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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
30/01/2020 |
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Actualizado : |
10/02/2020 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
GOSTIC, K.M.; WUNDER, E.A.; BISHT, V.; HAMOND, C.; JULIAN, T.R.; KO, A.I.; LLOYD-SMITH, J.O. |
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Afiliación : |
KATELYN M. GOSTIC, Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, United States; ELSIO A. WUNDER, Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, United States; Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Bahia, Brazil; VIMLA BISHT, Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, United States; CAMILA HAMOND, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, United States; TIMOTHY R. JULIAN, Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, Switzerland; Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland; ALBERT I. KO, Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, United States; Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Bahia, Brazil; JAMES O. LLOYD-SMITH, Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, United States; Fogarty International Center, National Institutes of Health, Bethesda, MD, United States. |
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Título : |
Mechanistic dose-response modelling of animal challenge data shows that intact skin is a crucial barrier to leptospiral infection. |
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Fecha de publicación : |
2019 |
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Fuente / Imprenta : |
Philosophical Transactions of the Royal Society B: Biological Sciences, 30 September 2019, Volume 374, Issue 1782, Article number 2019036. Doi: https://doi.org/10.1098/rstb.2019.0367 |
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ISSN : |
0962-8436 |
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DOI : |
10.1098/rstb.2019.0367 |
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Idioma : |
Inglés |
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Notas : |
Article history: Accepted: 2 April 2019 / Published:12 August 2019.
This article is part of the theme issue "Dynamic and integrative approaches to understanding pathogen spillover".
Electronic supplementary material is available online at https://dx.doi.org/10.6084/m9.figshare.c.4557260 |
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Contenido : |
ABSTRACT.
Leptospirosis is a widespread and potentially life-threatening zoonotic disease caused by spirochaetes of the genus Leptospira. Humans become infected primarily via contact with environmental reservoirs contaminated by the urine of shedding mammalian hosts. Populations in high transmission settings, such as urban slums and subsistence farming communities, are exposed to low doses of Leptospira on a daily basis. Under these conditions, numerous factors determine whether infection occurs, including the route of exposure and inoculum dose. Skin wounds and abrasions are risk factors for leptospirosis, but it is not known whether broken skin is necessary for spillover, or if low-dose exposures to intact skin and mucous membranes can also cause infection. To establish a quantitative relationship between dose, route and probability of infection, we performed challenge experiments in hamsters and rats, developed mechanistic dose-response models representing the spatial dynamics of within-host infection and persistence, and fitted models to experimental data. Results show intact skin is a strong barrier against infection, and that broken skin is the predominant route by which low-dose environmental exposures cause infection. These results identify skin integrity as a bottleneck to spillover of Leptospira and underscore the importance of barrier interventions in the prevention of leptospirosis. This article is part of the theme issue 'Dynamic and integrative approaches to understanding pathogen spillover'. © 2019 The Author(s) Published by the Royal Society. All rights reserved. MenosABSTRACT.
Leptospirosis is a widespread and potentially life-threatening zoonotic disease caused by spirochaetes of the genus Leptospira. Humans become infected primarily via contact with environmental reservoirs contaminated by the urine of shedding mammalian hosts. Populations in high transmission settings, such as urban slums and subsistence farming communities, are exposed to low doses of Leptospira on a daily basis. Under these conditions, numerous factors determine whether infection occurs, including the route of exposure and inoculum dose. Skin wounds and abrasions are risk factors for leptospirosis, but it is not known whether broken skin is necessary for spillover, or if low-dose exposures to intact skin and mucous membranes can also cause infection. To establish a quantitative relationship between dose, route and probability of infection, we performed challenge experiments in hamsters and rats, developed mechanistic dose-response models representing the spatial dynamics of within-host infection and persistence, and fitted models to experimental data. Results show intact skin is a strong barrier against infection, and that broken skin is the predominant route by which low-dose environmental exposures cause infection. These results identify skin integrity as a bottleneck to spillover of Leptospira and underscore the importance of barrier interventions in the prevention of leptospirosis. This article is part of the theme issue 'Dynamic and integrative approaches to u... Presentar Todo |
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Palabras claves : |
Animal model; Dose-response; Emerging infectious disease; PLATAFORMA SALUD ANIMAL; Zoonotic spillover. |
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Thesagro : |
LEPTOSPIRA; LEPTOSPIROSIS. |
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Asunto categoría : |
L73 Enfermedades de los animales |
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Marc : |
LEADER 02944naa a2200313 a 4500
001 1060727
005 2020-02-10
008 2019 bl uuuu u00u1 u #d
022 $a0962-8436
024 7 $a10.1098/rstb.2019.0367$2DOI
100 1 $aGOSTIC, K.M.
245 $aMechanistic dose-response modelling of animal challenge data shows that intact skin is a crucial barrier to leptospiral infection.$h[electronic resource]
260 $c2019
500 $aArticle history: Accepted: 2 April 2019 / Published:12 August 2019. This article is part of the theme issue "Dynamic and integrative approaches to understanding pathogen spillover". Electronic supplementary material is available online at https://dx.doi.org/10.6084/m9.figshare.c.4557260
520 $aABSTRACT. Leptospirosis is a widespread and potentially life-threatening zoonotic disease caused by spirochaetes of the genus Leptospira. Humans become infected primarily via contact with environmental reservoirs contaminated by the urine of shedding mammalian hosts. Populations in high transmission settings, such as urban slums and subsistence farming communities, are exposed to low doses of Leptospira on a daily basis. Under these conditions, numerous factors determine whether infection occurs, including the route of exposure and inoculum dose. Skin wounds and abrasions are risk factors for leptospirosis, but it is not known whether broken skin is necessary for spillover, or if low-dose exposures to intact skin and mucous membranes can also cause infection. To establish a quantitative relationship between dose, route and probability of infection, we performed challenge experiments in hamsters and rats, developed mechanistic dose-response models representing the spatial dynamics of within-host infection and persistence, and fitted models to experimental data. Results show intact skin is a strong barrier against infection, and that broken skin is the predominant route by which low-dose environmental exposures cause infection. These results identify skin integrity as a bottleneck to spillover of Leptospira and underscore the importance of barrier interventions in the prevention of leptospirosis. This article is part of the theme issue 'Dynamic and integrative approaches to understanding pathogen spillover'. © 2019 The Author(s) Published by the Royal Society. All rights reserved.
650 $aLEPTOSPIRA
650 $aLEPTOSPIROSIS
653 $aAnimal model
653 $aDose-response
653 $aEmerging infectious disease
653 $aPLATAFORMA SALUD ANIMAL
653 $aZoonotic spillover
700 1 $aWUNDER, E.A.
700 1 $aBISHT, V.
700 1 $aHAMOND, C.
700 1 $aJULIAN, T.R.
700 1 $aKO, A.I.
700 1 $aLLOYD-SMITH, J.O.
773 $tPhilosophical Transactions of the Royal Society B: Biological Sciences, 30 September 2019, Volume 374, Issue 1782, Article number 2019036. Doi: https://doi.org/10.1098/rstb.2019.0367
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