02878naa a2200361 a 450000100080000000500110000800800410001902200140006002400360007410000170011024502200012726000090034750007320035652009830108865300110207165300170208265300140209965300490211365300240216265300120218665300200219870000150221870000150223370000190224870000240226770000180229170000190230970000150232870000150234370000180235870000140237677301260239010639462023-04-27       2023    bl uuuu     u00u1 u    #d  a1517-83827 a10.1007/s42770-022-00898-92DOI1 aCASAUX, M.L.  aEpidemiological and clinicopathological findings in 15 fatal outbreaks of salmonellosis in dairy calves and virulence genes in the causative Salmonella enterica Typhimurium and Dublin strains.h[electronic resource]  c2023  aArticle history: Received 06 December 2021; Accepted 20 December 2022; Published 05 January 2023. -- Correspondence author:  Fraga, M.; Plataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria (INIA), Estación Experimental La Estanzuela, Ruta 50, Km 11, El Semillero, Uruguay; email:mfraga@inia.org.uy  -- Funding: This work was partially funded by INIA's grant PL-15, project FMV-104922 from the Uruguayan "Agencia Nacional de Investigación e Innovación" (ANII) and ANII (POS_NAC_2016_1_130296). -- Responsible Editor: Luiz Henrique Rosa. Supplementary information: https://static-content.springer.com/esm/art%3A10.1007%2Fs42770-022-00898-9/MediaObjects/42770_2022_898_MOESM1_ESM.xlsx  aABSTRACT.- Salmonella enterica is a major food-borne pathogen that affects cattle-rearing systems worldwide. Little information is available on the epidemiology and pathology of salmonellosis and the virulence genes (VGs) carried by Salmonella in spontaneous outbreaks in cattle. We describe epidemiological findings in 15 fatal outbreaks of salmonellosis in Uruguayan dairy farms and the age, clinical signs, and pathology in 20 affected calves. We also describe the serotypes and frequencies of 17 VGs in the causative Salmonella strains and explore their associations with epidemiological, clinical, and pathological findings. Salmonella Typhimurium and Dublin were identified in 11/15 and 4/15 outbreaks, respectively. The most frequent reason for consultation was digestive disease (8 outbreaks caused by S. Typhimurium), followed by sudden death (4 outbreaks, 3 caused by S. Dublin). © 2023, The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia.  aCalves  aEpidemiology  aPathology  aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL  aSalmonella enterica  aUruguay  aVirulence genes1 aNETO, W.S.1 aSCHILD, C.1 aCOSTA, R.A. DA1 aMACÍAS-RIOSECO, M.1 aCAFFARENA, D.1 aSILVEIRA, C.S.1 aARÁOZ, V.1 aDONCEL, B.1 aGIANNITTI, F.1 aFRAGA, M.  tBrazilian Journal of Microbiology, 2023, volume 54, isuue 1, pp. 475-490. doi: https://doi.org/10.1007/s42770-022-00898-9