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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
13/11/2015 |
Actualizado : |
15/10/2019 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
FRAGOMENI, B.O.; LOURENCO, D.A.L.; TSURUTA, S.; MASUDA, Y.; AGUILAR, I.; LEGARRA, A.; LAWLOR, T.J.; MIZTAL, I. |
Afiliación : |
IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Hot topic: Use of genomic recursions in single-step genomic best linear unbiased predictor (BLUP) with a large number of genotypes. |
Fecha de publicación : |
2015 |
Fuente / Imprenta : |
Journal of Dairy Science, 2015, v.98, no.6, p.4090-4094. OPEN ACCESS. |
ISSN : |
0022-0302 |
DOI : |
10.3168/jds.2014-9125 |
Idioma : |
Inglés |
Notas : |
Article history: Received November 18, 2014 / Accepted March 13, 2015 / Published online: April 8, 2015. |
Contenido : |
ABSTRACT.
The purpose of this study was to evaluate the accuracy of genomic selection in single-step genomic BLUP (ssGBLUP) when the inverse of the genomic relationship matrix (G) is derived by the "algorithm for proven and young animals" (APY). This algorithm implements genomic recursions on a subset of "proven" animals. Only a relationship matrix for animals treated as "proven" needs to be inverted, and the extra costs of adding animals treated as "young" are linear. Analyses involved 10,102,702 final scores on 6,930,618 Holstein cows. Final score, which is a composite of type traits, is popular trait in the United States and was easily available for this study. A total of 100,000 animals with genotypes were used in the analyses and included 23,000 sires (16,000 with >5 progeny), 27,000 cows, and 50,000 young animals. Genomic EBV (GEBV) were calculated with a regular inverse of G, and with the G inverse approximated by APY. Animals in the proven subset included only sires (23,000), sires + cows (50,000), only cows (27,000), or sires with >5 progeny (16,000). The correlations of GEBV with APY and regular GEBV for young genotyped animals were 0.994, 0.995, 0.992, and 0.992, respectively Later, animals in the proven subset were randomly sampled from all genotyped animals in sets of 2,000, 5,000, 10,000, 15,000, and 20,000; each sample was replicated 4 times. Respective correlations were 0.97 (5,000 sample), 0.98 (10,000 sample), and 0.99 (20,000 sample), with minimal difference between samples of the same size. Genomic EBV with APY were accurate when the number of animals used in the subset is between 10,000 and 20,000, with little difference between the ways of creating the subset. Due to the approximately linear cost of APY, ssGBLUP with APY could support any number of genotyped animals without affecting accuracy.
© 2015 American Dairy Science Association. MenosABSTRACT.
The purpose of this study was to evaluate the accuracy of genomic selection in single-step genomic BLUP (ssGBLUP) when the inverse of the genomic relationship matrix (G) is derived by the "algorithm for proven and young animals" (APY). This algorithm implements genomic recursions on a subset of "proven" animals. Only a relationship matrix for animals treated as "proven" needs to be inverted, and the extra costs of adding animals treated as "young" are linear. Analyses involved 10,102,702 final scores on 6,930,618 Holstein cows. Final score, which is a composite of type traits, is popular trait in the United States and was easily available for this study. A total of 100,000 animals with genotypes were used in the analyses and included 23,000 sires (16,000 with >5 progeny), 27,000 cows, and 50,000 young animals. Genomic EBV (GEBV) were calculated with a regular inverse of G, and with the G inverse approximated by APY. Animals in the proven subset included only sires (23,000), sires + cows (50,000), only cows (27,000), or sires with >5 progeny (16,000). The correlations of GEBV with APY and regular GEBV for young genotyped animals were 0.994, 0.995, 0.992, and 0.992, respectively Later, animals in the proven subset were randomly sampled from all genotyped animals in sets of 2,000, 5,000, 10,000, 15,000, and 20,000; each sample was replicated 4 times. Respective correlations were 0.97 (5,000 sample), 0.98 (10,000 sample), and 0.99 (20,000 sample), with minimal differe... Presentar Todo |
Palabras claves : |
ANIMALIA; GENOMIC RECURSION; GENOMIC SELECTION; SINGLE-STEP GENOMIC BLUP. |
Thesagro : |
BLUP; MEJORAMIENTO GENETICO ANIMAL. |
Asunto categoría : |
L10 Genética y mejoramiento animal |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/5183/1/Aguilar-I.-2015.-Jr.DairyScience-v.984-p.4090-4094.pdf
https://www.journalofdairyscience.org/article/S0022-0302(15)00238-6/pdf
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Marc : |
LEADER 02932naa a2200313 a 4500 001 1053873 005 2019-10-15 008 2015 bl uuuu u00u1 u #d 022 $a0022-0302 024 7 $a10.3168/jds.2014-9125$2DOI 100 1 $aFRAGOMENI, B.O. 245 $aHot topic$bUse of genomic recursions in single-step genomic best linear unbiased predictor (BLUP) with a large number of genotypes.$h[electronic resource] 260 $c2015 500 $aArticle history: Received November 18, 2014 / Accepted March 13, 2015 / Published online: April 8, 2015. 520 $aABSTRACT. The purpose of this study was to evaluate the accuracy of genomic selection in single-step genomic BLUP (ssGBLUP) when the inverse of the genomic relationship matrix (G) is derived by the "algorithm for proven and young animals" (APY). This algorithm implements genomic recursions on a subset of "proven" animals. Only a relationship matrix for animals treated as "proven" needs to be inverted, and the extra costs of adding animals treated as "young" are linear. Analyses involved 10,102,702 final scores on 6,930,618 Holstein cows. Final score, which is a composite of type traits, is popular trait in the United States and was easily available for this study. A total of 100,000 animals with genotypes were used in the analyses and included 23,000 sires (16,000 with >5 progeny), 27,000 cows, and 50,000 young animals. Genomic EBV (GEBV) were calculated with a regular inverse of G, and with the G inverse approximated by APY. Animals in the proven subset included only sires (23,000), sires + cows (50,000), only cows (27,000), or sires with >5 progeny (16,000). The correlations of GEBV with APY and regular GEBV for young genotyped animals were 0.994, 0.995, 0.992, and 0.992, respectively Later, animals in the proven subset were randomly sampled from all genotyped animals in sets of 2,000, 5,000, 10,000, 15,000, and 20,000; each sample was replicated 4 times. Respective correlations were 0.97 (5,000 sample), 0.98 (10,000 sample), and 0.99 (20,000 sample), with minimal difference between samples of the same size. Genomic EBV with APY were accurate when the number of animals used in the subset is between 10,000 and 20,000, with little difference between the ways of creating the subset. Due to the approximately linear cost of APY, ssGBLUP with APY could support any number of genotyped animals without affecting accuracy. © 2015 American Dairy Science Association. 650 $aBLUP 650 $aMEJORAMIENTO GENETICO ANIMAL 653 $aANIMALIA 653 $aGENOMIC RECURSION 653 $aGENOMIC SELECTION 653 $aSINGLE-STEP GENOMIC BLUP 700 1 $aLOURENCO, D.A.L. 700 1 $aTSURUTA, S. 700 1 $aMASUDA, Y. 700 1 $aAGUILAR, I. 700 1 $aLEGARRA, A. 700 1 $aLAWLOR, T.J. 700 1 $aMIZTAL, I. 773 $tJournal of Dairy Science, 2015$gv.98, no.6, p.4090-4094. OPEN ACCESS.
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Registro original : |
INIA Las Brujas (LB) |
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha actual : |
20/01/2022 |
Actualizado : |
20/01/2022 |
Tipo de producción científica : |
Abstracts/Resúmenes |
Autor : |
GARCÍA-ROCHE, M.; TALMÓN, D.; CAÑIBE, G.; MENDOZA, A.; QUIJANO, C.; CASSINA, A.; CARRIQUIRY, M. |
Afiliación : |
M. GARCÍA-ROCHE, Facultad de Agronomía, Universidad la República, Uruguay; Centro de Investigaciones Biomédicas, Facultad de Medicina, Universidad de la República, Uruguay; D. TALMÓN, Facultad de Agronomía, Universidad de la República, Uruguay; G. CAÑIBE, Facultad de Agronomía, Universidad de la República, Uruguay; ALEJANDRO FRANCISCO MENDOZA AGUIAR, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; C. QUIJANO, Centro de Investigaciones Biomédicas, Facultad de Medicina, Universidad de la República, Uruguay; A. CASSINA, Centro de Investigaciones Biomédicas, Facultad de Medicina, Universidad de la República, Uruguay; M. CARRIQUIRY, Facultad de Agronomía, Universidad la República, Uruguay; Centro de Investigaciones Biomédicas, Facultad de Medicina, Universidad de la República, Uruguay. |
Título : |
Expresión génica hepática de la vía del receptor alfa activado por proliferador de peroxisomas A (PPARA) en dos genotipos Holstein. [abstract]. |
Fecha de publicación : |
2021 |
Fuente / Imprenta : |
In: AUPA, Proceedings del VII Congreso Uruguayo de Producción Animal. Sección Cambio Climático y Producción Sostenible (Climate Change Section), 14 y 15 diciembre 2021. Archivos Latinoamericanos de Producción Animal, 29(Supl.1), p.2. |
Serie : |
(Archivos Latinoamericanos de Producción Animal, Vol.29, Supl.1) |
ISSN : |
1022-1301; online 2075-8359 |
Idioma : |
Español |
Contenido : |
Se utilizaron vacas Holstein multíparas de Nueva Zelanda (NZH, n = 10) y norteamericanas (NAH, n = 20) (512 ± 19 vs. 563 ± 29 kg de peso vivo, 3,1 ± 0,1 condición corporal y parto en otoño) con el objetivo de evaluar la vía PPARA ?un regulador del metabolismo de los ácidos grasos. |
Palabras claves : |
Ácidos grasos; Holstein-Friesian; Metabolismo hepático. |
Asunto categoría : |
L50 Fisiología y bioquímica animal |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/16194/1/2950-Article-Text-10068-5-10-20211213-02.pdf
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Marc : |
LEADER 01310nam a2200241 a 4500 001 1062651 005 2022-01-20 008 2021 bl uuuu u01u1 u #d 022 $a1022-1301; online 2075-8359 100 1 $aGARCÍA-ROCHE, M. 245 $aExpresión génica hepática de la vía del receptor alfa activado por proliferador de peroxisomas A (PPARA) en dos genotipos Holstein. [abstract].$h[electronic resource] 260 $aIn: AUPA, Proceedings del VII Congreso Uruguayo de Producción Animal. Sección Cambio Climático y Producción Sostenible (Climate Change Section), 14 y 15 diciembre 2021. Archivos Latinoamericanos de Producción Animal, 29(Supl.1), p.2.$c2021 490 $a(Archivos Latinoamericanos de Producción Animal, Vol.29, Supl.1) 520 $aSe utilizaron vacas Holstein multíparas de Nueva Zelanda (NZH, n = 10) y norteamericanas (NAH, n = 20) (512 ± 19 vs. 563 ± 29 kg de peso vivo, 3,1 ± 0,1 condición corporal y parto en otoño) con el objetivo de evaluar la vía PPARA ?un regulador del metabolismo de los ácidos grasos. 653 $aÁcidos grasos 653 $aHolstein-Friesian 653 $aMetabolismo hepático 700 1 $aTALMÓN, D. 700 1 $aCAÑIBE, G. 700 1 $aMENDOZA, A. 700 1 $aQUIJANO, C. 700 1 $aCASSINA, A. 700 1 $aCARRIQUIRY, M.
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