02603naa a2200265 a 450000100080000000500110000800800410001902200140006002400320007410000150010624501880012126000090030950003200031852013120063865300580195065300300200865300210203865300300205965300330208965300560212270000140217870000160219270000180220877301110222610641642023-05-24       2023    bl uuuu     u00u1 u    #d  a0022-03027 a10.3168/jds.2022-225552DOI1 aRABAZA, A.  aA meta-analysis of the effects of colostrum heat-treatment on its viscosity and IgG concentration, and the transfer of passive immunity in newborn dairy calves.h[electronic resource]  c2023  aArticle history: Received July 20, 2022; Accepted April 19, 2023; Published online May 08, 2023. -- Corresponding authors: Ana Rabaza, arabaza@pasteur.edu.uy; Federico Giannitti, fgiannitti@inia.org.uy -- License: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).  aABSTRACT.- Newborn ruminants depend on colostrum intake immediately after birth to obtain immunoglobulins for effective transfer of passive immunity (TPI). As colostrum may also be a vehicle of infectious agents, heat treatment of raw colostrum is a practice aimed at eliminating or reducing its pathogen load. Despite the usefulness of heat treatment in preventing the transmission of infectious colostrum-borne diseases, heat treatment of colostrum may have some side effects. A systematic review and meta-analysis were conducted to summarize the effects of colostrum heat treatment on its viscosity and IgG concentration, and serum IgG concentration as a proxy for TPI in newborn calves fed raw versus heat-treated colostrum. Moderators were studied to identify sources of heterogeneity. Literature databases were searched for peer-reviewed articles published between 1946 and 2022. A Master of Science thesis was also included. Five, 21, and 19 original publications were quantitatively evaluated in 3 separate meta-analyses, based on predefined selection criteria. Two-level and 3-level random effects meta-analysis revealed a significant overall effect of heat treatment on colostral viscosity and IgG concentration, and serum IgG concentration in newborns.  © 2023 American Dairy Science Association  aColostrum management and transfer of passive immunity  aColostrum-borne pathogens  aIgG denaturation  aMulti-level meta-analysis  aNeonatal infectious diseases  aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA1 aFRAGA, M.1 aMENDOZA, A.1 aGIANNITTI, F.  tJournal of Dairy Science, 2023. https://doi.org/10.3168/jds.2022-22555 -- [Article In Press]. OPEN ACCESS.