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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
24/10/2014 |
Actualizado : |
15/10/2019 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
ANAND-IVELL, R.; HIENDLEDER, S.; VIÑOLES, C.; MARTIN, G.B.; FITZSIMMONS, C.; EURICH, A.; HAFEN, B.; IVELL, R. |
Afiliación : |
RAVINDER ANAND-IVELL; STEFAN HIENDLEDER; CAROLINA VIÑOLES GIL, Instituto Nacional de Investigación Agropecuaria (INIA), Uruguay; GRAEME B. MARTIN; CAROLYN FITZSIMMONS; ANDREA EURICH; BETTINA HAFEN; RICHARD IVELL. |
Título : |
INSL3 in the ruminant: A powerful indicator of gender- and genetic-specific feto-maternal dialogue. |
Fecha de publicación : |
2014 |
Fuente / Imprenta : |
Plos ONE, 2014, v. 6, no.5, p. e19821. |
ISSN : |
1932-6203 |
DOI : |
10.1371/journal.pone.0019821 |
Idioma : |
Inglés |
Notas : |
Article history: Received December 20, 2010 / Accepted April 17, 2011 / Published May 16, 2011. |
Contenido : |
ABSTRACT,.
The hormone Insulin-like peptide 3 (INSL3) is a major secretory product of the Leydig cells from both fetal and adult testes. Consequently, it is a major gender-specific circulating hormone in the male fetus, where it is responsible for the first phase of testicular descent, and in the adult male. In most female mammals, circulating levels are very low, corresponding to only a small production of INSL3 by the mature ovaries. Female ruminants are exceptional in exhibiting high INSL3 gene expression by the thecal cells of antral follicles and by the corpora lutea. We have developed a specific and sensitive immunoassay to measure ruminant INSL3 and show that, corresponding to the high ovarian gene expression, non-pregnant adult female sheep and cows have up to four times the levels observed in other female mammals. Significantly, this level declines during mid-pregnancy in cows carrying a female fetus, in which INSL3 is undetectable. However, in cows carrying a male fetus, circulating maternal INSL3 becomes elevated further, presumably due to the transplacental transfer of fetal INSL3 into the maternal circulation. Within male fetal blood, INSL3 is high in mid-pregnancy (day 153) corresponding to the first transabdominal phase of testicular descent, and shows a marked dependence on paternal genetics, with pure bred or hybrid male fetuses of Bos taurus (Angus) paternal genome having 30% higher INSL3 levels than those of Bos indicus (Brahman) paternity. Thus INSL3 provides the first example of a gender-specific fetal hormone with the potential to influence both placental and maternal physiology.
© 2011 Anand-Ivell et al. MenosABSTRACT,.
The hormone Insulin-like peptide 3 (INSL3) is a major secretory product of the Leydig cells from both fetal and adult testes. Consequently, it is a major gender-specific circulating hormone in the male fetus, where it is responsible for the first phase of testicular descent, and in the adult male. In most female mammals, circulating levels are very low, corresponding to only a small production of INSL3 by the mature ovaries. Female ruminants are exceptional in exhibiting high INSL3 gene expression by the thecal cells of antral follicles and by the corpora lutea. We have developed a specific and sensitive immunoassay to measure ruminant INSL3 and show that, corresponding to the high ovarian gene expression, non-pregnant adult female sheep and cows have up to four times the levels observed in other female mammals. Significantly, this level declines during mid-pregnancy in cows carrying a female fetus, in which INSL3 is undetectable. However, in cows carrying a male fetus, circulating maternal INSL3 becomes elevated further, presumably due to the transplacental transfer of fetal INSL3 into the maternal circulation. Within male fetal blood, INSL3 is high in mid-pregnancy (day 153) corresponding to the first transabdominal phase of testicular descent, and shows a marked dependence on paternal genetics, with pure bred or hybrid male fetuses of Bos taurus (Angus) paternal genome having 30% higher INSL3 levels than those of Bos indicus (Brahman) paternity. Thus INSL3 pro... Presentar Todo |
Thesagro : |
MEJORAMIENTO GENÉTICO ANIMAL; RUMIANTES. |
Asunto categoría : |
L10 Genética y mejoramiento animal |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/3644/1/Vinoles-C.-20121.-PLOS-One-v.65.pdf
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0019821
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Marc : |
LEADER 02502naa a2200265 a 4500 001 1051295 005 2019-10-15 008 2014 bl uuuu u00u1 u #d 022 $a1932-6203 024 7 $a10.1371/journal.pone.0019821$2DOI 100 1 $aANAND-IVELL, R. 245 $aINSL3 in the ruminant$bA powerful indicator of gender- and genetic-specific feto-maternal dialogue.$h[electronic resource] 260 $c2014 500 $aArticle history: Received December 20, 2010 / Accepted April 17, 2011 / Published May 16, 2011. 520 $aABSTRACT,. The hormone Insulin-like peptide 3 (INSL3) is a major secretory product of the Leydig cells from both fetal and adult testes. Consequently, it is a major gender-specific circulating hormone in the male fetus, where it is responsible for the first phase of testicular descent, and in the adult male. In most female mammals, circulating levels are very low, corresponding to only a small production of INSL3 by the mature ovaries. Female ruminants are exceptional in exhibiting high INSL3 gene expression by the thecal cells of antral follicles and by the corpora lutea. We have developed a specific and sensitive immunoassay to measure ruminant INSL3 and show that, corresponding to the high ovarian gene expression, non-pregnant adult female sheep and cows have up to four times the levels observed in other female mammals. Significantly, this level declines during mid-pregnancy in cows carrying a female fetus, in which INSL3 is undetectable. However, in cows carrying a male fetus, circulating maternal INSL3 becomes elevated further, presumably due to the transplacental transfer of fetal INSL3 into the maternal circulation. Within male fetal blood, INSL3 is high in mid-pregnancy (day 153) corresponding to the first transabdominal phase of testicular descent, and shows a marked dependence on paternal genetics, with pure bred or hybrid male fetuses of Bos taurus (Angus) paternal genome having 30% higher INSL3 levels than those of Bos indicus (Brahman) paternity. Thus INSL3 provides the first example of a gender-specific fetal hormone with the potential to influence both placental and maternal physiology. © 2011 Anand-Ivell et al. 650 $aMEJORAMIENTO GENÉTICO ANIMAL 650 $aRUMIANTES 700 1 $aHIENDLEDER, S. 700 1 $aVIÑOLES, C. 700 1 $aMARTIN, G.B. 700 1 $aFITZSIMMONS, C. 700 1 $aEURICH, A. 700 1 $aHAFEN, B. 700 1 $aIVELL, R. 773 $tPlos ONE, 2014$gv. 6, no.5, p. e19821.
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INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Tacuarembó. |
Fecha actual : |
21/02/2014 |
Actualizado : |
11/05/2015 |
Tipo de producción científica : |
Artículos en Revistas Agropecuarias |
Autor : |
JAURENA, M.; OLMOS, F.; BEMHAJA, M.; BERRETTA, E.; LEZAMA, F.; PEREZ GOMAR, E.; ZERBINO, M.; CONDON, F.; BLUMETTO, O.; CASTAÑO, J.; ROCANOVA, M. |
Afiliación : |
MARTIN ALEJANDRO JAURENA BARRIOS, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FERNANDO ELCEAR OLMOS LOPEZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARIA DE LURDES BEMHAJA SARAIVA FERREIRA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ELBIO JOAQUIN BERRETTA CARVALLO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FELIPE LEZAMA HUERTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ENRIQUE PEREZ GOMAR CAPURRO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARIA STELLA ZERBINO BARDIER, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FEDERICO CONDON PRIANO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; OSCAR RICARDO BLUMETTO VELAZCO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JOSE PEDRO CASTAÑO SANCHEZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MAGDALENA ROCANOVA RODRIGUEZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Campo natural en Uruguay: biodiversidad y manejo para la sustentabilidad. |
Fecha de publicación : |
2008 |
Fuente / Imprenta : |
Suplemento Tecnológico INIA, 2008, p. 42-43. |
Idioma : |
Español |
Notas : |
Suplemento tecnológico Expo Prado 2008. |
Thesagro : |
BIODIVERSIDAD; CAMPO NATURAL; RECURSOS NATURALES; SUSTENTABILIDAD; URUGUAY. |
Asunto categoría : |
-- |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/4445/1/inia-2008-suplemento-tecnologico.pdf
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Marc : |
LEADER 00815naa a2200301 a 4500 001 1028145 005 2015-05-11 008 2008 bl uuuu u00u1 u #d 100 1 $aJAURENA, M. 245 $aCampo natural en Uruguay$bbiodiversidad y manejo para la sustentabilidad. 260 $c2008 500 $aSuplemento tecnológico Expo Prado 2008. 650 $aBIODIVERSIDAD 650 $aCAMPO NATURAL 650 $aRECURSOS NATURALES 650 $aSUSTENTABILIDAD 650 $aURUGUAY 700 1 $aOLMOS, F. 700 1 $aBEMHAJA, M. 700 1 $aBERRETTA, E. 700 1 $aLEZAMA, F. 700 1 $aPEREZ GOMAR, E. 700 1 $aZERBINO, M. 700 1 $aCONDON, F. 700 1 $aBLUMETTO, O. 700 1 $aCASTAÑO, J. 700 1 $aROCANOVA, M. 773 $tSuplemento Tecnológico INIA, 2008, p. 42-43.
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INIA Tacuarembó (TBO) |
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