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Registro completo
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Biblioteca (s) : |
INIA La Estanzuela. |
Fecha : |
31/05/2022 |
Actualizado : |
02/12/2022 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
COSTA, M.; SARAVIA, A.; UBIOS, D.; LORES, L.; DA COSTA, V.; FESTARI, M.F.; LANDEIRA, M.; RODRÍGUEZ-ZRAQUIA, S.A.; BANCHERO, G.; FREIRE, T. |
Afiliación : |
MONIQUE COSTA, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.; ANDERSON SARAVIA DE MELO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; DIEGO UBIOS, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay.; PABLO LORES, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.; VALERIA DA COSTA, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.; MARÍA FLORENCIA FESTARI, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.; MERCEDES LANDEIRA, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay; SANTIAGO A. RODRÍGUEZ-ZRAQUIA, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.; GEORGGET ELIZABETH BANCHERO HUNZIKER, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; TERESA FREIRE, Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay. |
Título : |
Liver function markers and haematological dynamics during acute and chronic phases of experimental Fasciola hepatica infection in cattle treated with triclabendazole. |
Fecha de publicación : |
2022 |
Fuente / Imprenta : |
Experimental Parasitology, July 2022, Volume 238, e108285. doi://doi.org/10.1016/j.exppara.2022.108285 |
ISSN : |
0014-4894 |
DOI : |
10.1016/j.exppara.2022.108285 |
Idioma : |
Inglés |
Notas : |
Article history: Received 13 September 2021; Revised 24 May 2022; Accepted 27 May 2022; Available online 30 May 2022; Published July 2022. -- Corresponding author : Freire, T.; Facultad de Medicina, Departamento de Inmunobiología. Gral. Flores 2125, Montevideo, Uruguay; email:tfreire@fmed.edu.uy -- |
Contenido : |
Abstract:
Fasciola hepatica, a worldwide-distributed liver fluke, is one of the causative agents of fasciolosis, a zoonotic disease that affects livestock and humans. In livestock, fasciolosis causes huge economic losses worldwide, reducing animal fertility, milk production, weight gain and condemnation of livers. In spite of the availability of drugs, such as triclabendazole (TCZ), for the treatment of fasciolosis, they do not necessarily prevent liver damage or parasite reinfection and can eventually increase parasite resistance. The aim of this research was to relate the hepatic function, haematological parameters, leukocyte counts in circulation and parasite egg shedding during F. hepatica acute and chronic phases of infection in cattle as well as to determine how these parameters change with TCZ-treatment of chronically infected cattle. Our results show that increased levels of serum aspartate aminotransferase (AST) and gamma glutamyltransferase (GGT) were detected in early stages of the experimental infection. Moreover, high circulating eosinophil count and plateletcrit levels were correlated with fluke number in livers from infected cattle. On the other hand, although TCZ-treatment in the chronic phase of infection reduced parasite burden and damage in the liver, it was not able to completely avoid them. In conclusion, our work sheds light into the physiopathological mechanisms induced during fluke infection in cattle, revealing the complexity of the host response to the infection, together with the effects of TCZ-treatment in chronically infected animals. © 2022 MenosAbstract:
Fasciola hepatica, a worldwide-distributed liver fluke, is one of the causative agents of fasciolosis, a zoonotic disease that affects livestock and humans. In livestock, fasciolosis causes huge economic losses worldwide, reducing animal fertility, milk production, weight gain and condemnation of livers. In spite of the availability of drugs, such as triclabendazole (TCZ), for the treatment of fasciolosis, they do not necessarily prevent liver damage or parasite reinfection and can eventually increase parasite resistance. The aim of this research was to relate the hepatic function, haematological parameters, leukocyte counts in circulation and parasite egg shedding during F. hepatica acute and chronic phases of infection in cattle as well as to determine how these parameters change with TCZ-treatment of chronically infected cattle. Our results show that increased levels of serum aspartate aminotransferase (AST) and gamma glutamyltransferase (GGT) were detected in early stages of the experimental infection. Moreover, high circulating eosinophil count and plateletcrit levels were correlated with fluke number in livers from infected cattle. On the other hand, although TCZ-treatment in the chronic phase of infection reduced parasite burden and damage in the liver, it was not able to completely avoid them. In conclusion, our work sheds light into the physiopathological mechanisms induced during fluke infection in cattle, revealing the c... Presentar Todo |
Palabras claves : |
Fasciola hepatica; Fasciolosis; Fluke; LIVER; PLATAFORMA DE SALUD ANIMAL; Triclabendazole. |
Asunto categoría : |
L73 Enfermedades de los animales |
Marc : |
LEADER 02984naa a2200337 a 4500 001 1063184 005 2022-12-02 008 2022 bl uuuu u00u1 u #d 022 $a0014-4894 024 7 $a10.1016/j.exppara.2022.108285$2DOI 100 1 $aCOSTA, M. 245 $aLiver function markers and haematological dynamics during acute and chronic phases of experimental Fasciola hepatica infection in cattle treated with triclabendazole.$h[electronic resource] 260 $c2022 500 $aArticle history: Received 13 September 2021; Revised 24 May 2022; Accepted 27 May 2022; Available online 30 May 2022; Published July 2022. -- Corresponding author : Freire, T.; Facultad de Medicina, Departamento de Inmunobiología. Gral. Flores 2125, Montevideo, Uruguay; email:tfreire@fmed.edu.uy -- 520 $aAbstract: Fasciola hepatica, a worldwide-distributed liver fluke, is one of the causative agents of fasciolosis, a zoonotic disease that affects livestock and humans. In livestock, fasciolosis causes huge economic losses worldwide, reducing animal fertility, milk production, weight gain and condemnation of livers. In spite of the availability of drugs, such as triclabendazole (TCZ), for the treatment of fasciolosis, they do not necessarily prevent liver damage or parasite reinfection and can eventually increase parasite resistance. The aim of this research was to relate the hepatic function, haematological parameters, leukocyte counts in circulation and parasite egg shedding during F. hepatica acute and chronic phases of infection in cattle as well as to determine how these parameters change with TCZ-treatment of chronically infected cattle. Our results show that increased levels of serum aspartate aminotransferase (AST) and gamma glutamyltransferase (GGT) were detected in early stages of the experimental infection. Moreover, high circulating eosinophil count and plateletcrit levels were correlated with fluke number in livers from infected cattle. On the other hand, although TCZ-treatment in the chronic phase of infection reduced parasite burden and damage in the liver, it was not able to completely avoid them. In conclusion, our work sheds light into the physiopathological mechanisms induced during fluke infection in cattle, revealing the complexity of the host response to the infection, together with the effects of TCZ-treatment in chronically infected animals. © 2022 653 $aFasciola hepatica 653 $aFasciolosis 653 $aFluke 653 $aLIVER 653 $aPLATAFORMA DE SALUD ANIMAL 653 $aTriclabendazole 700 1 $aSARAVIA, A. 700 1 $aUBIOS, D. 700 1 $aLORES, L. 700 1 $aDA COSTA, V. 700 1 $aFESTARI, M.F. 700 1 $aLANDEIRA, M. 700 1 $aRODRÍGUEZ-ZRAQUIA, S.A. 700 1 $aBANCHERO, G. 700 1 $aFREIRE, T. 773 $tExperimental Parasitology, July 2022, Volume 238, e108285. doi://doi.org/10.1016/j.exppara.2022.108285
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164. | | GARCÍA, J.A.; LIVIO, J.M.; MATTO, C.; DUTRA, F.; SCIOLI, V.; GIANNITTI, F.; LANGSTON, J.; POPPENGA, R.H.; CANTÓN, G.J.; UZAL, F.A. Pollen beetle (Astylus atromaculatus)-associated gastroenteric disease in cattle: report of 6 natural outbreaks. Full Scientific Report. Journal of Veterinary Diagnostic Investigation, 2024, Volume 36, Issue 1, Pages 95-102. https://doi.org/10.1177/10406387231215756 Article history: Article first published online: November 29, 2023; Issue published: January 2024. -- Correspondence: Uzal, F.A.; California Animal Health and Food Safety Laboratory, San Bernardino branches, School of Veterinary...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Las Brujas. |
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165. | | MACHADO, M; WILSON, T.M.; RIBEIRO DE SOUSA, D.E.; LOPES CÂMARA , A.C.; FURLAN, F.H.; SILVA ALMEIDA E MACÊDO, J.T; PUPIN, R.C.; AMARAL DE LEMOS, R.A; ARMIÉN, A.G.; BARROS, S.S.; RIET-CORREA, F.; BOTELHO DE CASTRO, M. Fatal lancehead pit viper (Bothrops spp.) envenomation in horses. Toxicon, December 2019, Volume 170, Pages 41-50. Article history: Received 9 May 2019/ Revised 16 July 2019/ Accepted 1 September 2019/ Available online 6 September 2019.Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA La Estanzuela. |
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166. | | GOSTIC, K.M.; WUNDER, E.A.; BISHT, V.; HAMOND, C.; JULIAN, T.R.; KO, A.I.; LLOYD-SMITH, J.O. Mechanistic dose-response modelling of animal challenge data shows that intact skin is a crucial barrier to leptospiral infection. Philosophical Transactions of the Royal Society B: Biological Sciences, 30 September 2019, Volume 374, Issue 1782, Article number 2019036. Doi: https://doi.org/10.1098/rstb.2019.0367 Article history: Accepted: 2 April 2019 / Published:12 August 2019.
This article is part of the theme issue "Dynamic and integrative approaches to understanding pathogen spillover".
Electronic supplementary material is available online at...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Las Brujas. |
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167. | | COSTA, M.; SARAVIA, A.; UBIOS, D.; LORES, L.; DA COSTA, V.; FESTARI, M.F.; LANDEIRA, M.; RODRÍGUEZ-ZRAQUIA, S.A.; BANCHERO, G.; FREIRE, T. Liver function markers and haematological dynamics during acute and chronic phases of experimental Fasciola hepatica infection in cattle treated with triclabendazole. Experimental Parasitology, July 2022, Volume 238, e108285. doi://doi.org/10.1016/j.exppara.2022.108285 Article history: Received 13 September 2021; Revised 24 May 2022; Accepted 27 May 2022; Available online 30 May 2022; Published July 2022. -- Corresponding author : Freire, T.; Facultad de Medicina, Departamento de Inmunobiología. Gral....Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA La Estanzuela. |
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169. | | CAFFARENA, D.; CASAUX, M.L.; SCHILD, C.; FRAGA, M.; CASTELLS, M.; RODNEY, C.; MAYA, L.; CORBELLINI, L.G.; RIET-CORREA, F.; GIANNITTI, F. Causes of neonatal calf diarrhea and mortality in pasture-based dairy herds in Uruguay: a farm-matched case-control study. Brazilian Journal of Microbiology, 2021. Doi: https://doi.org/10.1007/s42770-021-00440-3 Article history: Received 10 July 2020/Accepted 02 February 2021/Published 11 February 2021Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA La Estanzuela. |
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171. | | MACÍAS-RIOSECO, M.; RIET-CORREA, F.; MILLER, M.M.; SONDGEROTH, K.; FRAGA, M.; SILVEIRA, C.S.; UZAL, F.A.; GIANNITTI, F. Bovine abortion caused by Coxiella burnetii : report of a cluster of cases in Uruguay and review of the literature. Journal of Veterinary Diagnostic Investigation; Jul 2019, v. 31, n. 4, p.634-639. Article history: Article first published online: June 10, 2019//Issue published: July 1, 2019.Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA La Estanzuela. |
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173. | | SILVEIRA, C.S.; GRILLI, M.J.; BERON, M.; CAFFARENA, D.; FRAGA, M.; GIANNITTI, F.; FERNÁNDEZ-CIGANDA, S. Detecção e quantificação do vírus da leucose bovina em terneiros neonatos de estabelecimentos leiteiros do Uruguai. [resumo] In: Encontro Nacional de Diagnóstico Veterinário (ENDIVET), 11, Resumos, Cuiabá, Mato Grosso, Brazil, Novembro 21-23, 2022.Tipo: Abstracts/Resúmenes |
Biblioteca(s): INIA Las Brujas. |
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175. | | CASTELLS, M.; BERTONI, ESTEFANY; CAFFARENA, D.; CASAUX, M.L.; SCHILD, C.; VICTORIA, M.; RIET-CORREA, F.; GIANNITTI, F.; PARREÑO, V.; COLINA, R. Bovine astrovirus surveillance in Uruguay reveals high detection rate of a novel mamastrovirus species. Viruses, Dec 27, Vol. 12 , n.1, 2020. OPEN ACCESS. Doi: https://doi.org/10.3390/v12010032 Article history: Received: 26 October 2019 / Revised: 15 November 2019 / Accepted: 15 November 2019 / Published: 27 December 2019. Supplementary Materials: The following are available online at...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA La Estanzuela. |
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176. | | CAVALCANTI, A.A.C.; CAMPOS, A.C.; MORAES, A.G.M; PESSOA, C.R.M.; RIET-CORREA, F.; MELO, M.A.; AZEVEDO, E.O. Pemphigus foliaceus in a sheep. [Pênfigo foliáceo em uma ovelha]. Semina:Ciencias Agrarias, March 2019, Volume 40, Issue 2, Pages 1001-1004, 2019. OPEN ACCESS Article History: Received: Sept. 20, 2017. // Approved: Jan. 30, 2019.Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA La Estanzuela. |
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179. | | CASTELLS, M.; CAFFARENA, D.; CASAUX, M.L.; SCHILD, C.; MIÑO, S.; CASTELLS, F.; CASTELLS, D.; VICTORIA, M.; RIET-CORREA, F.; GIANNITTI, F.; PAREÑO, V.; COLINA, R. Phylogenetic analyses of rotavirus a from cattle in uruguay reveal the circulation of common and uncommon genotypes and suggest interspecies transmisión. Pathogens (Basel, Switzerland), July 2020, Volume 9, Issue 7, Article number 570, Pages 1-17. OPEN ACCESS. DOI: https://doi.org/10.3390/pathogens9070570 Article history: Received: 7 April 2020 / Revised: 20 June 2020 / Accepted: 30 June 2020 / Published: 14 July 2020.
This research was funded by Instituto Nacional de Investigación Agropecuaria (INIA), grant number PL_015...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA La Estanzuela. |
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180. | | PARODI, P.; RODRÍGUEZ, V.; SCHANZEMBACH, M.; MATTO, C.; GIANNECCHINI, E.; RIVERO, R. Descripción de un caso de Babesiosis bovina en un ternero. In: Jornadas Uruguayas de Buiatría, 47., 2019, Paysandú, UY.; Matto, ; Gianeechini, E. (Ed.). Paysandú: Centro Médico Veterinario de Paysandú/Sociedad Uruguaya de Buiatría, 2019. p.128-130Tipo: Trabajos en Congresos/Conferencias |
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