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| Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
18/12/2017 |
Actualizado : |
15/10/2019 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
LOURENCO, D.A.L.; FRAGOMENI, B.O.; BRADFORD, H.L.; MENEZES I.R.; FERRAZ, J.B.S.; AGUILAR, I.; MISZTAL, I. |
Afiliación : |
D.A.L. LOURENCO, Universidad de Georgia (UG); B.O. FRAGOMENI, Universidad de Georgia (UG); H.L. BRADFORD, Universidad de Georgia (UG); I.R. MENEZES, FZEA, University of Sao Paulo.; J.B.S. FERRAZ, FZEA, University of Sao Paulo.; IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; I. MISZTAL, Universidad de Georgia (UG). |
Título : |
Implications of SNP weighting on single-step genomic predictions for different reference population sizes. |
Fecha de publicación : |
2017 |
Fuente / Imprenta : |
Journal of Animal Breeding and Genetics, 2017, v. 134 (6), p. 463-471. |
DOI : |
10.1111/jbg.12288 |
Idioma : |
Inglés |
Notas : |
Article history: Received: 28 February 2017 / Accepted: 19 July 2017.
This study was partially funded by the American Angus Association (St. Joseph, MO), Zoetis (Kalamazoo, MI) and by Agriculture and Food Research Initiative Competitive Grants no. 2015-67015-22936 from the US Department of Agriculture's National Institute of Food and Agriculture. We gratefully acknowledge the very helpful comments by the two anonymous reviewers, and we thank Andra H. Nelson for assisting with data analysis. |
Contenido : |
ABSTRACT.
We investigated the importance of SNP weighting in populations with 2,000 to 25,000 genotyped animals. Populations were simulated with two effective sizes (20 or 100) and three numbers of QTL (10, 50 or 500). Pedigree information was available for six generations; phenotypes were recorded for the four middle generations. Animals from the last three generations were genotyped for 45,000 SNP. Single-step genomic BLUP (ssGBLUP) and weighted ssGBLUP (WssGBLUP) were used to estimate genomic EBV using a genomic relationship matrix (G). The WssGBLUP performed better in small genotyped populations; however, any advantage for WssGBLUP was reduced or eliminated when more animals were genotyped. WssGBLUP had greater resolution for genome-wide association (GWA) as did increasing the number of genotyped animals. For few QTL, accuracy was greater for WssGBLUP than ssGBLUP; however, for many QTL, accuracy was the same for both methods. The largest genotyped set was used to assess the dimensionality of genomic information (number of effective SNP). The number of effective SNP was considerably less in weighted G than in unweighted G. Once the number of independent SNP is well represented in the genotyped population, the impact of SNP weighting becomes less important.
© 2017 Blackwell Verlag GmbH |
Palabras claves : |
ACCURAY; BAYES B; SNP WEIGHTING; VARIABLE SELECTION; WEIGTED SSGBLUP. |
Asunto categoría : |
-- |
Marc : |
LEADER 02612naa a2200277 a 4500 001 1057902 005 2019-10-15 008 2017 bl uuuu u00u1 u #d 024 7 $a10.1111/jbg.12288$2DOI 100 1 $aLOURENCO, D.A.L. 245 $aImplications of SNP weighting on single-step genomic predictions for different reference population sizes.$h[electronic resource] 260 $c2017 500 $aArticle history: Received: 28 February 2017 / Accepted: 19 July 2017. This study was partially funded by the American Angus Association (St. Joseph, MO), Zoetis (Kalamazoo, MI) and by Agriculture and Food Research Initiative Competitive Grants no. 2015-67015-22936 from the US Department of Agriculture's National Institute of Food and Agriculture. We gratefully acknowledge the very helpful comments by the two anonymous reviewers, and we thank Andra H. Nelson for assisting with data analysis. 520 $aABSTRACT. We investigated the importance of SNP weighting in populations with 2,000 to 25,000 genotyped animals. Populations were simulated with two effective sizes (20 or 100) and three numbers of QTL (10, 50 or 500). Pedigree information was available for six generations; phenotypes were recorded for the four middle generations. Animals from the last three generations were genotyped for 45,000 SNP. Single-step genomic BLUP (ssGBLUP) and weighted ssGBLUP (WssGBLUP) were used to estimate genomic EBV using a genomic relationship matrix (G). The WssGBLUP performed better in small genotyped populations; however, any advantage for WssGBLUP was reduced or eliminated when more animals were genotyped. WssGBLUP had greater resolution for genome-wide association (GWA) as did increasing the number of genotyped animals. For few QTL, accuracy was greater for WssGBLUP than ssGBLUP; however, for many QTL, accuracy was the same for both methods. The largest genotyped set was used to assess the dimensionality of genomic information (number of effective SNP). The number of effective SNP was considerably less in weighted G than in unweighted G. Once the number of independent SNP is well represented in the genotyped population, the impact of SNP weighting becomes less important. © 2017 Blackwell Verlag GmbH 653 $aACCURAY 653 $aBAYES B 653 $aSNP WEIGHTING 653 $aVARIABLE SELECTION 653 $aWEIGTED SSGBLUP 700 1 $aFRAGOMENI, B.O. 700 1 $aBRADFORD, H.L. 700 1 $aMENEZES I.R. 700 1 $aFERRAZ, J.B.S. 700 1 $aAGUILAR, I. 700 1 $aMISZTAL, I. 773 $tJournal of Animal Breeding and Genetics, 2017$gv. 134 (6), p. 463-471.
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INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Tacuarembó. |
Fecha actual : |
21/02/2014 |
Actualizado : |
12/02/2019 |
Tipo de producción científica : |
Documentos |
Autor : |
MEDEROS, A. |
Afiliación : |
AMERICA ESTHER MEDEROS SILVEIRA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Comportamiento reproductivo de un rebaño con brucelosis ovina. |
Fecha de publicación : |
1994 |
Fuente / Imprenta : |
In: INIA TACUAREMBÓ. UNIDAD EXPERIMENTAL GLENCOE. JORNADA, 27 DE OCTUBRE, PAYSANDÚ, 1994. Pasturas y producción animal en basalto. Tacuarembó, Uruguay: INIA, 1994. |
Páginas : |
p. 59-61 |
Serie : |
(INIA Serie Actividades de Difusión ; 37) |
Idioma : |
Español |
Contenido : |
De trabajos realizados en el país y por nosotros en INIA Tacuarembó, se estimó que la enfermedad está afectando a un 10% de los carneros y un 50% de los establecimientos con producción ovina. |
Palabras claves : |
VETERINARY MEDICINE. |
Thesagro : |
BRUCELOSIS; ENFERMEDADES DE LOS ANIMALES; FERTILIDAD; OVINOS; SUELO BASALTICO; URUGUAY. |
Asunto categoría : |
L01 Ganadería |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/9435/1/SAD-37p59-61.pdf
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Marc : |
LEADER 00946naa a2200229 a 4500 001 1025159 005 2019-02-12 008 1994 bl uuuu u00u1 u #d 100 1 $aMEDEROS, A. 245 $aComportamiento reproductivo de un rebaño con brucelosis ovina. 260 $c1994 300 $ap. 59-61 490 $a(INIA Serie Actividades de Difusión ; 37) 520 $aDe trabajos realizados en el país y por nosotros en INIA Tacuarembó, se estimó que la enfermedad está afectando a un 10% de los carneros y un 50% de los establecimientos con producción ovina. 650 $aBRUCELOSIS 650 $aENFERMEDADES DE LOS ANIMALES 650 $aFERTILIDAD 650 $aOVINOS 650 $aSUELO BASALTICO 650 $aURUGUAY 653 $aVETERINARY MEDICINE 773 $tIn: INIA TACUAREMBÓ. UNIDAD EXPERIMENTAL GLENCOE. JORNADA, 27 DE OCTUBRE, PAYSANDÚ, 1994. Pasturas y producción animal en basalto. Tacuarembó, Uruguay: INIA, 1994.
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