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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
29/05/2020 |
Actualizado : |
12/02/2021 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
SIGDEL, A.; LIU, L.; ABDOLLAHI-ARPANAHI, R.; AGUILAR, I.; PEÑAGARICANO, F. |
Afiliación : |
ANIL SIGDEL, Department of Animal Sciences, University of Florida, Gainesville, FL,USA.; L. LIU, Department of Animal Sciences, University of Florida, Gainesville, FL,USA.; ROSTAM ABDOLLAHI-ARPANAHI, Department of Animal Sciences, University of Florida, Gainesville, FL,USA.; IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FRANCISCO PEÑAGARICANO, University of Florida Genetics Institute, University of Florida, Gainesville, FL, USA. |
Título : |
Genetic dissection of reproductive performance of dairy cows under heat stress. |
Fecha de publicación : |
2020 |
Fuente / Imprenta : |
Animal Genetics, 1 August 2020, Volume 51, Issue 4, Pages 511-520. OPEN ACCESS. Doi: https://doi.org/10.1111/age.12943 |
ISSN : |
0268-9146 |
DOI : |
10.1111/age.12943 |
Idioma : |
Inglés |
Notas : |
Article history: Accepted for publication 31 March 2020. / First published:03 May 2020.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Corresponding author: Peñagaricano, F.; Department of Animal Sciences, University of Florida, Gainesville, FL, United States; email:fpenagaricano@ufl.edu |
Contenido : |
ABSTRACT.
Heat stress negatively impacts the reproductive performance of dairy cows. The main objective of this study was to dissect the genetic basis underlying dairy cow fertility under heat stress conditions. Our first goal was to estimate genetic components of cow conception across lactations considering heat stress. Our second goal was to reveal individual genes and functional gene-sets that explain a cow?s ability to conceive under thermal stress. Data consisted of 74 221 insemination records on 13 704 Holstein cows. Multitrait linear repeatability test-day models with random regressions on a function of temperature?humidity index values were used for the analyses. Heritability estimates for cow conception under heat stress were around 2?3%, whereas genetic correlations between general and thermotolerance additive genetic effects were negative and ranged between ?0.35 and ?0.82, indicating an unfavorable relationship between cows? ability to conceive under thermo-neutral vs. thermo-stress conditions. Whole-genome scans identified at least six genomic regions on BTA1, BTA10, BTA11, BTA17, BTA21 and BTA23 associated with conception under thermal stress. These regions harbor candidate genes such as BRWD1, EXD2, ADAM20, EPAS1, TAOK3, and NOS1, which are directly implicated in reproductive functions and cellular response to heat stress. The gene-set enrichment analysis revealed functional terms related to fertilization, developmental biology, heat shock proteins and oxidative stress, among others. Overall, our findings contribute to a better understanding of the genetics underlying the reproductive performance of dairy cattle under heat stress conditions and point out novel genomic strategies for improving thermotolerance and fertility via marker-assisted breeding.
© 2020 The Authors. Animal Genetics published by John Wiley & Sons Ltd on behalf of Stichting International Foundation for Animal Genetics MenosABSTRACT.
Heat stress negatively impacts the reproductive performance of dairy cows. The main objective of this study was to dissect the genetic basis underlying dairy cow fertility under heat stress conditions. Our first goal was to estimate genetic components of cow conception across lactations considering heat stress. Our second goal was to reveal individual genes and functional gene-sets that explain a cow?s ability to conceive under thermal stress. Data consisted of 74 221 insemination records on 13 704 Holstein cows. Multitrait linear repeatability test-day models with random regressions on a function of temperature?humidity index values were used for the analyses. Heritability estimates for cow conception under heat stress were around 2?3%, whereas genetic correlations between general and thermotolerance additive genetic effects were negative and ranged between ?0.35 and ?0.82, indicating an unfavorable relationship between cows? ability to conceive under thermo-neutral vs. thermo-stress conditions. Whole-genome scans identified at least six genomic regions on BTA1, BTA10, BTA11, BTA17, BTA21 and BTA23 associated with conception under thermal stress. These regions harbor candidate genes such as BRWD1, EXD2, ADAM20, EPAS1, TAOK3, and NOS1, which are directly implicated in reproductive functions and cellular response to heat stress. The gene-set enrichment analysis revealed functional terms related to fertilization, developmental biology, heat shock proteins and oxidati... Presentar Todo |
Palabras claves : |
Cow conception rate; Pathway analysis; Thermotolerance; Whole-genome scan. |
Asunto categoría : |
-- |
URL : |
https://onlinelibrary.wiley.com/doi/epdf/10.1111/age.12943
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Marc : |
LEADER 03164naa a2200253 a 4500 001 1061089 005 2021-02-12 008 2020 bl uuuu u00u1 u #d 022 $a0268-9146 024 7 $a10.1111/age.12943$2DOI 100 1 $aSIGDEL, A. 245 $aGenetic dissection of reproductive performance of dairy cows under heat stress.$h[electronic resource] 260 $c2020 500 $aArticle history: Accepted for publication 31 March 2020. / First published:03 May 2020. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Corresponding author: Peñagaricano, F.; Department of Animal Sciences, University of Florida, Gainesville, FL, United States; email:fpenagaricano@ufl.edu 520 $aABSTRACT. Heat stress negatively impacts the reproductive performance of dairy cows. The main objective of this study was to dissect the genetic basis underlying dairy cow fertility under heat stress conditions. Our first goal was to estimate genetic components of cow conception across lactations considering heat stress. Our second goal was to reveal individual genes and functional gene-sets that explain a cow?s ability to conceive under thermal stress. Data consisted of 74 221 insemination records on 13 704 Holstein cows. Multitrait linear repeatability test-day models with random regressions on a function of temperature?humidity index values were used for the analyses. Heritability estimates for cow conception under heat stress were around 2?3%, whereas genetic correlations between general and thermotolerance additive genetic effects were negative and ranged between ?0.35 and ?0.82, indicating an unfavorable relationship between cows? ability to conceive under thermo-neutral vs. thermo-stress conditions. Whole-genome scans identified at least six genomic regions on BTA1, BTA10, BTA11, BTA17, BTA21 and BTA23 associated with conception under thermal stress. These regions harbor candidate genes such as BRWD1, EXD2, ADAM20, EPAS1, TAOK3, and NOS1, which are directly implicated in reproductive functions and cellular response to heat stress. The gene-set enrichment analysis revealed functional terms related to fertilization, developmental biology, heat shock proteins and oxidative stress, among others. Overall, our findings contribute to a better understanding of the genetics underlying the reproductive performance of dairy cattle under heat stress conditions and point out novel genomic strategies for improving thermotolerance and fertility via marker-assisted breeding. © 2020 The Authors. Animal Genetics published by John Wiley & Sons Ltd on behalf of Stichting International Foundation for Animal Genetics 653 $aCow conception rate 653 $aPathway analysis 653 $aThermotolerance 653 $aWhole-genome scan 700 1 $aLIU, L. 700 1 $aABDOLLAHI-ARPANAHI, R. 700 1 $aAGUILAR, I. 700 1 $aPEÑAGARICANO, F. 773 $tAnimal Genetics, 1 August 2020, Volume 51, Issue 4, Pages 511-520. OPEN ACCESS. Doi: https://doi.org/10.1111/age.12943
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128. | | CIAPPESONI, G.; GIMENO, D.; RAVAGNOLO, O.; DE BARBIERI, I.; AGUILAR, I.; MONTOSSI, F.; GRATTAROLA, M. Evaluación genética preliminar del Núcleo Fundacional Merino Fino: análisis combinado población Merino fino - generación 2003. ln: INIA Tacuarembó. Sociedad Criadores Merino Australiano del Uruguay. SUL. Proyecto Merino Fino del Uruguay: quinta distribución de carneros generados en el núcleo fundacional de merino fino de la Unidad Experimental Glencoe, INIA Tacuarembó, 1999 - 2004. Glencoe, Paysandú, 10 diciembre, 2004. Tacuarembó (Uruguay): INIA, 2004. p. 69-83 (INIA Serie Actividades de Difusión ; 392)Biblioteca(s): INIA Tacuarembó. |
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130. | | MISZTAL, I.; TSURUTA, S.; AGUILAR, I.; LEGARRA, A.; VAN RADEN, P.M.; LAWLOR, T.J. Methods to approximate reliabilities in single-step genomic evaluation. Journal of Dairy Science, 2013, v.96, no.1, p.647-654. OPEN ACCESS. Article history: Received April 24, 2012. / Accepted September 18, 2012.Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : A - 1 |
Biblioteca(s): INIA Las Brujas. |
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131. | | AGUILAR, I.; MISZTAL, I.; JOHNSON, D.L.; LEGARRA, A.; TSURUTA, S.; LAWLOR, T.J. Hot topic: A unified approach to utilize phenotypic, full pedigree, and genomic information for genetic evaluation of Holstein final score. Journal of Dairy Science, 2010, v. 93, no. 2, p. 743-752. OPEN ACCESS Article history: Received September 14, 2009 / Accepted November 10, 2009 / Published in issue: February 2010.Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : A - 1 |
Biblioteca(s): INIA Las Brujas. |
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132. | | MISZTAL, I.; LOURENCO, D.; TSURUTA, S.; AGUILAR, I.; MASUDA, Y.; BERMANN, M.; CESARANI, A.; LEGARRA, A. How ssGBLUP became suitable for national dairy cattle evaluations. [668]. Part 37 - Bovine dairy - genetic evaluation methods. In: Proceedings of the World Congress on Genetics Applied to Livestock Production (WCGALP), 12., Rotterdam, the Netherlands, 3-8 July 2022. doi: https://doi.org/10.3920/978-90-8686-940-4_668 2757-2760. Article history: Published online: February 9, 2023 -- Corresponding author: I. Misztal, email: ignacy@uga.eduTipo: Trabajos en Congresos/Conferencias |
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134. | | TSURUTA, S.; AGUILAR, I.; MISZTAL, I.; LEGARRA, A.; LAWLOR, T. J. Multiple trait genetic evaluation of linear type traits using genomic and phenotypic data in US Holsteins. Volume Genetic improvement programmes: Selection using molecular information - Poster Sessions, 0489. In: Proceedings of the World Congress on Genetics Applied to Livestock Production, 9., Leipzig, Germany, August 1-6, 2010. p. 0489.Tipo: Trabajos en Congresos/Conferencias |
Biblioteca(s): INIA Las Brujas. |
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136. | | MACEDO, F.; NAVAJAS, E.; AGUILAR, I.; GRASSO, A.; PIERUCCIONI, F.; CIAPPESONI, G. New parentage testing SNP panel for commercial breeds will be a useful tool for conservation of creole sheep. Volume Genetic Improvement Programs: Selection for harsh environments and management of animal genetic resources (Posters), , 441. In: Proceedings of the World Congress on Genetics Applied to Livestock Production, 10., Vancouver, BC, Canada, August 17-22, 2014. p. 441. 3 p.Tipo: Trabajos en Congresos/Conferencias |
Biblioteca(s): INIA Las Brujas. |
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139. | | LADO, B.; VÁZQUEZ, D.; QUINCKE, M.; SILVA, P.; AGUILAR, I.; GUTIÉRREZ, L. Resource allocation optimization with multi-trait genomic prediction for bread wheat (Triticum aestivum L.) baking quality. [Original article]. Theoretical and Applied Genetics, 1 December 2018, Volume 131, Issue 12, pp. 2719-2731. OPEN ACCESS. Article history: Received: 29 January 2018 / Accepted: 10 September 2018 / Published online: 19 September 2018.
Supplementary materials.
Acknowledgements: We express our appreciation for the effort of the technical personnel of INIA La...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Las Brujas. |
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