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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
16/09/2014 |
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Actualizado : |
23/10/2019 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
MISZTAL, I.; TSURUTA, S.; AGUILAR, I.; LEGARRA, A.; VAN RADEN, P.M.; LAWLOR, T.J. |
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Afiliación : |
IGNACIO AGUILAR GARCIA, Instituto Nacional de Investigación Agropecuaria (INIA), Uruguay. |
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Título : |
Methods to approximate reliabilities in single-step genomic evaluation. |
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Fecha de publicación : |
2013 |
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Fuente / Imprenta : |
Journal of Dairy Science, 2013, v.96, no.1, p.647-654. OPEN ACCESS. |
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ISSN : |
0022-0302 |
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DOI : |
10.3168/jds.2012-5656 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received April 24, 2012. / Accepted September 18, 2012. |
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Contenido : |
ABSTRACT.
Reliability of predictions from single-step genomic BLUP (ssGBLUP) can be calculated by matrix inversion, but that is not feasible for large data sets. Two methods of approximating reliability were developed based on the decomposition of a function of reliability into contributions from records, pedigrees, and genotypes. Those contributions can be expressed in record or daughter equivalents. The first approximation method involved inversion of a matrix that contains inverses of the genomic relationship matrix and the pedigree relationship matrix for genotyped animals. The second approximation method involved only the diagonal elements of those inverses. The 2 approximation methods were tested with a simulated data set. The correlations between ssGBLUP and approximated contributions from genomic information were 0.92 for the first approximation method and 0.56 for the second approximation method; contributions were inflated by 62 and 258%, respectively. The respective correlations for reliabilities were 0.98 and 0.72. After empirical correction for inflation, those correlations increased to 0.99 and 0.89. Approximations of reliabilities of predictions by ssGBLUP are accurate and computationally feasible for populations with up to 100,000 genotyped animals. A critical part of the approximations is quality control of information from single nucleotide polymorphisms and proper scaling of the genomic relationship matrix.
© 2013 American Dairy Science Association. |
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Thesagro : |
GENETICA ANIMAL; MEJORAMIENTO GENETICO ANIMAL; MÉTODOS ESTADÍSTICOS. |
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Asunto categoría : |
L10 Genética y mejoramiento animal |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/3143/1/Aguilar-J.-2013.-Jr.Dairy-Sci.-v.961-p.647-654.pdf
http://www.journalofdairyscience.org/article/S0022-0302(12)00802-8/pdf
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Marc : |
LEADER 02299naa a2200253 a 4500
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005 2019-10-23
008 2013 bl uuuu u00u1 u #d
022 $a0022-0302
024 7 $a10.3168/jds.2012-5656$2DOI
100 1 $aMISZTAL, I.
245 $aMethods to approximate reliabilities in single-step genomic evaluation.$h[electronic resource]
260 $c2013
500 $aArticle history: Received April 24, 2012. / Accepted September 18, 2012.
520 $aABSTRACT. Reliability of predictions from single-step genomic BLUP (ssGBLUP) can be calculated by matrix inversion, but that is not feasible for large data sets. Two methods of approximating reliability were developed based on the decomposition of a function of reliability into contributions from records, pedigrees, and genotypes. Those contributions can be expressed in record or daughter equivalents. The first approximation method involved inversion of a matrix that contains inverses of the genomic relationship matrix and the pedigree relationship matrix for genotyped animals. The second approximation method involved only the diagonal elements of those inverses. The 2 approximation methods were tested with a simulated data set. The correlations between ssGBLUP and approximated contributions from genomic information were 0.92 for the first approximation method and 0.56 for the second approximation method; contributions were inflated by 62 and 258%, respectively. The respective correlations for reliabilities were 0.98 and 0.72. After empirical correction for inflation, those correlations increased to 0.99 and 0.89. Approximations of reliabilities of predictions by ssGBLUP are accurate and computationally feasible for populations with up to 100,000 genotyped animals. A critical part of the approximations is quality control of information from single nucleotide polymorphisms and proper scaling of the genomic relationship matrix. © 2013 American Dairy Science Association.
650 $aGENETICA ANIMAL
650 $aMEJORAMIENTO GENETICO ANIMAL
650 $aMÉTODOS ESTADÍSTICOS
700 1 $aTSURUTA, S.
700 1 $aAGUILAR, I.
700 1 $aLEGARRA, A.
700 1 $aVAN RADEN, P.M.
700 1 $aLAWLOR, T.J.
773 $tJournal of Dairy Science, 2013$gv.96, no.1, p.647-654. OPEN ACCESS.
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Registro original : |
INIA Las Brujas (LB) |
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 | Acceso al texto completo restringido a Biblioteca INIA La Estanzuela. Por información adicional contacte bib_le@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA La Estanzuela. |
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Fecha actual : |
12/07/2022 |
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Actualizado : |
30/11/2022 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
Internacional - -- |
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Autor : |
LOZANO, J.; FERNÁNDEZ-CIGANDA, S.; GONZÁLEZ REVELLO, A.; HIRIGOYEN, D.; MARTÍNEZ, M.; SCORZA, C.; ZUNINO, P. |
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Afiliación : |
JOAQUIN LOZANO, Department of Microbiology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.; SOFÍA FERNÁNDEZ-CIGANDA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay./ Department of Microbiology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.; ÁLVARO GONZÁLEZ REVELLO, Department of Food Science and Technology, Facultad de Veterinaria, UdelaR, Montevideo, Uruguay.; DARÍO JAVIER HIRIGOYEN TREVIN, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARCELA MARTÍNEZ, Analytical Platform, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.; CECILIA SCORZA, Department of Experimental Neuropharmacology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.; PABLO ZUNINO, Department of Microbiology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay. |
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Título : |
Probiotic potential of GABA-producing lactobacilli isolated from Uruguayan artisanal cheese starter cultures. |
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Fecha de publicación : |
2022 |
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Fuente / Imprenta : |
Journal of Microbiology, 2022, volume 133, issue 3, pages 1610-1619. doi: https://doi.org/10.1111/jam.15664 |
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ISSN : |
1364-5072 |
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DOI : |
10.1111/jam.15664 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 18 March 2022; Revised 5 May 2022; Accepted 6 June 2022; Published online September 2022. -- Corresponding author: Zunino, P.; Department of Microbiology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay; email:pzunino@iibce.edu.uy -- |
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Contenido : |
Abstract: Aims: In this study, we sought to identify and characterize a collection of 101 lactobacilli strains isolated from natural whey starters used in Uruguayan artisan cheese production, based on their capacity to produce gamma-aminobutyric acid (GABA) and their probiotic potential. Methods and Results: The probiotic potential was assessed using low pH and bile salt resistance assays; bacterial adhesion to intestinal mucus was also evaluated. Selected strains were then identified by 16S sequencing, and their GABA-producing potential was confirmed and quantified using a UHPLC-MS system. Twenty-five strains were identified and characterized as GABA-producing lactobacilli belonging to the phylogenetical groups Lactiplantibacillus (n =19) and Lacticaseibacillus (n =6). Fifteen strains of the Lactiplantibacillus group showed a significantly higher GABA production than the rest. They showed the predicted ability to survive the passage through the gastrointestinal tract, according to the in vitro assays. Conclusions: A set of promising candidate strains was identified as potential probiotics with action on the gut-brain axis. Further studies are needed to assess their possible effects on behaviour using in vivo assay. Significance and Impact of the Study: This study shows the potential of strains isolated from local natural whey starters as probiotics and for biotechnological use in functional GABA-enriched foods formulation. © 2022 Society for Applied Microbiology. |
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Palabras claves : |
Fermented foods; Gut-brain axis; Lactic acid bacteria; Lactiplantibacilus; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL; PLATAFORMA DE SALUD ANIMAL; Probiotics. |
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Asunto categoría : |
L10 Genética y mejoramiento animal |
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Marc : |
LEADER 02779naa a2200313 a 4500
001 1063420
005 2022-11-30
008 2022 bl uuuu u00u1 u #d
022 $a1364-5072
024 7 $a10.1111/jam.15664$2DOI
100 1 $aLOZANO, J.
245 $aProbiotic potential of GABA-producing lactobacilli isolated from Uruguayan artisanal cheese starter cultures.$h[electronic resource]
260 $c2022
500 $aArticle history: Received 18 March 2022; Revised 5 May 2022; Accepted 6 June 2022; Published online September 2022. -- Corresponding author: Zunino, P.; Department of Microbiology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay; email:pzunino@iibce.edu.uy --
520 $aAbstract: Aims: In this study, we sought to identify and characterize a collection of 101 lactobacilli strains isolated from natural whey starters used in Uruguayan artisan cheese production, based on their capacity to produce gamma-aminobutyric acid (GABA) and their probiotic potential. Methods and Results: The probiotic potential was assessed using low pH and bile salt resistance assays; bacterial adhesion to intestinal mucus was also evaluated. Selected strains were then identified by 16S sequencing, and their GABA-producing potential was confirmed and quantified using a UHPLC-MS system. Twenty-five strains were identified and characterized as GABA-producing lactobacilli belonging to the phylogenetical groups Lactiplantibacillus (n =19) and Lacticaseibacillus (n =6). Fifteen strains of the Lactiplantibacillus group showed a significantly higher GABA production than the rest. They showed the predicted ability to survive the passage through the gastrointestinal tract, according to the in vitro assays. Conclusions: A set of promising candidate strains was identified as potential probiotics with action on the gut-brain axis. Further studies are needed to assess their possible effects on behaviour using in vivo assay. Significance and Impact of the Study: This study shows the potential of strains isolated from local natural whey starters as probiotics and for biotechnological use in functional GABA-enriched foods formulation. © 2022 Society for Applied Microbiology.
653 $aFermented foods
653 $aGut-brain axis
653 $aLactic acid bacteria
653 $aLactiplantibacilus
653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL
653 $aPLATAFORMA DE SALUD ANIMAL
653 $aProbiotics
700 1 $aFERNÁNDEZ-CIGANDA, S.
700 1 $aGONZÁLEZ REVELLO, A.
700 1 $aHIRIGOYEN, D.
700 1 $aMARTÍNEZ, M.
700 1 $aSCORZA, C.
700 1 $aZUNINO, P.
773 $tJournal of Microbiology, 2022, volume 133, issue 3, pages 1610-1619. doi: https://doi.org/10.1111/jam.15664
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