de Investigación Agropecuaria (INIA), Uruguay; OLGA RAVAGNOLO GUMILA, Instituto Nacional de Investigación Agropecuaria (INIA), Uruguay; FABIO MARCELO MONTOSSI PORCHILE, Instituto Nacional de Investigación Agropecuaria (INIA), Uruguay. |
Título : |
Objetivos de selección: hacia la contrucción de un índice de selección para ganado de carne en sistemas de ciclo completo en Uruguay. |
Fecha de publicación : |
2013 |
Fuente / Imprenta : |
In: MONTOSSI, F. (Ed.). Invernada de precisión: Pasturas, Calidad de Carne, Genética, Gestión Empresarial e Impacto Ambiental (GIPROCAR II) Montevideo (UY): INIA, 2013. |
Páginas : |
p. 155-164 |
Serie : |
(Serie Técnica; 211) |
ISSN : |
1688-9266 |
Idioma : |
Español |
Palabras claves : |
GANADO DE CARNE; SELECCION. |
Thesagro : |
BOVINOS; GANADO DE CARNE; SELECCION. |
Asunto categoría : |
-- |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/7665/1/St-211-2013-p.155-164.pdf
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Marc : |
LEADER 00810naa a2200229 a 4500 001 1050424 005 2018-02-03 008 2013 bl uuuu u00u1 u #d 022 $a1688-9266 100 1 $aSOARES DE LIMA, J. 245 $aObjetivos de selección$bhacia la contrucción de un índice de selección para ganado de carne en sistemas de ciclo completo en Uruguay. 260 $c2013 300 $ap. 155-164 490 $a(Serie Técnica; 211) 650 $aBOVINOS 650 $aGANADO DE CARNE 650 $aSELECCION 653 $aGANADO DE CARNE 653 $aSELECCION 700 1 $aRAVAGNOLO, O. 700 1 $aMONTOSSI, F. 773 $tIn: MONTOSSI, F. (Ed.). Invernada de precisión: Pasturas, Calidad de Carne, Genética, Gestión Empresarial e Impacto Ambiental (GIPROCAR II) Montevideo (UY): INIA, 2013.
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