| |
|
|
|
Registro completo
|
|
Biblioteca (s) : |
INIA Las Brujas. |
|
Fecha : |
30/06/2021 |
|
Actualizado : |
30/06/2021 |
|
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
|
Autor : |
MISZTAL, I.; AGUILAR, I.; LOURENCO, D.; MA, L.; STEIBEL, J.P. |
|
Afiliación : |
IGNACY MISZTAL, Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA.; IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; DANIELA LOURENCO, Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA.; LI MA, Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA.; JUAN PEDRO STEIBEL, Department of Animal Science, Michigan State University, East Lansing, MI 48824, USA. |
|
Título : |
Emerging issues in genomic selection. |
|
Complemento del título : |
Animal Genetics and Genomics. |
|
Fecha de publicación : |
2021 |
|
Fuente / Imprenta : |
Journal of Animal Science, June 2021, Volume 99, Issue 61, skab092. OPEN ACCESS. Doi: https://doi.org/10.1093/jas/skab092 |
|
ISSN : |
1525-3163 |
|
DOI : |
10.1093/jas/skab092 |
|
Idioma : |
Inglés |
|
Notas : |
Article history: Received 23 January 2021; Accepted 26 March 2021; Advance Access publication March 27, 2021.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
|
Contenido : |
ABSTRACT. - Genomic selection (GS) is now practiced successfully across many species. However, many questions remain, such as long-term effects, estimations of genomic parameters, robustness of genome-wide association study (GWAS) with small and large datasets, and stability of genomic predictions. This study summarizes presentations from the authors at the 2020 American Society of Animal Science (ASAS) symposium. The focus of many studies until now is on linkage disequilibrium between two loci. Ignoring higher-level equilibrium may lead to phantom dominance and epistasis. The Bulmer effect leads to a reduction of the additive variance; however, the selection for increased recombination rate can release anew genetic variance. With genomic information, estimates of genetic parameters may be biased by genomic preselection, but costs of estimation can increase drastically due to the dense form of the genomic information. To make the computation of estimates feasible, genotypes could be retained only for the most important animals, and methods of estimation should use algorithms that can recognize dense blocks in sparse matrices. GWASs using small genomic datasets frequently find many marker-trait associations, whereas studies using much bigger datasets find only a few. Most of the current tools use very simple models for GWAS, possibly causing artifacts. These models are adequate for large datasets where pseudo-phenotypes such as deregressed proofs indirectly account for important effects for traits of interest. Artifacts arising in GWAS with small datasets can be minimized by using data from all animals (whether genotyped or not), realistic models, and methods that account for population structure. Recent developments permit the computation of P-values from genomic best linear unbiased prediction (GBLUP), where models can be arbitrarily complex but restricted to genotyped animals only, and single-step GBLUP that also uses phenotypes from ungenotyped animals. Stability was an important part of nongenomic evaluations, where genetic predictions were stable in the absence of new data even with low prediction accuracies. Unfortunately, genomic evaluations for such animals change because all animals with genotypes are connected. A top-ranked animal can easily drop in the next evaluation, causing a crisis of confidence in genomic evaluations. While correlations between consecutive genomic evaluations are high, outliers can have differences as high as 1 SD. A solution to fluctuating genomic evaluations is to base selection decisions on groups of animals. Although many issues in GS have been solved, many new issues that require additional research continue to surface.
© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society of Animal Science. MenosABSTRACT. - Genomic selection (GS) is now practiced successfully across many species. However, many questions remain, such as long-term effects, estimations of genomic parameters, robustness of genome-wide association study (GWAS) with small and large datasets, and stability of genomic predictions. This study summarizes presentations from the authors at the 2020 American Society of Animal Science (ASAS) symposium. The focus of many studies until now is on linkage disequilibrium between two loci. Ignoring higher-level equilibrium may lead to phantom dominance and epistasis. The Bulmer effect leads to a reduction of the additive variance; however, the selection for increased recombination rate can release anew genetic variance. With genomic information, estimates of genetic parameters may be biased by genomic preselection, but costs of estimation can increase drastically due to the dense form of the genomic information. To make the computation of estimates feasible, genotypes could be retained only for the most important animals, and methods of estimation should use algorithms that can recognize dense blocks in sparse matrices. GWASs using small genomic datasets frequently find many marker-trait associations, whereas studies using much bigger datasets find only a few. Most of the current tools use very simple models for GWAS, possibly causing artifacts. These models are adequate for large datasets where pseudo-phenotypes such as deregressed proofs indirectly account for import... Presentar Todo |
|
Palabras claves : |
Genomic evaluation; Genomic selection; Genomwide association studies; Large data; Stability of genomic predictions. |
|
Asunto categoría : |
L10 Genética y mejoramiento animal |
|
URL : |
https://academic.oup.com/jas/article-pdf/99/6/skab092/38539545/skab092.pdf
|
|
Marc : |
LEADER 03992naa a2200265 a 4500
001 1062206
005 2021-06-30
008 2021 bl uuuu u00u1 u #d
022 $a1525-3163
024 7 $a10.1093/jas/skab092$2DOI
100 1 $aMISZTAL, I.
245 $aEmerging issues in genomic selection.$h[electronic resource]
260 $c2021
500 $aArticle history: Received 23 January 2021; Accepted 26 March 2021; Advance Access publication March 27, 2021. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
520 $aABSTRACT. - Genomic selection (GS) is now practiced successfully across many species. However, many questions remain, such as long-term effects, estimations of genomic parameters, robustness of genome-wide association study (GWAS) with small and large datasets, and stability of genomic predictions. This study summarizes presentations from the authors at the 2020 American Society of Animal Science (ASAS) symposium. The focus of many studies until now is on linkage disequilibrium between two loci. Ignoring higher-level equilibrium may lead to phantom dominance and epistasis. The Bulmer effect leads to a reduction of the additive variance; however, the selection for increased recombination rate can release anew genetic variance. With genomic information, estimates of genetic parameters may be biased by genomic preselection, but costs of estimation can increase drastically due to the dense form of the genomic information. To make the computation of estimates feasible, genotypes could be retained only for the most important animals, and methods of estimation should use algorithms that can recognize dense blocks in sparse matrices. GWASs using small genomic datasets frequently find many marker-trait associations, whereas studies using much bigger datasets find only a few. Most of the current tools use very simple models for GWAS, possibly causing artifacts. These models are adequate for large datasets where pseudo-phenotypes such as deregressed proofs indirectly account for important effects for traits of interest. Artifacts arising in GWAS with small datasets can be minimized by using data from all animals (whether genotyped or not), realistic models, and methods that account for population structure. Recent developments permit the computation of P-values from genomic best linear unbiased prediction (GBLUP), where models can be arbitrarily complex but restricted to genotyped animals only, and single-step GBLUP that also uses phenotypes from ungenotyped animals. Stability was an important part of nongenomic evaluations, where genetic predictions were stable in the absence of new data even with low prediction accuracies. Unfortunately, genomic evaluations for such animals change because all animals with genotypes are connected. A top-ranked animal can easily drop in the next evaluation, causing a crisis of confidence in genomic evaluations. While correlations between consecutive genomic evaluations are high, outliers can have differences as high as 1 SD. A solution to fluctuating genomic evaluations is to base selection decisions on groups of animals. Although many issues in GS have been solved, many new issues that require additional research continue to surface. © The Author(s) 2021. Published by Oxford University Press on behalf of the American Society of Animal Science.
653 $aGenomic evaluation
653 $aGenomic selection
653 $aGenomwide association studies
653 $aLarge data
653 $aStability of genomic predictions
700 1 $aAGUILAR, I.
700 1 $aLOURENCO, D.
700 1 $aMA, L.
700 1 $aSTEIBEL, J.P.
773 $tJournal of Animal Science, June 2021, Volume 99, Issue 61, skab092. OPEN ACCESS. Doi: https://doi.org/10.1093/jas/skab092
Descargar
Esconder MarcPresentar Marc Completo |
|
Registro original : |
INIA Las Brujas (LB) |
|
|
Biblioteca
|
Identificación
|
Origen
|
Tipo / Formato
|
Clasificación
|
Cutter
|
Registro
|
Volumen
|
Estado
|
Volver
|
|
|
|
Registro completo
|
|
Biblioteca (s) : |
INIA Tacuarembó. |
|
Fecha actual : |
08/10/2018 |
|
Actualizado : |
08/10/2018 |
|
Tipo de producción científica : |
Trabajos en Congresos/Conferencias |
|
Autor : |
PARANHOS DA COSTA, M.J.R.; PELLECCHIA, A.J.R.; JANAINA S. BRAGA; BORGES, T.D.; PÁSCOA, A.G.; DEL CAMPO, M. |
|
Afiliación : |
MATEUS J.R. PARANHOS DA COSTA; ARQUIMEDESS J.R. PELLECCHIA; JANAINA S. BRAGA; TAMARA D. BORGES; ADRIANO G. PÁSCOA; MARCIA DEL CAMPO GIGENA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
|
Título : |
Risks (odds ratios) of bruises on cattle carcasses in different animal categories: preliminary results. |
|
Fecha de publicación : |
2014 |
|
Fuente / Imprenta : |
In: INTERNATIONAL CONGRESS OF MEAT SCIENCE AND TECHNOLOGY (ICoMST), 60., 2014, Punta del Este, Uruguay. Proceedings... Montevideo: INIA, 2014. |
|
Idioma : |
Español |
|
Contenido : |
The objective of this study was to calculate the risks (odds ratios) of occurrence of bruises on cattle carcasses in different animal categories. The study was conducted in a slaughterhouse plant, located at São Paulo state, Brazil. Data collection was carried out during one year, assessing 22234 cattle carcasses. To calculate the risk (odds ratios) of bruises occurrences on cattle carcasses the GENMOD procedure of SAS was used, considering logistic regression models. The results showed significant variations among all classes of animal category, with cows having the higher risk of bruises occurrences . According to these results is possible to assume that cows had higher risk of bruises occurrences in their carcasses; probably due to their physical characteristics and higher reactivity, increasing their susceptibility to be bruised during handling. A possible strategy to minimize this risk would be the implementation of training programs, looking for the promotion of good practices in the routines of pre-slaughter handling. |
|
Palabras claves : |
CATTLE CARCASSES. |
|
Asunto categoría : |
-- |
|
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/11380/1/Del-Campo-2014.pdf
|
|
Marc : |
LEADER 01713nam a2200181 a 4500
001 1059172
005 2018-10-08
008 2014 bl uuuu u01u1 u #d
100 1 $aPARANHOS DA COSTA, M.J.R.
245 $aRisks (odds ratios) of bruises on cattle carcasses in different animal categories$bpreliminary results.$h[electronic resource]
260 $aIn: INTERNATIONAL CONGRESS OF MEAT SCIENCE AND TECHNOLOGY (ICoMST), 60., 2014, Punta del Este, Uruguay. Proceedings... Montevideo: INIA$c2014
520 $aThe objective of this study was to calculate the risks (odds ratios) of occurrence of bruises on cattle carcasses in different animal categories. The study was conducted in a slaughterhouse plant, located at São Paulo state, Brazil. Data collection was carried out during one year, assessing 22234 cattle carcasses. To calculate the risk (odds ratios) of bruises occurrences on cattle carcasses the GENMOD procedure of SAS was used, considering logistic regression models. The results showed significant variations among all classes of animal category, with cows having the higher risk of bruises occurrences . According to these results is possible to assume that cows had higher risk of bruises occurrences in their carcasses; probably due to their physical characteristics and higher reactivity, increasing their susceptibility to be bruised during handling. A possible strategy to minimize this risk would be the implementation of training programs, looking for the promotion of good practices in the routines of pre-slaughter handling.
653 $aCATTLE CARCASSES
700 1 $aPELLECCHIA, A.J.R.
700 1 $aJANAINA S. BRAGA
700 1 $aBORGES, T.D.
700 1 $aPÁSCOA, A.G.
700 1 $aDEL CAMPO, M.
Descargar
Esconder MarcPresentar Marc Completo |
|
Registro original : |
INIA Tacuarembó (TBO) |
|
|
Biblioteca
|
Identificación
|
Origen
|
Tipo / Formato
|
Clasificación
|
Cutter
|
Registro
|
Volumen
|
Estado
|
Volver
|
| Expresión de búsqueda válido. Check! |
|
|
