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Registro completo
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Biblioteca (s) : |
INIA La Estanzuela. |
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Fecha : |
02/03/2017 |
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Actualizado : |
26/02/2019 |
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Autor : |
GAFFNEY PM; BARR, B.; ROWE, J.D.; BETT, C.; DRYGIANNAKIS, I.; GIANNITTI, F.; TREJO, M.; GHASSEMIAN ,M.; MASLIAH, E.; SIGURDSON, C.J. |
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Afiliación : |
FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Protein profiling of isolated uterine AA amyloidosis causing fetal death in goats. |
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Fecha de publicación : |
2015 |
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Fuente / Imprenta : |
The FASEB Journal, 2015, v. 29, n.3, p.911-919. |
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DOI : |
10.1096/fj.14-256081 |
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Idioma : |
Inglés |
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Contenido : |
ABSTRACT Pathologic amyloid accumulates in theCNS or in peripheral organs, yet the mechanism underlying the
targeting of systemic amyloid deposits is unclear. Serum amyloid A (SAA) 1 and 2 are produced predominantly by
the liver and form amyloid most commonly in the spleen, liver, and kidney. In contrast, SAA3 is produced primarily
extrahepatically and has no causal link to amyloid formation. Here, we identified 8 amyloidosis cases with amyloid
composed of SAA3 expanding the uterine wall of goats with near-term fetuses. Uterine amyloid accumulated in
the endometrium, only at the site of placental attachment,compromising maternal-fetal gas and nutrient exchange
and leading to fetal ischemia and death. No other organ contained amyloid. SAA3 mRNA levels in the uterine endometrium
were as high as SAA2 in the liver, yet mass spectrometry of the insoluble uterine peptides identified
SAA3 as the predominant protein, and not SAA1 or SAA2. These findings suggest that high local SAA3 production
led to deposition at this unusual site. Although amyloid A (AA) amyloid deposits typically consist of an N-terminal
fragment of SAA1 or SAA2, here, abundant C-terminal peptides indicated that the uterine amyloid was largely
composed of full-length SAA3. The exclusive deposition of SAA3 amyloid in the uterus, together with elevated
uterine SAA3 transcripts, suggests that the uterine amyloid deposits were due to locally produced SAA3. This is
the first report of SAA3 as a cause of amyloidosis and of AA amyloid deposited exclusively in the uterus. MenosABSTRACT Pathologic amyloid accumulates in theCNS or in peripheral organs, yet the mechanism underlying the
targeting of systemic amyloid deposits is unclear. Serum amyloid A (SAA) 1 and 2 are produced predominantly by
the liver and form amyloid most commonly in the spleen, liver, and kidney. In contrast, SAA3 is produced primarily
extrahepatically and has no causal link to amyloid formation. Here, we identified 8 amyloidosis cases with amyloid
composed of SAA3 expanding the uterine wall of goats with near-term fetuses. Uterine amyloid accumulated in
the endometrium, only at the site of placental attachment,compromising maternal-fetal gas and nutrient exchange
and leading to fetal ischemia and death. No other organ contained amyloid. SAA3 mRNA levels in the uterine endometrium
were as high as SAA2 in the liver, yet mass spectrometry of the insoluble uterine peptides identified
SAA3 as the predominant protein, and not SAA1 or SAA2. These findings suggest that high local SAA3 production
led to deposition at this unusual site. Although amyloid A (AA) amyloid deposits typically consist of an N-terminal
fragment of SAA1 or SAA2, here, abundant C-terminal peptides indicated that the uterine amyloid was largely
composed of full-length SAA3. The exclusive deposition of SAA3 amyloid in the uterus, together with elevated
uterine SAA3 transcripts, suggests that the uterine amyloid deposits were due to locally produced SAA3. This is
the first report of SAA3 as a cause of amyloidosis and... Presentar Todo |
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Palabras claves : |
AMILOIDE; AMYLOID; ESPECTROMETRIA DE MASAS; MAL REPLIEGUE DE PROTEÍNA; MASS SPECTROMETRY; PROTEIN MISFOLDING; SALUD ANIMAL. |
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Thesagro : |
CABRAS. |
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Asunto categoría : |
L73 Enfermedades de los animales |
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Marc : |
LEADER 02476naa a2200337 a 4500
001 1056751
005 2019-02-26
008 2015 bl uuuu u00u1 u #d
024 7 $a10.1096/fj.14-256081$2DOI
100 1 $aGAFFNEY PM
245 $aProtein profiling of isolated uterine AA amyloidosis causing fetal death in goats.$h[electronic resource]
260 $c2015
520 $aABSTRACT Pathologic amyloid accumulates in theCNS or in peripheral organs, yet the mechanism underlying the targeting of systemic amyloid deposits is unclear. Serum amyloid A (SAA) 1 and 2 are produced predominantly by the liver and form amyloid most commonly in the spleen, liver, and kidney. In contrast, SAA3 is produced primarily extrahepatically and has no causal link to amyloid formation. Here, we identified 8 amyloidosis cases with amyloid composed of SAA3 expanding the uterine wall of goats with near-term fetuses. Uterine amyloid accumulated in the endometrium, only at the site of placental attachment,compromising maternal-fetal gas and nutrient exchange and leading to fetal ischemia and death. No other organ contained amyloid. SAA3 mRNA levels in the uterine endometrium were as high as SAA2 in the liver, yet mass spectrometry of the insoluble uterine peptides identified SAA3 as the predominant protein, and not SAA1 or SAA2. These findings suggest that high local SAA3 production led to deposition at this unusual site. Although amyloid A (AA) amyloid deposits typically consist of an N-terminal fragment of SAA1 or SAA2, here, abundant C-terminal peptides indicated that the uterine amyloid was largely composed of full-length SAA3. The exclusive deposition of SAA3 amyloid in the uterus, together with elevated uterine SAA3 transcripts, suggests that the uterine amyloid deposits were due to locally produced SAA3. This is the first report of SAA3 as a cause of amyloidosis and of AA amyloid deposited exclusively in the uterus.
650 $aCABRAS
653 $aAMILOIDE
653 $aAMYLOID
653 $aESPECTROMETRIA DE MASAS
653 $aMAL REPLIEGUE DE PROTEÍNA
653 $aMASS SPECTROMETRY
653 $aPROTEIN MISFOLDING
653 $aSALUD ANIMAL
700 1 $aBARR, B.
700 1 $aROWE, J.D.
700 1 $aBETT, C.
700 1 $aDRYGIANNAKIS, I.
700 1 $aGIANNITTI, F.
700 1 $aTREJO, M.
700 1 $aGHASSEMIAN ,M.
700 1 $aMASLIAH, E.
700 1 $aSIGURDSON, C.J.
773 $tThe FASEB Journal, 2015$gv. 29, n.3, p.911-919.
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Registro original : |
INIA La Estanzuela (LE) |
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| Registros recuperados : 165 | |
| 66. |  | CAFFARENA, D.; SCHILD, C.; RIVERO, R.; CASTRO-RAMOS, M.; GIANNITTI, F.; BANCHERO, G.; RIET-CORREA, F. Paratuberculosis en ovinos de Uruguay. In: SEMINARIO DE LA FUNDACIÓN "CHARLES LUIS DAVIS" EN ARGENTINA ,9ª., 2015. REUNIÓN DEL FORO PERMANENTE DE EDUCACIÓN DE LA PATOLOGÍA VETERINARIA, 7ª., 2015. Salta, AR: Facultad de Ciencias Agrarias y Veterinarias; Universidad Católica de Salta.| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA La Estanzuela. |
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| 67. | | GIANNITTI, F.; DORSCH, M.; SCHILD, C.; CAFFARENA, D.; SVERLOW, K.; ARMIÉN, A. G.; RIET-CORREA, F. Pathologic and immunohistochemical evidence of possible francisellaceae among aborted ovine fetuses, Uruguay. Emerging Infectious Diseases, 2023, volume 29, Issue 1, Pages 141-144. OPEN ACCESS. doi: https://doi.org/10.3201/eid2901.220698 Article history:
Correspondence author: Giannitti, F.; Plataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria, Rte no. 50, Km. no. 11, La Estanzuela, Colonia, Uruguay;...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 70. | | DONCEL, B.; PUENTES, J.D.; CAFFARENA, D.; RIET-CORREA, F.; COSTA, R.A. DA; GIANNITTI, F. Hypomagnesemia in beef cattle.[Hipomagnesemia em bovinos de corte.] Pesquisa Veterinária Brasileira, vol 41:e06826, 2021. Doi:https://doi.org/10.1590/1678-5150-pvb-6826 Article history: Received on December 7, 2020./Accepted for publication on December 21, 2020.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela. |
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| 72. | | CASAUX, ML.; SCHILD, C.; CAFFARENA, D.; GIANNITTI, F.; RIET-CORREA, F.; FRAGA, M. Sensibilidad antimicrobiana de cepas de Salmonella spp. aisladas de terneros de tambos de Uruguay, 2016. In:Reunión Científico Técnica de la Asociación Argentina de Veterinarios de Laboratorios de Diagnóstico ,21º, San Salvador de Jujuy ,Argentina, 6-8 octubre, 2016.| Biblioteca(s): INIA La Estanzuela. |
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| 73. | | SCHILD, C.; CAFFARENA, D.; GIL, A.; SANCHEZ, J.; RIET-CORREA, F.; GIANNITTI, F. A survey of management practices that influence calf welfare and an estimation of the annual calf mortality risk in pastured dairy herds in Uruguay. Journal of Dairy Science, Volume 103, Issue 10, pag. 9418-9429, October 2020. Doi: https://doi.org/10.3168/jds.2020-18177 Article history: Received January 8, 2020/Accepted May 26, 2020. Corresponding authors: cschild@inia.org.uy
and fgiannitti@inia.org.uy.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela. |
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| 74. | | SCHILD, C.; GIANNITTI, F.; COSTA, R.A.; PRELISACO, M.; MEDEIROS, R.; RIET-CORREA, F. Thyroid parafollicular (C) cell hyperplasia and carcinoma in a sheep with enzootic calcinosis due to Nierembergia rivularis (synonymous N.
repens) poisoning in Uruguay. In: American Association of Veterinary Laboratory Diagnosticians (AAVLD), 59º; United States Animal Health Association (USAHA) Annual Meeting, Greensboro, North Carolina, Oct 13-19, 2016.| Biblioteca(s): INIA La Estanzuela. |
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| 75. | | CABRERA, A.; FRESIA, P.; BERNÁ, L.; SILVEIRA, C.S.; MACÍAS-RIOSECO, M.; AREVALO, A.P.; CRISPO, M.; PRITSCH, O.; RIET-CORREA, F.; GIANNITTI, F.; GIANNITTI, F.; FRANCIA, M.E.; ROBELLO, C. Isolation and molecular characterization of four novel Neospora caninum strains. Genetics, Evolution, and Phylogeny - Short Communication. Parasitology Research, 1 December 2019, Volume 118, Issue 12, Pages 3535-3542. Doi: 10.1007/s00436-019-06474-9 Article history: Received: 11 April 2019 / Accepted: 24 September 2019 / Published online: 7 November 2019.
Funding Sponsor: Agencia Nacional de Investigación e Innovación (ANII).
Funding Text: This project was funded by grant...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 76. | | CARVALLO, F.R.; UZAL, F.A.; FLORES, C.; DIAB, S.S.; GIANNITTI, F.; CROSSLEY, B.; WÜNSCHMANN, A. Alimentary necrobacillosis in alpacas. Journal of Veterinary Diagnostic Investigation,2020,Mar;32(2):339-343. Doi: https://doi.org/10.1177/1040638720906409 Article history: Article first published online: February 18, 2020/ Issue published: March 1, 2020.
Corresponding Author: Francisco R. Carvallo, Department of Biomedical Sciences and Pathobiology, Virginia?Maryland College of Veterinary....| Biblioteca(s): INIA La Estanzuela. |
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| 77. | | SCHILD, C.; CAFFARENA, D.; RABAZA, A.; BANCHERO, G.; MAIA, L.A.; DANTAS, A.F.; GIANNITTI, F.; RIET-CORREA, F. Conidiobolomicosis en una oveja (Ovis aries) en el Uruguay. In: SEMINARIO DE LA FUNDACIÓN "CHARLES LUIS DAVIS" EN ARGENTINA ,9ª., 2015. REUNIÓN DEL FORO PERMANENTE DE EDUCACIÓN DE LA PATOLOGÍA VETERINARIA, 7ª., 2015. Salta, AR: Facultad de Ciencias Agrarias y Veterinarias; Universidad Católica de Salta.| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA La Estanzuela. |
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| 78. | | SCHILD, C.; CAFFARENA, D.; RABAZA, A.; BANCHERO, G.; GIANNITTI, F.; DANTAS, A.F.; MAIA, L.A.; RIET-CORREA, F. Conidiobolomicosis nasal en una oveja (Ovis aries) en Uruguay. (Nasal conidiobolomycosis in a sheep (Ovis aries) in Uruguay). Veterinaria (Montevideo), 2016, v. 52 n. 203. p.25-30.| Tipo: Artículos en Revistas Indexadas Nacionales | Circulación / Nivel : B - 5 |
| Biblioteca(s): INIA La Estanzuela. |
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| 79. | | SCHILD, C.; CAFFARENA, D.; RABAZA, A.; BANCHERO, G.; MAIA, L.A.; DANTAS, A.F.; GIANNITTI, F.; RIET-CORREA, F. Conidiobolomicosis nasal en una oveja (Ovis aries) en Uruguay. In: Seminario de la Fundación "Charles Louis Davis" en Argentina, 9. Facultad de Ciencias agrarias y Veterinarias ;Universidad Católica de Salta. Campus Castañares. 2015. Salta, Argentina. Autor en correspondencia: cschild@inia.org.uy| Biblioteca(s): INIA La Estanzuela. |
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| 80. | | MAYA, L.; PUENTES. R.; RIET-CORREA, F.; GIANNITTI, F.; RIVERO, R.; GINNNEECHINI, E.; FURTADO FLORES, E.; COLINA, R. Caracterización genética del virus de la diarrea viral bovina en Uruguay. In: Jornadas Uruguayas de Buiatría, 46., 2018, Paysandú, Uy., Matto, C.; Delpiazzo, R.(Ed.). Trabajos presentados. Paysandú: Centro Médico Veterinario de Paysandú/Sociedad Uruguaya de Buiatría, 2018. p. 183-185.| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA La Estanzuela. |
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| Registros recuperados : 165 | |
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