01924naa a2200325 a 450000100080000000500110000800800410001902200140006002400390007410000160011324500790012926000090020850004160021752005780063365300130121165300120122465300190123665300130125565300560126865300210132465300190134570000280136470000180139270000170141070000200142770000190144770000190146670000200148577300930150510644972024-03-05       2024    bl uuuu     u00u1 u    #d  a0041-01017 a10.1016/j.toxicon.2024.1076552DOI1 aMACHADO, M.  aLeucaena leucocephala toxicity in Brazilian horses.h[electronic resource]  c2024  aArticle history: Received 10 January 2024; Received in revised form 16 February 2024; Accepted 18 February 2024; Available online 19 February 2024. -- Correspondence: Machado, M.; Plataforma de Investigación en Salud Animal (PSA), Instituto Nacional de Investigación Agropecuaria (INIA), Estación Experimental del Norte, Tacuarembó, Uruguay; email:mmachado@inia.org.uy -- Handling Editor: Dr. Ray Norton. --  aABSTRACT.- Leucaena leucocephala poisoning is reported in horses in different Brazilian regions. The poisoning occurred one month after the horses were introduced into paddocks invaded by the plant or after 10 days of consuming cut Leucaena administered as the only food. Affected horses showed moderate to severe hair loss on the mane and tail, orthokeratotic hyperkeratosis with marked follicular telogenization, and hyperplasia of thyroid follicular cells. Mimosin concentration in leaves (5.5 mg/g) was determined by a new HLPC-UV method which is also reported. © 2024  aAlopecia  aHLPC-UV  aHorse diseases  aMimosine  aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA  aPoisonous plants  aTelogenization1 aQUEIROZ-MACHADO, C.R.R.1 aGARDNER, D.R.1 aCASTRO, M.B.1 aCÂMARA, A.C.L.1 aPIMENTEL, L.A.1 aGALIZA, G.J.N.1 aRIET-CORREA, F.  tToxicon. 2024, Volume 240, Article 107655. https://doi.org/10.1016/j.toxicon.2024.107655