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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
14/03/2022 |
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Actualizado : |
14/03/2022 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
CRISPO, P.M.; MENCHACA, A.; SCHLAPP, G.; MEIKLE, E.M.N. |
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Afiliación : |
MARTINA CRISPO, Unidad de Animales Transgénicos y de Experimentación (UATE), Institut Pasteur de Montevideo, Montevideo, Uruguay; JOSE ALEJO MENCHACA BARBEITO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; Fundación IRAUy, Montevideo, Uruguay; GERALDINE SCHLAPP, Unidad de Animales Transgénicos y de Experimentación (UATE), Institut Pasteur de Montevideo, Montevideo, Uruguay; MARÍA NOEL MEIKLE, Unidad de Animales Transgénicos y de Experimentación (UATE), Institut Pasteur de Montevideo, Montevideo, Uruguay. |
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Título : |
Generation of genetically modified animal models in Southamerica. [Génération d'animaux génétiquement modifies en Amerique du Sud.] |
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Fecha de publicación : |
2021 |
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Fuente / Imprenta : |
Bulletin de l'Academie Veterinaire de France, 2021, Volume 174. doi: https://doi.org/10.3406/bavf.2021.70957 |
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ISSN : |
0001-4192 |
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DOI : |
10.3406/bavf.2021.70957 |
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Idioma : |
Inglés |
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Notas : |
Article history: Communication présentée le 10 Juin 2021; manuscrit accepté le30 septembre 2021. |
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Contenido : |
ABSTRACT.- The generation of genetically modified animals has made possible to achieve great scientific advances in several fields. In 2006 we set up a Technological Unit at Institut Pasteur of Montevideo capable of conducting our own research program and provide researchers of Uruguay and the region with genetically modified mouse models. In 2014, we implemented the CRISPR/Cas9 system, which allowed us to broaden the scope of our activity and develop other projects involving mice and sheep, thus positioning this laboratory as a reference technological platform in South America. The legislation on Genetically Modified Organisms (GMOs) in several South American countries only considers modifications involving the addition of exogenous DNA, while legislation for genome editing involves a more appropriate regulation for this technology. This situation provides a regional advantage favoring the rapid development of genetically edited models including large animal species. © 2021 Academie Veterinaire de France. All rights reserved.
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RÉSUMÉ. - La création d'animaux génétiquement modifiés a permis de réaliser de grandes avancées scientifiques dans des domaines variés. En 2006 nous avons mis en place à l'Institut Pasteur de Montevideo une Unité Technologique capable de conduire un programme de recherche propre et de fournir aux chercheurs d'Uruguay et de la région des modèles de souris génétiquement modifiés. En 2014, nous avons mis en œuvre le système CRISPR/-Cas9, ce qui nous a permis d'élargir le cadre de notre activité et de développer d'autres projets impliquant la souris et le mouton, nous positionnant ainsi comme plateforme technologique de référence en Amérique du Sud. La législation relative aux Organismes Génétiquement Modifiés (OGMs) dans plusieurs pays d’Amérique du Sud ne prend en compte que les modifications comportant l'addition d'ADN exogène et en exclut donc l'édition génomique. Cette situation procure un avantage régional favorisant le développement rapide de modèles génétiquement éditées y compris dans des espèces animales de rentes. MenosABSTRACT.- The generation of genetically modified animals has made possible to achieve great scientific advances in several fields. In 2006 we set up a Technological Unit at Institut Pasteur of Montevideo capable of conducting our own research program and provide researchers of Uruguay and the region with genetically modified mouse models. In 2014, we implemented the CRISPR/Cas9 system, which allowed us to broaden the scope of our activity and develop other projects involving mice and sheep, thus positioning this laboratory as a reference technological platform in South America. The legislation on Genetically Modified Organisms (GMOs) in several South American countries only considers modifications involving the addition of exogenous DNA, while legislation for genome editing involves a more appropriate regulation for this technology. This situation provides a regional advantage favoring the rapid development of genetically edited models including large animal species. © 2021 Academie Veterinaire de France. All rights reserved.
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RÉSUMÉ. - La création d'animaux génétiquement modifiés a permis de réaliser de grandes avancées scientifiques dans des domaines variés. En 2006 nous avons mis en place à l'Institut Pasteur de Montevideo une Unité Technologique capable de conduire un programme de recherche propre et de fournir aux chercheurs d'Uruguay et de la région des modèles de souris génétiquement modifiés. En 2014, nous avons mi... Presentar Todo |
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Palabras claves : |
Animal experiment; CRISPR; CRISPR-CAS9 system; Édition génomique; Gene editing; Mouton; PLATAFORMA SALUD ANIMAL; Rodents; Rongeurs; Sheep. |
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Asunto categoría : |
L10 Genética y mejoramiento animal |
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URL : |
https://academie-veterinaire-defrance.org/fileadmin/user_upload/Publication/Bulletin-AVF/BAVF_2021/crispo_anim_genet_modif_bavf_2021.pdf
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Marc : |
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100 1 $aCRISPO, P.M.
245 $aGeneration of genetically modified animal models in Southamerica. [Génération d'animaux génétiquement modifies en Amerique du Sud.]$h[electronic resource]
260 $c2021
500 $aArticle history: Communication présentée le 10 Juin 2021; manuscrit accepté le30 septembre 2021.
520 $aABSTRACT.- The generation of genetically modified animals has made possible to achieve great scientific advances in several fields. In 2006 we set up a Technological Unit at Institut Pasteur of Montevideo capable of conducting our own research program and provide researchers of Uruguay and the region with genetically modified mouse models. In 2014, we implemented the CRISPR/Cas9 system, which allowed us to broaden the scope of our activity and develop other projects involving mice and sheep, thus positioning this laboratory as a reference technological platform in South America. The legislation on Genetically Modified Organisms (GMOs) in several South American countries only considers modifications involving the addition of exogenous DNA, while legislation for genome editing involves a more appropriate regulation for this technology. This situation provides a regional advantage favoring the rapid development of genetically edited models including large animal species. © 2021 Academie Veterinaire de France. All rights reserved. .-.-.-.-.--.-.-.-. RÉSUMÉ. - La création d'animaux génétiquement modifiés a permis de réaliser de grandes avancées scientifiques dans des domaines variés. En 2006 nous avons mis en place à l'Institut Pasteur de Montevideo une Unité Technologique capable de conduire un programme de recherche propre et de fournir aux chercheurs d'Uruguay et de la région des modèles de souris génétiquement modifiés. En 2014, nous avons mis en œuvre le système CRISPR/-Cas9, ce qui nous a permis d'élargir le cadre de notre activité et de développer d'autres projets impliquant la souris et le mouton, nous positionnant ainsi comme plateforme technologique de référence en Amérique du Sud. La législation relative aux Organismes Génétiquement Modifiés (OGMs) dans plusieurs pays d’Amérique du Sud ne prend en compte que les modifications comportant l'addition d'ADN exogène et en exclut donc l'édition génomique. Cette situation procure un avantage régional favorisant le développement rapide de modèles génétiquement éditées y compris dans des espèces animales de rentes.
653 $aAnimal experiment
653 $aCRISPR
653 $aCRISPR-CAS9 system
653 $aÉdition génomique
653 $aGene editing
653 $aMouton
653 $aPLATAFORMA SALUD ANIMAL
653 $aRodents
653 $aRongeurs
653 $aSheep
700 1 $aMENCHACA, A.
700 1 $aSCHLAPP, G.
700 1 $aMEIKLE, E.M.N.
773 $tBulletin de l'Academie Veterinaire de France, 2021, Volume 174. doi: https://doi.org/10.3406/bavf.2021.70957
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INIA Las Brujas (LB) |
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| Registros recuperados : 278 | |
| 164. |  | GARCÍA, J.A.; LIVIO, J.M.; MATTO, C.; DUTRA, F.; SCIOLI, V.; GIANNITTI, F.; LANGSTON, J.; POPPENGA, R.H.; CANTÓN, G.J.; UZAL, F.A. Pollen beetle (Astylus atromaculatus)-associated gastroenteric disease in cattle: report of 6 natural outbreaks. Full Scientific Report. Journal of Veterinary Diagnostic Investigation, 2024, Volume 36, Issue 1, Pages 95-102. https://doi.org/10.1177/10406387231215756 Article history: Article first published online: November 29, 2023; Issue published: January 2024. -- Correspondence: Uzal, F.A.; California Animal Health and Food Safety Laboratory, San Bernardino branches, School of Veterinary...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 165. | | MACHADO, M; WILSON, T.M.; RIBEIRO DE SOUSA, D.E.; LOPES CÂMARA , A.C.; FURLAN, F.H.; SILVA ALMEIDA E MACÊDO, J.T; PUPIN, R.C.; AMARAL DE LEMOS, R.A; ARMIÉN, A.G.; BARROS, S.S.; RIET-CORREA, F.; BOTELHO DE CASTRO, M. Fatal lancehead pit viper (Bothrops spp.) envenomation in horses. Toxicon, December 2019, Volume 170, Pages 41-50. Article history: Received 9 May 2019/ Revised 16 July 2019/ Accepted 1 September 2019/ Available online 6 September 2019.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela. |
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| 166. | | GOSTIC, K.M.; WUNDER, E.A.; BISHT, V.; HAMOND, C.; JULIAN, T.R.; KO, A.I.; LLOYD-SMITH, J.O. Mechanistic dose-response modelling of animal challenge data shows that intact skin is a crucial barrier to leptospiral infection. Philosophical Transactions of the Royal Society B: Biological Sciences, 30 September 2019, Volume 374, Issue 1782, Article number 2019036. Doi: https://doi.org/10.1098/rstb.2019.0367 Article history: Accepted: 2 April 2019 / Published:12 August 2019.
This article is part of the theme issue "Dynamic and integrative approaches to understanding pathogen spillover".
Electronic supplementary material is available online at...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 167. | | COSTA, M.; SARAVIA, A.; UBIOS, D.; LORES, L.; DA COSTA, V.; FESTARI, M.F.; LANDEIRA, M.; RODRÍGUEZ-ZRAQUIA, S.A.; BANCHERO, G.; FREIRE, T. Liver function markers and haematological dynamics during acute and chronic phases of experimental Fasciola hepatica infection in cattle treated with triclabendazole. Experimental Parasitology, July 2022, Volume 238, e108285. doi://doi.org/10.1016/j.exppara.2022.108285 Article history: Received 13 September 2021; Revised 24 May 2022; Accepted 27 May 2022; Available online 30 May 2022; Published July 2022. -- Corresponding author : Freire, T.; Facultad de Medicina, Departamento de Inmunobiología. Gral....| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela. |
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| 169. | | CAFFARENA, D.; CASAUX, M.L.; SCHILD, C.; FRAGA, M.; CASTELLS, M.; RODNEY, C.; MAYA, L.; CORBELLINI, L.G.; RIET-CORREA, F.; GIANNITTI, F. Causes of neonatal calf diarrhea and mortality in pasture-based dairy herds in Uruguay: a farm-matched case-control study. Brazilian Journal of Microbiology, 2021. Doi: https://doi.org/10.1007/s42770-021-00440-3 Article history: Received 10 July 2020/Accepted 02 February 2021/Published 11 February 2021| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela. |
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| 171. | | MACÍAS-RIOSECO, M.; RIET-CORREA, F.; MILLER, M.M.; SONDGEROTH, K.; FRAGA, M.; SILVEIRA, C.S.; UZAL, F.A.; GIANNITTI, F. Bovine abortion caused by Coxiella burnetii : report of a cluster of cases in Uruguay and review of the literature. Journal of Veterinary Diagnostic Investigation; Jul 2019, v. 31, n. 4, p.634-639. Article history: Article first published online: June 10, 2019//Issue published: July 1, 2019.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela. |
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| 173. | | SILVEIRA, C.S.; GRILLI, M.J.; BERON, M.; CAFFARENA, D.; FRAGA, M.; GIANNITTI, F.; FERNÁNDEZ-CIGANDA, S. Detecção e quantificação do vírus da leucose bovina em terneiros neonatos de estabelecimentos leiteiros do Uruguai. [resumo] In: Encontro Nacional de Diagnóstico Veterinário (ENDIVET), 11, Resumos, Cuiabá, Mato Grosso, Brazil, Novembro 21-23, 2022.| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA Las Brujas. |
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| 175. | | CASTELLS, M.; BERTONI, ESTEFANY; CAFFARENA, D.; CASAUX, M.L.; SCHILD, C.; VICTORIA, M.; RIET-CORREA, F.; GIANNITTI, F.; PARREÑO, V.; COLINA, R. Bovine astrovirus surveillance in Uruguay reveals high detection rate of a novel mamastrovirus species. Viruses, Dec 27, Vol. 12 , n.1, 2020. OPEN ACCESS. Doi: https://doi.org/10.3390/v12010032 Article history: Received: 26 October 2019 / Revised: 15 November 2019 / Accepted: 15 November 2019 / Published: 27 December 2019. Supplementary Materials: The following are available online at...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela. |
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| 176. | | CAVALCANTI, A.A.C.; CAMPOS, A.C.; MORAES, A.G.M; PESSOA, C.R.M.; RIET-CORREA, F.; MELO, M.A.; AZEVEDO, E.O. Pemphigus foliaceus in a sheep. [Pênfigo foliáceo em uma ovelha]. Semina:Ciencias Agrarias, March 2019, Volume 40, Issue 2, Pages 1001-1004, 2019. OPEN ACCESS Article History: Received: Sept. 20, 2017. // Approved: Jan. 30, 2019.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela. |
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| 179. | | CASTELLS, M.; CAFFARENA, D.; CASAUX, M.L.; SCHILD, C.; MIÑO, S.; CASTELLS, F.; CASTELLS, D.; VICTORIA, M.; RIET-CORREA, F.; GIANNITTI, F.; PAREÑO, V.; COLINA, R. Phylogenetic analyses of rotavirus a from cattle in uruguay reveal the circulation of common and uncommon genotypes and suggest interspecies transmisión. Pathogens (Basel, Switzerland), July 2020, Volume 9, Issue 7, Article number 570, Pages 1-17. OPEN ACCESS. DOI: https://doi.org/10.3390/pathogens9070570 Article history: Received: 7 April 2020 / Revised: 20 June 2020 / Accepted: 30 June 2020 / Published: 14 July 2020.
This research was funded by Instituto Nacional de Investigación Agropecuaria (INIA), grant number PL_015...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela. |
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| 180. | | PARODI, P.; RODRÍGUEZ, V.; SCHANZEMBACH, M.; MATTO, C.; GIANNECCHINI, E.; RIVERO, R. Descripción de un caso de Babesiosis bovina en un ternero. In: Jornadas Uruguayas de Buiatría, 47., 2019, Paysandú, UY.; Matto, ; Gianeechini, E. (Ed.). Paysandú: Centro Médico Veterinario de Paysandú/Sociedad Uruguaya de Buiatría, 2019. p.128-130| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA La Estanzuela. |
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| Registros recuperados : 278 | |
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