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Biblioteca (s) : |
INIA La Estanzuela. |
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Fecha : |
31/05/2022 |
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Actualizado : |
02/12/2022 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
COSTA, M.; SARAVIA, A.; UBIOS, D.; LORES, L.; DA COSTA, V.; FESTARI, M.F.; LANDEIRA, M.; RODRÍGUEZ-ZRAQUIA, S.A.; BANCHERO, G.; FREIRE, T. |
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Afiliación : |
MONIQUE COSTA, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.; ANDERSON SARAVIA DE MELO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; DIEGO UBIOS, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay.; PABLO LORES, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.; VALERIA DA COSTA, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.; MARÍA FLORENCIA FESTARI, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.; MERCEDES LANDEIRA, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay; SANTIAGO A. RODRÍGUEZ-ZRAQUIA, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.; GEORGGET ELIZABETH BANCHERO HUNZIKER, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; TERESA FREIRE, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay. |
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Título : |
Liver function markers and haematological dynamics during acute and chronic phases of experimental Fasciola hepatica infection in cattle treated with triclabendazole. |
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Fecha de publicación : |
2022 |
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Fuente / Imprenta : |
Experimental Parasitology, July 2022, Volume 238, e108285. doi://doi.org/10.1016/j.exppara.2022.108285 |
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ISSN : |
0014-4894 |
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DOI : |
10.1016/j.exppara.2022.108285 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 13 September 2021; Revised 24 May 2022; Accepted 27 May 2022; Available online 30 May 2022; Published July 2022. -- Corresponding author : Freire, T.; Facultad de Medicina, Departamento de Inmunobiología. Gral. Flores 2125, Montevideo, Uruguay; email:tfreire@fmed.edu.uy -- |
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Contenido : |
Abstract:
Fasciola hepatica, a worldwide-distributed liver fluke, is one of the causative agents of fasciolosis, a zoonotic disease that affects livestock and humans. In livestock, fasciolosis causes huge economic losses worldwide, reducing animal fertility, milk production, weight gain and condemnation of livers. In spite of the availability of drugs, such as triclabendazole (TCZ), for the treatment of fasciolosis, they do not necessarily prevent liver damage or parasite reinfection and can eventually increase parasite resistance. The aim of this research was to relate the hepatic function, haematological parameters, leukocyte counts in circulation and parasite egg shedding during F. hepatica acute and chronic phases of infection in cattle as well as to determine how these parameters change with TCZ-treatment of chronically infected cattle. Our results show that increased levels of serum aspartate aminotransferase (AST) and gamma glutamyltransferase (GGT) were detected in early stages of the experimental infection. Moreover, high circulating eosinophil count and plateletcrit levels were correlated with fluke number in livers from infected cattle. On the other hand, although TCZ-treatment in the chronic phase of infection reduced parasite burden and damage in the liver, it was not able to completely avoid them. In conclusion, our work sheds light into the physiopathological mechanisms induced during fluke infection in cattle, revealing the complexity of the host response to the infection, together with the effects of TCZ-treatment in chronically infected animals. © 2022 MenosAbstract:
Fasciola hepatica, a worldwide-distributed liver fluke, is one of the causative agents of fasciolosis, a zoonotic disease that affects livestock and humans. In livestock, fasciolosis causes huge economic losses worldwide, reducing animal fertility, milk production, weight gain and condemnation of livers. In spite of the availability of drugs, such as triclabendazole (TCZ), for the treatment of fasciolosis, they do not necessarily prevent liver damage or parasite reinfection and can eventually increase parasite resistance. The aim of this research was to relate the hepatic function, haematological parameters, leukocyte counts in circulation and parasite egg shedding during F. hepatica acute and chronic phases of infection in cattle as well as to determine how these parameters change with TCZ-treatment of chronically infected cattle. Our results show that increased levels of serum aspartate aminotransferase (AST) and gamma glutamyltransferase (GGT) were detected in early stages of the experimental infection. Moreover, high circulating eosinophil count and plateletcrit levels were correlated with fluke number in livers from infected cattle. On the other hand, although TCZ-treatment in the chronic phase of infection reduced parasite burden and damage in the liver, it was not able to completely avoid them. In conclusion, our work sheds light into the physiopathological mechanisms induced during fluke infection in cattle, revealing the complexity of the host response to ... Presentar Todo |
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Palabras claves : |
Fasciola hepatica; Fasciolosis; Fluke; LIVER; PLATAFORMA DE SALUD ANIMAL; Triclabendazole. |
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Asunto categoría : |
L73 Enfermedades de los animales |
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Marc : |
LEADER 02950naa a2200337 a 4500
001 1063184
005 2022-12-02
008 2022 bl uuuu u00u1 u #d
022 $a0014-4894
024 7 $a10.1016/j.exppara.2022.108285$2DOI
100 1 $aCOSTA, M.
245 $aLiver function markers and haematological dynamics during acute and chronic phases of experimental Fasciola hepatica infection in cattle treated with triclabendazole.$h[electronic resource]
260 $c2022
500 $aArticle history: Received 13 September 2021; Revised 24 May 2022; Accepted 27 May 2022; Available online 30 May 2022; Published July 2022. -- Corresponding author : Freire, T.; Facultad de Medicina, Departamento de Inmunobiología. Gral. Flores 2125, Montevideo, Uruguay; email:tfreire@fmed.edu.uy --
520 $aAbstract: Fasciola hepatica, a worldwide-distributed liver fluke, is one of the causative agents of fasciolosis, a zoonotic disease that affects livestock and humans. In livestock, fasciolosis causes huge economic losses worldwide, reducing animal fertility, milk production, weight gain and condemnation of livers. In spite of the availability of drugs, such as triclabendazole (TCZ), for the treatment of fasciolosis, they do not necessarily prevent liver damage or parasite reinfection and can eventually increase parasite resistance. The aim of this research was to relate the hepatic function, haematological parameters, leukocyte counts in circulation and parasite egg shedding during F. hepatica acute and chronic phases of infection in cattle as well as to determine how these parameters change with TCZ-treatment of chronically infected cattle. Our results show that increased levels of serum aspartate aminotransferase (AST) and gamma glutamyltransferase (GGT) were detected in early stages of the experimental infection. Moreover, high circulating eosinophil count and plateletcrit levels were correlated with fluke number in livers from infected cattle. On the other hand, although TCZ-treatment in the chronic phase of infection reduced parasite burden and damage in the liver, it was not able to completely avoid them. In conclusion, our work sheds light into the physiopathological mechanisms induced during fluke infection in cattle, revealing the complexity of the host response to the infection, together with the effects of TCZ-treatment in chronically infected animals. © 2022
653 $aFasciola hepatica
653 $aFasciolosis
653 $aFluke
653 $aLIVER
653 $aPLATAFORMA DE SALUD ANIMAL
653 $aTriclabendazole
700 1 $aSARAVIA, A.
700 1 $aUBIOS, D.
700 1 $aLORES, L.
700 1 $aDA COSTA, V.
700 1 $aFESTARI, M.F.
700 1 $aLANDEIRA, M.
700 1 $aRODRÍGUEZ-ZRAQUIA, S.A.
700 1 $aBANCHERO, G.
700 1 $aFREIRE, T.
773 $tExperimental Parasitology, July 2022, Volume 238, e108285. doi://doi.org/10.1016/j.exppara.2022.108285
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Registro original : |
INIA La Estanzuela (LE) |
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Registro completo
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Biblioteca (s) : |
INIA Treinta y Tres. |
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Fecha actual : |
03/01/2022 |
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Actualizado : |
10/01/2022 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
Internacional - -- |
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Autor : |
YUAN, S.; LINQUIST, B. A.; WILSON, L. T.; CASSMAN, K. G.; STUART, A. M.; PEDE, V.; SAITO, K.; AGUSTIANI, N.; ARISTYA, V. E.; KRISNADI, L. Y.; ZANON, A.J.; HEINEMANN, A. B.; CARRACELAS, G.; SUBASH, N.; BRAGMANAND, P. S.; LI, T.; PENG, S.; GRASSINI, P. |
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Afiliación : |
SHEN YUAN, National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, MARA Key Laboratory of Crop Ecophysiology and Farming System in the Middle Reaches of the Yangtze River, College of Plant Science and Technology, China.; BRUCE A. LINQUIST, Department of Plant Sciences, University of California-Davis, One Shields Ave., Davis, CA 95616, USA.; LLOYD T. WILSON, Texas A&M AgriLife Research Center, Beaumont, TX 77713, USA.; KENNETH G. CASSMAN, Department of Agronomy and Horticulture, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.; ALEXANDER M. STUART, International Rice Research Institute, DAPO Box 7777 Metro Manila, Philippines.; VALERIEN PEDE, International Rice Research Institute, DAPO Box 7777 Metro Manila, Philippines.; KASUKI SAITO, Africa Rice Center (AfricaRice), 01 B.P. 2551, Bouake 01, Côte d’Ivoire.; NURWULAN AGUSTIANI, Indonesian Center for Rice Research, Sukamandi 41256, Indonesia.; VINA EKA ARISTYA, Assessment Institute of Agricultural Technology (AIAT) Central Java, Ungaran 50552, Indonesia.; LEONARDUS Y. KRISNADI, Assessment Institute of Agricultural Technology (AIAT) East Java, Malang 65152, Indonesia.; ALENCAR JUNIOR ZANON, Universidade Federal de Santa Maria, Avenida Roraima n° 1000, 97105-900 Santa Maria, Rio Grande do Sul, Brazil.; ALEXANDRE BRYAN HEINEMANN, EMBRAPA Arroz e Feijão, Zona Rural GO-462, Santo Antônio de Goiás, Goias 75375-000, Brazil.; JULIO GONZALO CARRACELAS GARRIDO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; NATARAJA SUBASH, ICAR-Indian Institute of Farming Systems Research, Modipuram 250110 Uttar Pradesh, India.; POTHULA S. BRAHMANAND, ICAR-Indian Institute of Water Management, Bhubaneswar 751023 Odisha, India.; TAO LI, Applied GeoSolutions, DNDC Applications Research and Training, Durham, NH 03824, USA; 5APPLIED GEOSOLUTIONS, DNDC APPLICATIONS RESEARCH AND TRAINING, DURHAM, NH 03824, USA, Huazhong Agriculture University (HZAU), China.; PATRICIO GRASSINI, University of Nebraska - Lincoln. |
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Título : |
Sustainable intensification for a larger global rice bowl. |
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Fecha de publicación : |
2021 |
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Fuente / Imprenta : |
Nature Communications, December 2021, Article number 7163. OPEN ACCESS. doi: https://doi.org/10.1038/s41467-021-27424-z |
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Páginas : |
11 p. |
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DOI : |
10.1038/s41467-021-27424-z |
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Idioma : |
Inglés |
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Notas : |
Article history: Received: 7 April 2021; Accepted: 17 November 2021; Published online 09 December 2021.
Correspondence author: pgrassini2@unl.edu; speng@mail.hzau.edu.cn |
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Contenido : |
Future rice systems must produce more grain while minimizing the negative environmental impacts. A key question is how to orient agricultural research & development (R&D) programs at national to global scales to maximize the return on investment. Here we assess yield gap and resource-use efficiency (including water, pesticides, nitrogen, labor, energy, and associated global warming potential) across 32 rice cropping systems covering half of global rice harvested area. We show that achieving high yields and high resource-use efficiencies are not conflicting goals. Most cropping systems have room for increasing yield, resource-use efficiency, or both. In aggregate, current total rice production could be increased by 32%, and excess nitrogen almost eliminated, by focusing on a relatively small number of cropping systems with either large yield gaps or poor resource-use efficiencies. This study provides essential strategic insight on yield gap and resource-use efficiency for prioritizing national
and global agricultural R&D investments to ensure adequate rice supply while minimizing negative environmental impact in coming decades. |
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Palabras claves : |
ARROZ; INTENSIFICACIÓN DE LA AGRICULTURA; INTENSIFICACIÓN SOSTENIBLE; RICE. |
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Asunto categoría : |
A50 Investigación agraria |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/16177/1/Nature-Communications-Yuan-.pdf
https://www.nature.com/articles/s41467-021-27424-z
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Marc : |
LEADER 02454naa a2200409 a 4500
001 1062624
005 2022-01-10
008 2021 bl uuuu u00u1 u #d
024 7 $a10.1038/s41467-021-27424-z$2DOI
100 1 $aYUAN, S.
245 $aSustainable intensification for a larger global rice bowl.$h[electronic resource]
260 $c2021
300 $a11 p.
500 $aArticle history: Received: 7 April 2021; Accepted: 17 November 2021; Published online 09 December 2021. Correspondence author: pgrassini2@unl.edu; speng@mail.hzau.edu.cn
520 $aFuture rice systems must produce more grain while minimizing the negative environmental impacts. A key question is how to orient agricultural research & development (R&D) programs at national to global scales to maximize the return on investment. Here we assess yield gap and resource-use efficiency (including water, pesticides, nitrogen, labor, energy, and associated global warming potential) across 32 rice cropping systems covering half of global rice harvested area. We show that achieving high yields and high resource-use efficiencies are not conflicting goals. Most cropping systems have room for increasing yield, resource-use efficiency, or both. In aggregate, current total rice production could be increased by 32%, and excess nitrogen almost eliminated, by focusing on a relatively small number of cropping systems with either large yield gaps or poor resource-use efficiencies. This study provides essential strategic insight on yield gap and resource-use efficiency for prioritizing national and global agricultural R&D investments to ensure adequate rice supply while minimizing negative environmental impact in coming decades.
653 $aARROZ
653 $aINTENSIFICACIÓN DE LA AGRICULTURA
653 $aINTENSIFICACIÓN SOSTENIBLE
653 $aRICE
700 1 $aLINQUIST, B. A.
700 1 $aWILSON, L. T.
700 1 $aCASSMAN, K. G.
700 1 $aSTUART, A. M.
700 1 $aPEDE, V.
700 1 $aSAITO, K.
700 1 $aAGUSTIANI, N.
700 1 $aARISTYA, V. E.
700 1 $aKRISNADI, L. Y.
700 1 $aZANON, A.J.
700 1 $aHEINEMANN, A. B.
700 1 $aCARRACELAS, G.
700 1 $aSUBASH, N.
700 1 $aBRAGMANAND, P. S.
700 1 $aLI, T.
700 1 $aPENG, S.
700 1 $aGRASSINI, P.
773 $tNature Communications, December 2021, Article number 7163. OPEN ACCESS. doi: https://doi.org/10.1038/s41467-021-27424-z
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