02109naa a2200325 a 450000100080000000500110000800800410001902200140006002400390007410000160011324501310012926000090026050006460026952004910091565300210140665300200142765300230144765300280147065300210149865300130151970000250153270000180155770000180157570000200159370000180161370000170163170000200164870000170166877300980168510631952022-06-02       2022    bl uuuu     u00u1 u    #d  a0041-01017 a10.1016/j.toxicon.2022.05.0042DOI1 aMACHADO, M.  aNeurological and gastrointestinal manifestations of spontaneous poisoning by Ricinus communis in goats.h[electronic resource]  c2022  aArticle history: Received 20 April 2022; Received in revised form 4 May 2022; Accepted 13 May 2022; Available online 20 May 2022. Corresponding author: Machado, M.; Instituto Nacional de Investigación Agropecuaria, Plataforma de Salud Animal, Estación Experimental INIA Tacuarembó, Tacuarembó, Uruguay; email:mizaelmachado@hotmail.com  --  This research was financed in part by the Coordination for the Improvement of Higher Education Personnel - Brazil ( CAPES ) - Finance Code 001 . We thank the National Council for Scientific and Technological Development ( CNPq ) for the Research Productivity grant (PQ), process n. 307909/2021-2 .  aABSTRACT - An outbreak of Ricinus communis poisoning in goats with neurological and digestive changes was related to the ingestion of different vegetative parts of the plant. Two poisoned animals died within 5 h of the plant intake showing necrotic gastroenteritis and hepatocytes degeneration and necrosis. Toxicological analysis by HPLC-DAD assay demonstrated 21.1?25.1 μg/g of ricinine in samples of ruminal fluids and 10.1?10.9 μg/g in the liver of poisoned goats. © 2022  aCastor oil plant  aGastroenteritis  aNeurological signs  aPLATAFORMA SALUD ANIMAL  aPoisonous plants  aRicinine1 aQUEIROZ, CINTIA R.R.1 aWILSON, T. M.1 aSOUSA, D.E.R.1 aSOTO-BLANCO, B.1 aARMIÉN, A.G.1 aBARROS, S.S.1 aRIET-CORREA, F.1 aCASTRO, M.B.  tToxicon, July 2022, vol. 214, pages 74-77. doi: https://doi.org/10.1016/j.toxicon.2022.05.004