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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
27/09/2022 |
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Actualizado : |
27/09/2022 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
MACHADO, M.; RIET-CORREA, F.; PEDROSO, P.M.O.; MACÊDO, J.T.S.A. |
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Afiliación : |
MIZAEL MACHADO DA COSTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FRANKLIN RIET-CORREA AMARAL, Animal Sciences in the Tropics (PPGCAT), Faculdade de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia (UFBA), Av. Adhemar de Barros 500, Ondina, BA, Salvador, 40170-110, Brazil; PEDRO M.O. PEDROSO, Laboratório de Patologia Veterinária, Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, Via L4 Norte s/n, DF, Brasília, 70910-970, Brazil; JULIANA T.S.A. MACÊDO, Laboratório de Patologia Veterinária, Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, Via L4 Norte s/n, DF, Brasília, 70910-970, Brazil. |
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Título : |
Doramectin intoxication in malnourished 15-month-old cattle. [Intoxicação por doramectina em bovinos malnutridos de 15 meses de idade.] |
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Fecha de publicación : |
2022 |
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Fuente / Imprenta : |
Pesquisa Veterinaria Brasileira, 2022, Volume 42, Article e07102. OPEN ACCESS. doi: https://doi.org/10.1590/1678-5150-PVB-7102 |
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ISSN : |
1678-5150 (electronic) |
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DOI : |
10.1590/1678-5150-PVB-7102 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 15 May 2022; Accepted 31 May 2022; Publication 29 July 2022; Date of issue 2022.
Corresponding author: Riet-Correa, F.; Animal Sciences in the Tropics (PPGCAT), Faculdade de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia (UFBA), Av. Adhemar de Barros 500, Ondina, BA, Salvador, Brazil; email:franklinrietcorrea@gmail.com --
Article: Gold Open Access -- This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0/) |
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Contenido : |
ABSTRACT.- Macrocyclic lactones are widely used as endectocides in farm animals. Intoxications occur in situations of overdose and/or malnutrition, in young animals, and in genetically sensitive breeds. We describe the intoxication by doramectin in malnourished 15-month-old cattle that received 1.6 times the recommended dose. The animals presented salivation, ataxia, motor incoordination, reluctance to move, and sternal recumbency. Two animals recovered spontaneously; one died and was necropsied. No gross or microscopic changes were observed. This study suggests that doramectin may cause intoxication when administered to malnourished cattle in doses higher than those recommended and that knowing the history is essential to establish a diagnosis.
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RESUMO.- As lactonas macrocíciclas são amplamente utilizadas como endectocidas em animais de produção. Casos de intoxicação ocorrem em situações de sobredosagem e/ou desnutrição, em animais jovens ou em raças geneticamente suscetíveis. Descreve-se a intoxicação por doramectina em bovinos desnutridos, com 15 meses de idade, que receberam uma dose 1,6 vezes maior que a dose recomendada. Os animais apresentaram salivação, ataxia, incoordenação motora, relutância em se movimentar e decúbito esternal. Dois animais se recuperaram espontaneamente; um morreu e foi necropsiado. Não foram observadas alterações macro e microscópicas. Esse relato sugere que a doramectina pode causar intoxicação em bovinos desnutridos quando administrada em doses maiores que as recomendadas e que o histórico é fundamental para estabelecer o diagnóstico. MenosABSTRACT.- Macrocyclic lactones are widely used as endectocides in farm animals. Intoxications occur in situations of overdose and/or malnutrition, in young animals, and in genetically sensitive breeds. We describe the intoxication by doramectin in malnourished 15-month-old cattle that received 1.6 times the recommended dose. The animals presented salivation, ataxia, motor incoordination, reluctance to move, and sternal recumbency. Two animals recovered spontaneously; one died and was necropsied. No gross or microscopic changes were observed. This study suggests that doramectin may cause intoxication when administered to malnourished cattle in doses higher than those recommended and that knowing the history is essential to establish a diagnosis.
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RESUMO.- As lactonas macrocíciclas são amplamente utilizadas como endectocidas em animais de produção. Casos de intoxicação ocorrem em situações de sobredosagem e/ou desnutrição, em animais jovens ou em raças geneticamente suscetíveis. Descreve-se a intoxicação por doramectina em bovinos desnutridos, com 15 meses de idade, que receberam uma dose 1,6 vezes maior que a dose recomendada. Os animais apresentaram salivação, ataxia, incoordenação motora, relutância em se movimentar e decúbito esternal. Dois animais se recuperaram espontaneamente; um morreu e foi necropsiado. Não foram observadas alterações macro e microscópicas. Esse relato sugere que a doramectina pode causar intoxicação em bovinos desnutr... Presentar Todo |
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Palabras claves : |
Bovinos; Cattle; Doramectin; Doramectina; Neurological signs; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL; Sinais neurológicos; Toxicidade. |
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Asunto categoría : |
L01 Ganadería |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/16775/1/10.1590-1678-5150-PVB-7102.pdf
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Marc : |
LEADER 03176naa a2200289 a 4500
001 1063584
005 2022-09-27
008 2022 bl uuuu u00u1 u #d
022 $a1678-5150 (electronic)
024 7 $a10.1590/1678-5150-PVB-7102$2DOI
100 1 $aMACHADO, M.
245 $aDoramectin intoxication in malnourished 15-month-old cattle. [Intoxicação por doramectina em bovinos malnutridos de 15 meses de idade.]$h[electronic resource]
260 $c2022
500 $aArticle history: Received 15 May 2022; Accepted 31 May 2022; Publication 29 July 2022; Date of issue 2022. Corresponding author: Riet-Correa, F.; Animal Sciences in the Tropics (PPGCAT), Faculdade de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia (UFBA), Av. Adhemar de Barros 500, Ondina, BA, Salvador, Brazil; email:franklinrietcorrea@gmail.com -- Article: Gold Open Access -- This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0/)
520 $aABSTRACT.- Macrocyclic lactones are widely used as endectocides in farm animals. Intoxications occur in situations of overdose and/or malnutrition, in young animals, and in genetically sensitive breeds. We describe the intoxication by doramectin in malnourished 15-month-old cattle that received 1.6 times the recommended dose. The animals presented salivation, ataxia, motor incoordination, reluctance to move, and sternal recumbency. Two animals recovered spontaneously; one died and was necropsied. No gross or microscopic changes were observed. This study suggests that doramectin may cause intoxication when administered to malnourished cattle in doses higher than those recommended and that knowing the history is essential to establish a diagnosis. .-.-.-.-.-.-.-.-.-.-.-.-.-.-.- RESUMO.- As lactonas macrocíciclas são amplamente utilizadas como endectocidas em animais de produção. Casos de intoxicação ocorrem em situações de sobredosagem e/ou desnutrição, em animais jovens ou em raças geneticamente suscetíveis. Descreve-se a intoxicação por doramectina em bovinos desnutridos, com 15 meses de idade, que receberam uma dose 1,6 vezes maior que a dose recomendada. Os animais apresentaram salivação, ataxia, incoordenação motora, relutância em se movimentar e decúbito esternal. Dois animais se recuperaram espontaneamente; um morreu e foi necropsiado. Não foram observadas alterações macro e microscópicas. Esse relato sugere que a doramectina pode causar intoxicação em bovinos desnutridos quando administrada em doses maiores que as recomendadas e que o histórico é fundamental para estabelecer o diagnóstico.
653 $aBovinos
653 $aCattle
653 $aDoramectin
653 $aDoramectina
653 $aNeurological signs
653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL
653 $aSinais neurológicos
653 $aToxicidade
700 1 $aRIET-CORREA, F.
700 1 $aPEDROSO, P.M.O.
700 1 $aMACÊDO, J.T.S.A.
773 $tPesquisa Veterinaria Brasileira, 2022, Volume 42, Article e07102. OPEN ACCESS. doi: https://doi.org/10.1590/1678-5150-PVB-7102
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
10/07/2019 |
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Actualizado : |
10/07/2019 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
Internacional - -- |
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Autor : |
BESIL, N.; REZENDE, S.; ALONZO, N.; CESIO, M.V.; RIVAS, F.; HEINZEN, H. |
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Afiliación : |
NATALIA BESIL, Grupo de Análisis de Compuestos Traza (GACT), Departamento de Química del Litoral, Facultad de Química, CENUR Litoral Norte, Universidad de la República.; SOFÍA REZENDE, Grupo de Análisis de Compuestos Traza (GACT), Departamento de Química del Litoral, Facultad de Química, CENUR Litoral Norte, Universidad de la República, Paysandú, Uruguay.; NOEL ALONZO, Grupo de Análisis de Compuestos Traza (GACT), Departamento de Química del Litoral, Facultad de Química, CENUR Litoral Norte, Universidad de la República, Paysandú, Uruguay.; MARÍA VERÓNICA CESIO, Grupo de Análisis de Compuestos Traza (GACT), Departamento de Química del Litoral, Facultad de Química, CENUR Litoral Norte, Universidad de la República, Paysandú, Uruguay.; CARLOS FERNANDO RIVAS GRELA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; HORACIO HEINZEN, Grupo de Análisis de Compuestos Traza (GACT), Departamento de Química del Litoral, Facultad de Química, CENUR Litoral Norte, Universidad de la República, Paysandú, Uruguay. |
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Título : |
Analytical methods for the routinely evaluation of pesticide residues in lemon fruits and by products. |
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Complemento del título : |
Research article. |
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Fecha de publicación : |
2019 |
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Fuente / Imprenta : |
SN Applied Sciences, 2019, 1: 618. |
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ISSN : |
2523-3971 |
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DOI : |
10.1007%2Fs42452-019-0626-x |
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Idioma : |
Inglés |
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Notas : |
Article history: Received: 10 October 2018 / Accepted: 16 May 2019 / Published online: 22 May 2019. |
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Contenido : |
ABSTRACT.
Citrus fruits and their by-products such as concentrated juices and essential oils are important intermediate by-products in the food industry that can selectively accumulate plant protection agrochemicals employed in their production. They are very difcult matrices for pesticide residue analysis due their high number and concentration of phytochemicals that could hamper the determinations. The fruit processing leads to the concentration/dilution or elimination of some of these natural products that change totally the nature of the matrix where the pesticides partition unevenly. Looking at the industrial process of the fruit, a unifed vision for the pesticide residues analysis throughout the lemon fruit chain production, useful for the routine analysis of the above mentioned three matrices is presented. The driven concept is the minimization of matrix efects through sample dilution of the concentrated by-products, either after sample treatment or not. This approach will contribute to the maintenance of the whole instrumental system. QuEChERS AOAC 2007.01 was selected as the most suitable protocol for routine determination of, residues of 16 the pesticides most commonly used in the fruits during the citrus production through liquid chromatography coupled to tandem mass spectrometry (LC?MS/MS). The same protocol was applied for pesticide residue analysis in concentrated juice after diluting 4 times the sample to minimize the matrix efects. For the analysis of lemon essential oils, the dilution and shoot procedure proved to be useful for LC?MS/MS and gas chromatography?mass spectrometry determination. The three methodologies were validated following SANTE guidelines, with quantitation limits below the established European Union and Codex Alimentarius maximum residue limits. The developed methodologies are useful tools for the routine control analysis of pesticide residues in lemon matrices, allowing high sample throughput and enhancing labs productivity.
© Springer Nature Switzerland AG MenosABSTRACT.
Citrus fruits and their by-products such as concentrated juices and essential oils are important intermediate by-products in the food industry that can selectively accumulate plant protection agrochemicals employed in their production. They are very difcult matrices for pesticide residue analysis due their high number and concentration of phytochemicals that could hamper the determinations. The fruit processing leads to the concentration/dilution or elimination of some of these natural products that change totally the nature of the matrix where the pesticides partition unevenly. Looking at the industrial process of the fruit, a unifed vision for the pesticide residues analysis throughout the lemon fruit chain production, useful for the routine analysis of the above mentioned three matrices is presented. The driven concept is the minimization of matrix efects through sample dilution of the concentrated by-products, either after sample treatment or not. This approach will contribute to the maintenance of the whole instrumental system. QuEChERS AOAC 2007.01 was selected as the most suitable protocol for routine determination of, residues of 16 the pesticides most commonly used in the fruits during the citrus production through liquid chromatography coupled to tandem mass spectrometry (LC?MS/MS). The same protocol was applied for pesticide residue analysis in concentrated juice after diluting 4 times the sample to minimize the matrix efects. For the analysis of lemon e... Presentar Todo |
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Palabras claves : |
CONCENTRATED LEMON JUICE; ESSENTIAL OILS; GC–MS; LC–MS/MS; LEMON FRUIT; PESTICIDE RESIDUES. |
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Asunto categoría : |
F01 Cultivo |
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Marc : |
LEADER 02922naa a2200289 a 4500
001 1059939
005 2019-07-10
008 2019 bl uuuu u00u1 u #d
022 $a2523-3971
024 7 $a10.1007%2Fs42452-019-0626-x$2DOI
100 1 $aBESIL, N.
245 $aAnalytical methods for the routinely evaluation of pesticide residues in lemon fruits and by products.$h[electronic resource]
260 $c2019
500 $aArticle history: Received: 10 October 2018 / Accepted: 16 May 2019 / Published online: 22 May 2019.
520 $aABSTRACT. Citrus fruits and their by-products such as concentrated juices and essential oils are important intermediate by-products in the food industry that can selectively accumulate plant protection agrochemicals employed in their production. They are very difcult matrices for pesticide residue analysis due their high number and concentration of phytochemicals that could hamper the determinations. The fruit processing leads to the concentration/dilution or elimination of some of these natural products that change totally the nature of the matrix where the pesticides partition unevenly. Looking at the industrial process of the fruit, a unifed vision for the pesticide residues analysis throughout the lemon fruit chain production, useful for the routine analysis of the above mentioned three matrices is presented. The driven concept is the minimization of matrix efects through sample dilution of the concentrated by-products, either after sample treatment or not. This approach will contribute to the maintenance of the whole instrumental system. QuEChERS AOAC 2007.01 was selected as the most suitable protocol for routine determination of, residues of 16 the pesticides most commonly used in the fruits during the citrus production through liquid chromatography coupled to tandem mass spectrometry (LC?MS/MS). The same protocol was applied for pesticide residue analysis in concentrated juice after diluting 4 times the sample to minimize the matrix efects. For the analysis of lemon essential oils, the dilution and shoot procedure proved to be useful for LC?MS/MS and gas chromatography?mass spectrometry determination. The three methodologies were validated following SANTE guidelines, with quantitation limits below the established European Union and Codex Alimentarius maximum residue limits. The developed methodologies are useful tools for the routine control analysis of pesticide residues in lemon matrices, allowing high sample throughput and enhancing labs productivity. © Springer Nature Switzerland AG
653 $aCONCENTRATED LEMON JUICE
653 $aESSENTIAL OILS
653 $aGC–MS
653 $aLC–MS/MS
653 $aLEMON FRUIT
653 $aPESTICIDE RESIDUES
700 1 $aREZENDE, S.
700 1 $aALONZO, N.
700 1 $aCESIO, M.V.
700 1 $aRIVAS, F.
700 1 $aHEINZEN, H.
773 $tSN Applied Sciences, 2019, 1: 618.
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