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| Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
30/06/2023 |
Actualizado : |
30/06/2023 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
GIANNITTI, F.; GARCÍA, J. P.; ADAMS, V.; ARMENDANO, J.; BEINGESSER, J.; ROOD, J.; UZAL, F. A. |
Afiliación : |
FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JORGE P. GARCÍA, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina; VICKI ADAMS, Monash University, Parkville, Victoria, Australia; JOAQUÍN I. ARMENDANO, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina; JULIANN BEINGESSER, California Animal Health and Food Safety Laboratoy, University of California at Davis, San Bernardino, CA; JULIAN I. ROOD, Monash University, Parkville, Victoria, Australia; FRANCISCO A. UZAL, Monash University, Parkville, Victoria, Australia. |
Título : |
Experimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions. |
Complemento del título : |
Infectious Disease - Original Article. |
Fecha de publicación : |
2023 |
Fuente / Imprenta : |
Veterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669 |
ISSN : |
0300-9858 (print); 1544-2217 (online). |
DOI : |
10.1177/03009858231171669 |
Idioma : |
Inglés |
Notas : |
Article history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral Ave, San Bernardino, CA 92408, USA. Email: fauzal@ucdavis.edu -- Funding: This work was supported by grant R01 AI056177 from the National Institute of Allergy and Infectious Diseases (NIAID). Research at Monash University was also supported by funding provided by the Australian Research Council to the Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics (grant no. CE0562063). -- |
Contenido : |
ABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 groups. The authors conclude that no specific gross or histologic renal lesions are observed in sheep with experimental acute type D enterotoxemia. © The Author(s) 2023 MenosABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 ... Presentar Todo |
Palabras claves : |
Clostridium perfringens type D; Enterotoxemia; ETX; Experimental infection; Kidneys; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA; Renal pathology; Sheep. |
Asunto categoría : |
L10 Genética y mejoramiento animal |
Marc : |
LEADER 03386naa a2200325 a 4500 001 1064216 005 2023-06-30 008 2023 bl uuuu u00u1 u #d 022 $a0300-9858 (print); 1544-2217 (online). 024 7 $a10.1177/03009858231171669$2DOI 100 1 $aGIANNITTI, F. 245 $aExperimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions.$h[electronic resource] 260 $c2023 500 $aArticle history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral Ave, San Bernardino, CA 92408, USA. Email: fauzal@ucdavis.edu -- Funding: This work was supported by grant R01 AI056177 from the National Institute of Allergy and Infectious Diseases (NIAID). Research at Monash University was also supported by funding provided by the Australian Research Council to the Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics (grant no. CE0562063). -- 520 $aABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 groups. The authors conclude that no specific gross or histologic renal lesions are observed in sheep with experimental acute type D enterotoxemia. © The Author(s) 2023 653 $aClostridium perfringens type D 653 $aEnterotoxemia 653 $aETX 653 $aExperimental infection 653 $aKidneys 653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA 653 $aRenal pathology 653 $aSheep 700 1 $aGARCÍA, J. P. 700 1 $aADAMS, V. 700 1 $aARMENDANO, J. 700 1 $aBEINGESSER, J. 700 1 $aROOD, J. 700 1 $aUZAL, F. A. 773 $tVeterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669
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141. | | MACHADO, M.; CASTRO, M.B.; WILSON, T. M.; GONÇALVES , A. A. B.; PORTIANSKY, E.; RIET-CORREA, F.; BARROS, S. S. Poisoning by Nierembergia veitchii: Effects on vascular smooth muscle cells in the pathogenesis of enzootic calcinosis. Veterinary Pathology, 2022, Volume 59, Issue 5, pages 814-823. doi: https://doi.org/10.1177/03009858221098430 Article history: Article first published online May 19, 2022; Published online September 2022. -- Corresponding Author: Franklin Riet-Correa, Postgraduate Program in Animal Science in the Tropics, School of Veterinary Medicine and...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Las Brujas. |
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142. | | COSTA, M.; MANSILLA, F.; MANUEL SALA, J.; SARAVIA, A.; UBIOS, D.; LORES, P.; CAPOZZO, A.V.; FREIRE, T. Fasciola hepatica infection modifies lgG1 specific immune response to foot-and-mouth disease virus induced by vaccination. Vaccine. 2024, Volume 42, Issue 3, Pages 541-547. https://doi.org/10.1016/j.vaccine.2023.12.067 Article history: Received 19 August 2023; Received in revised form 15 December 2023; Accepted 20 December 2023; Available online 6 January 2024. -- Correspondence: Freire, T.; UdelaR, Facultad de Medicina, Departamento de Inmunobiología,...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Las Brujas. |
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143. | | DONCEL, B.; GIANNITTI, F.; LEMAIRE, C.; RIET-CORREA, F. Descriptive study of cow culling in dairy herds in Uruguay. (AH-P36). [poster-Animal Health] In: World Buiatrics Congress (WBC), 31 st., Abstract Book, Madrid, Spain, September 4-8, 2022. pp.30-31.Biblioteca(s): INIA Las Brujas. |
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144. | | DORSCH, M.; REGIDOR-CERRILLO, J.; ORTEGA-MORA, L.M.; SCIOLI, M.V.; MORRELL, E.L.; CANTÓN, G.J.; MOORE, D.P.; HECKER, Y.P. Microsatellite genotyping reveals extensive genetic diversity in bovine Neospora caninum from the humid Pampa region in Argentina. Parasitology Research, December 2020, Volume 119, Issue 12, Pages 4049-4059. Doi: https://doi-org/10.1007/s00436-020-06922-x Article history:Received: 12 August 2020 /Accepted: 5 October 2020Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA La Estanzuela. |
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146. | | SILVEIRA, C.S.; ARÁOZ, V.; CAFFARENA, D.; RIET-CORREA, F.; MIRABALLES, C.; GIANNITTI, F. Brote de intoxicación espontánea por larvas de Perreyia flavipes en un rodeo de bovinos Heredord de Flores, Uruguay. In: Jornadas Uruguayas de Buiatría, 49., 2022. Paysandú, Uruguay: Centro Médico Veterinario de Paysandú; Filial de la Sociedad de Medicina Veterinaria del Uruguaya; Sociedad Uruguaya de Buiatría, 9 al 11 Junio 2022.Tipo: Trabajos en Congresos/Conferencias |
Biblioteca(s): INIA Las Brujas. |
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148. | | SILVEIRA, C.S.; MAYA,L.; CASAUX, M.L.; SCHILD, C.; CAFFARENA, D.; ARÁOZ, V.; COSTA, R.A. DA; MACÍAS-RIOSECO, M.; PERDOMO, Y,; CASTELLS, M.; COLINA, R.; FRAGA, M.; RIET-CORREA, F.; GIANNITTI, F. Diseases associated with bovine viral diarrhea virus subtypes 1a and 2b in beef and dairy cattle in Uruguay. Brazilian Journal of Microbiology, 1 March 2020, Volume 51, Issue 1, Pages 357-368. OPEN ACCESS. Doi: https://doi.org/10.1007/s42770-019-00170-7 Article history:Received: 26 February 2019 /Accepted: 3 October 2019. The work was partially funded by INIA?s grant PL015 N-15156. CSS, MLC, CS, DC, VA, RAC, MMR, and MC acknowledge support from ANII and INIA through MSc or...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA La Estanzuela. |
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149. | | GIANNITTI, F.; GARCÍA, J. P.; ADAMS, V.; ARMENDANO, J.; BEINGESSER, J.; ROOD, J.; UZAL, F. A. Experimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions. Infectious Disease - Original Article. Veterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669 Article history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Las Brujas. |
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150. | | FERNÁNDEZ, E.A.; ROSALES, C.A.; GARZÓN, J. P.; ARGUDO, D.E.; AYALA, L.E.; GUEVARA, G.E.; MALDONADO, J.E.; PEREA, F.P. Morphological and histological characteristics of ovaries from two genetic groups of guinea pigs (Cavia porcellus) from South America. [Características morfológicas e histológicas de los ovarios de dos grupos genéticos de cuyes (Cavia porcellus) de América del Sur]. Sección: Artículos Primarios. Revista de Investigaciones Veterinarias del Perú, 2022, v. 33, n. 4, e23349. OPEN ACCESS. doi: https://doi.org/10.15381/rivep.v33i4.23349 Article history: Received January 11, 2022; Accepted for publication July 28, 2022; Published August 31, 2022. -- Publisher: Universidad Nacional Mayor de San Marcos. -- Correspondence author: Perea, F.P.; Facultad de Ciencias...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Las Brujas. |
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151. | | CASAUX, M.L.; D'ALESSANDRO, B.; VIGNOLI, R.; FRAGA, M. Phenotypic and genotypic survey of antibiotic resistance in Salmonella enterica isolates from dairy farms in Uruguay. Frontiers in Veterinary Science, 2023, Volume 10, article 1055432. OPEN ACCESS. doi: https://doi.org/10.3389/fvets.2023.1055432 Article history: Received 27 September 2022; Accepted 15 February 2023; Published 09 March 2023. -- Correspondence author: María Laura Casaux, lcasaux@inia.org.uy; Martín Fraga, mfraga@inia.org.uy -- Edited by: Julio Alvarez, VISAVET...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Las Brujas. |
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152. | | MACÍAS-RIOSECO, M.; COSTA, R.A.; ARAOZ, V.; CAFFARENA, D.; FRAGA, M.; PLA, M.; MARTÍNEZ, R.; ARMENDANO, J.; GIANNITTI, F.; RIET-CORREA, F. Muertes asociadas a estrés calórico en vacas de tambo de Uruguay. In: Jornadas Uruguayas de Buiatría, 45., 2017, Paysandú, Uy., Matto, C.; Delpiazzo, R.(Ed.). Trabajos presentados. Paysandú: Centro Médico Veterinario de Paysandú/Sociedad Uruguaya de Buiatría, 2017. p.141-143.Tipo: Trabajos en Congresos/Conferencias |
Biblioteca(s): INIA La Estanzuela. |
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154. | | SEIXAS, J.N.; SANGIMINO, J.; GIANNITTI, F.; DORSCH, M.; CESAR, D.; RABENECK, D.M.; SILVA-FLANNERY, L.; FAIR, P.; RITTER, J.M. Identification of unexpected Mycobateria in feline and canine cutaneous lesions by PCR on formalin-fixed paraffin-embedded tissues. [abstract]. In: ACVP (Annual Meeting, American College of Veterinary Pathologists) and ASVCP (American Society for Veterinary Clinical Pathology) Annual Meeting, Boston, Massachusetts, USA. November 12-15, 2022.Tipo: Abstracts/Resúmenes |
Biblioteca(s): INIA Las Brujas. |
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155. | | DORSCH, M.; GIANNITTI, F. Bovine listeric encephalitis (encephalic listeriosis). Diagnostic Exercise From The Davis-Thompson Foundation*, Answer Sheet, Case # 170, August 2021. *The Diagnostic Exercises are an initiative of the Latin Comparative Pathology Group (LCPG), the Latin American subdivision of The Davis-Thompson Foundation. These exercises are contributed by members and non-members from any country of...Tipo: Artículos Indexados |
Biblioteca(s): INIA Las Brujas. |
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156. | | COSTA, R.A. DA; SCHILD, C.; SILVEIRA, C.S.; MACÍAS-RIOSECO, M.; MIRAZO, S.; MAYA, L.; CLARIGET, J.M.; RIET-CORREA, F. Acute and chronic bovine pulmonary edema and emphysema in Uruguay. [Edema e enfisema pulmonar agudo e crônico em bovinos do Uruguai.] Pesquisa Veterinaria Brasileira 38(10):1929-1934, 1 October 2018. OPEN ACCESS Article history: Received on March 31, 2018. // Accepted for publication on April 3, 2018.Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA La Estanzuela. |
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157. | | MAURENTE BERÓN, M.; FERNÁNDEZ-CIGANDA, S.; GIANNITTI, F.; FRAGA, M. Comparison of PCR and qPCR for the detection of Mycobacterium avium subsp. paratuberculosis in feces and milk of dairy cows in Uruguay: a longitudinal study. (ID-P47). [poster-Infectious Diseases] Session: Posters. In: World Buiatrics Congress (WBC), 31 st., Abstract Book, Madrid, Spain, September 4-8, 2022.Biblioteca(s): INIA Las Brujas. |
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158. | | RABAZA, A.; FRAGA, M.; ZARANTONELLI, L.; PÉREZ-LORENZO, C.; HIRIGOYEN, D.; GIANNITTI, F. Brote de Fiebre Q: ejemplo del rol de los bovinos como centinelas epidemiológicos. [presentación oral] En: Infectología al Día. Jornada Científico Académica de la Cátedra de Enfermedades Infecciosas, 21a., Facultad de Medicina, Universidad de la República, Montevideo, Uruguay. Ago. 12-13, 2022.Tipo: Presentaciones Orales |
Biblioteca(s): INIA Las Brujas. |
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159. | | SILVEIRA, C.S.; MAYA, L.; CASAUX, L.; SCHILD, C.; DIAB,S.; COLINA, R.; STAVICA,J.; FRAGA, M.; RIET-CORREA, F.; GIANNITTI, F. Enfermedad de la mucosas causada por el virus de la diarrea viral bovina-1a(BVDV-1a) en una vaquillona Aberdeen Angus de Colonia, Uruguay. In: Jornadas Uruguayas de Buiatría, 45., 2017, Paysandú, Uy., Matto, C.; Delpiazzo, R.(Ed.). Trabajos presentados. Paysandú: Centro Médico Veterinario de Paysandú/Sociedad Uruguaya de Buiatría, 2017. p.178-180.Tipo: Trabajos en Congresos/Conferencias |
Biblioteca(s): INIA La Estanzuela. |
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160. | | UZAL, F.A.; STOVER, S.; MORGAN, J.; FINO, C.; DIAB, S.; GIANNITTI, F.; HILL, A.E.; ARTHUR, R. Sudden death of racehorses in California: what is new?. [abstract] In: Proceedings of the American Association of Veterinary Laboratory Diagnosticians (AAVLD), 65th and United States Animal Health Association (USAHA) Annual Meeting, 126th, Minneapolis, Minnesota, USA. Oct. 6-12, 2022. pp.118. AAVLD 2022, 65th Annual Meeting "Technological Advances in Veterinary Diagnosis: what's here and what's on the horizon?".Tipo: Abstracts/Resúmenes |
Biblioteca(s): INIA Las Brujas. |
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Registros recuperados : 278 | |
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