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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
20/03/2024 |
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Actualizado : |
20/03/2024 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
GIANNITTI, F.; MACHADO, M.; SILVEIRA, C.S.; CIBILS-STEWART, X.; BARAIBAR, N.; QUEIROZ-MACHADO, C.R.R.; POPPENGA, R.H.; MENCHACA, A.; UZAL, F.A.; GARCÍA, J.A.; MATTO, C.; DUTRA, F.; RUPRECHTER, G.; CAFFARENA, D.; SARAVIA, A. |
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Afiliación : |
FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MIZAEL MACHADO DA COSTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CAROLINE DA SILVA SILVEIRA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; XIMENA CIBILS-STEWART, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; NICOLÁS BARAIBAR PEDERSEN, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CINTIA R. R. QUEIROZ-MACHADO, Centro Universitario Regional Noroeste, Universidad de la República, Tacuarembó, Uruguay; ROBERT H. POPPENGA, School of Veterinary Medicine, University of California, Davis, Davis CA, United States; JOSE ALEJO MENCHACA BARBEITO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FRANCISCO A. UZAL, School of Veterinary Medicine, University of California, Davis, San Bernardino, CA, United States; JUAN A. GARCÍA, Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible, Balcarce, Argentina; CAROLINA MATTO, División Laboratorios Veterinarios, Ministerio de Ganadería, Agricultura y Pesca, Paysandú, Uruguay; FERNANDO DUTRA, División Laboratorios Veterinarios, Ministerio de Ganadería, Agricultura y Pesca, Treinta y Tres, Uruguay; GRETEL RUPRECHTER, Facultad de Veterinaria, Universidad de la República, Montevideo, Uruguay; RUBEN DARÍO CAFFARENA LEDESMA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; Facultad de Veterinaria, Universidad de la República, Montevideo, Uruguay; ANDERSON SARAVIA DE MELO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Experimental oral administration of pollen beetle (Astylus atromaculatus) to cattle results in an acute lethal gastrointestinal disease. |
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Complemento del título : |
Research article. |
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Fecha de publicación : |
2024 |
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Fuente / Imprenta : |
Veterinary Pathology. 2024. https://doi.org/10.1177/03009858241231557 -- [In Press] |
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ISSN : |
0300-9858 |
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DOI : |
10.1177/03009858241231557 |
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Idioma : |
Inglés |
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Notas : |
Article history: First published online March 4, 2024. -- Correspondence: Federico Giannitti, Plataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria, Estación Experimental La Estanzuela, Ruta 50 km 11, Semillero 70006, Colonia, Uruguay.
Email: fgiannitti@inia.org.uy -- Funding: This work was funded by grant P__27 from the "Instituto Nacional de Investigación Agropecuaria" (INIA), Uruguay. -- |
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Contenido : |
ABSTRACT.- In the summer of 2023, ingestion of Astylus atromaculatus (pollen beetle) was linked to spontaneous fatal disease in grazing cattle and sheep in Argentina and Uruguay. While the disease was experimentally reproduced in sheep and guinea pigs in the 1970's, no experimental reproductions have been attempted in cattle, and controversy exists as to whether this insect is indeed noxious to cattle and at which dose. Here, we demonstrate that A. atromaculatus causes acute fatal disease in Hereford calves at single oral dosages of 2.5, 4.5, 10.0, and 15.0 g of insect/kg body weight. Death or severe disease necessitating euthanasia occurred at 38 to 48 hours postinoculation regardless of the dose, suggesting that the single fatal dosage is likely <2.5 g/kg body weight (this dose representing approximately 850 mL of intact beetles in a 100 kg calf). Clinically, the disease was characterized by acute anorexia, prolonged recumbency, reluctance to move, listlessness/apathy, depression, ruminal hypomotility and tympany, hypothermia, bruxism with frothing at the mouth, and mucoid diarrhea progressing to death. Hematologic and biochemical alterations included hemoconcentration, stress/acute inflammatory leukogram, negative energy balance, and ketosis. The pathological hallmark of this experimental disease is acute necrotizing omaso-reticulo-rumenitis, fibrinohemorrhagic enteritis, and exfoliative colitis with intralesional chitinous insect fragments. While A. atromaculatus might contain a gastrointestinal toxin or pathogen, extensive toxicological testing failed to identify a causative toxin. Other pathomechanisms such as direct physical damage caused by insect fragments on the alimentary tract seem plausible, although further studies are needed to elucidate the pathogenesis of A. atromaculatus-associated disease. © The Author(s) 2024. MenosABSTRACT.- In the summer of 2023, ingestion of Astylus atromaculatus (pollen beetle) was linked to spontaneous fatal disease in grazing cattle and sheep in Argentina and Uruguay. While the disease was experimentally reproduced in sheep and guinea pigs in the 1970's, no experimental reproductions have been attempted in cattle, and controversy exists as to whether this insect is indeed noxious to cattle and at which dose. Here, we demonstrate that A. atromaculatus causes acute fatal disease in Hereford calves at single oral dosages of 2.5, 4.5, 10.0, and 15.0 g of insect/kg body weight. Death or severe disease necessitating euthanasia occurred at 38 to 48 hours postinoculation regardless of the dose, suggesting that the single fatal dosage is likely <2.5 g/kg body weight (this dose representing approximately 850 mL of intact beetles in a 100 kg calf). Clinically, the disease was characterized by acute anorexia, prolonged recumbency, reluctance to move, listlessness/apathy, depression, ruminal hypomotility and tympany, hypothermia, bruxism with frothing at the mouth, and mucoid diarrhea progressing to death. Hematologic and biochemical alterations included hemoconcentration, stress/acute inflammatory leukogram, negative energy balance, and ketosis. The pathological hallmark of this experimental disease is acute necrotizing omaso-reticulo-rumenitis, fibrinohemorrhagic enteritis, and exfoliative colitis with intralesional chitinous insect fragments. While A. atromaculatus might c... Presentar Todo |
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Palabras claves : |
Alimentary tract; Astylus atromaculatus; Bovine; Enteritis; Experimental disease; Insects; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA; Rumenitis; South America. |
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Asunto categoría : |
L01 Ganadería |
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Marc : |
LEADER 03582naa a2200433 a 4500
001 1064506
005 2024-03-20
008 2024 bl uuuu u00u1 u #d
022 $a0300-9858
024 7 $a10.1177/03009858241231557$2DOI
100 1 $aGIANNITTI, F.
245 $aExperimental oral administration of pollen beetle (Astylus atromaculatus) to cattle results in an acute lethal gastrointestinal disease.$h[electronic resource]
260 $c2024
500 $aArticle history: First published online March 4, 2024. -- Correspondence: Federico Giannitti, Plataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria, Estación Experimental La Estanzuela, Ruta 50 km 11, Semillero 70006, Colonia, Uruguay. Email: fgiannitti@inia.org.uy -- Funding: This work was funded by grant P__27 from the "Instituto Nacional de Investigación Agropecuaria" (INIA), Uruguay. --
520 $aABSTRACT.- In the summer of 2023, ingestion of Astylus atromaculatus (pollen beetle) was linked to spontaneous fatal disease in grazing cattle and sheep in Argentina and Uruguay. While the disease was experimentally reproduced in sheep and guinea pigs in the 1970's, no experimental reproductions have been attempted in cattle, and controversy exists as to whether this insect is indeed noxious to cattle and at which dose. Here, we demonstrate that A. atromaculatus causes acute fatal disease in Hereford calves at single oral dosages of 2.5, 4.5, 10.0, and 15.0 g of insect/kg body weight. Death or severe disease necessitating euthanasia occurred at 38 to 48 hours postinoculation regardless of the dose, suggesting that the single fatal dosage is likely <2.5 g/kg body weight (this dose representing approximately 850 mL of intact beetles in a 100 kg calf). Clinically, the disease was characterized by acute anorexia, prolonged recumbency, reluctance to move, listlessness/apathy, depression, ruminal hypomotility and tympany, hypothermia, bruxism with frothing at the mouth, and mucoid diarrhea progressing to death. Hematologic and biochemical alterations included hemoconcentration, stress/acute inflammatory leukogram, negative energy balance, and ketosis. The pathological hallmark of this experimental disease is acute necrotizing omaso-reticulo-rumenitis, fibrinohemorrhagic enteritis, and exfoliative colitis with intralesional chitinous insect fragments. While A. atromaculatus might contain a gastrointestinal toxin or pathogen, extensive toxicological testing failed to identify a causative toxin. Other pathomechanisms such as direct physical damage caused by insect fragments on the alimentary tract seem plausible, although further studies are needed to elucidate the pathogenesis of A. atromaculatus-associated disease. © The Author(s) 2024.
653 $aAlimentary tract
653 $aAstylus atromaculatus
653 $aBovine
653 $aEnteritis
653 $aExperimental disease
653 $aInsects
653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA
653 $aRumenitis
653 $aSouth America
700 1 $aMACHADO, M.
700 1 $aSILVEIRA, C.S.
700 1 $aCIBILS-STEWART, X.
700 1 $aBARAIBAR, N.
700 1 $aQUEIROZ-MACHADO, C.R.R.
700 1 $aPOPPENGA, R.H.
700 1 $aMENCHACA, A.
700 1 $aUZAL, F.A.
700 1 $aGARCÍA, J.A.
700 1 $aMATTO, C.
700 1 $aDUTRA, F.
700 1 $aRUPRECHTER, G.
700 1 $aCAFFARENA, D.
700 1 $aSARAVIA, A.
773 $tVeterinary Pathology. 2024. https://doi.org/10.1177/03009858241231557 -- [In Press]
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| Registros recuperados : 6 | |
| 2. |  | ESTEVES, P.; MASTROPIERRO, M.M.; CASTILLO, A.; DALLA RIZZA, M.; BELZILE, F.; HERNANDEZ, L.; QUINCKE, M. Métodos para aumentar la eficiencia del mejoramiento de trigo. In: CONGRESO NACIONAL DE TRIGO, 8o. ; SIMPOSIO DE CEREALES DE SIEMBRA OTOÑO INVERNAL, 6o. ; ENCUENTRO DEL MERCOSUR, 2º, Pergamino, Argentina: AIANBA, 14-16 setiembre,2016.| Biblioteca(s): INIA La Estanzuela. |
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| 3. | | ESTEVES, P.; MURCHIO, S.; CEPPA, M.; BONILLA, B.; DIEPPA, D.; CASTILLO, A.; DALLA RIZZA, M. Puesta en marcha del Proyecto: Producción de Haploides-duplicados de arroz, trigo y cebada. In: INIA (Instituto Nacional de Investigación Agropecuaria); Inia Las Brujas; Biotecnología. Apostando a la investigación para un futuro innovador. Jornada de Agrobiotecnología, IX. Jornada Técnica. Canelones (Uruguay): INIA , 2015. p. 17-19 (Actividades de Difusión; 755)| Biblioteca(s): INIA Las Brujas. |
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| 4. | | GALLINO, J. P.; CASTILLO, A.; CERETTA, S.; ESTEVES, P.; BONNECARRERE, V. A simple and inexpensive procedure to more quickly obtain new varieties in soybean. Crop Breeding and Applied Biotechnology, 2022, volume 22, Issue 1, e38212216. OPEN ACCESS. doi: https://doi.org/10.1590/1984-70332022v22n1a06 Article history: Received 24 May 2021; Accepted 12 Aug 2021; Published 30 Mar 2022; Publication in this collection 04 May 2022; Date of issue 2022.
Corresponding author: Gallino, J.P.; INIA, Estación Experimental "Wilson Ferreira...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 5. | | ESTEVES, P.; HERNANDEZ, L.; CASTILLO, A.; DALLA RIZZA, M.; QUINCKE, M. Tecnologías para el desarrollo de líneas recombinantes de trigo. MV 20 - COMUNICACIONES LIBRES - MV. MEJORAMIENTO VEGETAL In: JOURNAL OF BASIC & APPLIED GENETICS, 2016, Vol.27, Iss. 1 (Supp.). XVI LATIN AMERICAN CONGRESS OF GENETICS, IV CONGRESS OF THE URUGUAYAN SOCIETY OF GENETICS, XLIX ANNUAL MEETING OF THE GENETICS SOCIETY OF CHILE, XLV ARGENTINE CONGRESS OF GENETICS, 9-12 October 2016. PROCEEDINGS. Montevideo (Uruguay): SAG, 2016. p. 290| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA Las Brujas. |
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| 6. | | ESTEVES, P.; MASTROPIERRO, M.; CASTILLO, A.; HERNANDEZ, L.; RODRIGUEZ, M.; DE LEON, W.; PEREIRA, F.; QUINCKE, M. Herramientas biotecnológicas para el mejoramiento genético de cultivos. Revista INIA Uruguay, 2017, no.48, p. 62-66. (Revista INIA; 48)| Tipo: Artículos en Revistas Agropecuarias |
| Biblioteca(s): INIA Las Brujas; INIA Tacuarembó. |
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| Registros recuperados : 6 | |
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