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| Acceso al texto completo restringido a Biblioteca INIA Tacuarembó. Por información adicional contacte bibliotb@tb.inia.org.uy. |
Registro completo
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Biblioteca (s) : |
INIA Tacuarembó. |
Fecha : |
23/10/2020 |
Actualizado : |
23/10/2020 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
MACHADO, M.; DE MACÊDO PESSOA, C.R.; PESSOA, A. F. A.; SOUZA MENDES, R. DE; MEDEIROS, R. M. T. DE; DANTAS, A. F. M.; CASTRO, M. B. DE; RIET-CORREA, F. |
Afiliación : |
MIZAEL MACHADO DA COSTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CLARICE RICARDO DE MACÊDO PESSOA, Universidade Federal de Sergipe (UFS), Campus do Sertão, Nossa Senhora da Glória, SE, Brazil; ANDRÉ FLÁVIO ALMEIDA PESSOA, Universidade Federal de Sergipe (UFS), Campus do Sertão, Nossa Senhora da Glória, SE, Brazil; RODRIGO DE SOUZA MENDES, Escola de Saúde, Universidade Potiguar (UnP), Natal, RN, Brazil. 4 Centro de Saúde e Tecnologia Rural (CSTR), Universidade Federal de Campina Grande (UFCG), Patos, PB, Brazil; ANTÔNIO FLÁVIO MEDEIROS DANTAS, Centro de Saúde e Tecnologia Rural (CSTR), Universidade Federal de Campina Grande (UFCG), Patos, PB, Brazil; ANTÔNIO FLÁVIO MEDEIROS DANTAS, Centro de Saúde e Tecnologia Rural (CSTR), Universidade Federal de Campina Grande (UFCG), Patos, PB, Brazil; MÁRCIO BOTELHO DE CASTRO, Laboratório de Patologia Veterinária, H.V., Universidade de Brasília (UnB), Brasília, DF, Brazil; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
South American rattlesnake (Crotalus durissus spp.) envenomation in dogs in the semiarid region of Brazil. |
Fecha de publicación : |
2020 |
Fuente / Imprenta : |
Acta Scientiae Veterinariae, 2020, Volume 48, Article number 521. DOI: https://doi.org/10.22456/1679-9216.104578 |
DOI : |
10.22456/1679-9216.104578 |
Idioma : |
Inglés |
Notas : |
Article history: Received: 29 March 2020 Accepted: 17 June 2020 Published: 19 July 2020. Acknowledgments: Thanks are due to Dr. José María Gutiérrez (University of Costa Rica) for the critical reading of the manuscript and suggestions. |
Contenido : |
ABSTRACT: Background: South American rattlesnake (Crotalus durissus spp.) envenomation is rarely reported in small animals and livestock in Brazil. Minor swelling at the snakebite site, skeletal muscle, and renal damage, and severe neurological signs characterize the crotalic envenomation. This case report aims to present epidemiological, clinical, and pathological data of two cases of Crotalus durissus spp envenomation in dogs in the Northeast of Brazil. Cases: Envenomation by Crotalus durissus spp. was recorded in two dogs in Patos, State of Paraíba, Brazil. In Case 1, the dog presented flaccid paralysis, hyporeflexia, a deficit of cranial nerves, epistaxis, and gingival hemorrhages. Laboratory assay showed proteinuria, myoglobinuria, regenerative thrombocytopenia, and increased serum activities of creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). The dog was medicated with crotalic antivenom and wholly recovered from local and systemic clinical signs. In Case 2, the dog died and was detected fang marks at the ventral region of the left mandible (two small parallel perforations spaced 2.0 cm apart) at the snakebite site. Cyanosis of the oral cavity, congestion, and hemorrhages in several organs were observed at necropsy. Tubular nephrosis, muscular necrosis, hepatocytes swelling were observed. The owners witnessed snakebites, and the rattlesnakes (Crotalus durissus spp.) identified by the rattle at the end portion of the tail in both cases. Discussion: Natural South American rattlesnake envenomation presents complex clinical signs that makes diagnosis a challenge for veterinary practitioners. The criteria for the correct diagnosis and observed in the two dogs include witness of the snakebite, identification of the snake, detection of fang marks, clinical-pathological findings, and therapeutic response to treatment with specific anti-venom. The dog’s owners did not identify the subspecies of rattlesnakes; however, Crotalus durissus cascavella and Crotalus durissus collilineatus are the only species found in the Northeast region of Brazil. Crotoxin is the primary toxic component of South American rattlesnake, which induces neuromuscular blockage, and neurological signs (skeletal muscle flaccid paralysis, apathy, hyporeflexia, cranial nerve deficits). These clinical signs are similar to those observed in the two dogs. Respiratory distress, cyanosis, pulmonary edema, and hemorrhage are secondary to respiratory muscle paralysis and also detected in a dog (Case 2) with crotalic envenomation. Minor local swelling at the snakebite site, myotoxicity observed in both dogs (high serum activities of CK and AST - Case 1), degeneration
and necrosis of muscle fibers - Case 2), and fang marks observed in Case 2, strengthen the diagnosis of Crotalus durissus envenomation. Nephrotoxicity was also detected in both dogs (increased specific gravity of urine - Case 1 and myoglobin deposition and degeneration of renal epithelial tubular cells - Case 2). Coagulative disorders and hepatotoxicity are infrequently in domestic animals and humans with crotalic envenomation. High serum activities of ALP and ALT in Case 1, and swelling of hepatocytes in Case 2, suggest liver damage associated with the crotalic envenomation. The differential diagnosis of South American rattlesnake envenomation should be included in dogs with acute neuromuscular flaccid
paralysis, associated or not with bleeding disorders, myoglobinuria, and acute kidney injury. MenosABSTRACT: Background: South American rattlesnake (Crotalus durissus spp.) envenomation is rarely reported in small animals and livestock in Brazil. Minor swelling at the snakebite site, skeletal muscle, and renal damage, and severe neurological signs characterize the crotalic envenomation. This case report aims to present epidemiological, clinical, and pathological data of two cases of Crotalus durissus spp envenomation in dogs in the Northeast of Brazil. Cases: Envenomation by Crotalus durissus spp. was recorded in two dogs in Patos, State of Paraíba, Brazil. In Case 1, the dog presented flaccid paralysis, hyporeflexia, a deficit of cranial nerves, epistaxis, and gingival hemorrhages. Laboratory assay showed proteinuria, myoglobinuria, regenerative thrombocytopenia, and increased serum activities of creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). The dog was medicated with crotalic antivenom and wholly recovered from local and systemic clinical signs. In Case 2, the dog died and was detected fang marks at the ventral region of the left mandible (two small parallel perforations spaced 2.0 cm apart) at the snakebite site. Cyanosis of the oral cavity, congestion, and hemorrhages in several organs were observed at necropsy. Tubular nephrosis, muscular necrosis, hepatocytes swelling were observed. The owners witnessed snakebites, and the rattlesnakes (Crotalus durissus spp.) identified by the rattle at the e... Presentar Todo |
Palabras claves : |
CROTALIC ENVENOMATION; CROTALUS DURISSUS SPP; DOG; SNAKEBITE; TOXIC MYOPATHY. |
Asunto categoría : |
L70 Ciencias veterinarias e higiene - Aspectos generales |
Marc : |
LEADER 04714naa a2200289 a 4500 001 1061423 005 2020-10-23 008 2020 bl uuuu u00u1 u #d 024 7 $a10.22456/1679-9216.104578$2DOI 100 1 $aMACHADO, M. 245 $aSouth American rattlesnake (Crotalus durissus spp.) envenomation in dogs in the semiarid region of Brazil.$h[electronic resource] 260 $c2020 500 $aArticle history: Received: 29 March 2020 Accepted: 17 June 2020 Published: 19 July 2020. Acknowledgments: Thanks are due to Dr. José María Gutiérrez (University of Costa Rica) for the critical reading of the manuscript and suggestions. 520 $aABSTRACT: Background: South American rattlesnake (Crotalus durissus spp.) envenomation is rarely reported in small animals and livestock in Brazil. Minor swelling at the snakebite site, skeletal muscle, and renal damage, and severe neurological signs characterize the crotalic envenomation. This case report aims to present epidemiological, clinical, and pathological data of two cases of Crotalus durissus spp envenomation in dogs in the Northeast of Brazil. Cases: Envenomation by Crotalus durissus spp. was recorded in two dogs in Patos, State of Paraíba, Brazil. In Case 1, the dog presented flaccid paralysis, hyporeflexia, a deficit of cranial nerves, epistaxis, and gingival hemorrhages. Laboratory assay showed proteinuria, myoglobinuria, regenerative thrombocytopenia, and increased serum activities of creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). The dog was medicated with crotalic antivenom and wholly recovered from local and systemic clinical signs. In Case 2, the dog died and was detected fang marks at the ventral region of the left mandible (two small parallel perforations spaced 2.0 cm apart) at the snakebite site. Cyanosis of the oral cavity, congestion, and hemorrhages in several organs were observed at necropsy. Tubular nephrosis, muscular necrosis, hepatocytes swelling were observed. The owners witnessed snakebites, and the rattlesnakes (Crotalus durissus spp.) identified by the rattle at the end portion of the tail in both cases. Discussion: Natural South American rattlesnake envenomation presents complex clinical signs that makes diagnosis a challenge for veterinary practitioners. The criteria for the correct diagnosis and observed in the two dogs include witness of the snakebite, identification of the snake, detection of fang marks, clinical-pathological findings, and therapeutic response to treatment with specific anti-venom. The dog’s owners did not identify the subspecies of rattlesnakes; however, Crotalus durissus cascavella and Crotalus durissus collilineatus are the only species found in the Northeast region of Brazil. Crotoxin is the primary toxic component of South American rattlesnake, which induces neuromuscular blockage, and neurological signs (skeletal muscle flaccid paralysis, apathy, hyporeflexia, cranial nerve deficits). These clinical signs are similar to those observed in the two dogs. Respiratory distress, cyanosis, pulmonary edema, and hemorrhage are secondary to respiratory muscle paralysis and also detected in a dog (Case 2) with crotalic envenomation. Minor local swelling at the snakebite site, myotoxicity observed in both dogs (high serum activities of CK and AST - Case 1), degeneration and necrosis of muscle fibers - Case 2), and fang marks observed in Case 2, strengthen the diagnosis of Crotalus durissus envenomation. Nephrotoxicity was also detected in both dogs (increased specific gravity of urine - Case 1 and myoglobin deposition and degeneration of renal epithelial tubular cells - Case 2). Coagulative disorders and hepatotoxicity are infrequently in domestic animals and humans with crotalic envenomation. High serum activities of ALP and ALT in Case 1, and swelling of hepatocytes in Case 2, suggest liver damage associated with the crotalic envenomation. The differential diagnosis of South American rattlesnake envenomation should be included in dogs with acute neuromuscular flaccid paralysis, associated or not with bleeding disorders, myoglobinuria, and acute kidney injury. 653 $aCROTALIC ENVENOMATION 653 $aCROTALUS DURISSUS SPP 653 $aDOG 653 $aSNAKEBITE 653 $aTOXIC MYOPATHY 700 1 $aDE MACÊDO PESSOA, C.R. 700 1 $aPESSOA, A. F. A. 700 1 $aSOUZA MENDES, R. DE 700 1 $aMEDEIROS, R. M. T. DE 700 1 $aDANTAS, A. F. M. 700 1 $aCASTRO, M. B. DE 700 1 $aRIET-CORREA, F. 773 $tActa Scientiae Veterinariae, 2020, Volume 48, Article number 521. DOI: https://doi.org/10.22456/1679-9216.104578
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INIA Tacuarembó (TBO) |
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| Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha actual : |
26/09/2014 |
Actualizado : |
23/10/2019 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Circulación / Nivel : |
A - 1 |
Autor : |
RETTA, D.; DELLACASSA, E.; VILLAMIL, J.; SUÁREZ, S.A.; BANDONI, A.L. |
Afiliación : |
JOSE MILTON VILLAMIL LUCAS, Instituto Nacional de Investigación Agropecuaria (INIA), Uruguay. |
Título : |
Marcela, a promising medicinal and aromatic plant from Latin America: A review. |
Fecha de publicación : |
2012 |
Fuente / Imprenta : |
Industrial Crops and Products, 2012, v. 38, no.1, p.27-38. |
ISSN : |
0926-6690 |
DOI : |
10.1016/j.indcrop.2012.01.006 |
Idioma : |
Inglés |
Notas : |
Article history: Received 28 August 2011 / Received in revised form 26 December 2011 / Accepted 10 January 2012. |
Contenido : |
ABSTRACT.
Medicinal plants and their extracts are natural resources of compounds used for treatments in ethnomedicine and phytotherapy. They are also a source of natural products used in the development of new related compounds and drugs for conventional medicine. The increasing interest in use of herbal medicines requires a comprehensive assessment of research data in this field to help focus future efforts. Here we review the increasingly important role of Achyrocline satureioides (Lam.) DC (Asteraceae), marcela, which is used extensively in popular medicine. Like most medicinal plants, however, A. satureioides is generally not cultivated and most plants used commercially are harvested from ecologically and edaphically diverse natural habitats. We provide information on the current status of this promising medicinal and aromatic plant, and an overall view of its potential for production of material with more desirable physicochemical and phytochemical properties.
© 2012 Elsevier B.V. |
Thesagro : |
MARCELA; MEDICINALES. |
Asunto categoría : |
F40 Ecología vegetal |
Marc : |
LEADER 01761naa a2200229 a 4500 001 1050610 005 2019-10-23 008 2012 bl uuuu u00u1 u #d 022 $a0926-6690 024 7 $a10.1016/j.indcrop.2012.01.006$2DOI 100 1 $aRETTA, D. 245 $aMarcela, a promising medicinal and aromatic plant from Latin America$bA review.$h[electronic resource] 260 $c2012 500 $aArticle history: Received 28 August 2011 / Received in revised form 26 December 2011 / Accepted 10 January 2012. 520 $aABSTRACT. Medicinal plants and their extracts are natural resources of compounds used for treatments in ethnomedicine and phytotherapy. They are also a source of natural products used in the development of new related compounds and drugs for conventional medicine. The increasing interest in use of herbal medicines requires a comprehensive assessment of research data in this field to help focus future efforts. Here we review the increasingly important role of Achyrocline satureioides (Lam.) DC (Asteraceae), marcela, which is used extensively in popular medicine. Like most medicinal plants, however, A. satureioides is generally not cultivated and most plants used commercially are harvested from ecologically and edaphically diverse natural habitats. We provide information on the current status of this promising medicinal and aromatic plant, and an overall view of its potential for production of material with more desirable physicochemical and phytochemical properties. © 2012 Elsevier B.V. 650 $aMARCELA 650 $aMEDICINALES 700 1 $aDELLACASSA, E. 700 1 $aVILLAMIL, J. 700 1 $aSUÁREZ, S.A. 700 1 $aBANDONI, A.L. 773 $tIndustrial Crops and Products, 2012$gv. 38, no.1, p.27-38.
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