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| Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
14/06/2022 |
Actualizado : |
14/06/2022 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
JARA, E.; PEÑAGARICANO, F.; ARMSTRONG, E.; CIAPPESONI, G.; IRIARTE, A.; NAVAJAS, E. |
Afiliación : |
EUGENIO JARA, Unidad de Genética y Mejora Animal, Departamento de Producción Animal, Facultad de Veterinaria, Universidad de la República, Montevideo 11600, Uruguay; FRANCISCO PEÑAGARICANO, Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706, United State; EILEEN ARMSTRONG, Unidad de Genética y Mejora Animal, Departamento de Producción Animal, Facultad de Veterinaria, Universidad de la República, 11600, Montevideo, Uruguay; CARLOS GABRIEL CIAPPESONI SCARONE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANDRÉS IRIARTE, Laboratorio de Biología Computacional, Departamento de Desarrollo Biotecnológico, Instituto de Higiene, Facultad de Medicina, Universidad de la República, 11600, Montevideo, Uruguay; ELLY ANA NAVAJAS VALENTINI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Revealing the genetic basis of eyelid pigmentation in Hereford cattle. |
Fecha de publicación : |
2022 |
Fuente / Imprenta : |
Journal of Animal Science, 2022, Volume 100, Issue 5. doi: https://doi.org/10.1093/jas/skac110 |
ISSN : |
1525-3163 |
DOI : |
10.1093/jas/skac110 |
Idioma : |
Inglés |
Notas : |
Article history: Received December 14, 2021; Accepted April 4, 2022; Advance access publication 7 April 2022.
Corresponding author: Eugenio Jara, email: eugeniojara19@gmail.com -- |
Contenido : |
ABSTRACT - Ocular squamous cell carcinoma and infectious keratoconjunctivitis are common ocular pathologies in Hereford cattle with considerable economic impact. Both pathologies have been associated with low eyelid pigmentation, and thus, genetic selection for higher eyelid pigmentation could reduce their incidence. The objective of the present study was to reveal the genetic basis of eyelid pigmentation in Hereford cattle. The analysis included a single-step genome-wide association study (ssGWAS) and a subsequent gene-set analysis in order to identify individual genes, genetic mechanisms, and biological pathways implicated in this trait. Data consisted of eyelid pigmentation records in 1,165 Hereford bulls and steers, visually assessed in five categories between 0% and 100%. Genotypic data for 774,660 single-nucleotide polymorphism markers were available for 886 animals with pigmentation records. Pedigree information of three generations of ancestors of animals with phenotype was considered in this study, with a total of 4,929 animals. Our analyses revealed that eyelid pigmentation is a moderately heritable trait, with heritability estimates around 0.41. The ssGWAS identified at least eight regions, located on BTA1, BTA3, BTA5, BTA14, BTA16, BTA18, BTA19, and BTA24, associated with eyelid pigmentation. These regions harbor genes that are directly implicated in melanocyte biology and skin pigmentation, such as ADCY8, PLD1, KITLG, and PRKCA. The gene-set analysis revealed several functional terms closely related to melanogenesis, such as positive regulation of melanocyte differentiation and regulation of ERK1 and ERK2 cascade. Overall, our findings provide evidence that eyelid pigmentation is a heritable trait influenced by many loci. Indeed, the ssGWAS detected several candidate genes that are directly implicated in melanocyte biology, including melanogenesis. This study contributes to a better understanding of the genetic and biological basis of eyelid pigmentation and presents novel information that could aid to design breeding strategies for reducing the incidence of ocular pathologies in cattle. Additional research on the genetic link between eyelid pigmentation and ocular pathologies is needed. © The Author(s) 2022. MenosABSTRACT - Ocular squamous cell carcinoma and infectious keratoconjunctivitis are common ocular pathologies in Hereford cattle with considerable economic impact. Both pathologies have been associated with low eyelid pigmentation, and thus, genetic selection for higher eyelid pigmentation could reduce their incidence. The objective of the present study was to reveal the genetic basis of eyelid pigmentation in Hereford cattle. The analysis included a single-step genome-wide association study (ssGWAS) and a subsequent gene-set analysis in order to identify individual genes, genetic mechanisms, and biological pathways implicated in this trait. Data consisted of eyelid pigmentation records in 1,165 Hereford bulls and steers, visually assessed in five categories between 0% and 100%. Genotypic data for 774,660 single-nucleotide polymorphism markers were available for 886 animals with pigmentation records. Pedigree information of three generations of ancestors of animals with phenotype was considered in this study, with a total of 4,929 animals. Our analyses revealed that eyelid pigmentation is a moderately heritable trait, with heritability estimates around 0.41. The ssGWAS identified at least eight regions, located on BTA1, BTA3, BTA5, BTA14, BTA16, BTA18, BTA19, and BTA24, associated with eyelid pigmentation. These regions harbor genes that are directly implicated in melanocyte biology and skin pigmentation, such as ADCY8, PLD1, KITLG, and PRKCA. The gene-set analysis revealed se... Presentar Todo |
Palabras claves : |
Beef cattle; Melanocyte biology; Ocular pathologies. |
Asunto categoría : |
L01 Ganadería |
Marc : |
LEADER 03180naa a2200253 a 4500 001 1063291 005 2022-06-14 008 2022 bl uuuu u00u1 u #d 022 $a1525-3163 024 7 $a10.1093/jas/skac110$2DOI 100 1 $aJARA, E. 245 $aRevealing the genetic basis of eyelid pigmentation in Hereford cattle.$h[electronic resource] 260 $c2022 500 $aArticle history: Received December 14, 2021; Accepted April 4, 2022; Advance access publication 7 April 2022. Corresponding author: Eugenio Jara, email: eugeniojara19@gmail.com -- 520 $aABSTRACT - Ocular squamous cell carcinoma and infectious keratoconjunctivitis are common ocular pathologies in Hereford cattle with considerable economic impact. Both pathologies have been associated with low eyelid pigmentation, and thus, genetic selection for higher eyelid pigmentation could reduce their incidence. The objective of the present study was to reveal the genetic basis of eyelid pigmentation in Hereford cattle. The analysis included a single-step genome-wide association study (ssGWAS) and a subsequent gene-set analysis in order to identify individual genes, genetic mechanisms, and biological pathways implicated in this trait. Data consisted of eyelid pigmentation records in 1,165 Hereford bulls and steers, visually assessed in five categories between 0% and 100%. Genotypic data for 774,660 single-nucleotide polymorphism markers were available for 886 animals with pigmentation records. Pedigree information of three generations of ancestors of animals with phenotype was considered in this study, with a total of 4,929 animals. Our analyses revealed that eyelid pigmentation is a moderately heritable trait, with heritability estimates around 0.41. The ssGWAS identified at least eight regions, located on BTA1, BTA3, BTA5, BTA14, BTA16, BTA18, BTA19, and BTA24, associated with eyelid pigmentation. These regions harbor genes that are directly implicated in melanocyte biology and skin pigmentation, such as ADCY8, PLD1, KITLG, and PRKCA. The gene-set analysis revealed several functional terms closely related to melanogenesis, such as positive regulation of melanocyte differentiation and regulation of ERK1 and ERK2 cascade. Overall, our findings provide evidence that eyelid pigmentation is a heritable trait influenced by many loci. Indeed, the ssGWAS detected several candidate genes that are directly implicated in melanocyte biology, including melanogenesis. This study contributes to a better understanding of the genetic and biological basis of eyelid pigmentation and presents novel information that could aid to design breeding strategies for reducing the incidence of ocular pathologies in cattle. Additional research on the genetic link between eyelid pigmentation and ocular pathologies is needed. © The Author(s) 2022. 653 $aBeef cattle 653 $aMelanocyte biology 653 $aOcular pathologies 700 1 $aPEÑAGARICANO, F. 700 1 $aARMSTRONG, E. 700 1 $aCIAPPESONI, G. 700 1 $aIRIARTE, A. 700 1 $aNAVAJAS, E. 773 $tJournal of Animal Science, 2022, Volume 100, Issue 5. doi: https://doi.org/10.1093/jas/skac110
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41. | | PRAVIA, M.I.; NAVAJAS, E.; AGUILAR, I.; RAVAGNOLO, O. Evaluation of feed efficiency traits in different Hereford populations and their effect on variance component estimation. Animal Production Science, 2022, Volume 62, Issue 17, pages 1652-1660. doi: https://doi.org/10.1071/AN21420 Article history: Submitted 24 August 2021; Accepted 10 June 2022; Published online 1 August 2022. -- Handling Editor: Sue Hatcher. --
Corresponding author: Pravia, M.I.; Instituto Nacional de Investigación Agropecuaria (INIA), Estación...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Las Brujas. |
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51. | | PRAVIA, M.I.; NAVAJAS, E.; AGUILAR, I.; RAVAGNOLO, O. Incorporación de información genómica en la estimación del mérito genético de consumo residual de alimento. In: AUPA, Proceedings del VII Congreso Uruguayo de Producción Animal. Sección Cambio Climático y Producción Sostenible (Climate Change Section), 14 y 15 diciembre 2021. Archivos Latinoamericanos de Producción Animal, 29(Supl.1), p.74-76. (Archivos Latinoamericanos de Producción Animal, Vol.29, Supl.1) Corresponding author: M.I. Pravia, Instituto Nacional de Investigación Agropecuaria (INIA), Las Brujas, Rincón del Colorado, Canelones (Uruguay), mailto: mpravia@inia.org.uyTipo: Trabajos en Congresos/Conferencias |
Biblioteca(s): INIA Las Brujas. |
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52. | | CARRACELAS, B.; NAVAJAS, E.; VERA, B.; CIAPPESONI, G. SNP arrays evaluation as tools in genetic improvement in Corriedale sheep in Uruguay. [Evaluación de paneles de SNP como herramientas en la mejora genética de ovinos Corriedale en Uruguay]. [Avaliação de painéis de SNP como ferramentas em melhoramento genético de ovinos Corriedale no Uruguai]. Animal production and pastures. Agrociencia Uruguay, 2022, vol. 26, number 2, article e998. doi: https://doi.org/10.31285/AGRO.26.998 Article history: Received 09 Feb 2022; Accepted 30 May 2022; Published 19 Aug 2022. Editor: Mariana Carriquiry, Universidad de la República, Facultad de Agronomía, Montevideo, Uruguay. Correspondence: Beatriz Carracelas,...Tipo: Artículos en Revistas Indexadas Nacionales | Circulación / Nivel : Nacional - -- |
Biblioteca(s): INIA Las Brujas. |
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56. | | CARRACELAS, B.; PERAZA, P.; CIAPPESONI, G.; NAVAJAS, E. A straightforward technique to obtain genomic DNA from nasal swabs suitable for sheep SNP genotyping analysis. [Técnica simple para obtener ADN genómico adecuado para análisis de genotipado en ovinos a partir de hisopados nasales.]. [Uma técnica simples para obter DNA genômico a partir de esfregaços nasais adequado para análise de genotipagem em ovinos.] Animal production and pastures. Agrociencia Uruguay, 2024, Vol.28, e1452. https://doi.org/10.31285/AGRO.28.1452 -- OPEN ACCESS. Article history: Received 01 Mar 2024, Accepted 02 May 2024, Published 09 May 2024. -- Editor: Silvia Llambí, Universidad de la República, Montevideo, Uruguay. -- Correspondence: Beatriz Carracelas, bcarracelas@inia.org.uy -- Funding:...Tipo: Artículos en Revistas Indexadas Nacionales | Circulación / Nivel : Nacional - -- |
Biblioteca(s): INIA Las Brujas. |
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57. | | MACEDO, F.; PIERUCCIONI, F.; VILLANUEVA, B.; NAVAJAS, E. Uso de información genómica para optimizar apareamientos en ovinos criollos. [Resumen]. Congreso de la Asociación Latinoamericana de Producción Animal, 24.; Congreso de la Sociedad Chilena de Producción Animal, 40., Puerto Varas, Chile, 9 al 13 noviembre 2015. ln: Reunión ALPA (24., Puerto Varas, Chile). Resúmenes. Puerto Varas (Chile): ALPA, 2015. p. 938.Tipo: Abstracts/Resúmenes |
Biblioteca(s): INIA Las Brujas. |
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