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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
30/01/2020 |
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Actualizado : |
10/02/2020 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
GOSTIC, K.M.; WUNDER, E.A.; BISHT, V.; HAMOND, C.; JULIAN, T.R.; KO, A.I.; LLOYD-SMITH, J.O. |
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Afiliación : |
KATELYN M. GOSTIC, Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, United States; ELSIO A. WUNDER, Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, United States; Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Bahia, Brazil; VIMLA BISHT, Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, United States; CAMILA HAMOND, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, United States; TIMOTHY R. JULIAN, Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, Switzerland; Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland; ALBERT I. KO, Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, United States; Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Bahia, Brazil; JAMES O. LLOYD-SMITH, Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, United States; Fogarty International Center, National Institutes of Health, Bethesda, MD, United States. |
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Título : |
Mechanistic dose-response modelling of animal challenge data shows that intact skin is a crucial barrier to leptospiral infection. |
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Fecha de publicación : |
2019 |
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Fuente / Imprenta : |
Philosophical Transactions of the Royal Society B: Biological Sciences, 30 September 2019, Volume 374, Issue 1782, Article number 2019036. Doi: https://doi.org/10.1098/rstb.2019.0367 |
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ISSN : |
0962-8436 |
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DOI : |
10.1098/rstb.2019.0367 |
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Idioma : |
Inglés |
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Notas : |
Article history: Accepted: 2 April 2019 / Published:12 August 2019.
This article is part of the theme issue "Dynamic and integrative approaches to understanding pathogen spillover".
Electronic supplementary material is available online at https://dx.doi.org/10.6084/m9.figshare.c.4557260 |
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Contenido : |
ABSTRACT.
Leptospirosis is a widespread and potentially life-threatening zoonotic disease caused by spirochaetes of the genus Leptospira. Humans become infected primarily via contact with environmental reservoirs contaminated by the urine of shedding mammalian hosts. Populations in high transmission settings, such as urban slums and subsistence farming communities, are exposed to low doses of Leptospira on a daily basis. Under these conditions, numerous factors determine whether infection occurs, including the route of exposure and inoculum dose. Skin wounds and abrasions are risk factors for leptospirosis, but it is not known whether broken skin is necessary for spillover, or if low-dose exposures to intact skin and mucous membranes can also cause infection. To establish a quantitative relationship between dose, route and probability of infection, we performed challenge experiments in hamsters and rats, developed mechanistic dose-response models representing the spatial dynamics of within-host infection and persistence, and fitted models to experimental data. Results show intact skin is a strong barrier against infection, and that broken skin is the predominant route by which low-dose environmental exposures cause infection. These results identify skin integrity as a bottleneck to spillover of Leptospira and underscore the importance of barrier interventions in the prevention of leptospirosis. This article is part of the theme issue 'Dynamic and integrative approaches to understanding pathogen spillover'. © 2019 The Author(s) Published by the Royal Society. All rights reserved. MenosABSTRACT.
Leptospirosis is a widespread and potentially life-threatening zoonotic disease caused by spirochaetes of the genus Leptospira. Humans become infected primarily via contact with environmental reservoirs contaminated by the urine of shedding mammalian hosts. Populations in high transmission settings, such as urban slums and subsistence farming communities, are exposed to low doses of Leptospira on a daily basis. Under these conditions, numerous factors determine whether infection occurs, including the route of exposure and inoculum dose. Skin wounds and abrasions are risk factors for leptospirosis, but it is not known whether broken skin is necessary for spillover, or if low-dose exposures to intact skin and mucous membranes can also cause infection. To establish a quantitative relationship between dose, route and probability of infection, we performed challenge experiments in hamsters and rats, developed mechanistic dose-response models representing the spatial dynamics of within-host infection and persistence, and fitted models to experimental data. Results show intact skin is a strong barrier against infection, and that broken skin is the predominant route by which low-dose environmental exposures cause infection. These results identify skin integrity as a bottleneck to spillover of Leptospira and underscore the importance of barrier interventions in the prevention of leptospirosis. This article is part of the theme issue 'Dynamic and integrative approaches to u... Presentar Todo |
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Palabras claves : |
Animal model; Dose-response; Emerging infectious disease; PLATAFORMA SALUD ANIMAL; Zoonotic spillover. |
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Thesagro : |
LEPTOSPIRA; LEPTOSPIROSIS. |
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Asunto categoría : |
L73 Enfermedades de los animales |
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Marc : |
LEADER 02944naa a2200313 a 4500
001 1060727
005 2020-02-10
008 2019 bl uuuu u00u1 u #d
022 $a0962-8436
024 7 $a10.1098/rstb.2019.0367$2DOI
100 1 $aGOSTIC, K.M.
245 $aMechanistic dose-response modelling of animal challenge data shows that intact skin is a crucial barrier to leptospiral infection.$h[electronic resource]
260 $c2019
500 $aArticle history: Accepted: 2 April 2019 / Published:12 August 2019. This article is part of the theme issue "Dynamic and integrative approaches to understanding pathogen spillover". Electronic supplementary material is available online at https://dx.doi.org/10.6084/m9.figshare.c.4557260
520 $aABSTRACT. Leptospirosis is a widespread and potentially life-threatening zoonotic disease caused by spirochaetes of the genus Leptospira. Humans become infected primarily via contact with environmental reservoirs contaminated by the urine of shedding mammalian hosts. Populations in high transmission settings, such as urban slums and subsistence farming communities, are exposed to low doses of Leptospira on a daily basis. Under these conditions, numerous factors determine whether infection occurs, including the route of exposure and inoculum dose. Skin wounds and abrasions are risk factors for leptospirosis, but it is not known whether broken skin is necessary for spillover, or if low-dose exposures to intact skin and mucous membranes can also cause infection. To establish a quantitative relationship between dose, route and probability of infection, we performed challenge experiments in hamsters and rats, developed mechanistic dose-response models representing the spatial dynamics of within-host infection and persistence, and fitted models to experimental data. Results show intact skin is a strong barrier against infection, and that broken skin is the predominant route by which low-dose environmental exposures cause infection. These results identify skin integrity as a bottleneck to spillover of Leptospira and underscore the importance of barrier interventions in the prevention of leptospirosis. This article is part of the theme issue 'Dynamic and integrative approaches to understanding pathogen spillover'. © 2019 The Author(s) Published by the Royal Society. All rights reserved.
650 $aLEPTOSPIRA
650 $aLEPTOSPIROSIS
653 $aAnimal model
653 $aDose-response
653 $aEmerging infectious disease
653 $aPLATAFORMA SALUD ANIMAL
653 $aZoonotic spillover
700 1 $aWUNDER, E.A.
700 1 $aBISHT, V.
700 1 $aHAMOND, C.
700 1 $aJULIAN, T.R.
700 1 $aKO, A.I.
700 1 $aLLOYD-SMITH, J.O.
773 $tPhilosophical Transactions of the Royal Society B: Biological Sciences, 30 September 2019, Volume 374, Issue 1782, Article number 2019036. Doi: https://doi.org/10.1098/rstb.2019.0367
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Registro original : |
INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Tacuarembó; INIA Treinta y Tres. |
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Fecha actual : |
13/01/2015 |
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Actualizado : |
03/02/2018 |
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Tipo de producción científica : |
Capítulo en Libro Técnico-Científico |
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Autor : |
MONTOSSI, F.; DE BARBIERI, I.; CIAPPESONI, C.; SOARES DE LIMA, J.M.; PEREZ JONES, J.; DONAGARAY, F.; FROS, A.; LUZARDO, S.; MEDEROS, A.; DE MATTOS, D.; DE LOS CAMPOS, G.; NOLLA, M. |
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Afiliación : |
FABIO MARCELO MONTOSSI PORCHILE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; LUIS IGNACIO DE BARBIERI ETCHEBERRY, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CARLOS GABRIEL CIAPPESONI SCARONE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JUAN MANUEL SOARES DE LIMA LAPETINA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; J. PEREZ JONES, N-241 - SCMAU (SOCIEDAD DE CRIADORES MERINO AUTRALIANO DEL URUGUAY); F. DONAGARAY, N-241 - SCMAU (SOCIEDAD DE CRIADORES MERINO AUTRALIANO DEL URUGUAY); A. FROS, N-241 - SCMAU (SOCIEDAD DE CRIADORES MERINO AUTRALIANO DEL URUGUAY); SANTIAGO FELIPE LUZARDO VILLAR, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; AMERICA ESTHER MEDEROS SILVEIRA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; D. DE MATTOS, Ex funcionario de INIA; G DE LOS CAMPOS, Ex funcionario de INIA; M. NOLLA, Ex funcionario de INIA. |
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Título : |
Diez años del Proyecto Merino fino del Uruguay (1998-2008): aportes tecnológicos para la sostenibilidad de los sistemas productivos ganaderos de la región de basalto. |
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Fecha de publicación : |
2014 |
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Fuente / Imprenta : |
In: BERRETTA, E.; MONTOSSI, F.; BRITO, G. (Ed.). Alternativas tecnológicas para los sistemas ganaderos del basalto. Montevideo, UY: INIA, 2014. |
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Páginas : |
p. 279-318 |
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Serie : |
(Serie Técnica; 217) |
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ISSN : |
1688-9266 |
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Idioma : |
Español |
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Contenido : |
En septiembre del año 1998, se firmo un Convenio Marco entre el SUL, INIA y SCMAU, el cual dio origen al Proyecto Merino Fino del
Uruguay. Los detalles organizativos, derechos, obligaciones, etc., de este convenio fueron presentados por Montossi et al. (2007b).
El objetivo general del Proyecto fue desarrollar una alternativa de producción ovina que por medio de su difusión y posterior adopción,
permitiera mejorar la sostenibilidad socioeconómica de los productores de lana de las regiones de Basalto y Cristalino, considerando
las demandas actuales y futuras de la Cadena Agroindustrial de lana del país y de los mercados consumidores. |
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Palabras claves : |
PROYETO MERINO FINO. |
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Thesagro : |
BASALTO; MERINO FINO; OVINOS. |
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Asunto categoría : |
--
L01 Ganadería |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/3935/1/ST-217p279-318.pdf
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Marc : |
LEADER 01716naa a2200337 a 4500
001 1052005
005 2018-02-03
008 2014 bl uuuu u00u1 u #d
022 $a1688-9266
100 1 $aMONTOSSI, F.
245 $aDiez años del Proyecto Merino fino del Uruguay (1998-2008)$baportes tecnológicos para la sostenibilidad de los sistemas productivos ganaderos de la región de basalto.
260 $c2014
300 $ap. 279-318
490 $a(Serie Técnica; 217)
520 $aEn septiembre del año 1998, se firmo un Convenio Marco entre el SUL, INIA y SCMAU, el cual dio origen al Proyecto Merino Fino del Uruguay. Los detalles organizativos, derechos, obligaciones, etc., de este convenio fueron presentados por Montossi et al. (2007b). El objetivo general del Proyecto fue desarrollar una alternativa de producción ovina que por medio de su difusión y posterior adopción, permitiera mejorar la sostenibilidad socioeconómica de los productores de lana de las regiones de Basalto y Cristalino, considerando las demandas actuales y futuras de la Cadena Agroindustrial de lana del país y de los mercados consumidores.
650 $aBASALTO
650 $aMERINO FINO
650 $aOVINOS
653 $aPROYETO MERINO FINO
700 1 $aDE BARBIERI, I.
700 1 $aCIAPPESONI, C.
700 1 $aSOARES DE LIMA, J.M.
700 1 $aPEREZ JONES, J.
700 1 $aDONAGARAY, F.
700 1 $aFROS, A.
700 1 $aLUZARDO, S.
700 1 $aMEDEROS, A.
700 1 $aDE MATTOS, D.
700 1 $aDE LOS CAMPOS, G.
700 1 $aNOLLA, M.
773 $tIn: BERRETTA, E.; MONTOSSI, F.; BRITO, G. (Ed.). Alternativas tecnológicas para los sistemas ganaderos del basalto. Montevideo, UY: INIA, 2014.
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