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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
27/09/2022 |
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Actualizado : |
27/09/2022 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
MACHADO, M.; RIET-CORREA, F.; PEDROSO, P.M.O.; MACÊDO, J.T.S.A. |
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Afiliación : |
MIZAEL MACHADO DA COSTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FRANKLIN RIET-CORREA AMARAL, Animal Sciences in the Tropics (PPGCAT), Faculdade de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia (UFBA), Av. Adhemar de Barros 500, Ondina, BA, Salvador, 40170-110, Brazil; PEDRO M.O. PEDROSO, Laboratório de Patologia Veterinária, Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, Via L4 Norte s/n, DF, Brasília, 70910-970, Brazil; JULIANA T.S.A. MACÊDO, Laboratório de Patologia Veterinária, Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, Via L4 Norte s/n, DF, Brasília, 70910-970, Brazil. |
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Título : |
Doramectin intoxication in malnourished 15-month-old cattle. [Intoxicação por doramectina em bovinos malnutridos de 15 meses de idade.] |
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Fecha de publicación : |
2022 |
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Fuente / Imprenta : |
Pesquisa Veterinaria Brasileira, 2022, Volume 42, Article e07102. OPEN ACCESS. doi: https://doi.org/10.1590/1678-5150-PVB-7102 |
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ISSN : |
1678-5150 (electronic) |
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DOI : |
10.1590/1678-5150-PVB-7102 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 15 May 2022; Accepted 31 May 2022; Publication 29 July 2022; Date of issue 2022.
Corresponding author: Riet-Correa, F.; Animal Sciences in the Tropics (PPGCAT), Faculdade de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia (UFBA), Av. Adhemar de Barros 500, Ondina, BA, Salvador, Brazil; email:franklinrietcorrea@gmail.com --
Article: Gold Open Access -- This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0/) |
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Contenido : |
ABSTRACT.- Macrocyclic lactones are widely used as endectocides in farm animals. Intoxications occur in situations of overdose and/or malnutrition, in young animals, and in genetically sensitive breeds. We describe the intoxication by doramectin in malnourished 15-month-old cattle that received 1.6 times the recommended dose. The animals presented salivation, ataxia, motor incoordination, reluctance to move, and sternal recumbency. Two animals recovered spontaneously; one died and was necropsied. No gross or microscopic changes were observed. This study suggests that doramectin may cause intoxication when administered to malnourished cattle in doses higher than those recommended and that knowing the history is essential to establish a diagnosis.
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RESUMO.- As lactonas macrocíciclas são amplamente utilizadas como endectocidas em animais de produção. Casos de intoxicação ocorrem em situações de sobredosagem e/ou desnutrição, em animais jovens ou em raças geneticamente suscetíveis. Descreve-se a intoxicação por doramectina em bovinos desnutridos, com 15 meses de idade, que receberam uma dose 1,6 vezes maior que a dose recomendada. Os animais apresentaram salivação, ataxia, incoordenação motora, relutância em se movimentar e decúbito esternal. Dois animais se recuperaram espontaneamente; um morreu e foi necropsiado. Não foram observadas alterações macro e microscópicas. Esse relato sugere que a doramectina pode causar intoxicação em bovinos desnutridos quando administrada em doses maiores que as recomendadas e que o histórico é fundamental para estabelecer o diagnóstico. MenosABSTRACT.- Macrocyclic lactones are widely used as endectocides in farm animals. Intoxications occur in situations of overdose and/or malnutrition, in young animals, and in genetically sensitive breeds. We describe the intoxication by doramectin in malnourished 15-month-old cattle that received 1.6 times the recommended dose. The animals presented salivation, ataxia, motor incoordination, reluctance to move, and sternal recumbency. Two animals recovered spontaneously; one died and was necropsied. No gross or microscopic changes were observed. This study suggests that doramectin may cause intoxication when administered to malnourished cattle in doses higher than those recommended and that knowing the history is essential to establish a diagnosis.
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RESUMO.- As lactonas macrocíciclas são amplamente utilizadas como endectocidas em animais de produção. Casos de intoxicação ocorrem em situações de sobredosagem e/ou desnutrição, em animais jovens ou em raças geneticamente suscetíveis. Descreve-se a intoxicação por doramectina em bovinos desnutridos, com 15 meses de idade, que receberam uma dose 1,6 vezes maior que a dose recomendada. Os animais apresentaram salivação, ataxia, incoordenação motora, relutância em se movimentar e decúbito esternal. Dois animais se recuperaram espontaneamente; um morreu e foi necropsiado. Não foram observadas alterações macro e microscópicas. Esse relato sugere que a doramectina pode causar intoxicação em bovinos desnutr... Presentar Todo |
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Palabras claves : |
Bovinos; Cattle; Doramectin; Doramectina; Neurological signs; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL; Sinais neurológicos; Toxicidade. |
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Asunto categoría : |
L01 Ganadería |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/16775/1/10.1590-1678-5150-PVB-7102.pdf
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Marc : |
LEADER 03176naa a2200289 a 4500
001 1063584
005 2022-09-27
008 2022 bl uuuu u00u1 u #d
022 $a1678-5150 (electronic)
024 7 $a10.1590/1678-5150-PVB-7102$2DOI
100 1 $aMACHADO, M.
245 $aDoramectin intoxication in malnourished 15-month-old cattle. [Intoxicação por doramectina em bovinos malnutridos de 15 meses de idade.]$h[electronic resource]
260 $c2022
500 $aArticle history: Received 15 May 2022; Accepted 31 May 2022; Publication 29 July 2022; Date of issue 2022. Corresponding author: Riet-Correa, F.; Animal Sciences in the Tropics (PPGCAT), Faculdade de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia (UFBA), Av. Adhemar de Barros 500, Ondina, BA, Salvador, Brazil; email:franklinrietcorrea@gmail.com -- Article: Gold Open Access -- This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0/)
520 $aABSTRACT.- Macrocyclic lactones are widely used as endectocides in farm animals. Intoxications occur in situations of overdose and/or malnutrition, in young animals, and in genetically sensitive breeds. We describe the intoxication by doramectin in malnourished 15-month-old cattle that received 1.6 times the recommended dose. The animals presented salivation, ataxia, motor incoordination, reluctance to move, and sternal recumbency. Two animals recovered spontaneously; one died and was necropsied. No gross or microscopic changes were observed. This study suggests that doramectin may cause intoxication when administered to malnourished cattle in doses higher than those recommended and that knowing the history is essential to establish a diagnosis. .-.-.-.-.-.-.-.-.-.-.-.-.-.-.- RESUMO.- As lactonas macrocíciclas são amplamente utilizadas como endectocidas em animais de produção. Casos de intoxicação ocorrem em situações de sobredosagem e/ou desnutrição, em animais jovens ou em raças geneticamente suscetíveis. Descreve-se a intoxicação por doramectina em bovinos desnutridos, com 15 meses de idade, que receberam uma dose 1,6 vezes maior que a dose recomendada. Os animais apresentaram salivação, ataxia, incoordenação motora, relutância em se movimentar e decúbito esternal. Dois animais se recuperaram espontaneamente; um morreu e foi necropsiado. Não foram observadas alterações macro e microscópicas. Esse relato sugere que a doramectina pode causar intoxicação em bovinos desnutridos quando administrada em doses maiores que as recomendadas e que o histórico é fundamental para estabelecer o diagnóstico.
653 $aBovinos
653 $aCattle
653 $aDoramectin
653 $aDoramectina
653 $aNeurological signs
653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL
653 $aSinais neurológicos
653 $aToxicidade
700 1 $aRIET-CORREA, F.
700 1 $aPEDROSO, P.M.O.
700 1 $aMACÊDO, J.T.S.A.
773 $tPesquisa Veterinaria Brasileira, 2022, Volume 42, Article e07102. OPEN ACCESS. doi: https://doi.org/10.1590/1678-5150-PVB-7102
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Registro original : |
INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
23/11/2021 |
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Actualizado : |
23/11/2021 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
Internacional - -- |
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Autor : |
OBERTI, H.; SPANGENBERG, G.; COGAN, C.; REYNO, R.; FEIJOO, M.; MURCHIO, S.; DALLA RIZZA, M. |
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Afiliación : |
HÉCTOR OBERTI RVAROLA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; GERMAN SPANGENBERG, Agriculture Victoria, AgriBio, Centre for AgriBioscience, Bundoora, VIC, Australia; School of Applied Systems Biology, La Trobe University, Bundoora, VIC, Australia.; C. COGAN, Agriculture Victoria, AgriBio, Centre for AgriBioscience, Bundoora, VIC, Australia; School of Applied Systems Biology, La Trobe University, Bundoora, VIC, Australia.; RAFAEL ALEJANDRO REYNO PODESTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; M. FEIJOO, Centro Universitario Regional del Este (CURE), Polo de Desarrollo Universitario: Patogenicidad, toxicidad y genética en los ecosistemas pastoriles de la región Este de Uruguay, Treinta y Tres, Uruguay.; MARIA SARA MURCHIO VIGNOLO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARCO DALLA RIZZA VILARO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Genome-wide analysis of Claviceps paspali: insights into the secretome of the main species causing ergot disease in Paspalum spp. |
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Complemento del título : |
Research article. |
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Fecha de publicación : |
2021 |
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Fuente / Imprenta : |
BMC Genomics, December 2021, Volume 22, Issue 1, Article number 766. Gold Open Access, Green Open Access. doi: https://doi.org/10.1186/s12864-021-08077-0 |
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ISSN : |
1471-2164 |
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DOI : |
10.1186/s12864-021-08077-0 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 24 September 2020; Accepted 11 October 2021; Published 26 October 2021.
Funding: This project was supported by the National Institute of Agricultural Research of Uruguay (INIA) project BT-19, and by project ATN/KF-13883-UR from the Inter-American Development Bank. HO Scholarship was founded by through the INIA Postgraduate Scholarship Program. The funding bodies played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.
Acknowledgments: We thank Eduardo Abreo for C. paspali ILB388 isolate and for reading the manuscript, and Fernando Lattanzi for reading the manuscript.
Corresponding author: Dalla-Rizza, M.; Instituto Nacional de Investigación Agropecuaria (INIA). Unidad de Biotecnología. Estación Experimental INIA Las Brujas, Ruta 48 km, Canelones, Uruguay; email:mdallarizza@inia.org.uy |
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Contenido : |
ABSTRACT - Background: The phytopatogen Claviceps paspali is the causal agent of Ergot disease in Paspalum spp., which includes highly productive forage grasses such as P. dilatatum. This disease impacts dairy and beef production by affecting seed quality and producing mycotoxins that can affect performance in feeding animals. The molecular basis of pathogenicity of C. paspali remains unknown, which makes it more difficult to find solutions for this problem. Secreted proteins are related to fungi virulence and can manipulate plant immunity acting on different subcellular localizations. Therefore, identifying and characterizing secreted proteins in phytopathogenic fungi will provide a better understanding of how they overcome host defense and cause disease. The aim of this work is to analyze the whole genome sequences of three C. paspali isolates to obtain a comparative genome characterization based on possible secreted proteins and pathogenicity factors present in their genome. In planta RNA-seq analysis at an early stage of the interaction of C. paspali with P. dilatatum stigmas was also conducted in order to determine possible secreted proteins expressed in the infection process.
© Copyright 2021 Elsevier B.V., All rights reserved. |
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Palabras claves : |
Biotroph; Comparative genomics; Effectors; In silico prediction; Pathogenicity factors. |
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Asunto categoría : |
F01 Cultivo |
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URL : |
https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-021-08077-0.pdf
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Marc : |
LEADER 03099naa a2200289 a 4500
001 1062542
005 2021-11-23
008 2021 bl uuuu u00u1 u #d
022 $a1471-2164
024 7 $a10.1186/s12864-021-08077-0$2DOI
100 1 $aOBERTI, H.
245 $aGenome-wide analysis of Claviceps paspali$binsights into the secretome of the main species causing ergot disease in Paspalum spp.$h[electronic resource]
260 $c2021
500 $aArticle history: Received 24 September 2020; Accepted 11 October 2021; Published 26 October 2021. Funding: This project was supported by the National Institute of Agricultural Research of Uruguay (INIA) project BT-19, and by project ATN/KF-13883-UR from the Inter-American Development Bank. HO Scholarship was founded by through the INIA Postgraduate Scholarship Program. The funding bodies played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript. Acknowledgments: We thank Eduardo Abreo for C. paspali ILB388 isolate and for reading the manuscript, and Fernando Lattanzi for reading the manuscript. Corresponding author: Dalla-Rizza, M.; Instituto Nacional de Investigación Agropecuaria (INIA). Unidad de Biotecnología. Estación Experimental INIA Las Brujas, Ruta 48 km, Canelones, Uruguay; email:mdallarizza@inia.org.uy
520 $aABSTRACT - Background: The phytopatogen Claviceps paspali is the causal agent of Ergot disease in Paspalum spp., which includes highly productive forage grasses such as P. dilatatum. This disease impacts dairy and beef production by affecting seed quality and producing mycotoxins that can affect performance in feeding animals. The molecular basis of pathogenicity of C. paspali remains unknown, which makes it more difficult to find solutions for this problem. Secreted proteins are related to fungi virulence and can manipulate plant immunity acting on different subcellular localizations. Therefore, identifying and characterizing secreted proteins in phytopathogenic fungi will provide a better understanding of how they overcome host defense and cause disease. The aim of this work is to analyze the whole genome sequences of three C. paspali isolates to obtain a comparative genome characterization based on possible secreted proteins and pathogenicity factors present in their genome. In planta RNA-seq analysis at an early stage of the interaction of C. paspali with P. dilatatum stigmas was also conducted in order to determine possible secreted proteins expressed in the infection process. © Copyright 2021 Elsevier B.V., All rights reserved.
653 $aBiotroph
653 $aComparative genomics
653 $aEffectors
653 $aIn silico prediction
653 $aPathogenicity factors
700 1 $aSPANGENBERG, G.
700 1 $aCOGAN, C.
700 1 $aREYNO, R.
700 1 $aFEIJOO, M.
700 1 $aMURCHIO, S.
700 1 $aDALLA RIZZA, M.
773 $tBMC Genomics, December 2021, Volume 22, Issue 1, Article number 766. Gold Open Access, Green Open Access. doi: https://doi.org/10.1186/s12864-021-08077-0
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