02979naa a2200385 a 450000100080000000500110000800800410001902400310006010000160009124501670010726000090027450003070028352015330059065000110212365000150213465000190214965000120216865000100218065300250219065300220221565300140223765300150225165300210226665300200228765300100230765300200231765300120233770000190234970000170236870000170238570000210240270000150242370000190243877301360245710613322022-09-06       2020    bl uuuu     u00u1 u    #d7 a10.3390/vetsci70301162DOI1 aMENDOZA, Y.  aUnraveling honey bee-varroa destructor interactionbMultiple factors involved in differential resistance between two uruguayan populations.h[electronic resource]  c2020  aArticle history: Received: 26 July 2020/ Accepted: 17 August 2020/ Published: 20 August 2020./This research was funded by the Instituto Nacional de Investigación Agropecuaria (INIA), grant number PF10, and the Agencia Nacional de Investigación e Innovación (ANII), grant number POS-NAC-2013-1-12259.  aAbstract: The ectoparasite Varroa destructor is the greatest biotic threat of honey bees Apis mellifera in vast regions of the world. Recently, the study of natural mite-resistant populations has gained much interest to understand the action of natural selection on the mechanisms that limit the mite population.In this study, the components of the A. mellifera?V. destructor relationship were thoroughly examined and compared in resistant and susceptible honey bee populations from two regions of Uruguay.Mite-resistant honey bees have greater behavioral resistance (hygienic and grooming behaviors) than susceptible honey bees. At the end of the summer, resistant honey bees had fewer mites and a lower deformed wing virus (DWV) viral load than susceptible honey bees. DWV variant A was the only detected variant in honey bees and mites. Molecular analysis by Short Tandem Repeat showed that resistant honey bees were Africanized (A. m. scutellata hybrids), whereas susceptible honey bees were closer to European subspecies. Furthermore, significant genetic differentiation was also found between the mite populations. The obtained results show that the natural resistance of honey bees to V. destructor in Uruguay depends on several factors and that the genetic variants of both organisms can play a relevant role. Supplementary Materials: The following are available online at http://www.mdpi.com/2306-7381/7/3/116/s1,Figure S1: Honey bee population allocation by the Structure program based on the genotyping of 5 STR loci.  aABEJAS  aAPICULTURA  aCOMPORTAMIENTO  aURUGUAY  aVIRUS  aABEJAS AFRICANIZADAS  aABEJAS MELÍFERAS  aBEHAVIOUR  aHONEY BEES  aINMUNIDAD SOCIAL  aMICROSATELLITES  aMITES  aSOCIAL INMUNITY  aVIRUSES1 aTOMASCO , I.H.1 aANTÚNEZ, K.1 aCASTELLI, L.1 aBRANCHICCELA, B.1 aSANTOS, E.1 aINVERNIZZI, C.  tVeterinary Sciences, September 2020, Volume 7, Issue 3, Article number 116. OPEN ACCESS. Doi: https://doi.org/10.3390/vetsci7030116