04216naa a2200709 a 450000100080000000500110000800800410001902200140006002400360007410000190011024501610012926000090029050009520029952012780125165300120252965300190254165300220256065300130258265300100259570000140260570000170261970000210263670000190265770000180267670000210269470000160271570000210273170000190275270000150277170000190278670000210280570000170282670000180284370000160286170000200287770000170289770000210291470000170293570000150295270000150296770000180298270000210300070000160302170000170303770000210305470000160307570000150309170000170310670000180312370000170314170000160315870000300317470000230320470000180322770000290324570000270327470000170330170000150331870000170333370000150335077301410336510640442023-04-19       2023    bl uuuu     u00u1 u    #d  a1297-96867 a10.1186/s12711-023-00797-z2DOI1 aCECCOBELLI, S.  aA comprehensive analysis of the genetic diversity and environmental adaptability in worldwide Merino and Merino-derived sheep breeds.h[electronic resource]  c2023  aArticle history: Received 27 July 2022; Accepted 24 March 2023; Published 03 April 2023. -- Corresponding author: Simone Ceccobelli, email: s.ceccobelli@staff.univpm.it -- Document type: Article, Gold Open Access. -- FUNDING: This study was supported in part by the "Fondazione Cassa di Risparmio di Perugia" (Project "Promozione e valorizzazione delle razze ovine di derivazione Merinos", Agreement No. 2017.0470.013-Ricerca scientifica e tecnologica) and WOOLLY project approved by Apulia Regional government within the program "Contribution to innovative scientific research projects of high international standard" (art. 22 della legge regionale 30 novembre 2019, n. 52). The SNP-genotyping of the Groznensk and Salsk breeds was financially supported by the RMSHE, grant no. 075-15-2021-1037 (internal no. 15.BPK.21.0001). SNP-genotyping of Kyrgyz Mountain Merino was supported by RSF No. 21-6600007. -- Supplementary Information available. --  aBACKGROUND: To enhance and extend the knowledge about the global historical and phylogenetic relationships between Merino and Merino-derived breeds, 19 populations were genotyped with the OvineSNP50 BeadChip specifically for this study, while an additional 23 populations from the publicly available genotypes were retrieved. Three complementary statistical tests, Rsb (extended haplotype homozygosity between-populations), XP-EHH (cross-population extended haplotype homozygosity), and runs of homozygosity (ROH) islands were applied to identify genomic variants with potential impact on the adaptability of Merino genetic type in two contrasting climate zones. CONCLUSIONS: To the best of our knowledge, this is the first comprehensive dataset that includes most of the Merino and Merino-derived sheep breeds raised in different regions of the world. The results provide an in-depth picture of the genetic makeup of the current Merino and Merino-derived breeds, highlighting the possible selection pressures associated with the combined effect of anthropic and environmental factors. The study underlines the importance of Merino genetic types as invaluable resources of possible adaptive diversity in the context of the occurring climate changes. © 2023. The Author(s).  aAnimals  aDomestic sheep  aGenetic Variation  aGenotype  aSheep1 aLANDI, V.1 aSENCZUK , G.1 aMASTRANGELO , S.1 aSARDINA , M.T.1 aBEN-JEMAA, S.1 aPERSICHILLI , C.1 aKARSLI , T.1 aBÂLTEANU, V.-A.1 aRASCHIA , M.A.1 aPOLI, M.A.1 aCIAPPESONI, G.1 aMUCHADEYI , F.C.1 aDZOMBA, E.F.1 aKUNENE , N.W.1 aLÜHKEN, G.1 aDENISKOVA, T.E.1 aDOTSEV, A.V.1 aZINOVIEVA , N.A.1 aZSOLNAI , A.1 aANTON , I.1 aKUSZA , S.1 aCAROLINO , N.1 aSANTOS-SILVA, F.1 aKAWECKA, A.1 aSWIATEK , M.1 aNIZNIKOWSKI , R.1 aSPEHAR , M.1 aANAYA , G.1 aGRANERO , A.1 aPERLOIRO , T.1 aCARDOSO , P.1 aGRANDE , S.1 aLÓPEZ DE LOS SANTOS , B.1 aDANCHIN-BURGE , C.1 aPASQUINI , M.1 aMARTÍNEZ MARTÍNEZ , A.1 aDELGADO BERMEJO , J.V.1 aLASAGNA , E.1 aCIANI , E.1 aSARTI , F.M.1 aPILLA , F.  tGenetics, Selection, Evolution : GSE, 2023, volume 55, issue 1, article 24. OPEN ACCESS. doi: https://doi.org/10.1186/s12711-023-00797-z